Indwelling Neural Implants

Author : William M. Reichert
Publisher : CRC Press
Page : 296 pages
File Size : 46,8 Mb
Release : 2007-12-17
Category : Science
ISBN : 1420009303

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Indwelling Neural Implants by William M. Reichert Pdf

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.

Author : Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller
Publisher : Cambridge University Press
Page : 693 pages
File Size : 53,5 Mb
Release : 2014-04-24
Category : Medical
ISBN : 9781107011670

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Textbook of Neural Repair and Rehabilitation by Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller Pdf

Volume 1 of the Textbook of Neural Repair and Rehabilitation covers the basic sciences relevant to recovery of function following injury to the nervous system.

Author : Christopher Spicer
Publisher : Royal Society of Chemistry
Page : 323 pages
File Size : 43,6 Mb
Release : 2021-08-18
Category : Science
ISBN : 9781788017534

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The Chemistry of Inorganic Biomaterials by Christopher Spicer Pdf

This book overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publisher : National Academies Press
Page : 223 pages
File Size : 41,8 Mb
Release : 2003-08-22
Category : Science
ISBN : 9780309167857

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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research Pdf

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Author : Michael Thompson,Larisa-Emilia Cheran,Saman Sadeghi
Publisher : Royal Society of Chemistry
Page : 250 pages
File Size : 50,7 Mb
Release : 2013-08-14
Category : Science
ISBN : 9781849735414

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Sensor Technology in Neuroscience by Michael Thompson,Larisa-Emilia Cheran,Saman Sadeghi Pdf

Biosensor technology has rapidly expanded into a wide variety of applications in the last few years. Such fields include clinical diagnostics, environmental chemistry, drug discovery and pathogen detection, to name but a few. The structure of these sensors is based on the intimate combination of a biological entity with a transducer capable of generating an electrical signal to provide information on the biological system being studied. Until now there has been a limited treatment of the study of whole cells (as a biological component) due to the difficulty in connecting transducers to cell populations. This book focuses on several aspects of neural behaviour both in vitro and in vivo, and for the first time, the detection of populations of neurons (rather than single cells) will be presented. The fundamental behaviour and characterization of neurons on various substrates, using a variety of electronic devices such as transistors and microelectrode arrays will be discussed. Future perspectives discussed in the book include artificial intelligence using biological neural networks and nanoneuromedicine. The authors have considerable experience in biosensor technology, and have pioneered the study of neural populations using biosensors in collaboration with neurophysiologists and neuroendrocrinologists. This book will be invaluable to university neuroscience and analytical chemistry departments and students, academics and physicians will benefit from its accessible style and format.

Author : Bruna Corradetti
Publisher : Springer
Page : 241 pages
File Size : 46,7 Mb
Release : 2016-11-30
Category : Technology & Engineering
ISBN : 9783319454337

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The Immune Response to Implanted Materials and Devices by Bruna Corradetti Pdf

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Author : Kanishka Rajput,Nalini Vadivelu,Alan David Kaye,Rinoo Vasant Shah
Publisher : Springer Nature
Page : 429 pages
File Size : 53,9 Mb
Release : 2021-03-08
Category : Medical
ISBN : 9783030552626

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Pain Control in Ambulatory Surgery Centers by Kanishka Rajput,Nalini Vadivelu,Alan David Kaye,Rinoo Vasant Shah Pdf

This book provides a comprehensive review of the challenges, risk stratification, approaches and techniques needed to improve pain control in ambulatory surgery centers (ASCs). It addresses not only the management of acute perioperative pain but also describes modalities that could potentially reduce the risk of evolution of acute pain into chronic pain, in addition to weaning protocols and follow ups with primary surgical specialties and pain physicians as needed. Organized into five sections, the book begins with the foundations of managing ASCs, with specific attention paid to the current opioid epidemic and U.S. policies relating to prescribing opioids to patients. Section two and three then explore facets of multimodal analgesia and non-operating room locations, including the use of ultrasounds, sedation in specific procedures, regional anesthesia, ketamine infusions, and the management of perioperative nausea and intractable pain in outpatient surgery. Section four examines the unique challenges physicians face with certain patient demographics, such as the pediatric population, those suffering from sleep apnea, and those with a history of substance abuse. The book closes with information on discharge considerations, ambulatory surgery protocols, recovery room protocols, and mandatory pain management services. An invaluable reference for all health personnel and allied specialties, Pain Control in Ambulatory Surgery Centers (ASCs) meets the unmet need for a resource that covers optimum pain control in patients undergoing outpatient surgery as well as the urgent ASCs challenges that are presented on an immense scale with national and international impact.

Author : Valentin A. Pavlov
Publisher : Perspectives Cshl
Page : 350 pages
File Size : 47,5 Mb
Release : 2019
Category : Medical
ISBN : 1621823024

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Bioelectronic Medicine by Valentin A. Pavlov Pdf

"Cold Spring Harbor perspectives in medicine."

Author : Nitish V. Thakor
Publisher : Springer Nature
Page : 3686 pages
File Size : 47,9 Mb
Release : 2023-02-02
Category : Technology & Engineering
ISBN : 9789811655401

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Handbook of Neuroengineering by Nitish V. Thakor Pdf

This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Author : Asim Bhatti,Kendall H. Lee,Hamid Garmestani,Chee Peng Lim
Publisher : Springer
Page : 264 pages
File Size : 42,6 Mb
Release : 2017-03-23
Category : Technology & Engineering
ISBN : 9789811039577

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Emerging Trends in Neuro Engineering and Neural Computation by Asim Bhatti,Kendall H. Lee,Hamid Garmestani,Chee Peng Lim Pdf

This book focuses on neuro-engineering and neural computing, a multi-disciplinary field of research attracting considerable attention from engineers, neuroscientists, microbiologists and material scientists. It explores a range of topics concerning the design and development of innovative neural and brain interfacing technologies, as well as novel information acquisition and processing algorithms to make sense of the acquired data. The book also highlights emerging trends and advances regarding the applications of neuro-engineering in real-world scenarios, such as neural prostheses, diagnosis of neural degenerative diseases, deep brain stimulation, biosensors, real neural network-inspired artificial neural networks (ANNs) and the predictive modeling of information flows in neuronal networks. The book is broadly divided into three main sections including: current trends in technological developments, neural computation techniques to make sense of the neural behavioral data, and application of these technologies/techniques in the medical domain in the treatment of neural disorders.

Author : Claude Clément
Publisher : Springer Nature
Page : 281 pages
File Size : 47,7 Mb
Release : 2019-10-08
Category : Medical
ISBN : 9783030278526

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Brain-Computer Interface Technologies by Claude Clément Pdf

This book is about the field of brain-computer interfaces (BCI) and the unique and special environment of active implants that electrically interface with the brain, spinal cord, peripheral nerves, and organs. At the heart of the book is the matter of repairing and rehabilitating patients suffering from severe neurologic impairments, from paralysis to movement disorders and epilepsy, that often requires an invasive solution based on an implanted device. Past achievements, current work, and future perspectives of BCI and other interactions between medical devices and the human nervous system are described in detail from a pragmatic point of view. Reviews the Active Implantable Medical Devices (AIMDs) industry and how it is moving from cardiac to neuro applications Clear, easy to read, presentation of the field of neuro-technologies for human benefit Provides easy to understand explanations about the technical limitations, the physics of implants in the human body, and realistic long terms perspectives

Author : Dario Farina,Winnie Jensen,Metin Akay
Publisher : John Wiley & Sons
Page : 661 pages
File Size : 43,5 Mb
Release : 2013-05-21
Category : Science
ISBN : 9781118628638

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Introduction to Neural Engineering for Motor Rehabilitation by Dario Farina,Winnie Jensen,Metin Akay Pdf

Neural engineering is a discipline that uses engineering techniques to understand, repair, replace, enhance, or treat diseases of neural systems. Currently, no book other than this one covers this broad range of topics within motor rehabilitation technology. With a focus on cutting edge technology, it describes state-of-the-art methods within this field, from brain-computer interfaces to spinal and cortical plasticity. Touching on electrode design, signal processing, the neurophysiology of movement, robotics, and much more, this innovative volume collects the latest information for a wide range of readers working in biomedical engineering.

Author : Elliot Krames,P. Hunter Peckham,Ali R. Rezai
Publisher : Academic Press
Page : 1828 pages
File Size : 47,7 Mb
Release : 2018-01-05
Category : Science
ISBN : 9780128093023

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Neuromodulation by Elliot Krames,P. Hunter Peckham,Ali R. Rezai Pdf

Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine. Provides a comprehensive reference that covers all aspects of the growing field of neuromodulation Written by international, leading authorities in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering Includes new chapters on optogenetics, bioelectronics medicine and brain computer interfacing

Author : Andreas Taubert,Joao F. Mano,Jos¿ Carlos Rodr¿guez-Cabello
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 53,6 Mb
Release : 2013-07-12
Category : Science
ISBN : 9783527649631

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Biomaterials Surface Science by Andreas Taubert,Joao F. Mano,Jos¿ Carlos Rodr¿guez-Cabello Pdf

At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.

Author : William F. Agnew,Douglas B. McCreery
Publisher : Unknown
Page : 344 pages
File Size : 42,5 Mb
Release : 1990
Category : Electric Stimulation
ISBN : UOM:39015015456836

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Neural Prostheses by William F. Agnew,Douglas B. McCreery Pdf