Insulin Like Growth Factors In Health And Disease An Issue Of Endocrinology And Metabolism Clinics E Book

Author : Claire M. Perks,Jeff M.P. Holly
Publisher : Elsevier Health Sciences
Page : 960 pages
File Size : 47,5 Mb
Release : 2012-07-03
Category : Medical
ISBN : 9781455742776

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Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics - E-Book by Claire M. Perks,Jeff M.P. Holly Pdf

This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bone; cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.

Author : Claire M. Perks,Jeff M. P. Holly
Publisher : Saunders
Page : 0 pages
File Size : 48,5 Mb
Release : 2012-07
Category : Medical
ISBN : 1455738565

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Insulin-Like Growth Factors in Health and Disease, an Issue of Endocrinology and Metabolism Clinics by Claire M. Perks,Jeff M. P. Holly Pdf

This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bo≠ cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.

Author : David Clemmons,Iain C.A.F. Robinson
Publisher : Springer Science & Business Media
Page : 157 pages
File Size : 51,9 Mb
Release : 2009-12-01
Category : Medical
ISBN : 9783642043024

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IGFs:Local Repair and Survival Factors Throughout Life Span by David Clemmons,Iain C.A.F. Robinson Pdf

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

Author : M. Sue Houston,Jeffrey M. P. Holly,Eva L. Feldman
Publisher : Humana
Page : 359 pages
File Size : 46,5 Mb
Release : 2004-08-04
Category : Medical
ISBN : 1588291901

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IGF and Nutrition in Health and Disease by M. Sue Houston,Jeffrey M. P. Holly,Eva L. Feldman Pdf

A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

Author : Derek LeRoith,Mohan K. Raizada
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461529880

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Current Directions in Insulin-Like Growth Factor Research by Derek LeRoith,Mohan K. Raizada Pdf

The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.

Author : Allan Flyvbjerg,Hans ?rskov,George Alberti
Publisher : Unknown
Page : 344 pages
File Size : 45,9 Mb
Release : 1993-04-27
Category : Health & Fitness
ISBN : UOM:39015029517797

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Growth Hormone and Insulin-like Growth Factor I in Human and Experimental Diabetes by Allan Flyvbjerg,Hans ?rskov,George Alberti Pdf

Current research indicates that growth factors play a role in the physiological, metabolic, functional and structural changes seen in diabetes. This book combines the latest evidence regarding the effects of growth hormone and insulin-like growth factors in relation to metabolism in this disorder and the development of complications.

Author : Derek LeRoith
Publisher : CRC Press
Page : 328 pages
File Size : 52,9 Mb
Release : 1991-05-28
Category : Medical
ISBN : 0849357128

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Insulin-like Growth Factors by Derek LeRoith Pdf

During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

Author : Dr David Clemmons, PhD,Iain C A F Robinson,Vice-President Yves Christen
Publisher : Springer
Page : 172 pages
File Size : 45,5 Mb
Release : 2016-05-01
Category : Electronic
ISBN : 3662505835

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Igfs by Dr David Clemmons, PhD,Iain C A F Robinson,Vice-President Yves Christen Pdf

Insulin-like growth factors (IGFs) continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodeling and metabolic regulation. This book takes a close look at IGFs.

Author : Stefano Cianfarani,D. R. Clemmons,Martin O. Savage
Publisher : Karger Medical and Scientific Publishers
Page : 187 pages
File Size : 52,5 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579261

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IGF-I and IGF Binding Proteins by Stefano Cianfarani,D. R. Clemmons,Martin O. Savage Pdf

The IGF system pervades the fields of development, linear and cellular growth and metabolism. Not only is the functional integrity of the IGF system crucial for normal linear growth and metabolism, it is also of fundamental importance for normal fetal development. This book consists of a compilation of chapters based on presentations at a symposium entitled 'IGFs and IGFBPs: Assessment and Therapeutic Benefit'. Highly qualified basic scientists and endocrinologists report new advances in the broad field of IGF physiology and pathophysiology, related to clinical medicine. New and topical areas of the IGF field are covered, focussing particularly on clinically relevant topics related to growth, pediatric and adult growth hormone deficiency, metabolic disorders, diabetes mellitus and neurology. Molecular and developmental defects are discussed, as are the contributions to clinical diagnosis and management of measurement of IGFs and IGFBPs. The therapeutic potential of recombinant human IGFs and IGFBPs in a range of disorders is also covered. The present volume of Endocrine Development will be of particular interest to scientists and clinicians working in IGF and IGF-related fields and to clinicians working in both pediatric and adult endocrinology and metabolism.

Author : Allan Flyvbjerg,Hans Orskov,George Alberti
Publisher : Unknown
Page : 336 pages
File Size : 46,5 Mb
Release : 2024-06-17
Category : Electronic
ISBN : 0608212636

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Growth Hormone and Insulin-Like Growth Factor i in Human and Experimental Diabetes by Allan Flyvbjerg,Hans Orskov,George Alberti Pdf

Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Page : 241 pages
File Size : 54,9 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579926

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Growth Hormone Deficiency in Adults by Jens O. L. Jørgensen,Jens Sandahl Christiansen Pdf

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Author : Jean M. Kerver
Publisher : Unknown
Page : 144 pages
File Size : 47,6 Mb
Release : 2010
Category : Biochemical markers
ISBN : MSU:31293031637147

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Dietary Predictors of Components of the Insulin-like Growth Factor System in Adolescent Girls, Aged 14-18 Years by Jean M. Kerver Pdf

Author : Anne R. Cappola
Publisher : Elsevier Health Sciences
Page : 330 pages
File Size : 49,9 Mb
Release : 2013-06-28
Category : Medical
ISBN : 9781455771738

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Aging and Endocrinology, An Issue of Endocrinology and Metabolism Clinics, E-Book by Anne R. Cappola Pdf

This issue of Endocrinology Clinics brings the reader up to date on the important advances in research surrounding the role of aging on the endocrine system. Guest edited by Anne Cappola, the topics covered include reproductive aging in women, thyroid disorders, testosterone administration, osteoporosis in older adults, hormonal therapeutics and more.

Author : Paul N. Schofield
Publisher : Oxford University Press, USA
Page : 304 pages
File Size : 46,9 Mb
Release : 1992
Category : Language Arts & Disciplines
ISBN : UOM:39015025301006

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The Insulin-like Growth Factors by Paul N. Schofield Pdf

The past decade has seen an explosion in our understanding of the factors regulating cell proliferation and differentiation. One of the most exciting advances has been the recognition of the pivotal role of the peptide growth factors in these processes. The insulin-like growth factors, discovered in 1958 by Salmon and Daughaday, are now among the best characterized growth factors. This comprehensive work describes the recent advances in knowledge of their receptors and binding proteins together with their purification and cloning. This provides exciting insights into the role of these factors in the physiology of normal growth, embryonic development and areas of pathology such as wound healing and cancer. In this book an international group of contributors reviews the most up-to-date information on all aspects of the insulin-like growth factors, and critically discusses models for IGF action in their own systems. The book is a valuable source of information and ideas for researchers, and an accessible introduction to the subject for students and clinicians.

Author : Derek LeRoith
Publisher : Unknown
Page : 223 pages
File Size : 49,5 Mb
Release : 2003
Category : Electronic
ISBN : OCLC:315121678

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Insulin-like Growth Factors and Cancer by Derek LeRoith Pdf