Inhaled Medicines

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Inhaled Medicines

Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Inhaled Medicines Book PDF

Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Publisher : Academic Press
Page : 439 pages
File Size : 43,6 Mb
Release : 2021-01-20
Category : Business & Economics
ISBN : 9780128149751

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Inhaled Medicines by Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey Pdf

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Inhaled Delivery Systems for the Treatment of Asthma and COPD

Donald A. Mahler,Rajiv Dhand
Inhaled Delivery Systems for the Treatment of Asthma and COPD Book PDF

Author : Donald A. Mahler,Rajiv Dhand
Publisher : CRC Press
Page : 250 pages
File Size : 50,9 Mb
Release : 2023-07-19
Category : Medical
ISBN : 9781000884449

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Inhaled Delivery Systems for the Treatment of Asthma and COPD by Donald A. Mahler,Rajiv Dhand Pdf

Inhaled therapies form the cornerstone for treatment of patients with asthma and COPD. Evolving technology has resulted in availability of a wide range of devices for delivery of inhaled drugs. The four different delivery systems -- pressurized metered-dose inhalers, slow mist inhalers, dry powder inhalers, and nebulizers -- are unique in design and require distinct inhalational instructions for correct use. This book provides current information about inhalation devices, including their advantages and disadvantages, with guidance for optimal techniques of use. The book emphasizes appropriate selection of inhalation devices based on patient and health care professional factors as well as device attributes that allow selection of the right medication in the right inhalation device at the right time for the right patient. Key Features: • Addresses the objective of precision medicine – the right medication in the right inhaler device at the right time. • Inputs by international thought leaders who have published widely on inhaled medications and/or inhaled delivery systems for clinicians, trainees and respiratory therapists. • Discusses the development of audio-based systems and smart inhalers for patient monitoring.

Inhalation Drug Delivery

Paolo Colombo,Daniela Traini,Francesca Buttini
Inhalation Drug Delivery Book PDF

Author : Paolo Colombo,Daniela Traini,Francesca Buttini
Publisher : John Wiley & Sons
Page : 216 pages
File Size : 40,8 Mb
Release : 2013-02-11
Category : Science
ISBN : 9781118354124

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Inhalation Drug Delivery by Paolo Colombo,Daniela Traini,Francesca Buttini Pdf

There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.

Pharmaceutical Inhalation Aerosol Technology, Third Edition

Anthony J. Hickey,Sandro R. da Rocha
Pharmaceutical Inhalation Aerosol Technology Third Edition Book PDF

Author : Anthony J. Hickey,Sandro R. da Rocha
Publisher : CRC Press
Page : 784 pages
File Size : 47,9 Mb
Release : 2019-03-26
Category : Medical
ISBN : 9780429619564

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Pharmaceutical Inhalation Aerosol Technology, Third Edition by Anthony J. Hickey,Sandro R. da Rocha Pdf

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the ‘technology’ focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors

Pharmaceutical Inhalation Aerosol Technology, Second Edition

Anthony J. Hickey
Pharmaceutical Inhalation Aerosol Technology Second Edition Book PDF

Author : Anthony J. Hickey
Publisher : CRC Press
Page : 628 pages
File Size : 53,7 Mb
Release : 2003-09-03
Category : Medical
ISBN : 9780824756642

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Pharmaceutical Inhalation Aerosol Technology, Second Edition by Anthony J. Hickey Pdf

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Inhaled Pharmaceutical Product Development Perspectives

Anthony J. Hickey
Inhaled Pharmaceutical Product Development Perspectives Book PDF

Author : Anthony J. Hickey
Publisher : Elsevier
Page : 110 pages
File Size : 47,7 Mb
Release : 2017-11-23
Category : Science
ISBN : 9780128123362

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Inhaled Pharmaceutical Product Development Perspectives by Anthony J. Hickey Pdf

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

The Mechanics of Inhaled Pharmaceutical Aerosols

Warren H. Finlay
The Mechanics of Inhaled Pharmaceutical Aerosols Book PDF

Author : Warren H. Finlay
Publisher : Academic Press
Page : 302 pages
File Size : 43,6 Mb
Release : 2019-06-01
Category : Technology & Engineering
ISBN : 9780081027868

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The Mechanics of Inhaled Pharmaceutical Aerosols by Warren H. Finlay Pdf

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Pulmonary Drug Delivery

Ali Nokhodchi,Gary P. Martin
Pulmonary Drug Delivery Book PDF

Author : Ali Nokhodchi,Gary P. Martin
Publisher : John Wiley & Sons
Page : 391 pages
File Size : 54,8 Mb
Release : 2015-08-03
Category : Science
ISBN : 9781118799543

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Pulmonary Drug Delivery by Ali Nokhodchi,Gary P. Martin Pdf

Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

Inhaler Devices

Polina Prokopovich
Inhaler Devices Book PDF

Author : Polina Prokopovich
Publisher : Elsevier
Page : 191 pages
File Size : 51,6 Mb
Release : 2013-04-23
Category : Technology & Engineering
ISBN : 9780857098696

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Inhaler Devices by Polina Prokopovich Pdf

Given their direct impact on the health and quality of life for millions, inhalers represent a major turning point in the history of modern medicine. Inhaler devices: Fundamentals, design and drug delivery provides readers with an introduction to the fundamentals of inhaler technology, with a comprehensive discussion of the history of inhalers as well as a discussion on current research and development. Part one discusses the fundamentals and development of inhaler devices as well as drug formulations for inhalers. The treatment of asthma is also discussed. Part two reviews recent developments in drug formulation and nanotechnology for inhaler devices, emerging inhaler technology and possible future trends. Inhaler devices: Fundamentals, design and drug delivery is an essential design guide for good industrial practice, and will be an invaluable resource for those researching and treating conditions such as asthma; and those developing and manufacturing inhalation devices. Introduces the fundamentals of inhaler technology Discusses the history of inhalers as well as current research and development as well as possible future trends Considers the development of inhaler devices, drug formulations and discusses the treatment of asthma

Difficult To Treat Asthma

Sandhya Khurana,Fernando Holguin
Difficult To Treat Asthma Book PDF

Author : Sandhya Khurana,Fernando Holguin
Publisher : Springer Nature
Page : 334 pages
File Size : 52,5 Mb
Release : 2019-08-29
Category : Medical
ISBN : 9783030208127

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Difficult To Treat Asthma by Sandhya Khurana,Fernando Holguin Pdf

This book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ‘difficult to treat’. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting the best evidence treatment. This calls for complex and nuanced decision-making. Whether people with asthma gain and maintain control over their condition depends not only on the availability of effective drugs, but also multiple patient and healthcare provider behaviors. Therefore, now more than ever, it has become increasingly important to differentiate “difficult” from “severe refractory” asthma to allow identification of patients most likely to benefit from these therapies. This volume delves into the current understanding of mechanisms and increasingly recognized heterogeneity of this complex disease. It discusses a structured approach to identification and optimization of factors contributing to poor asthma control, including nonadherence, comorbidities and occupational/environmental triggers. The book includes ‘state of the art’ reviews on recent advances in traditional and targeted asthma therapies, as well as a glimpse into what the future may hold. Highlights include a comprehensive guide to management of severe asthma in children and pregnancy, as well as practical considerations to management of asthma based on different clinical phenotypes. Each chapter is authored by leading experts in the field who share their own clinical approach. This is an ideal guide for clinical pulmonologists and allergist/immunologists, as well as primary care providers, physician extenders in specialty practice, physicians in pulmonary/allergy training, and even industry partners.

Drug Delivery to the Lung

Hans Bisgaard,Chris O'Callaghan,Gerald C. Smaldone
Drug Delivery to the Lung Book PDF

Author : Hans Bisgaard,Chris O'Callaghan,Gerald C. Smaldone
Publisher : CRC Press
Page : 536 pages
File Size : 51,7 Mb
Release : 2001-10-02
Category : Medical
ISBN : 9780824741976

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Drug Delivery to the Lung by Hans Bisgaard,Chris O'Callaghan,Gerald C. Smaldone Pdf

This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract! Featuring over 1300 references, drawings, tables, photographs,

Controlled Pulmonary Drug Delivery

Hugh D.C. Smyth,Anthony J. Hickey
Controlled Pulmonary Drug Delivery Book PDF

Author : Hugh D.C. Smyth,Anthony J. Hickey
Publisher : Springer Science & Business Media
Page : 560 pages
File Size : 47,5 Mb
Release : 2011-06-24
Category : Medical
ISBN : 9781441997456

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Controlled Pulmonary Drug Delivery by Hugh D.C. Smyth,Anthony J. Hickey Pdf

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Inhalation Drug Delivery

Paolo Colombo,Daniela Traini,Francesca Buttini
Inhalation Drug Delivery Book PDF

Author : Paolo Colombo,Daniela Traini,Francesca Buttini
Publisher : John Wiley & Sons
Page : 216 pages
File Size : 52,8 Mb
Release : 2012-12-19
Category : Science
ISBN : 9781118397169

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Inhalation Drug Delivery by Paolo Colombo,Daniela Traini,Francesca Buttini Pdf

There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.

Advances in Pulmonary Drug Delivery

Philip Chi Lip Kwok,Hak-Kim Chan
Advances in Pulmonary Drug Delivery Book PDF

Author : Philip Chi Lip Kwok,Hak-Kim Chan
Publisher : CRC Press
Page : 246 pages
File Size : 47,5 Mb
Release : 2016-12-19
Category : Medical
ISBN : 9781315311968

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Advances in Pulmonary Drug Delivery by Philip Chi Lip Kwok,Hak-Kim Chan Pdf

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Inhalation Aerosols

Anthony J. Hickey,Heidi M. Mansour
Inhalation Aerosols Book PDF

Author : Anthony J. Hickey,Heidi M. Mansour
Publisher : CRC Press
Page : 417 pages
File Size : 53,9 Mb
Release : 2019-03-21
Category : Medical
ISBN : 9781351660525

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Inhalation Aerosols by Anthony J. Hickey,Heidi M. Mansour Pdf

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.