Immune Response Activation And Immunomodulation

Author : Rajeev Tyagi,Prakash Singh Bisen
Publisher : BoD – Books on Demand
Page : 180 pages
File Size : 43,9 Mb
Release : 2019-04-17
Category : Medical
ISBN : 9781789851519

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Immune Response Activation and Immunomodulation by Rajeev Tyagi,Prakash Singh Bisen Pdf

Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.

Author : Prakash S. Bisen,Rajeev K. Tyagi
Publisher : Unknown
Page : 178 pages
File Size : 49,8 Mb
Release : 2019
Category : Microbiology
ISBN : 1789851521

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Immune Response Activation and Immunomodulation by Prakash S. Bisen,Rajeev K. Tyagi Pdf

Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.

Author : Catarina R. Almeida,Barbara Bottazzi,Kate E. Lawlor,Dominic De Nardo
Publisher : Frontiers Media SA
Page : 204 pages
File Size : 47,9 Mb
Release : 2020-03-23
Category : Electronic
ISBN : 9782889635740

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Immunomodulation of Innate Immune Cells by Catarina R. Almeida,Barbara Bottazzi,Kate E. Lawlor,Dominic De Nardo Pdf

Author : Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma
Publisher : BoD – Books on Demand
Page : 208 pages
File Size : 44,5 Mb
Release : 2023-07-12
Category : Medical
ISBN : 9781837680719

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Immunosuppression and Immunomodulation by Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma Pdf

This book synthesizes the key concepts of immunosuppression and immunomodulation. A comprehensive understanding of these processes is necessary to develop vaccines and therapeutic interventions for diseases. This book examines the role of information molecules such as cytokines and chemokines and other proteins secreted by the host upon interacting with the pathogen(s) that modulate and suppress the immune system and assist the pathogen(s) in causing disease. Chapters discuss the modulation of inflammation, signaling pathways, the interaction of immune cells, and resulting immunity as well as its suppression.

Author : Nihal Engin Vrana
Publisher : CRC Press
Page : 328 pages
File Size : 40,7 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9781351377553

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Biomaterials and Immune Response by Nihal Engin Vrana Pdf

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Page : 296 pages
File Size : 50,6 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9780128214565

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Immunomodulatory Biomaterials by Stephen F. Badylak,Jennifer Elisseeff Pdf

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Author : Guy Huynh Thien Duc
Publisher : BoD – Books on Demand
Page : 278 pages
File Size : 48,9 Mb
Release : 2014-05-29
Category : Medical
ISBN : 9789535113744

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Immune Response Activation by Guy Huynh Thien Duc Pdf

The book Immune Response Activation is aiming to analyse the multifaceted aspects of the immune response, treating a number of representative cases in which the immune response is, on one hand, activated against pathogens, and, on the other hand, involved in pathologic settings, leading to allograft rejection, allergy and autoimmunity. The regulatory mechanisms in which the immune response can be modulated for rendering its effector components more efficient and/or not harmful to the organism is also dissected in translational purposes in cancer immunotherapy, local immunity against bacteria and viruses, as well as in allergy and autoimmunity.

Author : H. Hugh Fudenberg
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461593584

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Immunomodulation by H. Hugh Fudenberg Pdf

On May 14-16, 1982, a group of scientists met in Viareggio, Italy to present ideas, and exchange relevant data on current approaches on immunomodulators. We felt that the embodiment of the substance of that international symposium into this volume will be beneficial in keeping both clinicians and basic scientists abreast of the latest exciting developments in this rapidly accelerating field. We hope that the publication of this series of papers by an international panel of experts will enhance the nature of future inves t igat ive stud ies with such ent it ies . Under the rubric of immunology, it is obvious that such a term as "immunomodulation" could be construed as being all encompassing. However, it is intriguing that the immune modulators touched on in these sessions can be subcategorized into about five broad groups. Almost all substances, excepting those entities that are immuno logically inert, will have some modulating effects on immunity. From the coarse adjustment of antibody feedback inhibition upon cellular limnunity to the subtle finesse envisioned in Jerne's idiotypic network and s'lppressor T cells, immunomodulators attempt to either magnify or diminish those responses that are normally elicited by antigen. The broad groups - thymic hormones, D.L.E., Interferon, drugs, and the use of bacterial products appear to be at the forefront of much of the pioneering work on immunomodulation.

Author : Clinton B. Mathias,Jeremy P. McAleer,Doreen E. Szollosi
Publisher : Springer Nature
Page : 399 pages
File Size : 45,8 Mb
Release : 2019-10-18
Category : Medical
ISBN : 9783030199227

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Pharmacology of Immunotherapeutic Drugs by Clinton B. Mathias,Jeremy P. McAleer,Doreen E. Szollosi Pdf

Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.​

Author : Takayuki Yoshimoto,Tomohiro Yoshimoto
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 50,5 Mb
Release : 2013-10-28
Category : Medical
ISBN : 9784431544425

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Cytokine Frontiers by Takayuki Yoshimoto,Tomohiro Yoshimoto Pdf

This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 45,6 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author : Ward E. Bullock,Nabil Hanna,Toby K. Eisenstein
Publisher : Springer
Page : 389 pages
File Size : 47,5 Mb
Release : 2014-11-14
Category : Medical
ISBN : 9781475754216

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Host Defenses and Immunomodulation to Intracellular Pathogens by Ward E. Bullock,Nabil Hanna,Toby K. Eisenstein Pdf

This conference was held under the sponsorship of the Eastern Pennsylvania Branch of the American Society for Microbiology, as one in a continuing series of Basic Science Symposia. The untiring volunteer effects of the members of the Symposium Committee are deeply appreciated. The Bureau of Laboratories of the Pennsylvania Department of Health was a cosponsor and generously provided staff and secretarial services to handle the difficult task of registration. The Department of Microbiology and of Microbiology and Immunology at the five medical schools in Philadelphia -- Temple University School of Medicine, Medical College of Pennsylvania, Thomas Jefferson University, Hahnemann University and the University of Pennsylvania -- were academic cosponsors, and the support of the Chairpersons and the faculties are gratefully acknowledged.

Author : Suman Kapur,Maristela Portela
Publisher : BoD – Books on Demand
Page : 488 pages
File Size : 52,9 Mb
Release : 2012-02-24
Category : Medical
ISBN : 9789535101529

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Immunosuppression by Suman Kapur,Maristela Portela Pdf

A need for a book on immunology which primarily focuses on the needs of medical and clinical research students was recognized. This book, "Immunosuppression - Role in Health and Diseases" is relatively short and contains topics relevant to the understanding of human immune system and its role in health and diseases. Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Therapeutic immunosuppression has applications in clinical medicine, ranging from prevention and treatment of organ/bone marrow transplant rejection, management of autoimmune and inflammatory disorders. It brings important developments both in the field of molecular mechanisms involved and active therapeutic approaches employed for immunosuppression in various human disease conditions. There was a need to bring this information together in a single volume, as much of the recent developments are dispersed throughout biomedical literature, largely in specialized journals. This book will serve well the practicing physicians, surgeons and biomedical scientists as it provides an insight into various approaches to immunosuppression and reviews current developments in each area.

Author : Richard D. Granstein
Publisher : S. Karger AG (Switzerland)
Page : 360 pages
File Size : 40,8 Mb
Release : 1994
Category : Medical
ISBN : PURD:32754064505856

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Mechanisms of Immune Regulation by Richard D. Granstein Pdf

Among the topics reviewed are T and B cell tolerance, clonal deletion, suppressor cells, mechanisms of immune privileged sites and experimental models of tumor immunity. Oral tolerance, ultraviolet radiation and photosensitized effects on immunity, allograft management, T cell vaccination and regulation of immunity with T cell epitopes are discussed from the point of view of possible therapeutic application.

Author : Anubhab Mukherjee,Vijay Sagar Madamsetty
Publisher : Springer Nature
Page : 84 pages
File Size : 41,6 Mb
Release : 2022-05-31
Category : Technology & Engineering
ISBN : 9783031016691

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Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy by Anubhab Mukherjee,Vijay Sagar Madamsetty Pdf

Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.