Scientific Frontiers In Developmental Toxicology And Risk Assessment

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 42,6 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Author : Anonim
Publisher : Unknown
Page : 327 pages
File Size : 53,7 Mb
Release : 2000
Category : Abnormalities, Human
ISBN : OCLC:1097153558

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by Anonim Pdf

Author : Ronald D. Hood
Publisher : Van Nostrand Reinhold Company
Page : 296 pages
File Size : 44,9 Mb
Release : 1990
Category : Abnormalities
ISBN : UCAL:B5021886

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Developmental Toxicology by Ronald D. Hood Pdf

TECHNICAL

Author : Ronald D. Hood
Publisher : Wiley
Page : 279 pages
File Size : 48,6 Mb
Release : 1990-08-15
Category : Medical
ISBN : 0471290793

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Developmental Toxicology by Ronald D. Hood Pdf

Author : Ronald D. Hood
Publisher : CRC Press
Page : 794 pages
File Size : 44,9 Mb
Release : 1996-10-23
Category : Medical
ISBN : 0849301351

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Handbook of Developmental Toxicology by Ronald D. Hood Pdf

Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology.

Author : Chiara Frazzoli,Alberto Mantovani
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 42,9 Mb
Release : 2019-04-09
Category : Electronic
ISBN : 9782889457915

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The Environment-Animal-Human Web: A “One Health” View of Toxicological Risk Analysis by Chiara Frazzoli,Alberto Mantovani Pdf

One Health (OH) is the conceptual and operational framework that links environment, food-producing organisms and human health. OH is a developing field, that deals with the multifaceted web of feed-backs and interactions among its components. In order to avoid “drowning into complexity”, priority issues should be identified, either for research and for risk analysis. To date OH approaches have frequently pivoted on infectious agents shared among animals and humans and the related problems, such as antibiotic resistance. Nevertheless, the OH scenarios include, and should increasingly include, environment-and-health problems. Food and environment do interact. Environment influences the living organisms that produce human food and, in the meanwhile, food production outputs influence the environmental quality; as for foods of animal origin, feed materials and practices are driving components of the environment-food interactions. In this book, we aimed at highlighting the importance of environment, chemical exposures and toxicological issues in the field of OH, as well as the need for multidisciplinary integration in order to support OH approaches into diseases prevention and health promotion.

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology
Publisher : National Academies Press
Page : 266 pages
File Size : 49,5 Mb
Release : 2001-04-13
Category : Nature
ISBN : 0309073162

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Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology Pdf

The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
Publisher : National Academies Press
Page : 217 pages
File Size : 49,5 Mb
Release : 2007-11-05
Category : Nature
ISBN : 9780309151733

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Toxicity Testing in the 21st Century by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents Pdf

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Standing Committee on Risk Analysis Issues and Reviews
Publisher : National Academies Press
Page : 135 pages
File Size : 53,6 Mb
Release : 2010-06-07
Category : Nature
ISBN : 9780309156929

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Toxicity-Pathway-Based Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Standing Committee on Risk Analysis Issues and Reviews Pdf

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 53,6 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

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Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Author : Laura Robinson
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 51,5 Mb
Release : 2018-11-05
Category : Science
ISBN : 9781118881903

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A Practical Guide to Toxicology and Human Health Risk Assessment by Laura Robinson Pdf

Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author’s training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher : National Academies Press
Page : 300 pages
File Size : 47,7 Mb
Release : 2007-11-19
Category : Science
ISBN : 9780309178891

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Pdf

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author : Ronald D. Hood,Ronald D Hood
Publisher : CRC Press
Page : 1168 pages
File Size : 52,7 Mb
Release : 2005-08-30
Category : Medical
ISBN : 9781420040548

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Developmental and Reproductive Toxicology by Ronald D. Hood,Ronald D Hood Pdf

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology
Publisher : National Academies Press
Page : 261 pages
File Size : 53,5 Mb
Release : 2001-04-13
Category : Nature
ISBN : 9780309073165

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Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology Pdf

The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Environmental Impacts of Wind-Energy Projects
Publisher : National Academies Press
Page : 394 pages
File Size : 50,6 Mb
Release : 2007-08-27
Category : Science
ISBN : 9780309134088

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Environmental Impacts of Wind-Energy Projects by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Environmental Impacts of Wind-Energy Projects Pdf

The generation of electricity by wind energy has the potential to reduce environmental impacts caused by the use of fossil fuels. Although the use of wind energy to generate electricity is increasing rapidly in the United States, government guidance to help communities and developers evaluate and plan proposed wind-energy projects is lacking. Environmental Impacts of Wind-Energy Projects offers an analysis of the environmental benefits and drawbacks of wind energy, along with an evaluation guide to aid decision-making about projects. It includes a case study of the mid-Atlantic highlands, a mountainous area that spans parts of West Virginia, Virginia, Maryland, and Pennsylvania. This book will inform policy makers at the federal, state, and local levels.