Immunosuppression

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Tumour Site Concordance and Mechanisms of Carcinogenesis

Robert A. Baan,Bernard W. Stewart,Kurt Straif
Tumour Site Concordance and Mechanisms of Carcinogenesis Book PDF

Author : Robert A. Baan,Bernard W. Stewart,Kurt Straif
Publisher : International Agency for Research on Cancer
Page : 0 pages
File Size : 47,9 Mb
Release : 2019-05-22
Category : Medical
ISBN : 9283222172

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Tumour Site Concordance and Mechanisms of Carcinogenesis by Robert A. Baan,Bernard W. Stewart,Kurt Straif Pdf

This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment.

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 48,7 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Immunosuppression under Trial

Pierre Cochat
Immunosuppression under Trial Book PDF

Author : Pierre Cochat
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401146432

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Immunosuppression under Trial by Pierre Cochat Pdf

Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.

Secondary Neoplasias Following Chemotherapy, Radiotherapy and Immunosuppression

Ursula Rüther,Christa Nunnensiek,Hans-Joachim Schmoll
Secondary Neoplasias Following Chemotherapy Radiotherapy and Immunosuppression Book PDF

Author : Ursula Rüther,Christa Nunnensiek,Hans-Joachim Schmoll
Publisher : Karger Medical and Scientific Publishers
Page : 385 pages
File Size : 43,8 Mb
Release : 2000-01-01
Category : Medical
ISBN : 9783805571166

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Secondary Neoplasias Following Chemotherapy, Radiotherapy and Immunosuppression by Ursula Rüther,Christa Nunnensiek,Hans-Joachim Schmoll Pdf

'... This book, by Ruther and colleagues, is a very comprehensive review of the mechanisms of carcinogenesis, clinical features and therapies for secondary malignancies. '... Its an excellent resource for those interested in the subject, as well as oncologists who are increasingly forced to deal with second cancers. The material is well referenced.'

Biologic Markers in Immunotoxicology

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
Biologic Markers in Immunotoxicology Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
Publisher : National Academies Press
Page : 225 pages
File Size : 52,9 Mb
Release : 1992-02-01
Category : Science
ISBN : 9780309043892

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Biologic Markers in Immunotoxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology Pdf

Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markersâ€"sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.

Immunosuppression

Xuehui He
Immunosuppression Book PDF

Author : Xuehui He
Publisher : BoD – Books on Demand
Page : 105 pages
File Size : 45,6 Mb
Release : 2020-12-09
Category : Medical
ISBN : 9781839681233

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Immunosuppression by Xuehui He Pdf

Our immune system is equipped with a series of defence mechanisms to recognise and respond to non-self molecules. Although essential for fighting off infections and preventing cancers, destructive immune responses pose a considerable challenge in autoinflammation and transplantation. Currently available immunosuppressants help to control destructive immune responses. However, management of side-effects of lifelong immunosuppression, including cancer development and reduced survival, remain major problems. For this reason, an increasing amount of interest is directed towards the natural specific regulatory mechanism of the immune system. A better understanding of these mechanisms holds the key. This book presents a comprehensive overview of immune suppression in transplantation, cancer and viral infections. Chapters cover modulation of Treg as well as the new era of immunotherapy.

CDC Yellow Book 2018: Health Information for International Travel

Centers for Disease Control and Prevention CDC
CDC Yellow Book 2018 Health Information for International Travel Book PDF

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
Page : 672 pages
File Size : 50,8 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9780190628635

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CDC Yellow Book 2018: Health Information for International Travel by Centers for Disease Control and Prevention CDC Pdf

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Immunosuppression

Suman Kapur,Maristela Portela
Immunosuppression Book PDF

Author : Suman Kapur,Maristela Portela
Publisher : BoD – Books on Demand
Page : 488 pages
File Size : 55,9 Mb
Release : 2012-02-24
Category : Medical
ISBN : 9789535101529

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Immunosuppression by Suman Kapur,Maristela Portela Pdf

A need for a book on immunology which primarily focuses on the needs of medical and clinical research students was recognized. This book, "Immunosuppression - Role in Health and Diseases" is relatively short and contains topics relevant to the understanding of human immune system and its role in health and diseases. Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Therapeutic immunosuppression has applications in clinical medicine, ranging from prevention and treatment of organ/bone marrow transplant rejection, management of autoimmune and inflammatory disorders. It brings important developments both in the field of molecular mechanisms involved and active therapeutic approaches employed for immunosuppression in various human disease conditions. There was a need to bring this information together in a single volume, as much of the recent developments are dispersed throughout biomedical literature, largely in specialized journals. This book will serve well the practicing physicians, surgeons and biomedical scientists as it provides an insight into various approaches to immunosuppression and reviews current developments in each area.

Immunosuppression and Immunomodulation

Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma
Immunosuppression and Immunomodulation Book PDF

Author : Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma
Publisher : BoD – Books on Demand
Page : 208 pages
File Size : 43,7 Mb
Release : 2023-07-12
Category : Medical
ISBN : 9781837680719

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Immunosuppression and Immunomodulation by Rajeev K. Tyagi,Prakriti Sharma,Praveen Sharma Pdf

This book synthesizes the key concepts of immunosuppression and immunomodulation. A comprehensive understanding of these processes is necessary to develop vaccines and therapeutic interventions for diseases. This book examines the role of information molecules such as cytokines and chemokines and other proteins secreted by the host upon interacting with the pathogen(s) that modulate and suppress the immune system and assist the pathogen(s) in causing disease. Chapters discuss the modulation of inflammation, signaling pathways, the interaction of immune cells, and resulting immunity as well as its suppression.

Infections in the Immunosuppressed Patient

Pranatharthi H. Chandrasekar
Infections in the Immunosuppressed Patient Book PDF

Author : Pranatharthi H. Chandrasekar
Publisher : Oxford University Press
Page : 425 pages
File Size : 54,5 Mb
Release : 2016
Category : Medical
ISBN : 9780199938568

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Infections in the Immunosuppressed Patient by Pranatharthi H. Chandrasekar Pdf

Infections in the Immunosuppressed Patient offers an illustrated, case-based matrix for treatment of infections across all types of immunosuppressed patients. As the challenges of managing these infections continues to evolve, this collection offers lucid, authoritative guidance to diagnosing and treating these infections effectively. Comprising 81 cases from leading experts across specialties, this collection offers a guide to both common and uncommon presentations of infections in: · Cancer patients · Solid-organ transplant recipients · Stem-cell recipients · Patients on immunosuppressive drugs · Patients with other immunosuppressive conditions Supplemented with rich color illustrations and insights from more than 100 experts, Infections in the Immunosuppressed Patient is the new benchmark reference work for treatment of these difficult cases.

Pharmacology of Immunosuppression

Howard J. Eisen
Pharmacology of Immunosuppression Book PDF

Author : Howard J. Eisen
Publisher : Springer Nature
Page : 351 pages
File Size : 40,8 Mb
Release : 2022-07-06
Category : Medical
ISBN : 9783031051180

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Pharmacology of Immunosuppression by Howard J. Eisen Pdf

The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.

Local Immunosuppression of Organ Transplants

Scott A. Gruber
Local Immunosuppression of Organ Transplants Book PDF

Author : Scott A. Gruber
Publisher : Springer Science & Business Media
Page : 217 pages
File Size : 55,8 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9783662221051

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Local Immunosuppression of Organ Transplants by Scott A. Gruber Pdf

For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.

Personalized Immunosuppression in Transplantation

Michael Oellerich,Amitava Dasgupta
Personalized Immunosuppression in Transplantation Book PDF

Author : Michael Oellerich,Amitava Dasgupta
Publisher : Elsevier
Page : 316 pages
File Size : 40,5 Mb
Release : 2015-08-08
Category : Medical
ISBN : 9780128011331

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Personalized Immunosuppression in Transplantation by Michael Oellerich,Amitava Dasgupta Pdf

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Adverse Reactions to Biologics

L. Puig,W. Gulliver
Adverse Reactions to Biologics Book PDF

Author : L. Puig,W. Gulliver
Publisher : Karger Medical and Scientific Publishers
Page : 120 pages
File Size : 45,8 Mb
Release : 2017-11-07
Category : Medical
ISBN : 9783318061017

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Adverse Reactions to Biologics by L. Puig,W. Gulliver Pdf

In many areas of medicine physicians still face the great challenge of finding therapies that will meet the patients’ needs. In dermatology the challenge has arisen on multiple fronts through advances in the understanding of the immunopathogenesis of many inflammatory and malignant cutaneous disorders. Breakthroughs, combined with significant developments in targeted immunotherapy, have resulted in improved outcomes as these newer therapies are being used for both approved indications and as off-label therapies for various chronic inflammatory skin disorders and many forms of skin cancer. In the expectation that by truly understanding the safety profile of these targeted therapies patients’ outcomes will be significantly improved, this book offers insights into topics such as adverse reactions, infectious complications and the perioperative use of biologics in psoriasis, immunogenicity of biologic therapies, paradoxical reactions, safety of biologics used to treat autoimmune bullous diseases and primary cutaneous lymphomas, adverse reactions and skin manifestations of therapies targeting melanoma and non-melanoma skin cancer and other neoplastic diseases. Eminent researchers with extensive clinical experience have contributed to this publication, providing an in-depth overview of the latest knowledge in this field.

The Molecular Mechanisms of Regulatory T cell Immunosuppression

Kendall A. Smith
The Molecular Mechanisms of Regulatory T cell Immunosuppression Book PDF

Author : Kendall A. Smith
Publisher : Frontiers E-books
Page : 125 pages
File Size : 55,5 Mb
Release : 2024-06-17
Category : Electronic
ISBN : 9782889190935

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The Molecular Mechanisms of Regulatory T cell Immunosuppression by Kendall A. Smith Pdf

Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 production and action, and the production of suppressive cytokines such as IL-10 and Tumor Growth Factor-beta, to list a few. However, the field has thus far failed to come to a consensus, such that some investigators have now asserted that many molecular mechanisms may be operative, in fact that perhaps all of the described mechanisms may account for the suppressive effects of these cells, acting either simultaneously or sequentially. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for T-Reg immunosuppression.