Immunocytochemistry For Steroid Receptors

Author : Louis P. Pertschuk
Publisher : CRC Press
Page : 226 pages
File Size : 40,7 Mb
Release : 1990-08-15
Category : Medical
ISBN : 0849369436

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Immunocytochemistry for Steroid Receptors by Louis P. Pertschuk Pdf

A comprehensive review of the literature on steroid hormone receptor immuncytochemistry. It includes the development of the first monoclonal antireceptor antibody and initial procedures designed to localize steroid receptors in situ up to the present. The step-by-step instructions provide easy reading of topics such as tissue handling, processing, and interpretation. This text places particular emphasis on the studies of human material-especially mammary carcinoma. It presents specific details with chapters on estrogen and progesterone receptors in breast malignancies and benign breast disease. Each section of this outstanding book contains comprehensive photomicrographs that illustrate the most salient features discussed. Detailed graphs pertaining to theoretical particulars concerning technology and the relationship between image analysis and endocrine response are also included. This monograph is an excellent resource for all researchers concerned with hormone-dependent tissues, pathologists who have an interest in working with novel techniques for localizing steroid hormone receptors, and oncologists who must use assay results in the treatment of breast cancer.

Author : G. Leclercq,S. Toma,R. Paridaens,J. C. Heuson
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642821882

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Clinical Interest of Steroid Hormone Receptors in Breast Cancer by G. Leclercq,S. Toma,R. Paridaens,J. C. Heuson Pdf

Several papers dealing with the clinical relevance of steroid hormone receptors in breast cancer have already been published. However, no publication has overviewed studies currently being conducted in Europe, nor is there a register of the european centers performing receptor assays. It has been our purpose to fill these gaps. A large majority of authors who we contacted kindly agreed to con tribute to our book. Papers were grouped into six main parts according to their contents. The abundance of clinical data relevant to receptor assays led us to add critical summaries to help the reader to form his own opinions on the subject. We would like to thank Drs. R. J. B. King, G. Contesso, L. Santi, and E. Engelsman, who helped us in this regard. We hope that this book will enable the reader to become acquainted with the present state of European steroid hormone receptor studies devoted to breast cancer treatment. We also hope that it will promote cooperation between European oncologists involved in this field of research.

Author : M. K. Agarwal
Publisher : Walter de Gruyter GmbH & Co KG
Page : 532 pages
File Size : 47,5 Mb
Release : 2019-05-20
Category : Science
ISBN : 9783110846935

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Receptor Mediated Antisteroid Action by M. K. Agarwal Pdf

No detailed description available for "Receptor Mediated Antisteroid Action".

Author : Gerard Morel
Publisher : CRC Press
Page : 458 pages
File Size : 54,9 Mb
Release : 1997-02-26
Category : Science
ISBN : 0849326443

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Visualization of Receptors by Gerard Morel Pdf

A multiplicity of methods for visualization are described in Visualization of Receptors. This book of techniques covers immunocytology, radioautography, in situ hybridization, plasmon resonance, RT in vitro PCR, and X-ray crystal structure analysis. Lecturers, researchers, practitioners, technicians, and students will find all the principles and protocols they require and the means of implementing them. Topics discussed include localization of ligands (in vitro or in vivo), visualization of immunoreactivities of ligand and receptor proteins, detection and quantification of mRNA expression, amplification of signals, and determination of 3-D structure. Details of protocols with illustrations of results and commentaries are provided throughout the book.

Author : E. Ronald de Kloet
Publisher : Academic Press
Page : 573 pages
File Size : 53,7 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483288369

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Neurobiology of Steroids by E. Ronald de Kloet Pdf

Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions. Comprehensive protocols included for the study of Steroid kinetics and metabolism Steroid receptors Molecular and cellular effects of steroids Steroid effects on integrated systems

Author : Louis P. Pertschuk
Publisher : CRC Press
Page : 200 pages
File Size : 53,6 Mb
Release : 2019-07-23
Category : Medical
ISBN : 9781351082594

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Localization Of Putative Steroid Receptors by Louis P. Pertschuk Pdf

These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. In Volume I we have attempted to collect current available methods and experimental approahes which might be useful in solving present enigmas. The background and recent advances presented are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.

Author : J. Carlstedt-Duke
Publisher : Birkhäuser
Page : 360 pages
File Size : 42,6 Mb
Release : 2013-11-21
Category : Science
ISBN : 9783034854665

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The Steroid/Thyroid Hormone Receptor Family and Gene Regulation by J. Carlstedt-Duke Pdf

The Second International CBT (Center for Biotechnology) Synposium was held in Stockholm November 4-5 1988 and had the title "The steroid/thyroid hoITIDne receptor family and gene regulation". This meeting contained contributions from most leading laboratories within the field of steroid/thyroid hOITIDne receptors and gave a very exciting perspective on the dynamic development of this i:ntx>rt. ant research field. Today all known steroid hoITIDne receptors have been cloned and sequenced and novel members of this supergene family are constantly being discovered. Sane of these new receptors remain to be characterized regarding the nature of their ligand. Access to probes for steroid receptors has enabled studies on mechanisms of regulation of receptor gene expression. Deletion and II'Altational analysis of steroid receptor cDNAs followed by expression in cells together with suitable reporter genes has yielded a detailed knowledge about the functional significance of the various domains the receptors are composed of. In certain cases, steroid resistance in patients have been shown to be due to point mutations in the corresponding steroid receptor genes resulting in non-functional receptors. The availability of receptor cDNAs also makes it possible to express receptors at high levels in procaryotic and eucaryotic cells. It is e. g. possible to express the DNA-binding domain of the glucocorticoid receptor in E. coli as a fusion protein with protein A which interacts specifically with DNA. Such studies are necessary for production of sufficient quantities of receptors to allow crystallization and X-ray crystallography for detailed structural information.

Author : Gerhard Seifert
Publisher : Springer Science & Business Media
Page : 525 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642755156

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Cell Receptors by Gerhard Seifert Pdf

An up-to-date review of the morphology and pathological aspects of cell receptors, important because new therapies for various pathological conditions (genetic diseases, endocrine disorders, cancer, etc.) could be based on receptor interference.

Author : Winfried Rossmanith,W. A. Scherbaum
Publisher : Walter de Gruyter
Page : 232 pages
File Size : 45,9 Mb
Release : 2012-02-13
Category : Medical
ISBN : 9783110887648

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Neuroendocrinology of Sex Steroids by Winfried Rossmanith,W. A. Scherbaum Pdf

Author : P. Michael Conn
Publisher : Academic Press
Page : 457 pages
File Size : 40,9 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483259703

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Receptors by P. Michael Conn Pdf

Methods in Neurosciences, Volume 11: Receptors: Model Systems and Specific Receptors is a compilation of papers that describes techniques and information that are important to the neurosciences. This volume discusses preferred receptor techniques, molecular techniques, and methods to determine receptor subclasses and localization in the ligand design. The first paper discusses the steroid receptor found in the central nervous system for steroid hormones that affects strongly the structure and function of both developed and immature nervous systems. Another paper describes how a glycoprotein of 79.5 kDa (transferrin) carries iron in the blood stream for delivery to different tissues, after the transferrin has bound with a specific receptor on the surface of the cell. This book also explains the binding sites of pituitary adenylate cyclase-activating polypeptide in the human brain, while one paper analyzes the neurotensin receptors during the primary culture of neurons. This volume then also analyzes the structure and function of the fast nerve growth factor receptor, particularly how a signal on the outside of a cell is transmitted to the cell's interior. This collection is helpful for microbiologists, cellular researchers, students, and professors in the discipline of neurosciences.

Author : Virinder Moudgil
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 51,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781468455410

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Steroid Receptors in Health and Disease by Virinder Moudgil Pdf

During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con ference was to facilitate scientific exchange toward a better understand ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.

Author : Mark Wick
Publisher : CRC Press
Page : 673 pages
File Size : 55,9 Mb
Release : 1988-03-30
Category : Medical
ISBN : 9781466593497

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Monoclonal Antibodies in Diagnostic Immunohistochemistry by Mark Wick Pdf

This book describes the methodology of monoclonal antibody-mediated immunohistochemistry, as applied to practical tissue diagnosis. It focuses on human disease and discusses the spectrum of monoclonal antibodies in relation to its utility in solving differential diagnostic problems.

Author : Anonim
Publisher : Unknown
Page : 1796 pages
File Size : 50,7 Mb
Release : 2000
Category : Medicine
ISBN : OSU:32436010864583

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Cumulated Index Medicus by Anonim Pdf

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 45,5 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306475993

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Microscopy, Immunohistochemistry, and Antigen Retrieval Methods by M.A. Hayat Pdf

Histochemistry deals with the activities of chemical components in cells, and immunohistochemistry addresses the function of cell types in tissue or organs, such as those leading to acceptance or rejection of grafts or organs. This book is a methods volume focusing on antigen retrieval, particularly methods used in disease-related antigens. Because the book is a methods volume and a lab manual, it will have an audience of pathologists, biochemists, and lab technicians.

Author : Julia M. Polak,Susan Van Noorden
Publisher : Butterworth-Heinemann
Page : 780 pages
File Size : 54,9 Mb
Release : 1986
Category : Cytochemistry
ISBN : UOM:39015057836671

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Immunocytochemistry by Julia M. Polak,Susan Van Noorden Pdf