Immunology And Blood Transfusion

Author : C.Th. Smit Sibinga,P.C. Das,T.H. The
Publisher : Springer Science & Business Media
Page : 421 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530947

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Immunology and Blood Transfusion by C.Th. Smit Sibinga,P.C. Das,T.H. The Pdf

In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.

Author : Robert W Maitta
Publisher : Elsevier Health Sciences
Page : 380 pages
File Size : 45,5 Mb
Release : 2019-08-27
Category : Medical
ISBN : 9780323675109

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Immunologic Concepts in Transfusion Medicine by Robert W Maitta Pdf

Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.

Author : Carel J. van Oss
Publisher : CRC Press
Page : 480 pages
File Size : 41,7 Mb
Release : 1995-01-27
Category : Medical
ISBN : 9781482273441

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Transfusion Immunology and Medicine by Carel J. van Oss Pdf

Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities. Explains the immunological effects of blood transfusion as well as its immunological and

Author : Pritam Singh Ajmani
Publisher : Springer Nature
Page : 208 pages
File Size : 44,8 Mb
Release : 2020-11-02
Category : Medical
ISBN : 9789811584350

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Immunohematology and Blood banking by Pritam Singh Ajmani Pdf

The book covers the basics of genetics and immunology, technical aspects of blood banking and transfusion.It offers a concise, and practical approach for different blood tests and guidelines on the best ways to take donor history, screen donors, store blood components, ensure safety, and anticipate the potentially adverse effects of blood transfusion, components and its management at the bedside. Different chapters include important topics such as collection, storage and transportation of blood, introduction to blood transfusion, blood group serology, discovery of blood groups, donor selection, interview, and its preparation, and storage, pretransfusion testing, transfusion therapy, clinical considerations, and safety, quality assurance, and data management developed specifically for medical technologists and resident doctors. The book also goes beyond preoperative patient blood management, with detailed accounts of coagulation disorder management and the administration of coagulation products and platelet concentrates. The book also defines the components of a learning health system necessary to enable continued improvement in trauma care in both the civilian and the military sectors. This book offers a succinct and user-friendly resource with key points, boxes, tables & charts and is a quick reference guide for pathology and transfusion medicine residents and doctors in blood centers and hospitals dealing with regulatory aspects, transfusion safety, production and storage and donor care.

Author : Carel J. van Oss
Publisher : CRC Press
Page : 492 pages
File Size : 52,6 Mb
Release : 1995-01-27
Category : Medical
ISBN : 0824796403

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Transfusion Immunology and Medicine by Carel J. van Oss Pdf

Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities. Explains the immunological effects of blood transfusion as well as its immunological and microbiological hazards and offers potential remedies!

Author : George Garratty
Publisher : CRC Press
Page : 727 pages
File Size : 55,6 Mb
Release : 1993-09-21
Category : Medical
ISBN : 9781482293494

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Immunobiology of Transfusion Medicine by George Garratty Pdf

Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.

Author : C.Th. Smit Sibinga,P.C. Das,C.P. Engelfriet
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461320890

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White cells and platelets in blood transfusion by C.Th. Smit Sibinga,P.C. Das,C.P. Engelfriet Pdf

As a clinical discipline blood transfusion encompasses enormous vista, vary ing from biotechnology to molecular biology, from plasma products, cell biology and growth factors to interleukines. Growth of knowledge in this field has been rapid, and expertise is now required to be mastered and renewed in translating these ideas for patient care. Various types of cells could be harvested - progenitor stem cells derived from bone marrow or from circulating blood as a source for transplants; in the hemostatic armoury platelets could be used prophylactically; granulocytes and mononuclear cells are available for treatment of infections or immune modulations. However, their therapeutic use carries potential complications including graft versus host disease and CMV-infection. Prevention of such complications by irradiation and by removal of immunocompetent leukocytes are important issues. Thus, production of such therapeutic materials ought to address the issues at the earliest, to eliminate those problems while adhering to the con cept of high quality; the impact of storing platelets for longer periods by using improved plastic containers or storing almost indefinitely in frozen state should be explored. Rapid progress in cell culture techniques and bio technology have enriched the transfusion medicine armoury with lympho kines, interferons and cell colony growth factors which have great potentials for enhancement of basic knowledge as well as considerable therapeutic applications in patients.

Author : C.Th. Smit Sibinga,P.C. Das,B. Löwenberg
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461311379

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Cytokines and Growth Factors in Blood Transfusion by C.Th. Smit Sibinga,P.C. Das,B. Löwenberg Pdf

Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient. Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information. Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume: Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions. Function, production and diagnosis – laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors. Application in clinical medicine – clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis. Future potential use in transfusion medicine – erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.

Author : Dharam P. Singal
Publisher : CRC Press
Page : 208 pages
File Size : 45,6 Mb
Release : 1994-12-08
Category : Medical
ISBN : 0849347904

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Immunological Effects of Blood Transfusion by Dharam P. Singal Pdf

This concise monograph examines the novel and distinct feature of blood transfusion (BT). It critically reviews the areas of major concern to the public and scientific/medical community. Topics include: Transmission of disease(s) from the blood donor to the recipient and the transfusion-induced alloimmunization of the recipient BT-induced immunomodulatory effects, both beneficial and deleterious Beneficial effects in clinical organ transplantation and in treatment of women with unexplained recurrent abortions Adverse effects of BT in patients undergoing curative surgery for different types of cancer and in patients at risk for bacterial infections Deleterious effects of BT on enhanced tumor growth and infections in experimental animals Attempts by a number of investigators to treat autoimmune diseases by BT in humans and in experimental animals Mechanism(s) of the BT effect from various perspectives, including the component of blood, host factors, and hypotheses for beneficial and damaging effects

Author : Harvey G. Klein,David J. Anstee
Publisher : John Wiley & Sons
Page : 923 pages
File Size : 55,6 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470986851

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Mollison's Blood Transfusion in Clinical Medicine by Harvey G. Klein,David J. Anstee Pdf

“Both authors have dealt in an authoritative way withthe still rapidly expanding specialty and the eleventh edition ofthe book will be of the greatest value to all who are interested inthe scientific and practical aspects of blood transfusion inclinical medicine.” From the Foreword by Professor P.L. Mollison Highly respected, long-established book that has become the"bible" in transfusion medicine Why Buy This Book? Provides a sound basis for understanding modern transfusionmedicine Definitive reference source for any clinician involved withpatients requiring transfusion and for all staff working intransfusion services, immunohaematology laboratories and bloodbanks Highly practical advice on management issues for theclinician Completely revised and updated to reflect the rapid pace ofchange in transfusion medicine Written by two of the world's leading experts in the field

Author : Susan R. Hollán
Publisher : John Wiley & Sons
Page : 418 pages
File Size : 45,7 Mb
Release : 1983-01-01
Category : Blood
ISBN : 0471901644

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Recent Advances in Haematology, Immunology, and Blood Transfusion by Susan R. Hollán Pdf

Author : Sally V. Rudmann
Publisher : Elsevier Health Sciences
Page : 704 pages
File Size : 43,5 Mb
Release : 2005-02-18
Category : Medical
ISBN : 9780721603841

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Textbook of Blood Banking and Transfusion Medicine by Sally V. Rudmann Pdf

This comprehensive book on transfusion practices and immunohematology offers concise, thorough guidelines on the best ways to screen donors, store blood components, ensure safety, anticipate the potentially adverse affects of blood transfusion, and more. It begins with the basics of genetics and immunology, and then progresses to the technical aspects of blood banking and transfusion. Chapters are divided into sections on: Basic Science Review; Blood Group Serology; Donation, Preparation, and Storage; Pretransfusion Testing; Transfusion Therapy; Clinical Considerations; and Safety, Quality Assurance, and Data Management. Developed specifically for medical technologists, blood bank specialists, and residents, the new edition conforms to the most current standards of the American Association of Blood Banks (AABB). Expert Opinion essays, written by well-known, frequently published experts, discuss interesting topics of research or new advances in the field. Important terms are defined in the margins of the pages on which they appear, enabling readers to easily check the meaning of an unfamiliar term where it appears in context. Margin notes highlight important concepts and points, remind readers of previously discussed topics, offer an alternative perspective, or refer readers to other sources for further information. Material conforms to the most recent AABB standards for the most accurate, up-to-date information on immunohematology. Advanced concepts, beyond what is required for entry-level practice, are set apart from the rest of the text so readers can easily differentiate between basic and advanced information. A new chapter on Hematopoietic Stem Cells and Cellular Therapy (chapter 19) provides cutting-edge coverage of cellular therapy and its relevance to blood-banking. New content has been added on molecular genetics, component therapy, and International Society of Blood Transfusion (ISBT) nomenclature, as well as the latest information on HIV, hepatitis, quality assurance, and information systems. Coverage of new technologies, such as nucleic acid technology and gel technology, keeps readers current with advances in the field.

Author : Laura Dean
Publisher : Unknown
Page : 128 pages
File Size : 43,7 Mb
Release : 2005
Category : Blood group antigens
ISBN : OCLC:225053075

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Blood Groups and Red Cell Antigens by Laura Dean Pdf

Author : C.Th. Smit Sibinga,P.C. Das,L.R. Overby
Publisher : Springer Science & Business Media
Page : 259 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317616

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Biotechnology in blood transfusion by C.Th. Smit Sibinga,P.C. Das,L.R. Overby Pdf

This symposium is devoted to Biotechnology in Blood Transfusion; there are 22 experts discussing the state of the art in the application of monoclonal anti bodies, recombinant DNA technologies and heterologous expression systems to the improvement and sometimes replacement of blood products, charac terization of blood constituents, and the effect of these developments on blood transfusion procedures. Ten and maybe five years ago the title of a symposium such as this would have been Biosciences in blood transfusion, informing what basic developments in molecular biology, biochemistry and human physiology might pertain to blood transfusion in the distant future. That future is getting closer, and not only one is interested in basic developments in immunology, recognition and identification of viral and bacterial components and products, tissue and blood bloodgroup blood group typing, typing, but also in the potential application of these developments and their economic perspectives. That is what biotechnology is all alI about: basic science telIs tells us where and how we might look for new technologies, and the development of such tech nologies is only possible if there is a perspective for improvement in quality, safety, acceptance or performance to cost ratio.

Author : Cees Smit Sibinga,Harvey G. Klein
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 47,9 Mb
Release : 2000-09-30
Category : Medical
ISBN : 0792365348

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Molecular Biology in Blood Transfusion by Cees Smit Sibinga,Harvey G. Klein Pdf

The international symposia on blood transfusion in Groningen have taken place without interruption since 1976. Each year Dr. Smit-Sibinga and his team have not only organized a meeting on timely topics in blood transfusion, but also succeeded in attracting prominent chairmen and speakers. The subject of the 24th Symposium was Molecular Biology in Blood Transfusion and it was chaired by Dr. Harvey G. Klein, National Institutes of Health, USA. In this book of proceedings an extraordinary range of subjects is covered, including diagnostic aspects, virology, quality control, cell and protein processing as well as a section on new horizons in clinical medicine.