Hormone Resistance Syndromes

Author : J. Larry Jameson
Publisher : Springer Science & Business Media
Page : 285 pages
File Size : 48,6 Mb
Release : 1999-01-26
Category : Medical
ISBN : 9781592596980

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Hormone Resistance Syndromes by J. Larry Jameson Pdf

Leading clinicians review in depth the clinical and molecular aspects of the hormone resistance syndromes caused by receptor mutations. These mutations are involved in a large number of disorders, including dwarfism, Laron syndrome, pseudohypoparathyroidism, insulin resistance, resistance to thyroid hormone, glucocorticoid resistance, hereditary resistance to vitamin D, and estrogen resistance. Throughout, the book's distinguished contributors not only summarize the clinical features of these and related disorders, but also illuminate their molecular bases. Hormone Resistance Syndromes provides an authoritative summary and standard reference for all those clinicians and researchers actively studying these mutations today and affords a unique opportunity to understand hormone action in normal physiology.

Author : M. Maghnie,S. Loche,M. Cappa,L. Ghizzoni,R. Lorini
Publisher : Karger Medical and Scientific Publishers
Page : 170 pages
File Size : 46,6 Mb
Release : 2013-02-04
Category : Medical
ISBN : 9783318022681

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Hormone Resistance and Hypersensitivity by M. Maghnie,S. Loche,M. Cappa,L. Ghizzoni,R. Lorini Pdf

Over recent years, impressive advances in genetic/epigenetic technology have greatly improved the understanding of the pathogenesis of pediatric endocrine diseases due to hormone resistance and hypersensitivity.This book presents reviews of thyroid hormone and thyroid hormone receptor resistance, and genetics and epigenetics of parathyroid hormone resistance. Abnormalities of the pituitary-gonadal axis affecting puberty as well as androgen receptor are covered. Novel insights into the diseases affecting ACTH, glucocorticoid and aldosterone receptors are discussed. Further chapters address new aspects of the physiology of the GH and IGF-1 axis as well as the diseases related to GH-IGF-1 receptor and post-receptor signaling defects. A key chapter on metabolic insights into insulin resistance is also included. Covering clinical and genetic aspects of hormone resistance and hypersensitivity, this book will be a useful tool in the hands of scientists, physicians and other healthcare professionals who wish to be up to date with novel research findings in this area.

Author : J. Larry Jameson
Publisher : Unknown
Page : 296 pages
File Size : 46,9 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475754175

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Hormone Resistance Syndromes by J. Larry Jameson Pdf

Author : Paolo Beck-Peccoz
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781402078521

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Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis by Paolo Beck-Peccoz Pdf

Truly unique cutting edge state of the art information on basic and clinical research. A great help for the clinician to diagnose and treat this uncommon hormone resistance. Basic scientists learn how much has been discovered on the mechanism of hormone action from the mutations of the various genes involved to thyroid hormones and TSH.

Author : George P. Chrousos,D. Lynn Loriaux,Mortimer B. Lipsett
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468451016

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Steroid Hormone Resistance by George P. Chrousos,D. Lynn Loriaux,Mortimer B. Lipsett Pdf

This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.

Author : Peter Igaz,Attila Patócs
Publisher : Springer Nature
Page : 476 pages
File Size : 45,7 Mb
Release : 2019-10-06
Category : Science
ISBN : 9783030259051

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Genetics of Endocrine Diseases and Syndromes by Peter Igaz,Attila Patócs Pdf

This book provides a comprehensive overview of the genetic basis underlying endocrine diseases. It covers both the molecular and clinical consequences of these genetic defects, as well as the relevance for clinical care, highlighting issues of genetic counseling. Several endocrine diseases have a genetic background, and contemporary research in the field plays a crucial role in the clinical care of endocrine diseases. In recent years, there have been major developments in our understanding of the genetic basis of endocrine diseases. Several novel genes and mutations predisposing individuals to monogenic endocrine diseases have been discovered, and with the advent of next generation sequencing, a huge amount of new data has become available. Further, novel molecular mechanisms, such as genomic imprinting, have been implicated in the pathogenesis of endocrine diseases. A better understanding of the genetic background of these diseases is relevant not only from the research perspective, but also in terms of clinical care. As such, this book is an essential read for both researchers and clinicians working in the field.

Author : Margo P. Cohen,Piero P. Foa
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461247586

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Hormone Resistance and Other Endocrine Paradoxes by Margo P. Cohen,Piero P. Foa Pdf

Endocrinology and Metabolism: Progress in Research and Clinical Prac tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata gems.

Author : Markus Luster,Leonidas H. Duntas,Leonard Wartofsky
Publisher : Springer
Page : 770 pages
File Size : 45,7 Mb
Release : 2019-01-08
Category : Medical
ISBN : 9783319721026

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The Thyroid and Its Diseases by Markus Luster,Leonidas H. Duntas,Leonard Wartofsky Pdf

This book is an up-to-date and comprehensive guide to all the common thyroid disorders that may be seen by internists, endocrinologists, nuclear medicine physicians, and endocrine surgeons. While the fundamentals of thyroid hormone function and regulation in health and disease are well covered, the primary focus is on the clinical approach to thyroid disease, with detailed coverage of both initial diagnosis and management and the role of imaging. Because most endocrine diseases are chronic and lifelong, special emphasis is placed on long-term management and the common pitfalls that may be encountered by the clinician. The editors are internationally acknowledged leaders in the field of thyroid disease and have gathered an outstanding team of authors, all of whom are also highly expert in their respective areas, but who, equally importantly, write in a clear and lucid style. The numerous isotope scan and ultrasonographic images ensure that the book will serve as a valuable reference atlas to which the physician will return again and again.

Author : P. Jaquet
Publisher : S Karger Ag
Page : 104 pages
File Size : 45,5 Mb
Release : 1993-05-17
Category : Medical
ISBN : 3805557841

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Hormonal Resistance Syndromes by P. Jaquet Pdf

Author : Martin O. Savage
Publisher : Unknown
Page : 9 pages
File Size : 40,6 Mb
Release : 1996
Category : Insulin-like growth factor-binding proteins
ISBN : 0702020931

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Growth Hormone Resistance by Martin O. Savage Pdf

Examining growth hormone resistance, this text includes coverage of such topics as: growth hormone receptor signalling; metabolic actions of growth hormone - direct and indirect; and IGF bioactivity and its modification in growth hormone resistance in childhood.

Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Page : 241 pages
File Size : 54,9 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579926

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Growth Hormone Deficiency in Adults by Jens O. L. Jørgensen,Jens Sandahl Christiansen Pdf

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Author : Leonid Poretsky
Publisher : Springer Science & Business Media
Page : 764 pages
File Size : 45,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475762600

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Principles of Diabetes Mellitus by Leonid Poretsky Pdf

Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.

Author : Manuela Simoni,Ilpo T. Huhtaniemi
Publisher : Springer
Page : 1364 pages
File Size : 42,8 Mb
Release : 2017-09-18
Category : Medical
ISBN : 3319444409

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Endocrinology of the Testis and Male Reproduction by Manuela Simoni,Ilpo T. Huhtaniemi Pdf

This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function, the clinical approach to disorders of male reproduction, male hypogonadism, sexual dysfunction, and male infertility. In addition, sociodemographic, psychological, and ethical aspects of male reproductive disorders are discussed. The book is intended as a major reference for endocrinologists, andrologists, and sexologists, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.

Author : George P. Chrousos,Jerrold M. Olefsky,Ellis Samols
Publisher : Unknown
Page : 542 pages
File Size : 46,9 Mb
Release : 2002
Category : Medical
ISBN : 0781714974

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Hormone Resistance and Hypersensitivity States by George P. Chrousos,Jerrold M. Olefsky,Ellis Samols Pdf

Physiologic adaptations and pathologic states that result from changes of target tissue sensitivity to hormones are vital concerns in endocrinology. Part of the Modern Endocrinology Series, this text features an overview of the human hormone resistance and hypersensitivity syndromes due to pre-receptor, receptor and postreceptor abnormalities. Focuses on the pivotal study of the etiology of common conditions, such as obesity and essential hypertension, in chapters written by experts who have performed primary research in hormone action. A Brandon-Hill recommended title.

Author : Jack Challem,Burton Berkson,Melissa Diane Smith
Publisher : Turner Publishing Company
Page : 267 pages
File Size : 46,8 Mb
Release : 2008-04-21
Category : Health & Fitness
ISBN : 9780470311981

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Syndrome X by Jack Challem,Burton Berkson,Melissa Diane Smith Pdf

You can feel great again! "Syndrome X proactively lays out a nutritious, tasty, and simple diet plan to get us back to the basics of healthy nutrition."-Lendon H. Smith, M.D., New York Times bestselling author of Feed Your Body Right "Syndrome X is the best new book to help you understand the facts about nutrition, health, and aging. . . . It is full of new information and insights most readers have never had access to before. Everyone who values his or her health will want to read the book and then individualize the program to suit his or her needs-the authors have made this easier than ever to do."-Richard A. Kunin, M.D., author of Mega-Nutrition What is Syndrome X? It's a resistance to insulin-the hormone needed to burn food for energy-combined with high cholesterol or triglycerides, high blood pressure, or too much body fat. Syndrome X ages you prematurely and significantly increases your risk of heart disease, hypertension, obesity, eye disease, nervous system disorders, diabetes, Alzheimer's, cancer, and other age-related diseases. Syndrome X is the first book to tell you how to fight the epidemic disorder that is derailing the health of nearly a third of North Americans. It outlines a complete three-step program-including easy-to-follow diets, light physical activity, and readily available vitamins and nutritional supplements-that will safeguard you against developing Syndrome X or reverse it if you already have it.