Human Leukocyte Antigen Hla

Author : J.L. Tiwari,P.I. Terasaki
Publisher : Springer Science & Business Media
Page : 492 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461385455

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HLA and Disease Associations by J.L. Tiwari,P.I. Terasaki Pdf

The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

Author : Batool Mutar Mahdi
Publisher : BoD – Books on Demand
Page : 70 pages
File Size : 46,6 Mb
Release : 2019-03-13
Category : Medical
ISBN : 9781789857610

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Human Leukocyte Antigen (HLA) by Batool Mutar Mahdi Pdf

This book is a concise review of medically important applications of Human Leukocyte Antigen (HLA) in medicine. It covers both basic knowledge of HLA and its main clinical applications in medical practice. Its two major aims are to assist students who are preparing for clinical immunology examinations, and to help people who want to understand more about this subject with brief and flexible sources of information. This book presents current, medically important information on the rapidly changing field of tissue typing and its relation with diseases. It includes updated information on such topics as tissue typing in medicine and transplant immunology.

Author : John Lee
Publisher : Springer Science & Business Media
Page : 337 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461234548

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The HLA System by John Lee Pdf

This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.

Author : Narinder K Mehra
Publisher : Boydell & Brewer Ltd
Page : 616 pages
File Size : 45,8 Mb
Release : 2010-11-26
Category : Medical
ISBN : 818448870X

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The HLA Complex in Biology and Medicine by Narinder K Mehra Pdf

A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

Author : Robert Lechler,Anthony Warrens
Publisher : Academic Press
Page : 506 pages
File Size : 55,8 Mb
Release : 2000-05-09
Category : Medical
ISBN : UOM:39015042405707

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HLA in Health and Disease by Robert Lechler,Anthony Warrens Pdf

This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field

Author : Sevim Gönen
Publisher : BoD – Books on Demand
Page : 118 pages
File Size : 47,6 Mb
Release : 2023-06-14
Category : Medical
ISBN : 9781837697502

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Human Leukocyte Antigens - Updates and Advances by Sevim Gönen Pdf

Our understanding of immunogenetics is growing rapidly with new and exciting developments in all fields. This book provides a comprehensive overview of transplantation immunogenetics. Chapters address such topics as immune tolerance, human leukocyte antigens (HLAs) and transplantation, immunity and viral epidemics, and more.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 40,5 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Jawahar L. Tiwari,Paul I. Terasaki
Publisher : Unknown
Page : 472 pages
File Size : 41,8 Mb
Release : 1985
Category : Antigènes HLA - Utilisation diagnostique
ISBN : 3540960813

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HLA and Disease Associations by Jawahar L. Tiwari,Paul I. Terasaki Pdf

Author : Gautam Nand Allahbadia,Baris Ata,Steven R. Lindheim,Bryan J. Woodward,Bala Bhagavath
Publisher : Springer Nature
Page : 846 pages
File Size : 54,9 Mb
Release : 2020-08-05
Category : Medical
ISBN : 9789811523779

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Textbook of Assisted Reproduction by Gautam Nand Allahbadia,Baris Ata,Steven R. Lindheim,Bryan J. Woodward,Bala Bhagavath Pdf

Groundbreaking, comprehensive, and developed by a panel of leading international experts in the field, Textbook of Assisted Reproduction provides a multidisciplinary overview of the diagnosis and management of infertility, which affects 15% of all couples around the world. The book aims to cover all aspects of assisted reproduction. Particular attention is given to topics such as the assessment of infertile couples; assisted reproductive techniques (ARTs) including ovulation induction, intra uterine insemination (IUI), in vitro fertilization (IVF) and intracytoplasmic sperm injection (clinical and laboratory aspects); reproductive genetics; and obstetric and perinatal outcomes.

Author : Yongzhi Xi
Publisher : BoD – Books on Demand
Page : 386 pages
File Size : 50,6 Mb
Release : 2014-03-19
Category : Medical
ISBN : 9789535112303

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HLA and Associated Important Diseases by Yongzhi Xi Pdf

This year marks the 60th anniversary of HLA discovery by the French Nobel laureate physician Jean Dausset, as well as the 55th anniversary of the identification and naming of the first HLA. Under such circumstances, both basic HLA research and its clinical applications need a new book that comprehensively reflects the latest achievements in the field. Thus, Professor Xi as Editor has contributed to organize international experts in the areas of HLA-related basic research and clinical applications, to unite their knowledge in chapters covering various related topics, and finally to finish the book "HLA and Associated Important Diseases". The book consists of three sections which mainly include basic theoretical and technological developments, several important HLA-associated autoimmune diseases and HLA-associated infectious diseases.

Author : S. D. Litwin
Publisher : CRC Press
Page : 856 pages
File Size : 44,8 Mb
Release : 1989-01-10
Category : Science
ISBN : 0824778995

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Human Immunogenetics by S. D. Litwin Pdf

Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprise

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 46,6 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

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Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Author : Sebastian Boegel
Publisher : Humana
Page : 0 pages
File Size : 42,6 Mb
Release : 2024-07-22
Category : Medical
ISBN : 1071638734

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HLA Typing by Sebastian Boegel Pdf

This edition provides a collection of state-of-art methods and tools for human leukocyte antigen (HLA) and major histocompatibility complex (MHC) research. The book explores updated as well as novel in silico tools, resources, and wet lab protocols for HLA typing, including determination of the HLA class I and class II type of an individual in clinical work and research, such as in transplantation medicine and vaccine development in the context of infectious diseases or cancer immunotherapies. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed information and implementation advice that leads to best results. Up-to-date and practical, HLA Typing: Methods and Protocols, Second Edition serves as a valuable resource for any researcher interested in learning more about this vital field.

Author : Minjun Chen,Yvonne Will
Publisher : Humana Press
Page : 667 pages
File Size : 43,6 Mb
Release : 2018-03-21
Category : Medical
ISBN : 1493976761

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Drug-Induced Liver Toxicity by Minjun Chen,Yvonne Will Pdf

This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com.

Author : Robert Lechler
Publisher : Unknown
Page : 210 pages
File Size : 54,6 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015032427026

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HLA and Disease by Robert Lechler Pdf

This text describes the genetics and products of the HLA region and their relationship to diseases including diabetes, rheumatoid arthritis and SLE. The statistical principles relevant to the design and interpretation of HLA and disease studies are presented in simple and accessible language.