Homology Modeling

Author : Sławomir Filipek
Publisher : Springer Nature
Page : 379 pages
File Size : 41,5 Mb
Release : 2023-03-23
Category : Science
ISBN : 9781071629741

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Homology Modeling by Sławomir Filipek Pdf

This detailed volume provides state-of-the-art methodologies and reviews of important topics in the field of homology modeling. From homology modeling in the twilight zone and improving accuracy through sequence space analysis to approaches to construct multi-protein complex models, the book explores a wide variety of uses and applications of this valuable technique. Written for the highly successful Methods in Molecular Biology series, the chapters include introductions to their respective topics, lists of the necessary programs, webservers, and databases, step-by-step and readily reproducible protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Homology Modeling: Methods and Protocols serves as an ideal guide to recent homology modeling procedures, assumptions made, and model quality assessment that will illuminate the black box of homology modeling for novice readers and broaden the knowledge of this methodology for professionals.

Author : Andrew J. W. Orry,Ruben Abagyan
Publisher : Humana Press
Page : 419 pages
File Size : 47,8 Mb
Release : 2012-02-10
Category : Science
ISBN : 1617795879

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Homology Modeling by Andrew J. W. Orry,Ruben Abagyan Pdf

Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.

Author : Rafael Trindade Maia,Rômulo Maciel de Moraes Filho,Magnólia De Araújo Campos
Publisher : BoD – Books on Demand
Page : 147 pages
File Size : 44,6 Mb
Release : 2021-03-10
Category : Science
ISBN : 9781839628054

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Homology Molecular Modeling by Rafael Trindade Maia,Rômulo Maciel de Moraes Filho,Magnólia De Araújo Campos Pdf

Homology modeling is an extremely useful and versatile technique that is gaining more and more space and demand in research in computational and theoretical biology. This book, “Homology Molecular Modeling - Perspectives and Applications”, brings together unpublished chapters on this technique. In this book, 7 chapters are intimately related to the theme of molecular modeling, carefully selected and edited for academic and scientific readers. It is an indispensable read for anyone interested in the areas of bioinformatics and computational biology. Divided into 4 sections, the reader will have a didactic and comprehensive view of the theme, with updated and relevant concepts on the subject. This book was organized from researchers to researchers with the aim of spreading the fascinating area of molecular modeling by homology.

Author : Andrew J. W. Orry,Ruben Abagyan
Publisher : Humana Press
Page : 419 pages
File Size : 50,8 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493958801

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Homology Modeling by Andrew J. W. Orry,Ruben Abagyan Pdf

Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.

Author : Michael Jason Bower
Publisher : Unknown
Page : 356 pages
File Size : 54,6 Mb
Release : 1997
Category : Homology theory
ISBN : UCAL:X66713

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The Development of New Tools for Homology Modeling by Michael Jason Bower Pdf

Author : Li Fan
Publisher : Unknown
Page : 340 pages
File Size : 44,9 Mb
Release : 2000
Category : DNA polymerases
ISBN : MSU:31293020489138

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Homology Modeling of the Accessory Subunit of Drosophila Mitochondrial DNA Polymerase and Subunit Interaction Studies by Li Fan Pdf

Author : Neha Yadav,Anupam Yadav,Jagdish Chand Bansal,Kusum Deep,Joong Hoon Kim
Publisher : Springer
Page : 1238 pages
File Size : 41,5 Mb
Release : 2018-08-23
Category : Technology & Engineering
ISBN : 9789811307614

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Harmony Search and Nature Inspired Optimization Algorithms by Neha Yadav,Anupam Yadav,Jagdish Chand Bansal,Kusum Deep,Joong Hoon Kim Pdf

The book covers different aspects of real-world applications of optimization algorithms. It provides insights from the Fourth International Conference on Harmony Search, Soft Computing and Applications held at BML Munjal University, Gurgaon, India on February 7–9, 2018. It consists of research articles on novel and newly proposed optimization algorithms; the theoretical study of nature-inspired optimization algorithms; numerically established results of nature-inspired optimization algorithms; and real-world applications of optimization algorithms and synthetic benchmarking of optimization algorithms.

Author : Weibo Cai,Hao Hong
Publisher : BoD – Books on Demand
Page : 488 pages
File Size : 45,8 Mb
Release : 2012-03-30
Category : Science
ISBN : 9789535103974

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Protein-Protein Interactions by Weibo Cai,Hao Hong Pdf

Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Author : Anonim
Publisher : Elsevier
Page : 4609 pages
File Size : 50,9 Mb
Release : 2017-06-03
Category : Technology & Engineering
ISBN : 9780128032015

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Comprehensive Medicinal Chemistry III by Anonim Pdf

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Author : Jenny Gu,Philip E. Bourne
Publisher : John Wiley & Sons
Page : 1105 pages
File Size : 54,9 Mb
Release : 2011-09-20
Category : Science
ISBN : 9781118210567

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Structural Bioinformatics by Jenny Gu,Philip E. Bourne Pdf

Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: "This book is a gold mine of fundamental and practical information in an area not previously well represented in book form." —Biochemistry and Molecular Education "... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students." —BAMBED "...a useful and timely summary of a rapidly expanding field." —Nature Structural Biology "...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." —Briefings in Bioinformatics

Author : Marianna Torok
Publisher : Elsevier
Page : 568 pages
File Size : 47,9 Mb
Release : 2022-08-26
Category : Medical
ISBN : 9780128232712

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Contemporary Chemical Approaches for Green and Sustainable Drugs by Marianna Torok Pdf

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Author : Anders Liljas,Lars Liljas,Jure Piskur,Göran Lindblom,Poul Nissen,Morten Kjeldgaard
Publisher : World Scientific Publishing Company
Page : 580 pages
File Size : 47,9 Mb
Release : 2009-02-04
Category : Science
ISBN : 9789814365406

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Textbook of Structural Biology by Anders Liljas,Lars Liljas,Jure Piskur,Göran Lindblom,Poul Nissen,Morten Kjeldgaard Pdf

This is an important textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. Written by a team of leading scientists in the field, it covers all the essential aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution — the comparative structural biology. The focus is on interesting and relevant molecular structures as well as central biology. This comprehensive volume is richly illustrated with more than 200 color figures. So far, there has been a lack of comprehensive textbooks on structural biology that are up to date; this book is written to fill the gap. An accompanying CD contains high-resolution images that can be projected in a classroom.

Author : Ponnadurai Ramasami
Publisher : Walter de Gruyter GmbH & Co KG
Page : 194 pages
File Size : 55,5 Mb
Release : 2020-08-10
Category : Science
ISBN : 9783110631623

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Computational Chemistry Methods by Ponnadurai Ramasami Pdf

This book reviews a variety of methods in computational chemistry and their applications in different fields of current research. Ab initio methods and regression analyses are discussed with special focus on their application to investigate chemical structures as for example dyes or drug compounds. Further topics are the use of computational methods in the modeling of spectroscopic data or to study reaction mechanisms.

Author : Rajiv Tyagi
Publisher : Discovery Publishing House
Page : 250 pages
File Size : 43,6 Mb
Release : 2009
Category : Medical genetics
ISBN : 818356464X

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Computational Genetics by Rajiv Tyagi Pdf

Author : Tripathy, B.K.
Publisher : IGI Global
Page : 405 pages
File Size : 52,8 Mb
Release : 2013-12-31
Category : Computers
ISBN : 9781466649415

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Advances in Secure Computing, Internet Services, and Applications by Tripathy, B.K. Pdf

Technological advancements have extracted a vast amount of useful knowledge and information for applications and services. These developments have evoked intelligent solutions that have been utilized in efforts to secure this data and avoid potential complex problems. Advances in Secure Computing, Internet Services, and Applications presents current research on the applications of computational intelligence in order to focus on the challenge humans face when securing knowledge and data. This book is a vital reference source for researchers, lecturers, professors, students, and developers, who have interest in secure computing and recent advanced in real life applications.