How To Overcome The Antibiotic Crisis

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How to Overcome the Antibiotic Crisis

Marc Stadler,Petra Dersch
How to Overcome the Antibiotic Crisis Book PDF

Author : Marc Stadler,Petra Dersch
Publisher : Unknown
Page : 128 pages
File Size : 50,7 Mb
Release : 2016
Category : Antibiotics
ISBN : 3319492837

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How to Overcome the Antibiotic Crisis by Marc Stadler,Petra Dersch Pdf

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the "bad bugs" are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

How to Overcome the Antibiotic Crisis

Marc Stadler,Petra Dersch
How to Overcome the Antibiotic Crisis Book PDF

Author : Marc Stadler,Petra Dersch
Publisher : Springer
Page : 496 pages
File Size : 54,5 Mb
Release : 2016-12-21
Category : Medical
ISBN : 9783319492841

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How to Overcome the Antibiotic Crisis by Marc Stadler,Petra Dersch Pdf

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Treating Infectious Diseases in a Microbial World

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Treating Infectious Diseases in a Microbial World Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 45,8 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

When Antibiotics Fail

The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
When Antibiotics Fail Book PDF

Author : The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
Publisher : Council of Canadian Academies
Page : 268 pages
File Size : 48,6 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9781926522753

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When Antibiotics Fail by The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada Pdf

When Antibiotics Fail examines the current impacts of AMR on our healthcare system, projects the future impact on Canada’s GDP, and looks at how widespread resistance will influence the day-to-day lives of Canadians. The report examines these issues through a One Health lens, recognizing the interconnected nature of AMR, from healthcare settings to the environment to the agriculture sector. It is the most comprehensive report to date on the economic impact of AMR in Canada.

Antibiotics

Mary E. Wilson
Antibiotics Book PDF

Author : Mary E. Wilson
Publisher : What Everyone Needs to Know(r)
Page : 433 pages
File Size : 43,9 Mb
Release : 2019
Category : Medical
ISBN : 9780190663414

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Antibiotics by Mary E. Wilson Pdf

Virtually everyone has taken antibiotics. They can be lifesavers -- and they can be useless. What are they? How are they used? And what happens as the effectiveness of antibiotics continues to decline? Antibiotics: What Everyone Needs to Know(R) examines the personal and societal implications of our planet's most important -- and frequently misused -- medications. In a question-and-answer format, it unpacks the most complicated aspects of this issue, including: How antibiotics are used (and overused) in humans, plants, and livestock; the causes and consequences of bacterial resistance to antibiotics; how the globalized world enables antibiotic resistance to spread quickly; and the difficult decisions ahead for both medical care and the food system. Grounded in the latest scientific research and crafted for general readers, Antibiotics: What Everyone Needs to Know(R) offers a clear-eyed overview of where we are, and what the future holds, as antibiotics lose their power.

Mechanisms of antibiotic resistance

Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Mechanisms of antibiotic resistance Book PDF

Author : Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Publisher : Frontiers Media SA
Page : 226 pages
File Size : 42,5 Mb
Release : 2015-06-01
Category : Antibiotics
ISBN : 9782889195268

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Mechanisms of antibiotic resistance by Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang Pdf

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Strategies to Overcome Superbug Invasions: Emerging Research and Opportunities

Chopra, Dimple Sethi,Kaul, Ankur
Strategies to Overcome Superbug Invasions Emerging Research and Opportunities Book PDF

Author : Chopra, Dimple Sethi,Kaul, Ankur
Publisher : IGI Global
Page : 319 pages
File Size : 42,5 Mb
Release : 2021-06-25
Category : Medical
ISBN : 9781799803096

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Strategies to Overcome Superbug Invasions: Emerging Research and Opportunities by Chopra, Dimple Sethi,Kaul, Ankur Pdf

Recently, there has been an upsurge in microbial infections. Extensive and inappropriate usage of antimicrobial drugs in treating infections has led to the evolution of a resistant strain of microorganisms and irreversible immunosuppression in humans. Medical institutions and hospitals require solutions to combat these contagions in order to avoid future epidemics. Strategies to Overcome Superbug Invasions: Emerging Research and Opportunities highlights current research and potential strategies to prevent the emergence and re-emergence of drug-resistant pathogenic microbial strains. The content within this publication examines biosensing, global initiatives, nanomaterials, and alternative therapies. It is designed for microbiologists, biotechnologists, pharmacists, pharmacologists, virologists, formulation scientists, infectious disease specialists, government officials, policymakers, healthcare practitioners, doctors, nurses, hospital directors, researchers, surgeons, and academicians who are seeking research on innovative solutions for multi-drug-resistant infections.

Antimicrobial Resistance

World Health Organization
Antimicrobial Resistance Book PDF

Author : World Health Organization
Publisher : Unknown
Page : 232 pages
File Size : 49,9 Mb
Release : 2014
Category : Medical
ISBN : 9241564741

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Antimicrobial Resistance by World Health Organization Pdf

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

Ethics and Drug Resistance: Collective Responsibility for Global Public Health

Euzebiusz Jamrozik,Michael Selgelid
Ethics and Drug Resistance Collective Responsibility for Global Public Health Book PDF

Author : Euzebiusz Jamrozik,Michael Selgelid
Publisher : Springer
Page : 448 pages
File Size : 54,9 Mb
Release : 2021-08-21
Category : Philosophy
ISBN : 303027876X

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Ethics and Drug Resistance: Collective Responsibility for Global Public Health by Euzebiusz Jamrozik,Michael Selgelid Pdf

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

Antibiotic Discovery and Development

Thomas J. Dougherty,Michael J. Pucci
Antibiotic Discovery and Development Book PDF

Author : Thomas J. Dougherty,Michael J. Pucci
Publisher : Springer Science & Business Media
Page : 1119 pages
File Size : 53,7 Mb
Release : 2011-12-18
Category : Medical
ISBN : 9781461414001

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Antibiotic Discovery and Development by Thomas J. Dougherty,Michael J. Pucci Pdf

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Antibiotic Use in Animals

Sara Savic
Antibiotic Use in Animals Book PDF

Author : Sara Savic
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 48,7 Mb
Release : 2018-01-31
Category : Medical
ISBN : 9789535137504

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Antibiotic Use in Animals by Sara Savic Pdf

The book Antibiotic Use in Animals has everything said in the title, but it is not only meant for the veterinarians. It is intended to be used also by the medical doctors, animal owners, consumers of food of animal origin, etc. The book has five sections: "Introduction," "Use of Antibiotics in Animals," "Antibiotics and Nutrition," "Probiotics," and "Antimicrobial Resistance." Each of the sections discusses about one side of the antibiotic usage. Each group of authors has dedicated their work to one of the topics with key roles of antibiotics in the health of animals and public health in general. This book is a work of scientists and researchers in the topic of antibiotic use, and with this book, we hope to open new questions and deepen the research on roles of antibiotics in everyday life.

Antibiotics and Antibiotic Resistance

Ola Sköld
Antibiotics and Antibiotic Resistance Book PDF

Author : Ola Sköld
Publisher : John Wiley & Sons
Page : 181 pages
File Size : 42,5 Mb
Release : 2011-10-07
Category : Medical
ISBN : 9781118075586

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Antibiotics and Antibiotic Resistance by Ola Sköld Pdf

This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.

Drug Resistance in Bacteria, Fungi, Malaria, and Cancer

Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
Drug Resistance in Bacteria Fungi Malaria and Cancer Book PDF

Author : Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
Publisher : Springer
Page : 630 pages
File Size : 44,7 Mb
Release : 2017-03-21
Category : Medical
ISBN : 9783319486833

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Drug Resistance in Bacteria, Fungi, Malaria, and Cancer by Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia Pdf

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Extending the Cure

Ramanan Laxminarayan,Anup Malani,David Howard,David L. Smith
Extending the Cure Book PDF

Author : Ramanan Laxminarayan,Anup Malani,David Howard,David L. Smith
Publisher : Routledge
Page : 193 pages
File Size : 48,8 Mb
Release : 2010-09-30
Category : Medical
ISBN : 9781136527609

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Extending the Cure by Ramanan Laxminarayan,Anup Malani,David Howard,David L. Smith Pdf

Our ability to treat common bacterial infections with antibiotics goes back only 65 years. However, the authors of this report make it clear that sustaining a supply of effective and affordable antibiotics cannot be without changes to the incentives facing patients, physicians, hospitals, insurers, and pharmaceutical manufacturers. In fact, increasing resistance to these drugs is already exacting a terrible price. Every day in the United States, approximately 172 men, women, and children die from infections caused by antibiotic-resistant bacteria in hospitals alone. Beyond those deaths, antibiotic resistance is costing billions of dollars through prolonged hospital stays and the need for doctors to resort to ever more costly drugs to use as substitute treatments. Extending the Cure presents the problem of antibiotic resistance as a conflict between individual decision makers and their short-term interest and the interest of society as a whole, in both present and future: The effort that doctors make to please each patient by prescribing a drug when it might not be properly indicated, poor monitoring of discharged patients to ensure that they do not transmit drug-resistant pathogens to other persons, excesses in the marketing of new antibiotics, and the broad overuse of antibiotics all contribute to the development and spread of antibiotic-resistant bacteria. The book explores a range of policy options that would encourage patients, health care providers, and managed care organizations to serve as more responsible stewards of existing antibiotics as well as proposals that would give pharmaceutical firms greater incentives to develop new antibiotics and avoid overselling. If the problem continues unaddressed, antibiotic resistance has the potential to derail the health care system and return us to a world where people of all ages routinely die from simple infections. As a basis for future research and a spur to a critically important dialogue, Extending the Cure is a fundamental first step in addressing this public health crisis. The Extending the Cure project is funded in part by the Robert Wood Johnson Foundation through its Pioneer Portfolio.

Antimicrobial Resistance in Developing Countries

Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke
Antimicrobial Resistance in Developing Countries Book PDF

Author : Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke
Publisher : Springer Science & Business Media
Page : 553 pages
File Size : 40,5 Mb
Release : 2009-10-08
Category : Science
ISBN : 9780387893709

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Antimicrobial Resistance in Developing Countries by Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke Pdf

Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.