Immunomodulation

Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Page : 296 pages
File Size : 51,7 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9780128214565

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Immunomodulatory Biomaterials by Stephen F. Badylak,Jennifer Elisseeff Pdf

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Author : Nihal Engin Vrana
Publisher : CRC Press
Page : 249 pages
File Size : 43,6 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9781351377560

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Biomaterials and Immune Response by Nihal Engin Vrana Pdf

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 54,7 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author : H. Hugh Fudenberg
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461593584

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Immunomodulation by H. Hugh Fudenberg Pdf

On May 14-16, 1982, a group of scientists met in Viareggio, Italy to present ideas, and exchange relevant data on current approaches on immunomodulators. We felt that the embodiment of the substance of that international symposium into this volume will be beneficial in keeping both clinicians and basic scientists abreast of the latest exciting developments in this rapidly accelerating field. We hope that the publication of this series of papers by an international panel of experts will enhance the nature of future inves t igat ive stud ies with such ent it ies . Under the rubric of immunology, it is obvious that such a term as "immunomodulation" could be construed as being all encompassing. However, it is intriguing that the immune modulators touched on in these sessions can be subcategorized into about five broad groups. Almost all substances, excepting those entities that are immuno logically inert, will have some modulating effects on immunity. From the coarse adjustment of antibody feedback inhibition upon cellular limnunity to the subtle finesse envisioned in Jerne's idiotypic network and s'lppressor T cells, immunomodulators attempt to either magnify or diminish those responses that are normally elicited by antigen. The broad groups - thymic hormones, D.L.E., Interferon, drugs, and the use of bacterial products appear to be at the forefront of much of the pioneering work on immunomodulation.

Author : Neelam S. Sangwan,Mohamed A. Farag,Luzia Valentina Modolo
Publisher : Springer Nature
Page : 547 pages
File Size : 50,8 Mb
Release : 2022-08-30
Category : Medical
ISBN : 9789811681172

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Plants and Phytomolecules for Immunomodulation by Neelam S. Sangwan,Mohamed A. Farag,Luzia Valentina Modolo Pdf

This book describes the process of immunomodulation and the plants which possess immunomodulation properties to boost the immune system. The immunomodulation process is highly relevant to address emerging as well as existing diseases in humans. A better immune system triggers the cellular responses for neutralizing and combating the onset of disease conditions. Chapters in the book discuss plants that have profound effects on the health and well-being of humans. They discuss the natural phytochemicals that have immense diversity and uniqueness of molecules. Molecules belonging to phenylpropanoids, terpenoids, steroids, alkaloids, and tannins etc possess a variety of pharmacological activities. The chapters describe how bioactive exert effects even when taken as part of the diet, supplement, and or as traditional herbal medicine. This book provides up-to-date scientific knowledge about the activities and mechanisms and leads in the area of medicinal plants and phytochemicals with immunomodulation properties. This book is meant for students, academics, researchers, and industry professionals interested in pharmacology, immunology, and plant secondary metabolites.

Author : Bernald Charley
Publisher : Academic Press
Page : 348 pages
File Size : 50,5 Mb
Release : 1990-11-28
Category : Science
ISBN : 9780323154888

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Immunomodulation in Domestic Food Animals by Bernald Charley Pdf

Immunomodulation in Domestic Food Animals covers the developments in the immunology and regulation of the immune response in domestic food animals. This book is organized into four parts encompassing 12 chapters that describe numerous factors affecting an immune response of animals and the management of these factors for food animal production. Part I provides an overview of the basic concepts of immunomodulation and the rationale for manipulating the immune response in food animals. Part II contains information on immunopotentiation using chemicals and a thorough discussion of adjuvant use. The molecular biology and in vivo use of cytokines in food animals is presented in Part III. Lastly, Part IV discusses physiologically regulated immunomodulation, including nutritional modulation of the immune response and neuroendocrine-immune interactions. This book is of great value to immunologists, microbiologists, and feed scientists and researchers.

Author : Catarina R. Almeida,Barbara Bottazzi,Kate E. Lawlor,Dominic De Nardo
Publisher : Frontiers Media SA
Page : 204 pages
File Size : 46,5 Mb
Release : 2020-03-23
Category : Electronic
ISBN : 9782889635740

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Immunomodulation of Innate Immune Cells by Catarina R. Almeida,Barbara Bottazzi,Kate E. Lawlor,Dominic De Nardo Pdf

Author : Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma
Publisher : BoD – Books on Demand
Page : 208 pages
File Size : 42,9 Mb
Release : 2023-07-12
Category : Medical
ISBN : 9781837680719

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Immunosuppression and Immunomodulation by Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma Pdf

This book synthesizes the key concepts of immunosuppression and immunomodulation. A comprehensive understanding of these processes is necessary to develop vaccines and therapeutic interventions for diseases. This book examines the role of information molecules such as cytokines and chemokines and other proteins secreted by the host upon interacting with the pathogen(s) that modulate and suppress the immune system and assist the pathogen(s) in causing disease. Chapters discuss the modulation of inflammation, signaling pathways, the interaction of immune cells, and resulting immunity as well as its suppression.

Author : A. Morell,E. Rewald
Publisher : CRC Press
Page : 248 pages
File Size : 40,9 Mb
Release : 1993-07-15
Category : Medical
ISBN : 1850705100

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Immunomodulation by Intravenous Immunoglobulin by A. Morell,E. Rewald Pdf

This work provides a comprehensive review of the role of intravenous immunoglobulins in a wide range of immune-related diseases. Over 20 research workers from America and Europe together examine many important aspects of this subject and, in particular, assess the role of immunoglobulins in the treatment of asthma and allergy, autoimmune disorders, juvenile arthritis and recurrent pregnancy loss.

Author : Herman Friedman
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468441154

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Immunomodulation by Bacteria and Their Products by Herman Friedman Pdf

It is almost axiomatic that an explosive increase in knowledge and interest concerning host immune defense mechanisms and the immune response system in general is occurring. Many new developments are evident at the interphase between the areas of immunology, infectious diseases, and host defenses to microorganisms. It is now widely rec ognized that a functioning host immune defense system consists of a variety of lymphoid cells. These include effector and affector cells consisting of both Band T cells and their progeny. Mononuclear phago cytes which are widely distributed throughout the body are also intimately involved in these processes. These cells are involved not only in the clearance of particulate matter including bacteria, viruses and fungi, but also presumably in host defense against neo plasia. Among the many triumphs of the biological revolution over the past decade or so is the rapidly developing understanding of how these cells and their products, including antibody, lymphokines, monokines, etc. , function and interact. It is now recognized that although the immune defense system is involved in defense against infectious agents, it is also now be coming quite clear that many infectious agents, including bacteria, viruses and fungi, as well as their products, can interact with the immune response system. For example, it has been long recognized that many of the "adjuvants" which enhance the immune responses in nonspecific ways are derived from microorganisms. Microbial products have marked effects on the immume response system.

Author : Krassimir Metodiev
Publisher : BoD – Books on Demand
Page : 314 pages
File Size : 44,6 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122104

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Immunopathology and Immunomodulation by Krassimir Metodiev Pdf

This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors.

Author : Herman Friedman,John J. Madden,Thomas W. Klein
Publisher : Springer Science & Business Media
Page : 315 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461553472

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Drugs of Abuse, Immunomodulation, and Aids by Herman Friedman,John J. Madden,Thomas W. Klein Pdf

Introduction and Perspectives This volume represents the Proceedings of the Fifth Annual Symposium on Drugs of Abuse, Immunomodulation, and AIDS. The meeting was held in Nashville, Tennessee, June 12-14, 1997. In this symposium, as in the past, newer knowledge was reviewed concerning the relationship between the immune and the nervous systems with regard to the effects of drugs of abuse. This symposium focused on the relationship between the immune system and the nervous system with regard to the effects of drugs of abuse and infections such as the immunodeficiency virus that causes AIDS. As in the past symposia, presentations fo cused on the brain-immune axis from the viewpoint of drugs of abuse rather than from the subject of the brain or immunity alone. The aim of this series of conferences has been to clarify the consequences ofimmunomodulation induced by drugs of abuse on susceptibility and pathogenesis of infectious diseases, both in man and in various animal model systems. Recreational use of drugs of abuse, such as morphine, cocaine, and marijuana, as well as alcohol, by large numbers of individuals in this country and around the world has aroused serious concerns about the consequences of use of such drugs, especially on the normal physiological responses of an individual, including immune mechanisms. It is now widely known that many drugs of abuse, including marijuana, are used by millions ofindi viduals in this country and by even more abroad.

Author : Rajesh K. Kesharwani,Raj K. Keservani
Publisher : CRC Press
Page : 276 pages
File Size : 47,9 Mb
Release : 2023-10-20
Category : Medical
ISBN : 9781000800296

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COVID-19 and Immunomodulation with Special Emphasis on Nutraceutical and Herbal Formulation by Rajesh K. Kesharwani,Raj K. Keservani Pdf

The unique volume, COVID-19 and Immunomodulation with Special Emphasis on Nutraceutical and Herbal Formulation, covers recent advances in the management, prevention, and application of nutraceuticals and herbs in preventing and treating COVID-19. It demonstrates the beneficial immunomodulatory properties of nutraceuticals, spices, polyphenols, customary (traditional) medications, natural products, ayurveda, antioxidants, trace elements, vitamins, vaccines, etc., for COVID-19. Key features: Evaluates the benefits of herbal immunomodulators for safety and having fewer (if any) side effects, as opposed to conventional/artificial drugs Considers the role of ayurvedic medicines in the control and prevention of COVID-19 viruses Summarizes the most current discoveries and key factors of SARS-CoV-2 genetics, pathophysiology, and the host immune response Looks at the efficacy of vaccines against COVID-19 infection and the vaccines currently available Explains the pharmacological results alongside precise immunomodulator agents, like immunostimulators and immunosuppressants Looks at the containment and prevention strategies for COVID-19 infection and offers strategies for the future The information provided here details how the use of selected nutraceuticals and herbals can be helpful, similarly to pharmacological remedies, in stopping some COVID-19-associated complications in infected patients. It will be a valuable resource for researchers in pharmaceutical science, medicine, COVID and related diseases, and others.

Author : Charles J. Malemud,Eben Alsberg
Publisher : Springer
Page : 85 pages
File Size : 45,5 Mb
Release : 2016-12-10
Category : Science
ISBN : 9783319467337

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Mesenchymal Stem Cells and Immunomodulation by Charles J. Malemud,Eben Alsberg Pdf

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.

Author : Rajeev Tyagi,Prakash Singh Bisen
Publisher : BoD – Books on Demand
Page : 180 pages
File Size : 46,8 Mb
Release : 2019-04-17
Category : Medical
ISBN : 9781789851519

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Immune Response Activation and Immunomodulation by Rajeev Tyagi,Prakash Singh Bisen Pdf

Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.