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Author : Thomas F. Lee
Publisher : Springer
Page : 322 pages
File Size : 52,8 Mb
Release : 2013-12-11
Category : Medical
ISBN : 9781489960221
Describes the ten-year, multimillion dollar Human Genome Project and its process of gene mapping; includes concerns of critics of the project.
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 54,7 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author : Charles R. Cantor,Cassandra L. Smith
Publisher : John Wiley & Sons
Page : 621 pages
File Size : 43,9 Mb
Release : 2004-01-06
Category : Science
ISBN : 9780471461869
A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features: * Topical organization within chapters for easy reference * A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters * Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids * Informed predictions for the future of DNA sequencing
Author : Timothy F Murphy,Marc A Lappé
Publisher : Univ of California Press
Page : 194 pages
File Size : 49,9 Mb
Release : 2024-07-26
Category : Medical
ISBN : 9780520414655
The Human Genome Project is an expensive, ambitious, and controversial attempt to locate and map every one of the approximately 100,000 genes in the human body. If it works, and we are able, for instance, to identify markers for genetic diseases long before they develop, who will have the right to obtain such information? What will be the consequences for health care, health insurance, employability, and research priorities? And, more broadly, how will attitudes toward human differences be affected, morally and socially, by the setting of a genetic "standard"? The compatibility of individual rights and genetic fairness is challenged by the technological possibilities of the future, making it difficult to create an agenda for a "just genetics." Beginning with an account of the utopian dreams and authoritarian tendencies of historical eugenics movements, this book's nine essays probe the potential social uses and abuses of detailed genetic information. Lucid and wide-ranging, these contributions will interest bioethicists, legal scholars, and policy makers. Essays: "The Genome Project and the Meaning of Difference," Timothy F. Murphy "Eugenics and the Human Genome Project: Is the Past Prologue?," Daniel J. Kevles "Handle with Care: Race, Class, and Genetics," Arthur L. Caplan "Public Choices and Private Choices: Legal Regulation of Genetic Testing," Lori B. Andrews "Rules for Gene Banks: Protecting Privacy in the Genetics Age," George J. Annas "Use of Genetic Information by Private Insurers," Robert J. Pokorski "The Genome Project, Individual Differences, and Just Health Care," Norman Daniels "Just Genetics: A Problem Agenda," Leonard M. Fleck "Justice and the Limitations of Genetic Knowledge," Marc A. Lappé This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1994.
Author : Kevin Davies
Publisher : JHU Press
Page : 358 pages
File Size : 42,6 Mb
Release : 2002-10
Category : Medical
ISBN : 0801871409
This newly updated edition sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for generations to come.
Author : Viktor K. McElheny
Publisher : Basic Books
Page : 384 pages
File Size : 47,8 Mb
Release : 2012-07-31
Category : Science
ISBN : 9780465032600
Drawing the Map of Life is the dramatic story of the Human Genome Project from its origins, through the race to order the 3 billion subunits of DNA, to the surprises emerging as scientists seek to exploit the molecule of heredity. It's the first account to deal in depth with the intellectual roots of the project, the motivations that drove it, and the hype that often masked genuine triumphs. Distinguished science journalist Victor McElheny offers vivid, insightful profiles of key people, such as David Botstein, Eric Lander, Francis Collins, James Watson, Michael Hunkapiller, and Craig Venter. McElheny also shows that the Human Genome Project is a striking example of how new techniques (such as restriction enzymes and sequencing methods) often arrive first, shaping the questions scientists then ask. Drawing on years of original interviews and reporting in the inner circles of biological science, Drawing the Map of Life is the definitive, up-to-date story of today's greatest scientific quest. No one who wishes to understand genome mapping and how it is transforming our lives can afford to miss this book.
Author : Walter Fred Bodmer,Robin McKie
Publisher : Oxford University Press, USA
Page : 274 pages
File Size : 51,5 Mb
Release : 1997
Category : Nature
ISBN : 9780195114874
James Watson, a discoverer of the structure of DNA, described it as "the most golden of molecules," the true chemical for life. Indeed, it is the essential component from which our genes are made. In it is encoded the genetic language that controls our destinies. Astonishingly powerful, just six millionths of a gram of DNA carries as much information as ten volumes of the Oxford English Dictionary. The "Book of Man," is the term used by Walter Bodmer and Robin McKie for the DNA that is the instruction set according to which all humans are made. At conception, a single cell--the fertilized egg--is produced, and it is this one cell that has the potential to form a new and unique individual under the guidance of the DNA within its nucleus. The human body is made up of a hundred million million cells of many different sorts, and all contain the inherited information that comes from that first, single cell created at fertilization. Bodmer and McKie assert that when we learn how to read DNA's pages and chapters we will obtain the information relevant to the understanding of most diseases, individual differences in behavior, and a new awareness of our own history and evolution. The Book of Man explores how genetic information is now being read and interpreted by focusing on biology's most ambitious undertaking to date--the Human Genome Project, an attempt to uncover all the 100,000 genes that control our development and detail the DNA alphabet of each. The authors go on to wrestle with the moral and ethical issues of modern genetics, making a case for a rational appraisal of genetic engineering and for the public to become sufficiently "DNA literate" in order to appreciate the crucial role it plays in our lives. From Gregor Mendel's discovery of the laws of inheritance to the high-tech, crime-stopping power of forensics science and the fascinating but sometimes troublesome implications of the latest science of genetic engineering, The Book of Man brilliantly explores and explains the quest that is changing our understanding of what it means to be a human being.
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 50,7 Mb
Release : 1992
Category : Human gene mapping
ISBN : OCLC:28586807
Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 44,6 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author : Tom Wilkie
Publisher : Univ of California Press
Page : 216 pages
File Size : 50,7 Mb
Release : 1993-01-01
Category : Science
ISBN : 0520085531
The Human Genome Project has been called a scientific "search for the Holy Grail" or the genetics equivalent of the moon race. Thousands of researchers worldwide are analyzing the details of human DNA, hoping to identify all of the tens of thousands of human genes that are the blueprint for the human body. Physicist and writer Tom Wilkie offers a lively, compelling history of this scientifically fascinating and politically contentious undertaking. Beginning with the discovery of DNA by James Watson and Francis Crick in 1953, Wilkie's narrative unfolds with the intrigue of a detective story. He reviews in nontechnical terms the many step-by-step developments from different scientific teams that finally made it seem as if it would be possible to sequence the human genome. He goes on to consider the potential social consequences, good and bad, of learning to manipulate the human genetic code. What will happen as we try to prevent and cure disease or attempt to "improve" ourselves and our children by genetic means? A most readable introduction to the science of genetics and the potential consequences of the Human Genome Project, Perilous Knowledge provides background for the startling headlines that quite possibly signal changes to all human life in the next century. "After decades of painstaking research, seemingly disparate paths into the sciences of molecular biology, chemistry, biology and genetics have converged. Suddenly the scientists realize that they are . . . at the peak of a mountain where all the surrounding landscape is clear to their view. They are confident now that they can tackle one of the biggest and most profound issues in their science: unravelling the message of human inheritance."--from the Preface The Human Genome Project has been called a scientific "search for the Holy Grail" or the genetics equivalent of the moon race. Thousands of researchers worldwide are analyzing the details of human DNA, hoping to identify all of the tens of thousands of human genes that are the blueprint for the human body. Physicist and writer Tom Wilkie offers a lively, compelling history of this scientifically fascinating and politically contentious undertaking. Beginning with the discovery of DNA by James Watson and Francis Crick in 1953, Wilkie's narrative unfolds with the intrigue of a detective story. He reviews in nontechnical terms the many step-by-step developments from different scientific teams that finally made it seem as if it would be possible to sequence the human genome. He goes on to consider the potential social consequences, good and bad, of learning to manipulate the human genetic code. What will happen as we try to prevent and cure disease or attempt to "improve" ourselves and our children by genetic means? A most readable introduction to the science of genetics and the potential consequences of the Human Genome Project, Perilous Knowledge provides background for the startling headlines that quite possibly signal changes to all human life in the next century. "After decades of painstaking research, seemingly disparate paths into the sciences of molecular biology, chemistry, biology and genetics have converged. Suddenly the scientists realize that they are . . . at the peak of a mountain where all the surrounding landscape is clear to their view. They are confident now that they can tackle one of the biggest and most profound issues in their science: unravelling the message of human inheritance."--from the Preface
Author : Janey Levy
Publisher : Gareth Stevens Publishing LLLP
Page : 34 pages
File Size : 52,6 Mb
Release : 2018-12-15
Category : Juvenile Nonfiction
ISBN : 9781538231371
The Human Genome Project was a groundbreaking, life-altering development of the late 20th century and a major evolution in science and medicine. Readers of this remarkable volume will follow the scientists of the international, collaborative research program as they map the human genome. They'll learn about the science behind the project as well as the scientific and medical possibilities opened by it. Vivid photographs support the fascinating text, and sidebars, fact boxes, and captions enrich your reader's experience.
Author : Rodney Loeppky
Publisher : Routledge
Page : 256 pages
File Size : 49,6 Mb
Release : 2013-09-13
Category : Business & Economics
ISBN : 9781135471156
This book deals with the rapid changes in contemporary molecular biology, particularly genome sciences, and the manner in which they can be understood through the lens of political economy. Specifically, the work investigates the case of the United States-led Genome Project (HGP), in order to show that even large-scale basic science is closely bound up in the progression of capitalist social relations. The work has, in part, been motivated by the lack of rigorous analysis of the HGP. Most the existing literature tends to present either a chronological review of events surrounding the HGP or describe it thematically. In contrast, this book contributes to a needed discussion concerning the 'why and how' of the HGP emergence. It elucidates the features within capitalist social relations which have simultaneously enable the HGP and ensure its amenability to systemic demands. The work's most compelling elements are both historical and analytical. Historically, it places the HGP within the context of wider political, economic and social issues. Related to this, it puts forward an analytical, explanatory understanding of the project's emergence, making it a valuable tool for both political economists, science & society theorists, and even bioethicists.
Author : Victor K. McElheny
Publisher : ReadHowYouWant.com
Page : 662 pages
File Size : 45,7 Mb
Release : 2010-10-19
Category : Fiction
ISBN : 9781458760104
Drawing the Map of Life is the dramatic story of the Human Genome Project from its origins, through the race to order the 3 billion subunits of DNA, to the surprises emerging as scientists seek to exploit the molecule of heredity. It's the first account to deal in depth with the intellectual roots of the project, the motivations that drove it, and the hype that often masked genuine triumphs. Distinguished science journalist Victor McElheny offers vivid, insightful profiles of key people, such as David Botstein, Eric Lander, Francis Collins, James Watson, Michael Hunkapiller, and Craig Venter. McElheny also shows that the Human Genome Project is a striking example of how new techniques (such as restriction enzymes and sequencing methods) often arrive first, shaping the questions scientists then ask. Drawing on years of original interviews and reporting in the inner circles of biological science, Drawing the Map of Life is the definitive, up-to-date story of today's greatest scientific quest. No one who wishes to understand genome mapping and how it is transforming our lives can afford to miss this book.
Author : Kelly E. Happe
Publisher : NYU Press
Page : 305 pages
File Size : 44,9 Mb
Release : 2013-05-06
Category : Social Science
ISBN : 9780814790694
Winner of the 2014 Diamond Anniversary Book Award Finalist for the 2014 National Communications Association Critical and Cultural Studies Division Book of the Year Award In 2000, the National Human Genome Research Institute announced the completion of a “draft” of the human genome, the sequence information of nearly all 3 billion base pairs of DNA. Since then, interest in the hereditary basis of disease has increased considerably. In The Material Gene, Kelly E. Happe considers the broad implications of this development by treating “heredity” as both a scientific and political concept. Beginning with the argument that eugenics was an ideological project that recast the problems of industrialization as pathologies of gender, race, and class, the book traces the legacy of this ideology in contemporary practices of genomics. Delving into the discrete and often obscure epistemologies and discursive practices of genomic scientists, Happe maps the ways in which the hereditarian body, one that is also normatively gendered and racialized, is the new site whereby economic injustice, environmental pollution, racism, and sexism are implicitly reinterpreted as pathologies of genes and by extension, the bodies they inhabit. Comparing genomic approaches to medicine and public health with discourses of epidemiology, social movements, and humanistic theories of the body and society, The Material Gene reworks our common assumption of what might count as effective, just, and socially transformative notions of health and disease.
Author : Susan L. Speaker,M. Susan Lindee,Elizabeth Hanson
Publisher : Chemical Heritage Foundation
Page : 44 pages
File Size : 50,6 Mb
Release : 1993
Category : Science
ISBN : 0941901106
This simple, concise introduction to the HGP for the general reader explores the origins of the genome project and reactions in the scientific community; important technologies and techniques; institutions connected with the HGP, including designated genome centers, important suppliers of resources, and corporations; systems of communication; and ethical, legal, and social issues. A publication of the Biomolecular Sciences Initiative of CHF's Beckman Center for the History of Chemistry.