Human Genome Epidemiology 2nd Edition

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Human Genome Epidemiology, 2nd Edition

Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis,Julian Little
Human Genome Epidemiology 2nd Edition Book PDF

Author : Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis,Julian Little
Publisher : Oxford University Press
Page : 704 pages
File Size : 53,8 Mb
Release : 2010-01-20
Category : Medical
ISBN : 0199749345

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Human Genome Epidemiology, 2nd Edition by Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis,Julian Little Pdf

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

Human Genome Epidemiology, 2nd Edition

Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis
Human Genome Epidemiology 2nd Edition Book PDF

Author : Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis
Publisher : Oxford University Press
Page : 701 pages
File Size : 46,7 Mb
Release : 2010-01-20
Category : Medical
ISBN : 9780195398441

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Human Genome Epidemiology, 2nd Edition by Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis Pdf

This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice.

Human Genome Epidemiology

Muin J. Khoury,Julian Little,Wylie Burke
Human Genome Epidemiology Book PDF

Author : Muin J. Khoury,Julian Little,Wylie Burke
Publisher : Oxford University Press
Page : 571 pages
File Size : 47,6 Mb
Release : 2004
Category : Medical
ISBN : 9780195146745

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Human Genome Epidemiology by Muin J. Khoury,Julian Little,Wylie Burke Pdf

This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services.

An Introduction to Genetic Epidemiology

Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
An Introduction to Genetic Epidemiology Book PDF

Author : Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
Publisher : Policy Press
Page : 240 pages
File Size : 48,5 Mb
Release : 2011-05-31
Category : Medical
ISBN : 9781861348975

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An Introduction to Genetic Epidemiology by Palmer, Lyle J.,Burton, Paul R.,George Davey Smith Pdf

This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.

A Statistical Approach to Genetic Epidemiology

Andreas Ziegler,Inke R. Kônig,Friedrich Pahlke
A Statistical Approach to Genetic Epidemiology Book PDF

Author : Andreas Ziegler,Inke R. Kônig,Friedrich Pahlke
Publisher : John Wiley & Sons
Page : 522 pages
File Size : 45,6 Mb
Release : 2011-08-24
Category : Science
ISBN : 9783527633661

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A Statistical Approach to Genetic Epidemiology by Andreas Ziegler,Inke R. Kônig,Friedrich Pahlke Pdf

A Statistical Approach to Genetic Epidemiology After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-Süssmilch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on “Model Free Linkage Analysis of Quantitative Traits” in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery.

Biostatistics for Human Genetic Epidemiology

Bertram K. C. Chan
Biostatistics for Human Genetic Epidemiology Book PDF

Author : Bertram K. C. Chan
Publisher : Springer
Page : 355 pages
File Size : 51,9 Mb
Release : 2018-10-24
Category : Medical
ISBN : 9783319937915

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Biostatistics for Human Genetic Epidemiology by Bertram K. C. Chan Pdf

The book illustrates how biostatistics may numerically summarize human genetic epidemiology using R, and may be used successfully to solve problems in quantitative Genetic Epidemiology Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications. Biostatistics for Human Genetic Epidemiology is an ideal reference for professionals and students in Medicine (particularly in Preventive Medicine and Public Health Medical Practices), as well as in Genetics, Epidemiology, and Biostatistics.

Genetic Epidemiology

Melissa A. Austin,Terri H. Beaty,W. David Dotson
Genetic Epidemiology Book PDF

Author : Melissa A. Austin,Terri H. Beaty,W. David Dotson
Publisher : CABI
Page : 199 pages
File Size : 52,9 Mb
Release : 2013
Category : Medical
ISBN : 9781780641812

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Genetic Epidemiology by Melissa A. Austin,Terri H. Beaty,W. David Dotson Pdf

Genetic epidemiology plays a key role in discovering genetic factors influencing health and disease, and in understanding how genes and environmental risk factors interact. There is growing interest in this field within public health, with the goal of translating the results into promoting health and preventing disease in both families and populations. This textbook provides graduate students with a working knowledge of genetic epidemiology research methods. Following an overview of the field, the book reviews key genetic concepts, provides an update on relevant genomic technology, including genome-wide chips and DNA sequencing, and describes methods for assessing the magnitude of genetic influences on diseases and risk factors. The book focuses on research study designs for discovering disease susceptibility genes, including family-based linkage analysis, candidate gene and genome-side association studies, assessing gene-environment interactions and epistasis, studies of Non-Mendelian inheritance, and statistical analyses of data from these studies. Specific applications of each research method are illustrated using a variety of diseases and risk factors relevant to public health, and useful web-based genetic analysis software, human reference panels, and repositories, that can greatly facilitate this work, are described.

Fundamentals of Genetic Epidemiology

Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen
Fundamentals of Genetic Epidemiology Book PDF

Author : Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen
Publisher : Monographs in Epidemiology and
Page : 394 pages
File Size : 47,5 Mb
Release : 1993
Category : Medical
ISBN : 9780195052886

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Fundamentals of Genetic Epidemiology by Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen Pdf

This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.

Genetics and Public Health in the 21st Century

Muin J. Khoury,Wylie Burke,Elizabeth Jean Thomson
Genetics and Public Health in the 21st Century Book PDF

Author : Muin J. Khoury,Wylie Burke,Elizabeth Jean Thomson
Publisher : Oxford University Press, USA
Page : 661 pages
File Size : 53,6 Mb
Release : 2000
Category : Language Arts & Disciplines
ISBN : 9780195128307

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Genetics and Public Health in the 21st Century by Muin J. Khoury,Wylie Burke,Elizabeth Jean Thomson Pdf

The first broad survey of these two fields, this book deleniates a framework for integrating advances in human genetics into public health practice.

Molecular Epidemiology

Paul A. Schulte,Frederica P. Perera
Molecular Epidemiology Book PDF

Author : Paul A. Schulte,Frederica P. Perera
Publisher : Academic Press
Page : 588 pages
File Size : 54,8 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138574

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Molecular Epidemiology by Paul A. Schulte,Frederica P. Perera Pdf

This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Statistical Methods in Genetic Epidemiology

Duncan C. Thomas
Statistical Methods in Genetic Epidemiology Book PDF

Author : Duncan C. Thomas
Publisher : Oxford University Press
Page : 458 pages
File Size : 51,9 Mb
Release : 2004-01-29
Category : Medical
ISBN : 9780199748051

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Statistical Methods in Genetic Epidemiology by Duncan C. Thomas Pdf

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

A Statistical Approach to Genetic Epidemiology

Andreas Ziegler,Inke R. König
A Statistical Approach to Genetic Epidemiology Book PDF

Author : Andreas Ziegler,Inke R. König
Publisher : John Wiley & Sons
Page : 522 pages
File Size : 43,5 Mb
Release : 2010-05-24
Category : Science
ISBN : 9783527324538

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A Statistical Approach to Genetic Epidemiology by Andreas Ziegler,Inke R. König Pdf

This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke Konig, who has been teaching the subject over many years. The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes new chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition the book contains many problems and solutions.

Genetics and Evolution of Infectious Diseases

Michel Tibayrenc
Genetics and Evolution of Infectious Diseases Book PDF

Author : Michel Tibayrenc
Publisher : Elsevier
Page : 773 pages
File Size : 45,7 Mb
Release : 2010-12-17
Category : Medical
ISBN : 9780123848901

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Genetics and Evolution of Infectious Diseases by Michel Tibayrenc Pdf

Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field

Translational Cardiometabolic Genomic Medicine

Annabelle Rodriguez-Oquendo
Translational Cardiometabolic Genomic Medicine Book PDF

Author : Annabelle Rodriguez-Oquendo
Publisher : Academic Press
Page : 354 pages
File Size : 48,6 Mb
Release : 2015-09-07
Category : Science
ISBN : 9780128004746

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Translational Cardiometabolic Genomic Medicine by Annabelle Rodriguez-Oquendo Pdf

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Genetic Epidemiology

Evangelos Evangelou
Genetic Epidemiology Book PDF

Author : Evangelos Evangelou
Publisher : Humana Press
Page : 299 pages
File Size : 46,5 Mb
Release : 2018-06-07
Category : Medical
ISBN : 1493978675

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Genetic Epidemiology by Evangelos Evangelou Pdf

This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.