Identification And Quantification Of Drugs Metabolites And Metabolizing Enzymes By Lc Ms

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Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS

Swapan Chowdhury
Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS Book PDF

Author : Swapan Chowdhury
Publisher : Elsevier
Page : 354 pages
File Size : 48,8 Mb
Release : 2005-11-04
Category : Science
ISBN : 0080456065

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Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS by Swapan Chowdhury Pdf

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Shuguang Ma,Swapan Chowdhury
Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters Book PDF

Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier
Page : 710 pages
File Size : 40,6 Mb
Release : 2020-07-09
Category : Science
ISBN : 9780128200193

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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters by Shuguang Ma,Swapan Chowdhury Pdf

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Mass Spectrometry in Drug Metabolism and Disposition

Mike S. Lee,Mingshe Zhu
Mass Spectrometry in Drug Metabolism and Disposition Book PDF

Author : Mike S. Lee,Mingshe Zhu
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 42,5 Mb
Release : 2011-03-16
Category : Science
ISBN : 9780470934692

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Mass Spectrometry in Drug Metabolism and Disposition by Mike S. Lee,Mingshe Zhu Pdf

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Drug Transporters

Martin F. Fromm,Richard B. Kim
Drug Transporters Book PDF

Author : Martin F. Fromm,Richard B. Kim
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 52,7 Mb
Release : 2010-11-19
Category : Medical
ISBN : 9783642145414

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Drug Transporters by Martin F. Fromm,Richard B. Kim Pdf

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Using Mass Spectrometry for Drug Metabolism Studies, Second Edition

Walter A. Korfmacher
Using Mass Spectrometry for Drug Metabolism Studies Second Edition Book PDF

Author : Walter A. Korfmacher
Publisher : CRC Press
Page : 451 pages
File Size : 41,9 Mb
Release : 2009-11-03
Category : Science
ISBN : 1420092219

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Using Mass Spectrometry for Drug Metabolism Studies, Second Edition by Walter A. Korfmacher Pdf

The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.

Drug Metabolism in Drug Design and Development

Donglu Zhang,Mingshe Zhu,William G. Humphreys
Drug Metabolism in Drug Design and Development Book PDF

Author : Donglu Zhang,Mingshe Zhu,William G. Humphreys
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 48,9 Mb
Release : 2007-11-16
Category : Science
ISBN : 0470191686

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Drug Metabolism in Drug Design and Development by Donglu Zhang,Mingshe Zhu,William G. Humphreys Pdf

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

LC-MS/MS in Proteomics

Pedro R. Cutillas,John F. Timms
LC MS MS in Proteomics Book PDF

Author : Pedro R. Cutillas,John F. Timms
Publisher : Humana Press
Page : 330 pages
File Size : 53,8 Mb
Release : 2011-04-06
Category : Science
ISBN : 1607617811

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LC-MS/MS in Proteomics by Pedro R. Cutillas,John F. Timms Pdf

With the development of new quantitative strategies and powerful bioinformatics tools to cope with the analysis of the large amounts of data generated in proteomics experiments, liquid chromatography with tandem mass spectrometry (LC-MS/MS) is making possible the analysis of proteins on a global scale, meaning that proteomics can now start competing with cDNA microarrays for the analysis of whole genomes. In LC-MS/MS in Proteomics: Methods and Applications, experts in the field provide protocols and up-to-date reviews of the applications of LC-MS/MS, with a particular focus on MS-based methods of protein and peptide quantification and the analysis of post-translational modifications. Beginning with overviews of the use of LC-M/MS in protein analysis, the book continues with topics such as protocols for the analysis of post-translational modifications, with particular focus on phosphorylation and glycosylation, popular techniques for quantitative proteomics, such as multiple reaction monitoring, metabolic labelling, and chemical tagging, biomarker discovery in biological fluids, as well as novel applications of LC-MS/MS. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, LC-MS/MS in Proteomics: Methods and Applications presents the techniques and concepts necessary in order to aid proteomic practitioners in the application of LC-MS/MS to essentially any biological problem.

Drug Metabolism, Pharmacokinetics and Bioanalysis

Hye Suk Lee,Kwang-Hyeon Liu
Drug Metabolism Pharmacokinetics and Bioanalysis Book PDF

Author : Hye Suk Lee,Kwang-Hyeon Liu
Publisher : MDPI
Page : 230 pages
File Size : 47,7 Mb
Release : 2019-06-12
Category : Medical
ISBN : 9783038979166

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Drug Metabolism, Pharmacokinetics and Bioanalysis by Hye Suk Lee,Kwang-Hyeon Liu Pdf

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Mass Spectrometry in Drug Metabolism

Frigerio
Mass Spectrometry in Drug Metabolism Book PDF

Author : Frigerio
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 51,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461341512

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Mass Spectrometry in Drug Metabolism by Frigerio Pdf

When a dose of drug is administered, three main phases of drug action may be distingushed. In the "pharmaceutical" phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ("pharmaco kinetic" phase) includes absorption, distribution, metabolism, and excretion. That fraction of the dose which finally reaches the circulation after absorption will be available for biological action in the third, or "pharmacodynamic" phase when the drug reaches the target tissues and a drug-receptor interaction takes place. The objectives in studies of drug metabolism are: (a) to identify the pathways by which drugs are transformed in the body; (b) to ascertain quantitatively the importance of each pathway and intermediate; (c) to identify and quantify endogenous constituents influenced by the drug or its metabolites which may interfere with common metabolic processes. Since metabolites usually differ from their precursors by only a single chemical group, the resulting metabolic pathways generally consist of a series of closely related compounds. Mass spectrometry is uniquely suited for the analysis of drugs and metabolites for several reasons: only a minimal amount of sample preparation is needed, closely related compounds can be analyzed in a single step, structures can often be deduced directly from the mass spectra without the need for pure reference spectra, and constituents can be quantified with relative ease even when present in fractional nanogram quantity.

Handbook of Drug Metabolism, Third Edition

Paul G. Pearson,Larry C. Wienkers
Handbook of Drug Metabolism Third Edition Book PDF

Author : Paul G. Pearson,Larry C. Wienkers
Publisher : CRC Press
Page : 755 pages
File Size : 55,7 Mb
Release : 2019-05-20
Category : Medical
ISBN : 9781482262049

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Handbook of Drug Metabolism, Third Edition by Paul G. Pearson,Larry C. Wienkers Pdf

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Ragu Ramanathan
Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book PDF

Author : Ragu Ramanathan
Publisher : John Wiley & Sons
Page : 326 pages
File Size : 52,5 Mb
Release : 2011-09-20
Category : Science
ISBN : 9781118211571

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Mass Spectrometry in Drug Metabolism and Pharmacokinetics by Ragu Ramanathan Pdf

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.

Encyclopedia of Analytical Science

Anonim
Encyclopedia of Analytical Science Book PDF

Author : Anonim
Publisher : Elsevier
Page : 5142 pages
File Size : 51,9 Mb
Release : 2019-04-02
Category : Science
ISBN : 9780081019849

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Encyclopedia of Analytical Science by Anonim Pdf

The third edition of the Encyclopedia of Analytical Science, Ten Volume Set is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science, Ten Volume Set provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher

Drug Testing in Hair

Pascal Kintz
Drug Testing in Hair Book PDF

Author : Pascal Kintz
Publisher : CRC Press
Page : 310 pages
File Size : 42,5 Mb
Release : 1996-05-07
Category : Law
ISBN : 0849381126

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Drug Testing in Hair by Pascal Kintz Pdf

Drug Testing in Hair is the first book on this timely and controversial topic. The book's purpose is to validate hair testing as an accepted form of evidence for use in courts and elsewhere, such as the military and the workplace. This volume presents the most recent experiments and clinical applications to provide missing information and insight into the unanswered questions of hair testing. Active researchers working in hair testing have contributed chapters to this book. New data, never before published, are incorporated into the text, so the reader receives cutting-edge information from experts in the field. This is must-have information on everything you need to know about drug testing in hair.

Handbook of Radioactivity Analysis

Michael F. L'Annunziata
Handbook of Radioactivity Analysis Book PDF

Author : Michael F. L'Annunziata
Publisher : Academic Press
Page : 1076 pages
File Size : 46,7 Mb
Release : 2020-03-07
Category : Science
ISBN : 9780128143964

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Handbook of Radioactivity Analysis by Michael F. L'Annunziata Pdf

Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, constitute an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes.Users will find the latest advances in the applications of radioactivity analysis across various fields, including environmental monitoring, radiochemical standardization, high-resolution beta imaging, automated radiochemical separation, nuclear forensics, and more. Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a new chapter on the analysis of environmental radionuclides Provides the latest advances in the applications of liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, Cherenkov counting, flow-cell radionuclide analysis, radionuclide standardization, aerosol analysis, high-resolution beta imaging techniques, analytical techniques in nuclear forensics, and nuclear safeguards Describes the timesaving techniques of computer-controlled automatic separation and activity analysis of radionuclides Provides an extensive table of the radiation characteristics of most radionuclides of interest for the radioanalytical chemist

High-Throughput Analysis in the Pharmaceutical Industry

Perry G. Wang
High Throughput Analysis in the Pharmaceutical Industry Book PDF

Author : Perry G. Wang
Publisher : CRC Press
Page : 432 pages
File Size : 42,8 Mb
Release : 2008-08-20
Category : Medical
ISBN : 9781420059540

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High-Throughput Analysis in the Pharmaceutical Industry by Perry G. Wang Pdf

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres