Inflammation And Immunity In Depression

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Inflammation and Immunity in Depression

Bernhard Baune
Inflammation and Immunity in Depression Book PDF

Author : Bernhard Baune
Publisher : Academic Press
Page : 636 pages
File Size : 42,8 Mb
Release : 2018-05-23
Category : Medical
ISBN : 9780128110744

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Inflammation and Immunity in Depression by Bernhard Baune Pdf

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Inflammation, 4 Volume Set

Jean-Marc Cavaillon,Mervyn Singer
Inflammation 4 Volume Set Book PDF

Author : Jean-Marc Cavaillon,Mervyn Singer
Publisher : John Wiley & Sons
Page : 1818 pages
File Size : 45,7 Mb
Release : 2018-02-20
Category : Medical
ISBN : 9783527338993

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Inflammation, 4 Volume Set by Jean-Marc Cavaillon,Mervyn Singer Pdf

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Inflammation in Psychiatry

A. Halaris,B.E. Leonard
Inflammation in Psychiatry Book PDF

Author : A. Halaris,B.E. Leonard
Publisher : Karger Medical and Scientific Publishers
Page : 218 pages
File Size : 51,6 Mb
Release : 2013-02-27
Category : Medical
ISBN : 9783318023114

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Inflammation in Psychiatry by A. Halaris,B.E. Leonard Pdf

Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co-morbid conditions, notably diabetes, cardiovascular disease and cerebrovascular disease. The possible mechanisms underlying the bidirectionality of co-morbid medical and psychiatric disorders can be viewed as a consequence of inflammatory changes. These emerging novel concepts illustrate how the knowledge of inflammation can enable meaningful integration of psychopathology with physical co-morbidity. The innovative articles in this volume highlight the intricate link between psychiatry and psychoimmunology and underscore the central role of inflammation in furthering our understanding of the pathophysiology underlying mental health and illness.

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Robert Dantzer,Lucile Capuron
Inflammation Associated Depression Evidence Mechanisms and Implications Book PDF

Author : Robert Dantzer,Lucile Capuron
Publisher : Springer
Page : 357 pages
File Size : 52,6 Mb
Release : 2016-12-28
Category : Medical
ISBN : 9783319511528

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Inflammation-Associated Depression: Evidence, Mechanisms and Implications by Robert Dantzer,Lucile Capuron Pdf

Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

The Immune System and Mental Health

Hymie Anisman,Shawn Hayley,Alexander Kusnecov
The Immune System and Mental Health Book PDF

Author : Hymie Anisman,Shawn Hayley,Alexander Kusnecov
Publisher : Academic Press
Page : 700 pages
File Size : 54,7 Mb
Release : 2018-07-19
Category : Medical
ISBN : 9780128113523

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The Immune System and Mental Health by Hymie Anisman,Shawn Hayley,Alexander Kusnecov Pdf

The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson’s and Alzheimer’s-like dementia are explored. Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health

Cytokines, Stress, and Depression

Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya
Cytokines Stress and Depression Book PDF

Author : Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 50,5 Mb
Release : 1999-07-31
Category : Medical
ISBN : 9780306461354

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Cytokines, Stress, and Depression by Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya Pdf

Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.

Immuno-Psychiatry

Michael Berk,Marion Leboyer,Iris E. Sommer
Immuno Psychiatry Book PDF

Author : Michael Berk,Marion Leboyer,Iris E. Sommer
Publisher : Springer Nature
Page : 438 pages
File Size : 47,9 Mb
Release : 2021-08-14
Category : Medical
ISBN : 9783030712297

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Immuno-Psychiatry by Michael Berk,Marion Leboyer,Iris E. Sommer Pdf

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

The Neurobiological Basis of Suicide

Yogesh Dwivedi
The Neurobiological Basis of Suicide Book PDF

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 49,7 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

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The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Immune Function in Sport and Exercise

Michael Gleeson
Immune Function in Sport and Exercise Book PDF

Author : Michael Gleeson
Publisher : Elsevier Health Sciences
Page : 338 pages
File Size : 51,8 Mb
Release : 2006-01-01
Category : Medical
ISBN : 9780443101182

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Immune Function in Sport and Exercise by Michael Gleeson Pdf

This title is directed primarily towards health care professionals outside of the United States. Designed to help readers understand and evaluate the relationship between exercise, immune function and infection risk, this book presents evidence for the "J-shaped" relationship between exercise load and infection risk. It also describes the components of the human immune system and key functions that protect the body from disease, the impact of acute and chronic psychological stress on immune function, and practical guidelines for minimizing the risk of immunodepression and infection in athletes. Further chapters explore different ways of measuring immune function, as well as the effects of heavy training on innate and specific (acquired) immunity, exercise in environmental extremes, and nutrition. Connections between exercise, infection risk, and immune function in special populations (elderly, obese, diabetic and HIV patients) are also addressed. Authored by a team of highly experienced experts. The "J-shaped" relationship between exercise load and infection risk is described, backed by current research and evidence. Components of the immune system and normal immune function are explained in detail, as well as methods for measuring immune function. The impact of acute and chronic psychological stress on immune function is presented, along with suggestions for minimizing the risk of immunodepression and infection in athletes. The effects of heavy training, exercise in environmental extremes, and nutrition are discussed with regard to their impact on innate and specific (acquired) immunity. Immune function in special populations (elderly, obese, diabetic and HIV patients) is also addressed, exploring links between exercise and infection risk in these groups. Evidence-based coverage includes a list of references in each chapter, as well as suggestions for further reading that direct readers to important texts and review articles. Information is presented in an easily accessible format, following a logical progression of material. LEach chapter begins with a list of learning objectives and ends with a list of key points to reinforce learning. A glossary at the end of the book defines all key terms and abbreviations.

The Loss of Sadness

Allan V. Horwitz,Jerome C. Wakefield
The Loss of Sadness Book PDF

Author : Allan V. Horwitz,Jerome C. Wakefield
Publisher : Oxford University Press
Page : 304 pages
File Size : 45,7 Mb
Release : 2007-06-18
Category : Health & Fitness
ISBN : 9780195313048

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The Loss of Sadness by Allan V. Horwitz,Jerome C. Wakefield Pdf

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Stress Challenges and Immunity in Space

Alexander Choukèr
Stress Challenges and Immunity in Space Book PDF

Author : Alexander Choukèr
Publisher : Springer
Page : 0 pages
File Size : 42,6 Mb
Release : 2020-12-03
Category : Medical
ISBN : 3030169987

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Stress Challenges and Immunity in Space by Alexander Choukèr Pdf

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Autism

Abha Chauhan,Ved Chauhan,Ted Brown
Autism Book PDF

Author : Abha Chauhan,Ved Chauhan,Ted Brown
Publisher : CRC Press
Page : 452 pages
File Size : 52,6 Mb
Release : 2009-10-26
Category : Medical
ISBN : 1420068873

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Autism by Abha Chauhan,Ved Chauhan,Ted Brown Pdf

In 2007, the Centers for Disease Control and Prevention issued an autism alarm, estimating that one in 150 children may be affected by autism spectrum disorder. Autism has been treated mainly with technical approaches: principally applied behavior analysis and psychopharmacology. The findings in this book implicate oxidative stress as a common feature in autism, and support the claim that oxidative stress and intracellular redox imbalance can be induced or triggered in autism by exposure to certain environmental agents. Such findings could point the way to new treatment approaches in autism. Autism: Oxidative Stress, Inflammation, and Immune Abnormalities brings together a wealth of cutting-edge evidence that is already influencing how we treat this serious condition. It looks at the role of neuropathological abnormalities, genetics, and those factors common to oxidative stress such as inflammation, immune dysfunction, aberrant cellular signaling, and gene-environment interactions. Among dozens of research topics, this volume — Looks at interactions between genetic and environmental factors such as the maternal immune environment and prenatal/postnatal environmental stressors Summarizes evidence for oxidative damage and inflammation in autism Introduces a PDD behavior inventory as a tool for assessing autism Considers autism as an aberrant adaptive response to neuroinflammation and oxidative stress Examines the role of abnormal calcium signaling and the hypothesis that it may represent a target for novel therapeutics Presents a hypothesis that autism arises from the dysregulation of a unified gut/brain system rather than originating in the brain alone Proposes the utility of using a biopsychosocial method to treat autism This book shows us that autism is not only developmental but also a chronic condition based on active pathophysiology, and that it is not only behavioral but also presents somatic and systemic features. The findings in these chapters support the theory that oxidative stress plays an important role in autism. They also point to the value of conducting in-depth mechanistic studies as a way to uncover new targets for therapeutic intervention in autism.

Neurobiology of Depression

Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Neurobiology of Depression Book PDF

Author : Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Publisher : Academic Press
Page : 471 pages
File Size : 46,8 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9780128133347

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Neurobiology of Depression by Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate Pdf

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

The Autoimmune Brain

David S. Younger
The Autoimmune Brain Book PDF

Author : David S. Younger
Publisher : Rowman & Littlefield
Page : 289 pages
File Size : 51,8 Mb
Release : 2019-11-10
Category : Health & Fitness
ISBN : 9781538117712

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The Autoimmune Brain by David S. Younger Pdf

There are millions of people who experience issues related to brain health—depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain—yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or anti-anxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age—from children to teens or seniors—people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. The Autoimmune Brain connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease; Anxiety; Arthritis; Autism; Autonomic disturbances; Bacterial and viral infections; Bipolar Disorder; Cancer; Celiac disease and gluten intolerances; Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease); Chronic Pain; Dementia; Depression; Endocrine Disorders; Immune modulatory therapy using IVIg; Lyme disease and co-infections; Mast cell activation syndrome; Medical cannabis; Obsessive Compulsive Disorder; Orthostatic hypotension; Peripheral Neuropathy; Porphyria; Post-Traumatic Stress Disorder; and Postural orthostatic tachycardia.

The Psychoneuroimmunology of Chronic Disease

Kathleen A. Kendall-Tackett
The Psychoneuroimmunology of Chronic Disease Book PDF

Author : Kathleen A. Kendall-Tackett
Publisher : American Psychological Association (APA)
Page : 286 pages
File Size : 42,8 Mb
Release : 2010
Category : Medical
ISBN : NWU:35558005756297

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The Psychoneuroimmunology of Chronic Disease by Kathleen A. Kendall-Tackett Pdf

Recent years have witnessed considerable growth in the field of psychoneuroimmunology (PNI), which describes how psychological factors, such as stress and depression, impact the neurological and immune systems. Research increasingly indicates that psychological states play a key role in the development and exacerbation of inflammatory diseases such as heart disease, diabetes, multiple sclerosis, Alzheimers, and autoimmune disorders. In this book, editor Kathleen Kendall-Tackett and an elite group of researchers explore the ways physical and psychological stressors such as poor sleep, PTSD, and depression, trigger the inflammatory response and increase the risk of disease. They approach this material from a variety of perspectives. Chapters in Part I describe the biological processes involved in inflammation, focusing on both the typical bodily response to threat as well as on the long-term deleterious effects of stress upon the immune system; while chapters in Part II examine the role of psychosocial stress in disease etiology. Throughout, chapter authors present evidence of connections between mind and body, and emphasize the need for improved communication between physicians and mental health care providers. This book will be a valuable resource for researchers as well as practitioners who hope to share the benefits of these findings with their clients.