Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 41,8 Mb
Release : 2024-06-17
Category : Electronic
ISBN : OCLC:1125727614
Cutaneous Melanoma
Anonim
Immune Checkpoint Inhibitors
Immune Checkpoint Inhibitors Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Immune Checkpoint Inhibitors book. This book definitely worth reading, it is an incredibly well-written.
Immune Checkpoint Inhibitors in Cancer
Fumito Ito,Marc Ernstoff
Author : Fumito Ito,Marc Ernstoff
Publisher : Elsevier Health Sciences
Page : 400 pages
File Size : 49,8 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9780323549509
Immune Checkpoint Inhibitors in Cancer by Fumito Ito,Marc Ernstoff Pdf
Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It’s an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. Helps you translate current research and literature into practical information for daily practice. Presents information logically organized by disease site. Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. Consolidates today’s available information on this timely topic into one convenient resource.
Immunotherapy of Hepatocellular Carcinoma
Tim F. Greten
Author : Tim F. Greten
Publisher : Springer
Page : 167 pages
File Size : 51,8 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319649580
Immunotherapy of Hepatocellular Carcinoma by Tim F. Greten Pdf
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Drug-Induced Liver Injury
Anonim
Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 48,6 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176
Drug-Induced Liver Injury by Anonim Pdf
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
SITC’s Guide to Managing Immunotherapy Toxicity
Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD
Author : Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD
Publisher : Springer Publishing Company
Page : 250 pages
File Size : 43,5 Mb
Release : 2019-03-15
Category : Medical
ISBN : 9780826172150
SITC’s Guide to Managing Immunotherapy Toxicity by Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD Pdf
The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer
Immuno-Oncology
O. Michielin,G. Coukos
Author : O. Michielin,G. Coukos
Publisher : Karger Medical and Scientific Publishers
Page : 140 pages
File Size : 53,9 Mb
Release : 2015-09-09
Category : Medical
ISBN : 9783318055900
Immuno-Oncology by O. Michielin,G. Coukos Pdf
Over the last decade, immuno-oncology has witnessed an astonishing pace of discovery and innovation translating into unprecedented successes in the clinical setting, arguably representing one of the most profound and transforming revolution in the history of cancer therapy. This book provides a concise and accurate outline of the main developments in major tumor types including melanoma, lung, breast, brain and renal cell cancers. In addition, transversal chapters that describe the commonalities of some of the therapeutic strategies are provided to cover topics like immune checkpoint biology, T cell engineering or rational combination therapies. Each chapter has been authored by senior key opinion leaders in their respective fields to provide the most up-to-date view on cancer immuno-oncology. To reflect on the key translational aspect of immuno-oncology, all chapters are making explicit connections between basic science discoveries and the resulting translational therapeutic strategies. Immuno-Oncology will be an invaluable source of information for scientists interested in the translation of basic immunology into the clinical practice, as well as for clinician interested in deepening their knowledge of current and upcoming immune strategies in the fight against cancers.
Immune Checkpoint Inhibitors
Afsheen Raza
Author : Afsheen Raza
Publisher : BoD – Books on Demand
Page : 214 pages
File Size : 40,6 Mb
Release : 2023-03-08
Category : Medical
ISBN : 9781803565903
Immune Checkpoint Inhibitors by Afsheen Raza Pdf
Immune Checkpoint Inhibitors - New Insights and Recent Progress explores a vast array of subjects related to immune checkpoint inhibitors and presents novel insights in this emerging field. Chapters address such topics as mechanistic approaches of emerging immune checkpoint inhibitors, their role in clinical and pre-clinical trials, the manipulation of the system by immune-related adverse events that hinder the utility of these immune molecules, and the predictive and prognostic aspects of these molecules as biomarkers of response in immunotherapy. The book is useful for students, clinicians, and scientists to gain updated information on managing patients treated with immune checkpoint inhibitors.
Immune Checkpoint Molecules and Cancer Immunotherapy
Alexandr V. Bazhin,Amedeo Amedei,Svetlana Karakhanova
Author : Alexandr V. Bazhin,Amedeo Amedei,Svetlana Karakhanova
Publisher : Frontiers Media SA
Page : 197 pages
File Size : 50,6 Mb
Release : 2019-01-22
Category : Electronic
ISBN : 9782889457328
Immune Checkpoint Molecules and Cancer Immunotherapy by Alexandr V. Bazhin,Amedeo Amedei,Svetlana Karakhanova Pdf
Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors
National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 89 pages
File Size : 42,7 Mb
Release : 2019-10-05
Category : Medical
ISBN : 9780309490863
Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum Pdf
In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote an immune response to cancer, researchers have developed immune checkpoint inhibitors that enable T-cells to recognize cancer cells as foreign and to prevent deactivation of an immune system response. To examine the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors, the National Cancer Policy Forum held a workshop on July 16â€"17, 2018, in Washington, DC. This workshop convened stakeholders with a broad range of expertise, including cancer researchers, clinicians, patient advocates, and representatives from industry, academia, and government. This publication summarizes the presentations and discussions from the workshop.
Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
Said Dermime,Maysaloun Merhi,Taha Merghoub
Author : Said Dermime,Maysaloun Merhi,Taha Merghoub
Publisher : Frontiers Media SA
Page : 284 pages
File Size : 40,7 Mb
Release : 2021-12-28
Category : Medical
ISBN : 9782889718634
Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer by Said Dermime,Maysaloun Merhi,Taha Merghoub Pdf
Treatment of Bone and Soft Tissue Sarcomas
Per-Ulf Tunn
Author : Per-Ulf Tunn
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 48,7 Mb
Release : 2008-12-28
Category : Medical
ISBN : 9783540779605
Treatment of Bone and Soft Tissue Sarcomas by Per-Ulf Tunn Pdf
Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.
Lymphocyte Activation
L.E. Samelson,H. Renz
Author : L.E. Samelson,H. Renz
Publisher : Unknown
Page : 0 pages
File Size : 42,5 Mb
Release : 1994
Category : Medical
ISBN : 3318018988
Lymphocyte Activation by L.E. Samelson,H. Renz Pdf
Hepatotoxicity
Hyman J. Zimmerman
Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 47,8 Mb
Release : 1999
Category : Medical
ISBN : 0781719526
Hepatotoxicity by Hyman J. Zimmerman Pdf
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Oncoimmunology
Laurence Zitvogel,Guido Kroemer
Author : Laurence Zitvogel,Guido Kroemer
Publisher : Springer
Page : 724 pages
File Size : 52,5 Mb
Release : 2017-12-13
Category : Medical
ISBN : 9783319624310
Oncoimmunology by Laurence Zitvogel,Guido Kroemer Pdf
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Regulation of Cancer Immune Checkpoints
Jie Xu
Author : Jie Xu
Publisher : Springer Nature
Page : 657 pages
File Size : 50,7 Mb
Release : 2020-03-17
Category : Medical
ISBN : 9789811532665
Regulation of Cancer Immune Checkpoints by Jie Xu Pdf
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
