Download Full eBooks in PDF
Recent Advances In Haematology Immunology And Blood Transfusion Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Recent Advances In Haematology Immunology And Blood Transfusion book. This book definitely worth reading, it is an incredibly well-written.
Author : Susan R. Hollán
Publisher : John Wiley & Sons
Page : 418 pages
File Size : 51,5 Mb
Release : 1983-01-01
Category : Blood
ISBN : 0471901644
Author : C.Th. Smit Sibinga,P.C. Das,T.H. The
Publisher : Springer Science & Business Media
Page : 421 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530947
In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1712 pages
File Size : 51,9 Mb
Release : 1985
Category : Medicine
ISBN : UOM:39015010011107
First multi-year cumulation covers six years: 1965-70.
Author : Barbara J. Bain,Rajeev Gupta
Publisher : John Wiley & Sons
Page : 247 pages
File Size : 40,9 Mb
Release : 2008-06-09
Category : Medical
ISBN : 9780470794777
A–Z of Haematology provides an essential "quick reference guide" to definitions covering the entire spectrum of haematology, from blood transfusion and coagulation through to recent advances in molecular haematology. It is the indispensable guide for all those practising or studying haematology including research scientists and biomedical scientists working in diagnostic laboratories. Scientists working in cytogenetics and immunophenotyping will also find it a valuable repository of relevant knowledge. A–Z of Haematology includes: Definitions cover the entire spectrum of haematology, from blood transfusion and coagulation through to molecular haematology Essential "quick reference guide" for all those practising or studying haematology Over 100 figures to explain and clarify difficult concepts Inclusion of all CD numbers and oncogenes to be encountered in daily practice Appendices of laboratory data and normal values included
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1000 pages
File Size : 55,8 Mb
Release : 2024-07-02
Category : Medicine
ISBN : STANFORD:36105214549011
Author : Harvey G. Klein,David J. Anstee
Publisher : John Wiley & Sons
Page : 956 pages
File Size : 41,6 Mb
Release : 2014-02-03
Category : Medical
ISBN : 9781405199407
Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.
Author : C.Th. Smit Sibinga,P.C. Das,T.J. Greenwalt
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461323297
Proceedings of the Tenth Annual Symposium on Blood Transfusion, Groningen 1985, organized by the Red Cross Blood Bank Groningen-Drenthe
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 50,8 Mb
Release : 1988
Category : Medicine
ISBN : UOM:39015074107577
First multi-year cumulation covers six years: 1965-70.
Author : C.Th. Smit Sibinga,P.C. Das,C.P. Engelfriet
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461320890
As a clinical discipline blood transfusion encompasses enormous vista, vary ing from biotechnology to molecular biology, from plasma products, cell biology and growth factors to interleukines. Growth of knowledge in this field has been rapid, and expertise is now required to be mastered and renewed in translating these ideas for patient care. Various types of cells could be harvested - progenitor stem cells derived from bone marrow or from circulating blood as a source for transplants; in the hemostatic armoury platelets could be used prophylactically; granulocytes and mononuclear cells are available for treatment of infections or immune modulations. However, their therapeutic use carries potential complications including graft versus host disease and CMV-infection. Prevention of such complications by irradiation and by removal of immunocompetent leukocytes are important issues. Thus, production of such therapeutic materials ought to address the issues at the earliest, to eliminate those problems while adhering to the con cept of high quality; the impact of storing platelets for longer periods by using improved plastic containers or storing almost indefinitely in frozen state should be explored. Rapid progress in cell culture techniques and bio technology have enriched the transfusion medicine armoury with lympho kines, interferons and cell colony growth factors which have great potentials for enhancement of basic knowledge as well as considerable therapeutic applications in patients.
Author : C.Th. Smit Sibinga,P.C. Das,B. Löwenberg
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461311379
Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient. Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information. Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume: Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions. Function, production and diagnosis – laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors. Application in clinical medicine – clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis. Future potential use in transfusion medicine – erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.
Author : C.Th. Smit Sibinga,P.C. Das,H.F. Taswell
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461328353
THE PHILOSOPHY OF QUALITY ASSURANCE IN THE BLOOD BANK H. F. Taswell One year before this symposium, Cees Smit Sibinga and I began to discuss an approach to quality assurance in the blood bank which we felt would be both important and practical and could serve as the basis for the choice of subjects to be presented in the symposium. As an introduction to this book, I would like to outline our approach, the subjects chosen and the rationale behind our choice. What is the fundamental purpose of a blood bank and trans fusion service? Simply stated, the purpose of a blood bank and transfusion service and of a quality assurance program in blood banking is, for the one to provide and, the other to assure safe and effective transfusion therapy. This objective is in contrast to that of other clinical laboratories. The objective in a clinical chemistry laboratory is to produce accurate test results which will be meaningful to the clinician taking care of his patient. In most clinical laboratories, therefore, the goals of a quality assurance program are largely quantitative, that is, to assure accurate numerical test results. In contrast, in the blood bank, the goals of quality assurance are primarily qualitative, that is, to assure safe and effective transfusion. As a result, two somewhat different approaches to quality assurance are necessary.
Author : Cees Smit Sibinga,Harvey G. Klein
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 49,8 Mb
Release : 2000-09-30
Category : Medical
ISBN : 0792365348
The international symposia on blood transfusion in Groningen have taken place without interruption since 1976. Each year Dr. Smit-Sibinga and his team have not only organized a meeting on timely topics in blood transfusion, but also succeeded in attracting prominent chairmen and speakers. The subject of the 24th Symposium was Molecular Biology in Blood Transfusion and it was chaired by Dr. Harvey G. Klein, National Institutes of Health, USA. In this book of proceedings an extraordinary range of subjects is covered, including diagnostic aspects, virology, quality control, cell and protein processing as well as a section on new horizons in clinical medicine.
Author : C.Th. Smit Sibinga,P.C. Das,E.L. Snyder
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 51,5 Mb
Release : 1996-10-31
Category : Medical
ISBN : 0792342550
Transfusion medicine is an excellent way for the healthy community to help the sick. However, service providers and patients have much to gain from the establishment of guidelines concerning when and how it is used. An important first step would be to introduce informed consent for transfusion recipients. Discussions with blood banks and assessment of clinical demand would also be necessary, taking into account the needs of patients and physicians, and the availability of products. Unfortunately, the efficacy and safety of transfusion products can be difficult to ascertain. Furthermore, although major advances have been made in safety, the risks of giving and receiving blood are still seen as high. It is vital to learn what underlies that perception and how to counter it. The policies and protocols used to establish surgical criteria for blood transfusions should be explored. Finally, clinical audits can help evaluate the risk:benefit ratio of transfusion; they may be carried out by hospital transfusion committees but are likely to be more successful with the support of national and international legislative and regulatory bodies. The implementation of appropriate initiatives now will improve the outlook for the future of transfusion medicine, perhaps with ex-vivo expanded haemopoietic cell therapy as the next milestone. All these key points and controversies are explored in this book, which paints a broad picture of the current status and future trends in transfusion medicine.
Author : Andrew Blann,Nessar Ahmed
Publisher : John Wiley & Sons
Page : 644 pages
File Size : 40,5 Mb
Release : 2022-12-27
Category : Science
ISBN : 9781119864110
The second edition of the leading introduction to blood science, updated new illustrations and case studies Blood Science: Principles and Pathology integrates hematology and blood transfusion, clinical biochemistry, and immunology to provide a thorough introduction to this rapidly expanding discipline. Reflecting recent changes in education and training for healthcare scientists, this comprehensive textbook covers the analytical techniques used in blood science, the diagnosis and management of various blood disorders, and more. Fully revised, the second edition presents new case studies and high-quality images throughout, illustrating the practical skills and knowledge required by today's undergraduate students and practitioners. Detailed yet accessible chapters contain learning objectives and summaries, links to further readings and resources, and real-world case studies with easy-to-follow interpretations. Throughout the text, the authors highlight how laboratory data and clinical details are used to investigate patients with actual or suspected diseases in real-world scenarios Multi-disciplinary view merging biochemical, hematological, immunological, and genetical knowledge into a single discipline: Blood science Discusses advances in molecular genetics identifying mutations resulting in the occurrence of certain pathological conditions such as leukaemia Presents an expanded concluding chapter with detailed case reports that integrate biochemistry, immunology, and haematology which all contribute to the investigation of respective conditions. Explains the potentials for developing tests such as non-coding RNAs Offers further reading suggestions to dive even deeper in discussed subjects and concepts Designed to meet the needs of undergraduate students taking blood science modules in biomedical, biological, and healthcare science programs, Blood Science: Principles and Pathology, Second Edition is also an invaluable guide for new graduates entering the field as well as those training for professional qualifications or working with blood samples in laboratory-based environments.
Author : George Garratty
Publisher : CRC Press
Page : 732 pages
File Size : 45,8 Mb
Release : 1993-09-21
Category : Medical
ISBN : 1420001701
Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.