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Author : Ugo Moens
Publisher : MDPI
Page : 197 pages
File Size : 51,6 Mb
Release : 2018-09-21
Category : Electronic books
ISBN : 9783038972204
This book is a printed edition of the Special Issue "Human Polyomaviruses and Papillomaviruses" that was published in IJMS
Author : Ugo Moens (Ed.)
Publisher : Unknown
Page : 128 pages
File Size : 45,7 Mb
Release : 2024-06-29
Category : Electronic
ISBN : OCLC:1117867775
Author : Ugo Moens
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2018
Category : Electronic
ISBN : 3038972215
The interest in human polyomaviruses (HPyV) has seen a renaissance because of new species that have been isolated and their previously unknown association with diseases. Likewise, the increasing evidence for the association of human papillomaviruses (HPV) with oropharyngeal cancer has sparked the attention of researchers and clinicians. The Special Issue "Human Polyomaviruses and Papillomaviruses" presents studies describing the nuclear egress of BK polyomavirus mediated by the viral agnoprotein and the cellular a-SNAP protein. In addition, a study examines the promoter activity of two different variants of human polyomavirus 9 in different cell lines. This Special Issue offers an interesting perspective on the epidemiology of HR-HPV in different cancers and on the mechanisms by which these viruses target host cell proteins to replicate their genome, express their genes, interfere with autophagy, and induce cancer. Other topics that are highlighted include the role of co-factors, such as smoking and co-infection, novel therapeutic strategies, and surface immunoregulatory proteins, chemokines, and cytokines as possible biomarkers to determine the stage of a tumor and to predict clinical outcomes.
Author : Herbert Johannes Pfister,Marisa Gariglio,Sigrun Smola
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 45,9 Mb
Release : 2019-02-06
Category : Electronic
ISBN : 9782889457281
Nonmelanoma skin cancer (NMSC), more recently defined as keratinocyte carcinoma (KC), is the most frequent malignant tumor among Caucasians. This book deals with widely distributed cutaneous papillomaviruses and polyomaviruses, which are able to establish life-long persistent infections. They are frequently clinically inapparent in the general population, but can cause skin cancer in immunocompromised hosts or in the aging skin undergoing immunosenescence, thereby leading to major medical problems. The incidence of cutaneous squamous cell carcinoma (cSCC) in immunosuppressed organ transplant recipients is 60-250 times higher than that observed in the general population, which is highly suggestive of viral etiology. The treatment of metastatic melanoma with BRAF-inhibitors can induce cSCC formation within only 8-12 weeks. The clinicopathological characteristics of these tumors led to speculations on a possible involvement of oncogenic viruses. The evidence presented in this eBook indicates that high priority should be given to the implementation of a prophylactic and/or therapeutic vaccination program against cutaneous papillomaviruses to prevent NMSC in immunosuppressed allograft recipients.
Author : Robert Garcea,Daniel DiMaio
Publisher : Springer Science & Business Media
Page : 435 pages
File Size : 48,7 Mb
Release : 2007-08-19
Category : Medical
ISBN : 9780387365237
This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body.
Author : Davy Vanden Broeck
Publisher : BoD – Books on Demand
Page : 364 pages
File Size : 52,8 Mb
Release : 2012-01-20
Category : Medical
ISBN : 9789533078601
Cervical cancer is the second most prevalent cancer among women worldwide, and infection with Human Papilloma Virus (HPV) has been identified as the causal agent for this condition. The natural history of cervical cancer is characterized by slow disease progression, rendering the condition, in essence, preventable and even treatable when diagnosed in early stages. Pap smear and the recently introduced prophylactic vaccines are the most prominent prevention options, but despite the availability of these primary and secondary screening tools, the global burden of disease is unfortunately still very high. This book will focus on the clinical aspects of HPV and related disease, highlighting the latest developments in this field.
Author : David Jenkins,Xavier Bosch
Publisher : Academic Press
Page : 460 pages
File Size : 40,7 Mb
Release : 2019-11
Category : Medical
ISBN : 9780128144572
Human Papillomavirus: Proving and Using a Viral Cause for Cancer presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine that exploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine. Presents a comprehensive, up-to-date review of the role of HPV in cancer from those involved in its study Includes the way evidence on the role and utility of HPV based prevention has been accumulated over almost 40 years Gives a series of vignettes of individual scientists involved in the development of the science of HPV and cancer at different stages and their experiences and reasons for involvement
Author : Kari J. Syrjänen,Lutz Gissmann,Leopold G. Koss, MD, FCRP
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642710971
In recent years, papillomaviruses in general and human papillo maviruses in particular have been recognized as possible agents of important diseases, including some forms of human cancer. The purpose of this book is to present a concise panorama of the pre sent status of knowledge of this topic. This knowledge is as impor tant to molecular biologists and virologists as it is to clinicians and pathologists. To bridge the gap among these diverse groups of investigators, we conceived of a book covering a broad spectrum of the basic scientific, clinical, and pathological aspects of diseases associated with papillomaviruses. Although the principal thrust of this book is directed at human papillomaviruses, fundamental knowledge of animal viruses is essential to the current understand ing of the molecular mechanisms of cell transformation. For this reason, a chapter on animal viruses has also been included. Some of the experimental work having to do with the elucidation of transformation and other aspects of interaction between the virus and the cell cannot be based on human papillomaviruses because of a lack of suitable experimental models. Hence, some of the chapters dealing with fundamental aspects of viral molecular biol ogy are based on animal models. We were very fortunate in having persuaded a number of distin guished colleagues to contribute to this work.
Author : M.K. Ramírez-Fort,F. Khan,P.L. Rady,S.K. Tyring
Publisher : Karger Medical and Scientific Publishers
Page : 282 pages
File Size : 48,8 Mb
Release : 2014-03-13
Category : Medical
ISBN : 9783318025279
Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. In this volume, experts present a comprehensive view of HPV research with an emphasis on clinical presentations, diagnosis, management and vaccine development. The state of the art in molecular biology is provided in addition to discussions on clinical morphology and the utility of dermatoscopy in identifying HPV disease. In a multidisciplinary approach to dermatological, plastic and reconstructive, gynecological, otolaryngological and colorectal management, different treatment strategies are highlighted. Finally, Dr. Neil Christensen discusses viral immunology, and the difficulties and successes in the development of an HPV vaccine. Bringing together basic science and clinical information on HPV, this book is an excellent resource and reference for all researchers and clinicians who encounter human papillomavirus-related disease.
Author : Blossom Damania,James Pipas
Publisher : Springer Science & Business Media
Page : 805 pages
File Size : 51,8 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387689456
This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Author : Yashpal Singh Malik,Raj Kumar Singh,Mahendra Pal Yadav
Publisher : Springer Nature
Page : 471 pages
File Size : 50,9 Mb
Release : 2019-11-14
Category : Medical
ISBN : 9789811390739
This book discusses the prominence and implication of the viral diseases that are a major threat to animals around the globe. A number of these diseases have also shown links with human populations, which has implications for public health. This book offers detailed and up-to-date information on viral diseases in livestock and poultry that were and/or are still a problem. Including cutting-edge developments, it also highlights several landmark contributions in the field of virology from India. Additionally, the book features tables and figures showing important clinical data and recommendations, with references for further information. It also explores the economic impact of viral diseases for farmers and the livestock industry, providing several examples. Further, it presents the latest information on viral diseases in global context, with a focus on state-of-art, molecular tools for the development of diagnostics, prophylactics and therapeutics. Lastly, the book also describes the challenges posed by the emerging and transboundary viral infections and our preparedness to counter them.
Author : Wang-Shick Ryu
Publisher : Academic Press
Page : 440 pages
File Size : 48,7 Mb
Release : 2016-03-30
Category : Science
ISBN : 9780128009994
Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank
Author : Van G. Wilson
Publisher : Springer Nature
Page : 359 pages
File Size : 44,8 Mb
Release : 2022-03-01
Category : Medical
ISBN : 9783030854874
This book guides through the fascinating world of viruses and makes readers enjoy science in an accessible way. Virologist and author Professor Van Wilson imparts knowledge about what viruses are, how they work, and how much they impact life on Earth. The book equips the reader with the scientific basics behind virus function and presents the historic milestones of virus research and discovery. Well-known viruses such as HIV or Influenza are tackled alongside novel pathogens like coronavirus SARS-CoV-2. Professor Wilson explores where they come from and how they impact our society. Last but not least the book provides exciting insights into how our immune system reacts to different viruses and how vaccines contribute to conquer pandemics. While scientifically informative, this book makes the field of virology understandable to a lay audience and encourages readers to further thinking. And more importantly, it conveys the wonder, beauty, and mystery of these ubiquitous, microscopic marvels. This book addresses anyone interested in understanding the principles of virology, viral diseases, or the impact of viruses on human societies.
Author : Nasimul Ahsan
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 40,7 Mb
Release : 2007-06-25
Category : Medical
ISBN : 9780387329574
Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.
Author : Per Ljungman,David Snydman,Michael Boeckh
Publisher : Springer
Page : 983 pages
File Size : 53,8 Mb
Release : 2016-10-03
Category : Medical
ISBN : 9783319287973
As the number of patients undergoing hematotopoietic or solid organ transplantation increases, a deep understanding of the field of transplant infectious diseases grows increasingly vital. With its extensively revised and updated review of surgical infections, treatment, prevention, and practice, this book is the ultimate guide to advances in the field of transplant infections that are rapidly implemented into practice both in diagnostic technologies, new therapies, new transplant practices, and challenges such as the threat of multiresistant bacteria and the increasing use of transplantation in the developing parts of the world. Written by experts in their fields, this book is the only comprehensive source of cutting-edge information on transplant infections and has been a trusted guide to medical professionals worldwide for nearly two decades. Transplant Infections is of paramount value to infectious disease specialists, transplant physicians, medical students, fellows, residents, and all medical professionals working with surgical patients.
