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Author : Siniša Malešević
Publisher : Cambridge University Press
Page : 379 pages
File Size : 41,9 Mb
Release : 2022-10-06
Category : Social Science
ISBN : 9781009162791
Malešević offers a novel sociological answer to the age-old question: 'Why do humans fight?', by emphasising the centrality of social contexts that make fighting possible.
Author : J. J. Green
Publisher : Space Colony One, Part Two
Page : 324 pages
File Size : 51,7 Mb
Release : 2019-12-21
Category : Fiction
ISBN : 1913476049
Fighting for freedom from galactic tyranny General Cherry Lindstrom is responsible for the defense of the colony world, Concordia. This last outpost of human civilization lives under constant threat of attack from hostile aliens who claim the planet as their own. But decades have passed since the last assault, and the colonists have grown complacent. Thanks to the effects of time dilation, only Cherry and a handful of others remember the devastation wreaked on Concordia previously. The Concordians don't understand the danger the colony is in. Cherry must find a way to convince them and to build effective fighting force--before it's too late. Two galactic civilizations. One planet. Who will win? Humanity's Fight is book two in the second part of the space colonization epic, Space Colony One.
Author : Shoshana Zuboff
Publisher : PublicAffairs
Page : 658 pages
File Size : 51,7 Mb
Release : 2019-01-15
Category : Business & Economics
ISBN : 9781610395700
The challenges to humanity posed by the digital future, the first detailed examination of the unprecedented form of power called "surveillance capitalism," and the quest by powerful corporations to predict and control our behavior. In this masterwork of original thinking and research, Shoshana Zuboff provides startling insights into the phenomenon that she has named surveillance capitalism. The stakes could not be higher: a global architecture of behavior modification threatens human nature in the twenty-first century just as industrial capitalism disfigured the natural world in the twentieth. Zuboff vividly brings to life the consequences as surveillance capitalism advances from Silicon Valley into every economic sector. Vast wealth and power are accumulated in ominous new "behavioral futures markets," where predictions about our behavior are bought and sold, and the production of goods and services is subordinated to a new "means of behavioral modification." The threat has shifted from a totalitarian Big Brother state to a ubiquitous digital architecture: a "Big Other" operating in the interests of surveillance capital. Here is the crucible of an unprecedented form of power marked by extreme concentrations of knowledge and free from democratic oversight. Zuboff's comprehensive and moving analysis lays bare the threats to twenty-first century society: a controlled "hive" of total connection that seduces with promises of total certainty for maximum profit -- at the expense of democracy, freedom, and our human future. With little resistance from law or society, surveillance capitalism is on the verge of dominating the social order and shaping the digital future -- if we let it.
Author : Inka Sastalla,Denise M. Monack,Katharina F. Kubatzky
Publisher : Frontiers Media SA
Page : 192 pages
File Size : 40,5 Mb
Release : 2016-10-07
Category : Immunologic diseases. Allergy
ISBN : 9782889199914
Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Author : J.J. Marshall
Publisher : Author House
Page : 573 pages
File Size : 49,9 Mb
Release : 2014-01-30
Category : Fiction
ISBN : 9781491891858
Landon Corbett is spiralling out of control. From the wastelands of London to an isolated mountain village; from New York City to the International Space Station, Landon Corbetts revenge knows no limits. Alec is at the heart of the war that now rages between the two factions of humanity. Caught in the middle, he no longer holds the key to peace Alec is the key to peace. Landon Corbett wants him dead and the Alliance of Spheres on Earth is only too happy to hand him over for the chance to save the lives of everyone on Earth. But from those with corrupt morals to those with hearts of passion and gratitude, Alec and his friends are given the chance to fight one more time. And after six months, the war is reaching its climax. There is only one resolution to stopping the Board of Officials: cut the head off of the snake and kill Landon Corbett. But he remains as elusive and dangerous as ever. Alec, Jonah, Sky, Jay and Trent have suffered terrible losses, but the biggest loss is yet to come and it will leave none of them untouched.
Author : Barry Schoub
Publisher : NYU Press
Page : 202 pages
File Size : 45,7 Mb
Release : 2024-07
Category : Business & Economics
ISBN : 9781776148974
Fighting an Invisible Enemy narrates the founding in 2002 and growth of the internationally renowned centre of excellence for communicable diseases, the National Institute for Communicable Diseases (NICD) in South Africa. In a continent riven with a panoply of formidable contagious pathogens, the book describes how the nascent NICD travelled a rocky road to maturity. Starting humbly, as did many of its sister public health institutions around the world, the road was strewn with daunting obstacles of financial restrictions, bureaucratic straitjacketing, international isolation during the apartheid era and, in later years, the calumny of governmental AIDS denial. Following the triumph of the eradication of the once-dreaded smallpox, the NICD now plays a crucial role in the global effort to eradicate poliomyelitis. While the country has the misfortune of the largest HIV/AIDS pandemic in the world, the Institute’s HIV research unit has become a world leader. More remote from public notice are the laboratories and support epidemiologists carry out for ongoing surveillance of communicable diseases and the alerts they provide for any signal of an impending outbreak or pandemic. The Institute’s value to public health was clearly shown in the recent Covid-19 pandemic. The maxim that we are only safe when everyone everywhere is safe, underlines the importance of international partnerships and the key role the NICD plays, not only for the country but also for global health. This is a flagship organisation in public health in South Africa and this book paints a vivid portrait of its incredible accomplishments.
Author : Svenja Adolphs,Dawn Knight
Publisher : Routledge
Page : 606 pages
File Size : 45,5 Mb
Release : 2020-04-16
Category : Language Arts & Disciplines
ISBN : 9781000049725
The Routledge Handbook of English Language and Digital Humanities serves as a reference point for key developments related to the ways in which the digital turn has shaped the study of the English language and of how the resulting methodological approaches have permeated other disciplines. It draws on modern linguistics and discourse analysis for its analytical methods and applies these approaches to the exploration and theorisation of issues within the humanities. Divided into three sections, this handbook covers: sources and corpora; analytical approaches; English language at the interface with other areas of research in the digital humanities. In covering these areas, more traditional approaches and methodologies in the humanities are recast and research challenges are re-framed through the lens of the digital. The essays in this volume highlight the opportunities for new questions to be asked and long-standing questions to be reconsidered when drawing on the digital in humanities research. This is a ground-breaking collection of essays offering incisive and essential reading for anyone with an interest in the English language and digital humanities.
Author : Jordan J. Copeland
Publisher : BRILL
Page : 193 pages
File Size : 51,7 Mb
Release : 2020-03-31
Category : Social Science
ISBN : 9781848880870
The papers collected in this volume document the exchange and development of ideas that comprised the 5th Global Conference on Visions of Humanity in Cyberculture, Cyberspace, and Science Fiction, hosted at Mansfield College, Oxford, United Kingdom, in July 2010.
Author : Dan Smyer Yü,Karin Dean
Publisher : Taylor & Francis
Page : 262 pages
File Size : 44,8 Mb
Release : 2021-09-30
Category : History
ISBN : 9781000458428
This book explores the historical interconnections between Bengal, Burma, and Yunnan (China), and views the corridor as a transregion that exhibits mobility, connectivity and diversity as well as place-based ecogeological uniqueness. With a focus on the concept of corridor geographies that have shared human and environmental histories beyond sharply demarcated territorial sovereignties of modern individual nation-states, it presents the variety and complexity of premodern and modern pathways, corridors, borders, and networks of livelihood-making, local political alliances, trade and commerce, religions, political systems, and colonial encounters. The book discusses crucial themes including environmental edgings of human-nonhuman habitats, transregional migratory routes and habitats of megafauna, elephant corridors in Yunnan–Myanmar–Bengal landscape, framing spaces between India and China, Tibetan–Myanmar corridors, transboundary river systems, narratives of a Rohingya jade trader, cross-border flow of De’ang’s fermented tea, householding in upland Laos, cultural identities, and trans-border livelihoods. Comprehensive and topical, with its wide-ranging case studies, this book will be of interest to scholars and researchers of history, routes and border studies, sociology and social anthropology, South East Asian history, South Asian history, Chinese studies, environmental history, human geography, international relations, ecology, and cultural studies.
Author : Sarah S. Willen
Publisher : University of Pennsylvania Press
Page : 320 pages
File Size : 54,7 Mb
Release : 2019-08-02
Category : Social Science
ISBN : 9780812251340
In Fighting for Dignity, Sarah S. Willen explores what happened when the Israeli government launched an aggressive deportation campaign targeting newly arrived migrants from countries as varied as Ghana and the Philippines, Nigeria, Colombia, and Ukraine. Although the campaign was billed as a solution to high unemployment, it had another goal as well: to promote an exclusionary vision of Israel as a Jewish state in which non-Jews have no place. The deportation campaign quickly devastated Tel Aviv's migrant communities and set the stage for even more aggressive antimigrant and antirefugee policies in the years to come. Fighting for Dignity traces the roots of this deportation campaign in Israeli history and the Israeli-Palestinian conflict and shows how policies that illegalize and criminalize migrants wreak havoc in their lives, endanger their health, and curtail the human capacity to flourish. Children born to migrant parents are especially vulnerable to developmental and psychosocial risks. Drawing on nearly two decades of ethnographic engagement in homes and in churches, medical offices, advocacy organizations, and public spaces, Willen shows how migrants struggle to craft meaningful, flourishing lives despite the exclusions and vulnerabilities they endure. To complement their perspectives, she introduces Israeli activists who reject their government's exclusionary agenda and strive to build bridges across difference, repair violations of migrants' dignity, and resist policies that violate their own moral convictions. Willen's vivid and unflinching ethnography challenges us to reconsider our understandings of global migration, human rights, the Middle East— and even dignity itself.
Author : Senior Lecturer in Computer Science Sara Heitlinger,Professor of Urban Informatics Marcus Foth,Course Leader Ba Design for Climate Justice Design School Rachel Clarke
Publisher : Oxford University Press
Page : 353 pages
File Size : 42,6 Mb
Release : 2024-09-04
Category : Computers
ISBN : 9780192884169
Drawing from existing theory, policy, practice and speculative design about how cities may evolve, the book illustrates key concepts using case studies that respond to the complex relationships between human and non-human others (such as animals and plants, as well as soil, rivers, data and sensors) in urban space.
Author : Edmund Russell
Publisher : Cambridge University Press
Page : 340 pages
File Size : 51,8 Mb
Release : 2001-02-12
Category : History
ISBN : 0521799376
This 2001 book shows the intersection of chemical warfare and pest control in the twentieth century.
Author : Ilana Feldman
Publisher : Duke University Press
Page : 390 pages
File Size : 55,6 Mb
Release : 2010-11-30
Category : Political Science
ISBN : 9780822348214
Collection of essays that consider how humanity--as a social, ethical, and political category--is produced through particular governing techniques and in turn gives rise to new forms of government.
Author : Nancy S. Heller,Daniel G. Heller
Publisher : iUniverse
Page : 266 pages
File Size : 44,5 Mb
Release : 2007-01-23
Category : Fiction
ISBN : 9780595863839
1ST FLAP COPY Several years ago, while I was rounding at one of the Brigham and Women's Hospital nurseries, a new father shared a funny story with me. Early the previous morning, this new father went to the hospital lobby in search of coffee and bagels. While waiting in line at the coffee shop, the father noticed a man enter the lobby. He was struck by the odd appearance of this man. In the midst of a brutally cold New England winter, this man was dressed in a bicycle racing shirt, shorts, ski socks pulled up to his knobby knees, ankle weights, a hos- pital ID badge around his neck, and a propeller att- ached to the top of his bicycle helmet. When he returned to his wife's hospital room, he told her about his experience. This new dad worked in the human services field and was very impressed that the hospital was so progressive as to hire such an obviously mentally challenged person. About ten minutes passed when the new parents heard a loud knock on the hospital room door. To their surprise, shock, astonishment and horror, the same man walked into the room?complete with the propeller helmet, shorts, ski socks, ankle weights. Now the man had a stethoscope around his neck and was pushing a portable crib with their new baby! Greeting the shocked and befuddled new parents, the man proudly announced his arrival. "Hi, I'm Dr. Heller. I'm your pediatrician and am here to exam- ine your baby." Dr. Dan was, without a doubt, the most unique, charismatic and outgoing individual who one will ever meet. As one mother remarked to me, 'You will always remember the first time you met Dr. Dan." Bruce Bunnell, MD, Dr. Heller's partner of 15 years at Centre Pediatrics, told this story at a memorial sevice for Dr. Heller in 2005. 2nd FLAP: "Having Dr. Heller for a doctor was like having Mary Poppins for a nanny." -Parent, Sara B. "Dr. Dan was an original-that's the only way I know how to put it. He is such a huge part of our family history that memories keep flooding in. For example, when our daughter finally slept through the night after months of disturbing our sleep, my husband and I were not only shocked: as new parents, we were also worried that her brand new sleep pattern might signal a serious medical problem. Dr. Dan was on when I called, and I will never forget how he questioned me closely about symp- toms and listened very carefully to all I said. Then, as I hung on to every word of diagnosis he could provide for me, he slowly explained, 'That, Mrs. L, is what we in the medical profession refer to as ...a blessing!'" -Parent, Susan L.
Author : A. Guarino,E.M.M. Quigley,W.A. Walker
Publisher : Karger Medical and Scientific Publishers
Page : 216 pages
File Size : 47,7 Mb
Release : 2013-04-29
Category : Medical
ISBN : 9783318023251
Our microflora is an individual personal feature, providing a distinct tag to individuals. However, our intestinal microbiome is strongly affected by genetic, nutritional, and other external factors, and evolves with age. An effect of different microbial patterns on health appears very likely as there seem to be specific changes of intestinal microflora associated with various diseases. Specific microbial tags may thus be used as biomarkers of disease: to diagnose it, to monitor its evolution, and eventually to predict its response to treatment. This scenario opens the opportunity for targeting intestinal microflora using probiotics, both for prevention and treatment of an increasing number of conditions. Probiotic therapy is applied either as an adjunct to other treatments or as primary therapy, and evidence of efficacy is accumulating in several conditions, affecting either the intestine or nonintestinal organs. This publication provides an update on probiotics directed at physicians, biologists, biotechnologists, and researchers working in the food industry and agriculture, as well as in the environmental and basic sciences.
