Hydroxy Pyridones As Antifungal Agents With Special Emphasis On Onychomycosis
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Hydroxy-Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis by Sam Shuster Pdf
This book summarizes the results of two symposia held on hydroxy-pyridones as antifungal agents organized on the occasion of the International Summit on Cutaneous Antifungal Therapy 1996 in Vancouver and the 19th World Congress of Dermatology 1997 in Sydney. Some of the papers deal with the basic mechanisms of action and how these translate into product features, e.g. activity spectrum. Other papers describe the unique properties of hydroxy-pyridones, such as high penetration into and through keratinic tissues or their activity as dual inhibitor on 5-lipoxygenase and cyclooxygenase which leads to a remarkable antiinflammatory effect. Last but not least various accounts are given which show how this unique product profile aids the treatment of various fungal diseases, especially onychomycosis.
Topical Nail Products and Ungual Drug Delivery by S Narasimha Murthy,Howard I. Maibach Pdf
Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail. A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book. Topics Include Nail anatomy, physiology, diseases, and treatment Permeability of the nail plate Topical nail formulations Approaches to enhance ungual and trans-ungual drug delivery In vitro and in vivo models to evaluate topical nail formulations Nail sampling techniques Bioengineering of the nail Trans-ungual iontophoresis Pharmacokinetics of drugs in the nail apparatus Onychopharmacokinetics: proposed model insight Photodynamic therapy of nail diseases The nail as a surrogate for investigating drug use
M Lindsay Grayson,Suzanne M Crowe,James S McCarthy,John Mills,Johan W Mouton,S Ragnar Norrby,David L Paterson,Michael A Pfaller
Author : M Lindsay Grayson,Suzanne M Crowe,James S McCarthy,John Mills,Johan W Mouton,S Ragnar Norrby,David L Paterson,Michael A Pfaller Publisher : CRC Press Page : 3211 pages File Size : 54,8 Mb Release : 2010-10-29 Category : Medical ISBN : 9781444147520
Kucers' The Use of Antibiotics Sixth Edition by M Lindsay Grayson,Suzanne M Crowe,James S McCarthy,John Mills,Johan W Mouton,S Ragnar Norrby,David L Paterson,Michael A Pfaller Pdf
'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Drug Discovery Targeting Drug-Resistant Bacteria by Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta Pdf
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war
Medical Mycology by Mehdi Razzaghi-Abyaneh,Masoomeh Shams-Ghahfarokhi,Mahendra Rai Pdf
The identification of medically important fungi has been an important area of study that warrants further extensive research. The use oftraditional and molecular methods of identification, provides new insights into differentiation of species and ultimately the line of treatment can be determined. This book incorporates a diverse group of medically important fungi and diseases, including common dermatophytes, onychomycosis, Coccidiomycosis, Paracoccidioidomycosis, Mycotic keratitis, Sporotrichosis, Histoplasmosis and determination of identity of medically important fingi by uising modern techniques such as PCH and the use of MALDI-TOF: as a rapid and new approach in fungal diagnosis and differentiation.
Kucers' The Use of Antibiotics by M. Lindsay Grayson,Sara E. Cosgrove,Suzanne Crowe,William Hope,James S. McCarthy,John Mills,Johan W. Mouton,David L. Paterson Pdf
Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference. Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.
Malassezia and the Skin by Teun Boekhout,Eveline Guého-Kellermann,Peter Mayser,Aristea Velegraki Pdf
This book covers all necessary aspects on the global epidemiology of Malassezia species and their effect on various diseases. Valuable treatment advice is given in order to improve the treatment outcome of affected patients.
World Clinics in Dermatology: Fungal Infections by Rashmi Sarkar,Surabhi Sinha Pdf
Salient Features: - This book focuses on world clinics dermatology: fungal infections topical treatments. - Fungal diseases are common dermatologic complaints in medical practice and definitely one of the commonest skin infections seen worldwide. - Antifungal agents can be used both topically and systemically; however, systemic agents are reserved for more widespread or severe fungal infections. - Dermatophytoses are usually amenable to topical agents if localized, but may need oral antifungals if multisite infection is present or the dermatophytosis is at certain areas like soles, nails, or scalp, etc. - Topical antifungals have limited but important indications. - This book consists of 11 chapters, which include topical antifungals and classes of topical antifungal drugs, dermatophytoses, other cutaneous superficial fungal infections and their topical treatment, onychomycoses, topical polyenes, allylamine and benzylamine topical antifungals, topical azole antifungals, hydroxypyridone topical antifungal, antifungal resistance, and counseling for dermatophytosis. - The current issue of World Clinics in Dermatology 2019 gives a wide insight into older and newer exciting broad-spectrum topical antifungals. - This book will be equally helpful to practitioners, dermatology departments and students of dermatology, all over the world.
Brian K. Alldredge,Robin L. Corelli,Michael E. Ernst
Author : Brian K. Alldredge,Robin L. Corelli,Michael E. Ernst Publisher : Lippincott Williams & Wilkins Page : 2562 pages File Size : 50,5 Mb Release : 2012-02-01 Category : Medical ISBN : 9781609137137
Dermatology by Otto Braun-Falco,Gerd Plewig,Helmut Heinrich Wolff,Walter H.C. Burgdorf Pdf
Completely revised and updated, Dermatology covers all the classical and related fields of dermatology, providing a wealth of information on clinical features, pathophysiology, and differential diagnosis. Over 900 color photographs acquaint the reader with a variety of dermatological diseases. Each chapter contains detailed proposals for comprehensive therapy.
Dietary Phytochemicals and Microbes by Amlan K. Patra Pdf
Humans have utilized the bioactive principles of different plants for various beneficial physiological properties including antimicrobial properties for many centuries. However, interests of using medicinal plants declined in the 20th century with the availability of effective synthetic antimicrobial drugs. The development of microbial resistance to various drugs has accelerated research interests towards the use of phytochemicals as alternatives to synthetic drugs in the recent years. This book presents an comprehensive reviews on the antimicrobial and antiviral properties of numerous recently reported phytochemicals, and their mechanisms of antimicrobial actions. Some of the chapters have critically discussed the beneficial and adverse effects of antibacterial, and stimulatory activities of dietary phytochemicals on rumen microbial populations, and gut microbial populations of humans and animals. Microbial adaptation and resistance of microbes to phytochemicals has also been highlighted. On the applied apects, the use of phytochemicals against drug resistance microbes, to treat microbial diseases, for food preservation, to inhibit methanogenic archaea in the rumen, and to modulate lipid biohydrogenating microbial populations to increase conjugated linoleic acids in animal-derived foods have been presented in different chapters.
Encyclopedic Reference of Molecular Pharmacology by Stefan Offermanns,Walter Rosenthal Pdf
Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.