Immunologic Approaches To The Classification And Management Of Lymphomas And Leukemias

Author : John M. Bennett,Kenneth A. Foon
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317135

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Immunologic Approaches to the Classification and Management of Lymphomas and Leukemias by John M. Bennett,Kenneth A. Foon Pdf

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general on cology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 53,8 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Author : Emil J. Freireich,Hagop Kantarjian
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 48,6 Mb
Release : 1993-03-31
Category : Medical
ISBN : 0792319672

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Leukemia: Advances in Research and Treatment by Emil J. Freireich,Hagop Kantarjian Pdf

Leukemia continues to offer the scientist a unique opportunity to gain new knowledge about the malignant transformation. As a result, this multi-authored volume, devoted to advances which have occurred over the last seven years, provides the reader with an important new understanding of leukemia, but perhaps even more important, predicts analogous, new developments in the other malignant diagnoses. In this respect, this volume represents the cutting edge of cancer research. This text is unique in that it includes in a single volume the leading contributors to their respective fields covering what the editors feel are the major advances in our knowledge of the biology and therapy of leukemia over the last seven years.

Author : Owen A. O'Connor,Won Seog Kim,Pier L. Zinzani
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 43,5 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9781119671312

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The Peripheral T-Cell Lymphomas by Owen A. O'Connor,Won Seog Kim,Pier L. Zinzani Pdf

THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

Author : Robert I. Handin,Samuel E. Lux,Thomas P. Stossel
Publisher : Lippincott Williams & Wilkins
Page : 2358 pages
File Size : 54,7 Mb
Release : 2003
Category : Medical
ISBN : 0781719933

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Blood by Robert I. Handin,Samuel E. Lux,Thomas P. Stossel Pdf

Following its highly successful and well-respected first edition, this thoroughly revised edition offers much more! Edited and authored by leading authorities in hematology, this scientific reference textbook now comes with a CD-ROM. Additional features include some of the more salient standard and current therapeutics and an easily accessible appendix that provides great reference. The CD-ROM contains 100 of the most critical illustrations from the text—great for quick consultation from your computer.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1178 pages
File Size : 50,8 Mb
Release : 1989
Category : Medicine
ISBN : MINN:31951D00419854T

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : E. Campo,N. L. Harris,S. A. Pileri,E. S. Jaffe,H. Stein,J. Thiele
Publisher : IARC Who Classification of Tum
Page : 586 pages
File Size : 55,5 Mb
Release : 2017-09-18
Category : Medical
ISBN : 928324494X

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WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues by E. Campo,N. L. Harris,S. A. Pileri,E. S. Jaffe,H. Stein,J. Thiele Pdf

WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues is a Revised Fourth Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants further include new ICD-O codes, epidemiology, clinical features, macroscopy, prognosis, and predictive factors. This classification, prepared by 132 authors from 23 countries, contains about 1300 color images and tables and more than 4500 references.

Author : Peter Keating,Alberto Cambrosio
Publisher : MIT Press
Page : 574 pages
File Size : 50,7 Mb
Release : 2003
Category : Computers
ISBN : 0262112760

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Biomedical Platforms by Peter Keating,Alberto Cambrosio Pdf

An examination of postwar medicine based on the notion of the biomedical platform--the theoretical and clinical meeting ground between the normal and the pathological.

Author : H.M. Pinedo,J. Verweij,H.D. Suit
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461538967

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Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment by H.M. Pinedo,J. Verweij,H.D. Suit Pdf

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative, but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, which is revised frequently to keep the coverage up to date, and which is easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions, such as lung can cer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diag nosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 782 pages
File Size : 46,5 Mb
Release : 2024-06-16
Category : Medicine
ISBN : UOM:39015046741230

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : Paul H. Sugarbaker
Publisher : Springer Science & Business Media
Page : 405 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461538820

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Management of Gastric Cancer by Paul H. Sugarbaker Pdf

Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.

Author : Franco M. Muggia
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461538769

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New Drugs, Concepts and Results in Cancer Chemotherapy by Franco M. Muggia Pdf

Author : I. Craig Henderson
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461534969

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Adjuvant Therapy of Breast Cancer by I. Craig Henderson Pdf

The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.

Author : Christopher Benz,E.T. Liu
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 43,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530886

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Oncogenes and Tumor Suppressor Genes in Human Malignancies by Christopher Benz,E.T. Liu Pdf

The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage ment.

Author : Wolf-Dieter Ludwig,Eckhard Thiel
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 44,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642848957

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Recent Advances in Cell Biology of Acute Leukemia by Wolf-Dieter Ludwig,Eckhard Thiel Pdf

The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.