Immunopharmacology Of Epithelial Barriers

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Immunopharmacology of Epithelial Barriers

Roy Goldie
Immunopharmacology of Epithelial Barriers Book PDF

Author : Roy Goldie
Publisher : Elsevier
Page : 304 pages
File Size : 55,9 Mb
Release : 1994-04-05
Category : Medical
ISBN : 0122880307

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Immunopharmacology of Epithelial Barriers by Roy Goldie Pdf

The realisation that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology. This volume adopts a step-by-step approach, whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive but integrated treatise of epithelial function and its immunopharmacology, which aims to serve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immunopharmacology as they are currently understood.

Immunopharmacology

Manzoor M. Khan
Immunopharmacology Book PDF

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 54,9 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387779768

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Immunopharmacology by Manzoor M. Khan Pdf

During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Immunopharmacology

Manzoor M. Khan
Immunopharmacology Book PDF

Author : Manzoor M. Khan
Publisher : Springer
Page : 442 pages
File Size : 49,5 Mb
Release : 2016-06-21
Category : Medical
ISBN : 9783319302737

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Immunopharmacology by Manzoor M. Khan Pdf

The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010. These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT. Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies – both binding and neutralizing – to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells. From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer.

Immunopharmacology of Joints and Connective Tissues

Clive P. Page,M. Elisabeth Davies,John T. Dingle
Immunopharmacology of Joints and Connective Tissues Book PDF

Author : Clive P. Page,M. Elisabeth Davies,John T. Dingle
Publisher : Elsevier
Page : 296 pages
File Size : 45,5 Mb
Release : 1994-03-07
Category : Medical
ISBN : 0122063457

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Immunopharmacology of Joints and Connective Tissues by Clive P. Page,M. Elisabeth Davies,John T. Dingle Pdf

The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of diseases as well as those under development ("Drugs").

Immunopharmacology of the Gastrointestinal System

John L. Wallace
Immunopharmacology of the Gastrointestinal System Book PDF

Author : John L. Wallace
Publisher : Academic Press
Page : 198 pages
File Size : 42,6 Mb
Release : 1993-03-01
Category : Medical
ISBN : 9781483289335

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Immunopharmacology of the Gastrointestinal System by John L. Wallace Pdf

Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.

Nijkamp and Parnham's Principles of Immunopharmacology

Michael J. Parnham,Frans P. Nijkamp,Adriano G. Rossi
Nijkamp and Parnham s Principles of Immunopharmacology Book PDF

Author : Michael J. Parnham,Frans P. Nijkamp,Adriano G. Rossi
Publisher : Springer Nature
Page : 888 pages
File Size : 53,8 Mb
Release : 2019-12-10
Category : Medical
ISBN : 9783030108113

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Nijkamp and Parnham's Principles of Immunopharmacology by Michael J. Parnham,Frans P. Nijkamp,Adriano G. Rossi Pdf

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

Phosphodiesterase Inhibitors

Anonim
Phosphodiesterase Inhibitors Book PDF

Author : Anonim
Publisher : Elsevier
Page : 228 pages
File Size : 50,6 Mb
Release : 1996-08-16
Category : Science
ISBN : 9780080538815

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Phosphodiesterase Inhibitors by Anonim Pdf

Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike

The Kinin System

Stephen G. Farmer
The Kinin System Book PDF

Author : Stephen G. Farmer
Publisher : Academic Press
Page : 371 pages
File Size : 42,7 Mb
Release : 1997-04-01
Category : Medical
ISBN : 9780080542522

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The Kinin System by Stephen G. Farmer Pdf

Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.

Lipid Mediators

Fiona M. Cunningham
Lipid Mediators Book PDF

Author : Fiona M. Cunningham
Publisher : Elsevier
Page : 392 pages
File Size : 40,7 Mb
Release : 2016-10-27
Category : Health & Fitness
ISBN : 9781483217635

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Lipid Mediators by Fiona M. Cunningham Pdf

The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.

Airway Wall Remodelling in Asthma

A. G. Stewart
Airway Wall Remodelling in Asthma Book PDF

Author : A. G. Stewart
Publisher : CRC Press
Page : 378 pages
File Size : 42,9 Mb
Release : 2020-10-28
Category : Medical
ISBN : 9781000142174

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Airway Wall Remodelling in Asthma by A. G. Stewart Pdf

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.

Cellular Mechanisms in Airways Inflammation

Clive P. Page,Katharine H. Banner,Domenico Spina
Cellular Mechanisms in Airways Inflammation Book PDF

Author : Clive P. Page,Katharine H. Banner,Domenico Spina
Publisher : Birkhäuser
Page : 370 pages
File Size : 47,9 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9783034884761

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Cellular Mechanisms in Airways Inflammation by Clive P. Page,Katharine H. Banner,Domenico Spina Pdf

Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulate inflammatory cell function is essential for the development of novel anti-inflammatory drugs for the treatment of common respiratory diseases such as asthma and COPD. This book provides a collection of valuable reviews on the major inflammatory cells involved in airways disease and examines the pharmacology of current anti-inflammatory drugs used in the treatment of airways disease. Moreover, an insight into the development of emerging drug therapies is also highlighted. This book is a must for the library of any researcher or clinician interested in the pathophysiology of airways disease.

Drugs for the Treatment of Respiratory Diseases

Domenico Spina
Drugs for the Treatment of Respiratory Diseases Book PDF

Author : Domenico Spina
Publisher : Cambridge University Press
Page : 622 pages
File Size : 53,9 Mb
Release : 2003-01-30
Category : Medical
ISBN : 0521773210

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Drugs for the Treatment of Respiratory Diseases by Domenico Spina Pdf

Respiratory diseases affect millions of people each year and represent a major health burden around the world. This timely reference surveys and evaluates the drug treatments available for the main categories of lung diseases including asthma, tuberculosis, chronic obstructive pulmonary disease, lung cancer, and respiratory infections. The recent re-emergence of tuberculosis and the increase in asthma in certain populations underlines the importance of finding effective new treatments for these diseases. This publication, a comprehensive reference, is one of the first to survey current and novel drug treatments for this group of diseases. It is certain to establish itself as an essential source of reference for respiratory physicians, clinicians and clinical pharmacologists.

Asthma

Peter J. Barnes,Ian W. Rodger,Neil C. Thomson
Asthma Book PDF

Author : Peter J. Barnes,Ian W. Rodger,Neil C. Thomson
Publisher : Elsevier
Page : 973 pages
File Size : 45,8 Mb
Release : 1998-04-20
Category : Medical
ISBN : 9780080525525

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Asthma by Peter J. Barnes,Ian W. Rodger,Neil C. Thomson Pdf

Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field. Comprehensive coverage of both basic science and clinical aspects of asthma Extensively referenced throughout

Immunopharmacology and Inflammation

Carlo Riccardi,Francesca Levi-Schaffer,Ekaterini Tiligada
Immunopharmacology and Inflammation Book PDF

Author : Carlo Riccardi,Francesca Levi-Schaffer,Ekaterini Tiligada
Publisher : Springer
Page : 331 pages
File Size : 41,9 Mb
Release : 2018-06-09
Category : Medical
ISBN : 9783319776583

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Immunopharmacology and Inflammation by Carlo Riccardi,Francesca Levi-Schaffer,Ekaterini Tiligada Pdf

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

Gastrointestinal Mucosal Repair and Experimental Therapeutics

Chi-Hin Cho,Jian-Ying Wang
Gastrointestinal Mucosal Repair and Experimental Therapeutics Book PDF

Author : Chi-Hin Cho,Jian-Ying Wang
Publisher : Karger Medical and Scientific Publishers
Page : 260 pages
File Size : 42,6 Mb
Release : 2002-01-01
Category : Medical
ISBN : 9783805573825

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Gastrointestinal Mucosal Repair and Experimental Therapeutics by Chi-Hin Cho,Jian-Ying Wang Pdf

Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C/DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field.