Immunomodulatory Effects Of Drugs For Treatment Of Immune Related Diseases

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Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

Azzam A. Maghazachi
Immunomodulatory Effects of Drugs for Treatment of Immune Related Diseases Book PDF

Author : Azzam A. Maghazachi
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 45,5 Mb
Release : 2017-09-18
Category : Electronic book
ISBN : 9782889452880

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Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases by Azzam A. Maghazachi Pdf

More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Treating Infectious Diseases in a Microbial World

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Treating Infectious Diseases in a Microbial World Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 46,8 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Immunomodulators and Human Health

Rajesh K. Kesharwani,Raj K. Keservani,Anil K. Sharma
Immunomodulators and Human Health Book PDF

Author : Rajesh K. Kesharwani,Raj K. Keservani,Anil K. Sharma
Publisher : Springer Nature
Page : 513 pages
File Size : 52,9 Mb
Release : 2022-06-17
Category : Medical
ISBN : 9789811663796

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Immunomodulators and Human Health by Rajesh K. Kesharwani,Raj K. Keservani,Anil K. Sharma Pdf

This book focuses on a broad range of immunomodulators, including both natural and synthetic ones. It highlights their role in human health. The book discusses nanotechnology-based immunomodulators with special emphasis on different types of formulation to boost the immune system. It highlights the role of immunomodulators against different microbes. This book describes important topics such as Classification and uses of various immunomodulators; Potential role of herbs and spices on immune system; Immune booster activity of prebiotics; Recent advances of nutraceutical and functional foods in Immune health; Antioxidants and immunomodulation; Nanotechnology and immunomodulators in cancer; Immunomodulatory role for the treatment and management of tuberculosis; Immunomodulation in autoimmune disorders; Herbal immunomodulators and COVID-19; Role of Cytokines as Immunomodulators and Immunomodulatory effects of endocrine disrupting chemicals. This book covers various aspects of product innovation, development, and launching of nutritional and pharmaceutical products with reference to immunomodulators. This book is meant for researchers and students in the field of immunology and pharmaceutical sciences.

Immunomodulation

H. Hugh Fudenberg
Immunomodulation Book PDF

Author : H. Hugh Fudenberg
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461593584

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Immunomodulation by H. Hugh Fudenberg Pdf

On May 14-16, 1982, a group of scientists met in Viareggio, Italy to present ideas, and exchange relevant data on current approaches on immunomodulators. We felt that the embodiment of the substance of that international symposium into this volume will be beneficial in keeping both clinicians and basic scientists abreast of the latest exciting developments in this rapidly accelerating field. We hope that the publication of this series of papers by an international panel of experts will enhance the nature of future inves t igat ive stud ies with such ent it ies . Under the rubric of immunology, it is obvious that such a term as "immunomodulation" could be construed as being all encompassing. However, it is intriguing that the immune modulators touched on in these sessions can be subcategorized into about five broad groups. Almost all substances, excepting those entities that are immuno logically inert, will have some modulating effects on immunity. From the coarse adjustment of antibody feedback inhibition upon cellular limnunity to the subtle finesse envisioned in Jerne's idiotypic network and s'lppressor T cells, immunomodulators attempt to either magnify or diminish those responses that are normally elicited by antigen. The broad groups - thymic hormones, D.L.E., Interferon, drugs, and the use of bacterial products appear to be at the forefront of much of the pioneering work on immunomodulation.

Antibody Therapy

Paul Imbach
Antibody Therapy Book PDF

Author : Paul Imbach
Publisher : Springer
Page : 363 pages
File Size : 54,6 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9783319680385

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Antibody Therapy by Paul Imbach Pdf

This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.

SITC’s Guide to Managing Immunotherapy Toxicity

Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD
SITC s Guide to Managing Immunotherapy Toxicity Book PDF

Author : Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD
Publisher : Springer Publishing Company
Page : 250 pages
File Size : 49,8 Mb
Release : 2019-03-15
Category : Medical
ISBN : 9780826172150

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SITC’s Guide to Managing Immunotherapy Toxicity by Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD Pdf

The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer

Immune Rebalancing

Diana Boraschi,Giselle Penton-Rol
Immune Rebalancing Book PDF

Author : Diana Boraschi,Giselle Penton-Rol
Publisher : Academic Press
Page : 298 pages
File Size : 53,7 Mb
Release : 2016-01-25
Category : Medical
ISBN : 9780128033364

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Immune Rebalancing by Diana Boraschi,Giselle Penton-Rol Pdf

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

Pharmacotherapeutics for Veterinary Dispensing

Katrina L. Mealey
Pharmacotherapeutics for Veterinary Dispensing Book PDF

Author : Katrina L. Mealey
Publisher : John Wiley & Sons
Page : 893 pages
File Size : 43,5 Mb
Release : 2019-02-07
Category : Medical
ISBN : 9781119532576

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Pharmacotherapeutics for Veterinary Dispensing by Katrina L. Mealey Pdf

Delivers the foundational and practical knowledge required for pharmacists to become an integral part of the veterinary health care team, improving therapeutic outcome while preventing serious adverse drug reactions in veterinary patients Pharmacotherapeutics for Veterinary Dispensing enables pharmacists and pharmacy students to expand the breadth of their pharmacological knowledge to include common veterinary species. The book offers a practical yet complete resource for dispensing drugs for canine and feline patients, with additional chapters on horses, birds, reptiles, small mammals, and food animals. Edited by a globally recognized expert in veterinary pharmacology, and including chapters written by veterinarians with expertise in pharmacotherapy and pharmacists with expertise in veterinary medicine, this book is designed to help pharmacists enhance the quality of veterinary patient care. This book is the first to combine the expertise of both veterinarians and pharmacists to enable pharmacists to apply their knowledge and skills to assure optimal therapeutic outcomes for patients of all species. Pharmacotherapeutics for Veterinary Dispensing: Puts the information needed to safely dispense prescription and OTC drugs for veterinary patients at the pharmacists’ fingertips Focuses on crucial details of canine and feline pharmacotherapeutics Helps pharmacists avoid adverse drug reactions including pharmacogenomic and breed-related drug sensitivities Offers an authoritative resource written by leading veterinary pharmacy experts designed to integrate pharmacists into the veterinary healthcare team Includes crucial regulatory information unique to veterinary drug dispensing and compounding Pharmacotherapeutics for Veterinary Dispensing is an essential reference for all pharmacists and pharmacy students that might find themselves dispensing drugs to veterinary patients, as well as for veterinarians and others involved with dispensing veterinary drugs. “Pharmacotherapeutics for Veterinary Dispensing is a book long overdue for the pharmacy profession....Whether you have practiced veterinary pharmacy your whole career or have never practiced veterinary pharmacy, this book has much to offer. Veterinarians are encouraged to suggest this book to pharmacists with whom they work and interact.” - JAVMA Vol 255 No. 6

Hepatotoxicity

Hyman J. Zimmerman
Hepatotoxicity Book PDF

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 45,5 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Phytopharmaceuticals

Durgesh Nandini Chauhan,Kamal Shah
Phytopharmaceuticals Book PDF

Author : Durgesh Nandini Chauhan,Kamal Shah
Publisher : John Wiley & Sons
Page : 498 pages
File Size : 52,5 Mb
Release : 2021-06-29
Category : Science
ISBN : 9781119681915

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Phytopharmaceuticals by Durgesh Nandini Chauhan,Kamal Shah Pdf

Medicinal plants contain a variety of bioactive compounds, (also referred to as phytochemicals). in the leaves, stems, flowers and fruits. This book covers these bioactive compounds, their available sources, how the bioactive molecules are isolated from the plants, the biochemistry, structural composition and potential biological activities. Also discussed are the pharmacological aspects of medicinal plants, phytochemistry and biological activities of different natural products, ethnobotany and medicinal properties, as well as a novel dietary approach for various disease management and therapeutic potential. The importance of phytopharmaceutical of plants and potential applications in the food and pharma industries is highlighted.

Drug-Induced Liver Injury

Anonim
Drug Induced Liver Injury Book PDF

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 52,8 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Antibiotics as Anti-Inflammatory and Immunomodulatory Agents

Bruce K. Rubin,Jun Tamaoki
Antibiotics as Anti Inflammatory and Immunomodulatory Agents Book PDF

Author : Bruce K. Rubin,Jun Tamaoki
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 44,8 Mb
Release : 2006-03-30
Category : Medical
ISBN : 9783764373108

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Antibiotics as Anti-Inflammatory and Immunomodulatory Agents by Bruce K. Rubin,Jun Tamaoki Pdf

Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer. The volume is intended for pulmonary physicians, researchers in inflammation research, and pharmaceutical companies interested in the development of such agents. It provides background information for the clinician as well as in depth exploration of cutting edge science.

The Chemotherapy Source Book

Michael Clinton Perry
The Chemotherapy Source Book Book PDF

Author : Michael Clinton Perry
Publisher : Lippincott Williams & Wilkins
Page : 820 pages
File Size : 44,9 Mb
Release : 2008
Category : Medical
ISBN : 0781773288

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The Chemotherapy Source Book by Michael Clinton Perry Pdf

The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.

Principles of Molecular Cardiology

Marschall S. Runge,Cam Patterson
Principles of Molecular Cardiology Book PDF

Author : Marschall S. Runge,Cam Patterson
Publisher : Springer Science & Business Media
Page : 604 pages
File Size : 44,5 Mb
Release : 2007-11-14
Category : Medical
ISBN : 9781592598786

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Principles of Molecular Cardiology by Marschall S. Runge,Cam Patterson Pdf

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

CDC Yellow Book 2018: Health Information for International Travel

Centers for Disease Control and Prevention CDC
CDC Yellow Book 2018 Health Information for International Travel Book PDF

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
Page : 672 pages
File Size : 48,6 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9780190628635

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CDC Yellow Book 2018: Health Information for International Travel by Centers for Disease Control and Prevention CDC Pdf

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.