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Immunopharmacology of the Microcirculation by Susan D. Brain Pdf
The sum of a range of imflammatory events at the microvascular level leads to the expression of one of many inflammatory diseases. The microcirculation is a target for existing and potential anti-inflammatory therapies and it is anticipated that a greater knowledge of the immunopharmacology of the microcirculation will lead to novel therapeutic targets. This volume covers examples of these imflammatory diseases, the in vitro and in vivo techniques used to study them, and the therapeutic agents used to combat them.
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.
This book covers the physiological processes relevant to inflammation. It centers on the recruitment of leukocytes to sites of injury and infection, their function in the tissue and the eventual resolution of inflammation.
Poisoning by Plants, Mycotoxins, and Related Toxins by Franklin Riet-Correa Pdf
This comprehensive collection of up-to-the-minute research in the field of poisonous plants investigates the effects of toxins on animals and humans. It covers the effects of poisonous plants on the liver, the reproductive system, and the nervous system, as well as exploring the field of herbal medicine. In a specialized section devoted to control measures, the book highlights techniques such as vaccination and taste aversion, providing the reader with important information on safeguarding against disaster. This volume is an essential reference for veterinarians, researchers, toxicologists and chemists.
Immunopharmacology of Free Radical Species by Anonim Pdf
Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.
This is a second edition of the book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been implicated in anti-tumor response. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This book provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration of these cells. It contains unique information on the neutrophil's role in viral infectious diseases and cancer. It also presents the recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases. Contents: The Remarkable Neutrophil! Developing a Blueprint for Integrated Cellular SignalingThe Neutrophil Respiratory Burst OxidaseNovel Neutrophil Receptors and Their Signal TransductionMechanisms of Neutrophil MigrationNeutrophils and ApoptosisRegulation of Neutrophil Functions by Long Chain Fatty AcidsCytokine Production by NeutrophilsNeutrophils in Viral InfectionsPolymorphonuclear Neutrophils and Cancer: Ambivalent Role in Host Defense Against TumorUse of Colony-Stimulating Factors for Treatment of Neutropenia and Infectious DiseasesNeutrophil Transfusion Therapy in G-CSF Era Readership: Researchers, academics and students (including medical undergraduates) in biochemistry, cell biology, physiology, immunology, infectious diseases and oncology. Key Features:A unique review of neutrophil signaling, and the role of rac 1 and rac 2 in neutrophil functionThe role of fatty acids in neutrophil function — information not available in other booksThe role of neutrophils in viral infections — usually beyond the radar screen of investigatorsThe role of neutrophil function in cancer — a topic of recent, great interest to many research groupsDiscussion of therapeutic strategies to enhance neutrophil function in different diseasesKeywords:Neutrophil;Signal Transduction;Reactive Oxygen Species;Apoptosis;Chemotaxis;Viral Infectious Disease;Cancer
Immunopharmacology of Lymphocytes by Marek Rola-Pleszczynski Pdf
Lymphocytes constitute the central cell type of the immune system. Over the last two decades, very powerful tools have become available with which to define their characteristics and functions. For example, monoclonal antibodies have allowed fine phenotypic characterization of various subpopulations of lymphocytes. The discovery of an ever-growing number of cytokines and growth factors, along with the structural elucidation of their receptors, was a result of refined bioassays, cloning and sequencing techniques. Lymphocytes, more than any other cell type, function in a network of cellular and humoral interactions. These humoral interactions include not only cytokines, but also hormones, neurotransmitters and lipid mediators. In addition, the manipulation of the immune system is effected by numerous exogenous substances with the properties of agonists, antagonists, metabolic inhibitors or biological response modifiers. It is in this context that this volume forms an essential part of the Handbook of Immunopharmacology series. The main focus of the book is on T lymphocytes and NK cells. The physiology and immunopharmacology of B cells, although not covered in a separate chapter, form an integral part of the sections on modulation by inflammatory mediators, hormones and neuropeptides. This volume acts as a good starting point on which to build and a stepping stone to future discoveries.
Immunopharmacology and Inflammation by Carlo Riccardi,Francesca Levi-Schaffer,Ekaterini Tiligada Pdf
A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.
The consequences of diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial-asthma, rheumatoid arthritis and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drugs development. As a consequence, this area has not gained the prominence of other fields such as molecular pharmacology or neuropharmacology, and a focul information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can effect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). This volume provides a comprehensive overview of the adhsion molecules, processes and concepts that govern both inflammatory and infectious diseases, and also deals in detail with the specific in vivo pathways involved. The first chapter introduces some of the molecules that mediate leukocyte adhesion and ranges from their discovery using monoclonal antibodies and a congenital adhesion deficiency, to their antagonism in preliminary clinical trials as novel therapeutics. An in-depth analysis of the structure, distribution and function of the cell surface glycoproteins that regulates lymphocyte (specific immune response), granulocyte (acute inflammatory response) and metastatic cell (malignant processes) adhesions respectively is provided by the next three chapters. Chapters 5 and 7 detail the molecular structure, intracellular pathways, specificty of carbohydrate interactions, and signalling of the molecules that regulate leukocyte-leukocyte and leukocyte-mesenchymal cell interactions. There follows an exploration into the contributions of specific molecules in inflammatory diseases in various organs from chapters 8-11. The concluding part is unique to this volume by reviewing the comparable, and in some cases same, cell surface molecules that mediate virus, bacteria and parasite interactions with host cells. The research is far from complete, but Adhesion Molecules is extremely comprehensive and will be a valuable resource for many a year to come.
First published in 1875 and read by more than eight million people, this nondenominational book has a 119-year history of healing and inspiration. To attract a new audience, this time-honored message of healing has a powerful new cover, easy-to-read page layout, and word index. Named one of "75 Books by Women Whose Words Have Changed the World".
Current Perspectives of the Extracorporeal Circulation by D. Baykut,A. Krian Pdf
The rapid technical improvement of the extracorporeal circulation in the past decades has led to safer, more comfortable and more compatible operations in cardiac surgery and interventions which used to be an adventure are now routine practice. Although most technical variables can easily be accommo dated today, the physical influence of artificial circulation systems on blood and tissue still remains uncertain in many cases. One of our main observations in the use of the extracorporeal circulation is that the prolonged interaction with unphysiological surfaces and forces of ten releases a cascade of blood and tissue reactions, resulting in a complex type of "disease". Thus, the symptoms can range from unspecific pulmonary inflammations to a severe renal failure or from coagulation problems to a heavy cerebrovascular stroke. Based on these facts, an interdisciplinary workshop named "Current Per spectives of the Extracorporeal Circulation" took place in Duisburg, Ger many on March 26, 1999. The rationale behind the word "interdisciplinary" was to make a step for ward to establish a joint field of knowledge which would be capable of link ing the experiences and transfer the know-how of various specialists like car diac surgeons, neurologists, physiologists or the healthcare industry with their contributions to this essential topic from different perspectives.
Author : Paul G. Hellewell,Timothy J. Williams Publisher : Academic Press Page : 360 pages File Size : 53,5 Mb Release : 1994-05-06 Category : Medical ISBN : UOM:39015032956610
Immunopharmacology of Neutrophils by Paul G. Hellewell,Timothy J. Williams Pdf
About the Series: The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). About the Book: This book addresses the key issues that face neutrophils during their very short but extremely important lives. The discovery that neutrophils have the capacity to phagocytose and kill foreign organisms set the stage for a fascinating research field that continues to stimulate exciting new findings throughout the world. Neutrophils target the sites of infection or injury, and are thus equipped with sensors for soluble signals ("chemoattractants") generated in the tissue in response to tissue infection or injury, and sensors for molecules on surfaces. These receptors are important so that the cell can distinguish, for example, activated endothelium to stimulate adherence and emigration, or alternatively the bacterial surface to stimulate phagocytosis and killing. A deficiency in any of these mechanisms can result in life-threatening infection. An over-reaction can result in damage to the tissues that the neutrophil should be programmed to protect.