Immunochemistry Of Proteins

Author : M. Z. Atassi
Publisher : Springer Science & Business Media
Page : 333 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461329220

Get Book

Immunochemistry of Proteins by M. Z. Atassi Pdf

The structural features responsible for the immunogenicity of certain parts of native protein molecules have been of interest to immunochem ists and protein chemists for over three decades. However, until re cently no concerted effort was (or could be) devoted to the elucidation of the complete antigenic structure of a protein. In order for these en deavors to be successful and meaningful, knowledge of both the amino acid sequence and the detailed three-dimensional structure of the protein is necessary. Such information was not available for a protein until early in the 1960s. This and the fact that protein chemistry was not in fact sufficiently developed early in the 1960s to enable the successful unrav eling of the entire antigenic structure of a protein were major reasons for the slow progress in this field. Determination of the antigenic structures of proteins, therefore, posed a chemical challenge of enormous propor tions. For these reasons, many investigators diverted their attention to study of the immunochemistry of amino acid polymers in the hope that the information derived from these systems might prove useful in the understanding of the immunochemistry of proteins. A great many data on these systems were accumulated that have provided valuable infor mation on the immune mechanism. Unfortunately, it has now become clear the information from amino acid polymers has not helped in under standing the immunochemistry of proteins.

Author : M. Zouhair Atassi
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461341901

Get Book

Immunochemistry of Proteins by M. Zouhair Atassi Pdf

The structural features responsible for the immunogenicity of certain parts of native protein molecules have been of interest to immunochemists and protein chemists for over three decades. Following the early work of Land steiner in 1942, which showed that peptide fragments from silk fibroin exhibited an inhibitory activity toward the reaction of the protein with its antibodies, fragments from many other protein systems have been isolated and studied. However, no concerted effort was (or could be) devoted to the elucidation of the complete antigenic structure of a protein. In order for these endeavors to be successful and meaningful, knowledge of both the amino acid sequence and the detailed three-dimensional structure of the protein is necessary. Such information was not available for a protein until early in the 1960s. This and the fact that protein chemistry was not in fact sufficiently developed early in the 1960s to enable the successful completion of the entire antigenic structure of a protein were major contributing factors for the slow progress in this field. Determination of the antigenic structures of proteins therefore posed a chemical challenge of enormous proportions. For these reasons, many investigators diverted their attention to study of the immunochemistry of homo- or mixed amino acid polymers in the hope that the information derived from these systems might prove useful in the understanding of the immunochemistry of proteins.

Author : M. Atassi
Publisher : Springer
Page : 472 pages
File Size : 44,9 Mb
Release : 1977
Category : Medical
ISBN : UOM:39015004435601

Get Book

Immunochemistry of Proteins by M. Atassi Pdf

The structural features responsible for the immunogenicity of certain parts of native protein molecules have been of interest to immunochemists and protein chemists for over three decades. Following the early work of Landsteiner in 1942, which showed that peptide fragments from silk fibroin exhibited an inhibitory activity toward the reaction of the protein with its antibodies, fragments from many other protein systems have been isolated and studied. However, no concerted effort was (or could be) devoted to the elucidation of the complete antigenic structure of a protein. In order for these endeavors to be successful and meaningful, knowledge of both the amino acid sequence and the detailed three-dimensional structure of the protein are necessary. Such information was not available for a protein until early in the 1960s. This and the fact that protein chemistry was not in fact sufficiently developed early in the 1 960s to enable the success ful completion of the entire antigenic structure of a protein were major contributing factors for the slow progress in this field. Determination of the antigenic structures of proteins, therefore, posed a chemical challenge of enormous proportions. For these reasons, many investigators diverted their attention to study the immunochemistry of homo- or mixed amino acid polymers in the hope that the information derived from these systems may prove useful in the understanding of the immunochemistry of proteins. A great many data on these systems were accumulated that have proved valuable in gaining some information on the immune mechanism.

Author : Anonim
Publisher : Unknown
Page : 321 pages
File Size : 49,8 Mb
Release : 1979
Category : Immunochemistry
ISBN : OCLC:841703246

Get Book

Immunochemistry of Proteins. by Anonim Pdf

Author : M. Z. Atassi
Publisher : Unknown
Page : 510 pages
File Size : 51,6 Mb
Release : 1977
Category : Immunochemistry
ISBN : 1461341914

Get Book

Immunochemistry of Proteins by M. Z. Atassi Pdf

Author : M. Zouhair Atassi
Publisher : Springer Science & Business Media
Page : 501 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461588580

Get Book

Immunobiology of Proteins and Peptides · I by M. Zouhair Atassi Pdf

One of the central questions in immunology is the understanding in molecular terms of antigen-antibody interactions and of the cellu lar recognition of antigens. It is hoped that this understanding will extend eventually to the immunobiological basis of host defense to infectious agents and of tissue damage or deranged cell functions which stem from these reactions. A variety of natural and artificial substances have been used as models for these studies. Emphasis was placed upon substances of known and relatively uncomplicated chemical structures. These included polysaccharides, amino acid polymers, nu cleic acids and haptens. On the other hand. until recently there has been very little information on protein antigens. The complexity of these molecules posed an immense chemical obstacle to precise immuno chemical analysis. Indeed, it is this difficulty with proteins that spurred the synthesis and immunological studies of amino acid poly mers. The control and normal regulation of the immune system at the cellular-molecular interface and the great majority of antigens asso ciated with immune disorders are attributed to protein molecules. In the last few years great advances have been made in the analysis and synthesis of the antigenic sites of some proteins. The entire antigenic structures of myoglobin and lysozyme and the partial anti genic structures of several other proteins have been determined. Moreover, in the past seven years several biological responses resulting from the reactions of proteins and their peptides with cells of the immune system were described.

Author : M. Zouhair Atassi
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468443318

Get Book

Immunobiology of Proteins and Peptides—II by M. Zouhair Atassi Pdf

The immune response is largely dependent on molecular inter actions involving proteins. The recognition of antigen molecules, whether they are proteins or non-proteins, whether they are self or non-self, takes place at the molecular-cellular interface through membrane receptor molecules that are proteins. The initial step of recognition activates a complex series of cellular events requiring some mechanism of cell-cell interactions and communi cations, eventually leading to antibody production. This biolo gical cascade is controlled at several positions along its con secutive pathways by protein molecules, either in the free form or as receptors on membranes of cells committed to this activity. Clearly, then, the proper understanding of the response by cells of the immune system will depend, to a great measure, on the definition of the molecular events involving protein interactions. Obviously, cells work via molecules and molecules work via cells and, at this level of functional resolution, molecular immunology and cellular immunology will merge and will depend heavily on protein chemistry.

Author : Felix Haurowitz
Publisher : Unknown
Page : 328 pages
File Size : 54,6 Mb
Release : 1968
Category : Antigens
ISBN : UCAL:B4339268

Get Book

Immunochemistry and the Biosynthesis of Antibodies by Felix Haurowitz Pdf

Antikörper / Biochemie.

Author : Furthmayr
Publisher : CRC Press
Page : 273 pages
File Size : 48,9 Mb
Release : 2018-01-18
Category : Science
ISBN : 9781351081863

Get Book

Immunochemistry Of The Extracellular Matrix by Furthmayr Pdf

The main purpose of the two volumes on Immunochemistry of the Extracellular Matrix is to describe state of the art methods, which have been proven to provide antibody reagents of defined specificity to collagens as well as other glycoproteins found in association within connective tissue. The isolation and purification of collagens, procollagens, and related connective tissue proteins are described for several tissues, tissue culture cells and species. Immunization with these collagens in laboratory animals yields antibodies with different characteristic specificities: to the procollagen extension fragments, the non-helical segments of the a-chains, to helical and denatured determinants.

Author : F. Inman
Publisher : Springer Science & Business Media
Page : 196 pages
File Size : 44,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475713435

Get Book

Contemporary Topics in Immunochemistry by F. Inman Pdf

In 1897, Ehrlich suggested that natural preformed receptors from the surface of cells provided immunity to various chemical substances. Many years later, in 1940, Pauling proffered the concept that antibodies comprised a single poly peptide chain and that each end of the protein could form an antigen-binding site. Burnet tried to explain the diversity of antibody specificity by hypothesizing that it was cell-derived. These hypotheses probably have led to as much or more experimentation and discussion than any other of the many conjectures set forth to explain immunity on a molecular and cellular basis. Extensive investigations, initially stimulated by these propositions, proved Pauling's notion incorrect. In its demise, however, the multichain structure of the immunoglobulins was realized. In retrospect it be comes obvious that Ehrlich's idea, though not correct, was borne of amazing logic and cognition. Expansion of Burnet's theory seems to be occurring presently; much excitement is engendered by the finding of cell-bound immunoglobulin receptors. Ouring the preceding dozen years, immunochemists have accumulated enormous quantities of data. Though there is so much yet to be done, as a result of this research one may now discuss antigen-binding sites in relation to the protein's primary structure. There is even considerable understanding of the cellular assembly of some immunoglobulins. Entire books can be written about the chemistry of antigens and of complement.

Author : R. Nezlin
Publisher : Springer Science & Business Media
Page : 395 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468417913

Get Book

Biochemistry of Antibodies by R. Nezlin Pdf

When the history of immunology in the twentieth century is written, the decade of the 1960's will, in all probability, stand out as the period of greatest advance in the development of molecular immunology. It is appropriate and useful, therefore, that a schol arly and integrated presentation of this progress should be made available in English. The translation of Dr. Nezlin's "Biochem istry of Antibodies" from Russian admirably fulfills this need in the form of a scientific monograph directed to medical and biolog ical scientists. The appearance of this monograph also serves to emphasize the conceptual unification of diverse immunological phenomena which has emerged from progress in molecular immunology. This unity is a consequence of the key role played by the antibody mol ecule (either in solution or cell-bound) in every biological process properly described as immunological. Indeed, immunology as an independent natural science can be described as the study of the structure, interactions, and biosynthes is of the antibody molecule.

Author : M Z Atassi
Publisher : Unknown
Page : 244 pages
File Size : 46,9 Mb
Release : 1982-09-01
Category : Electronic
ISBN : 1468443321

Get Book

Immunobiology of Proteins and Peptides II by M Z Atassi Pdf

Author : Tibor Dévényi,János Gergely
Publisher : Elsevier Science & Technology
Page : 354 pages
File Size : 48,7 Mb
Release : 1974
Category : Science
ISBN : UOM:39015000266521

Get Book

Amino Acids, Peptides and Proteins by Tibor Dévényi,János Gergely Pdf

Author : M Zouhair Atassi
Publisher : Springer
Page : 524 pages
File Size : 51,9 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1461588596

Get Book

Immunobiology of Proteins and Peptides . I by M Zouhair Atassi Pdf

Author : A.M. Ward,J. Whicher
Publisher : Springer
Page : 268 pages
File Size : 48,5 Mb
Release : 1979-02-28
Category : Medical
ISBN : UCAL:B5136505

Get Book

Immunochemistry in Clinical Laboratory Medicine by A.M. Ward,J. Whicher Pdf

The rapid growth of specific protein estimations in the clinical laboratory over the last 10 years has been due to advances both in methodology and in the understanding of the role of the various plasma proteins in health and disease. This expansion has been made possible by the development of both gel phase and fluid phase techniques for the estimation of proteins and the ready availability of antisera to individual plasma proteins. The specificity of the immunological reaction has allowed the more precise identification and estimation of individual plasma proteins than was possible with dye binding or other chemical techniques, but at the same time these methods have introduced other possible errors and pitfalls. Advances in understanding of the structure and function of various plasma proteins has pointed the way to new clinical applications of plasma protein estimation in the diagnosis and monitoring of disease. The Symposium, of which these are the proceedings, was planned to bring together a number of experts in the field to discuss the available methods and their clinical application.