Integrated Strategies For Drug Discovery Using Mass Spectrometry

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Integrated Strategies for Drug Discovery Using Mass Spectrometry

Mike S. Lee
Integrated Strategies for Drug Discovery Using Mass Spectrometry Book PDF

Author : Mike S. Lee
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 42,7 Mb
Release : 2005-09-02
Category : Science
ISBN : 9780471721024

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Integrated Strategies for Drug Discovery Using Mass Spectrometry by Mike S. Lee Pdf

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

High-Throughput Mass Spectrometry in Drug Discovery

Chang Liu,Hui Zhang
High Throughput Mass Spectrometry in Drug Discovery Book PDF

Author : Chang Liu,Hui Zhang
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 42,6 Mb
Release : 2023-06-29
Category : Science
ISBN : 9781119678465

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High-Throughput Mass Spectrometry in Drug Discovery by Chang Liu,Hui Zhang Pdf

High-Throughput Mass Spectrometry in Drug Discovery Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry. High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development. High-Throughput Mass Spectrometry in Drug Discovery readers will also find: Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more An authorial team with extensive combined experience in research and industrial applications Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.

Protein and Peptide Mass Spectrometry in Drug Discovery

Michael L. Gross,Guodong Chen,Birendra Pramanik
Protein and Peptide Mass Spectrometry in Drug Discovery Book PDF

Author : Michael L. Gross,Guodong Chen,Birendra Pramanik
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 42,8 Mb
Release : 2011-09-26
Category : Medical
ISBN : 9781118116548

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Protein and Peptide Mass Spectrometry in Drug Discovery by Michael L. Gross,Guodong Chen,Birendra Pramanik Pdf

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Using Mass Spectrometry for Drug Metabolism Studies, Second Edition

Walter A. Korfmacher
Using Mass Spectrometry for Drug Metabolism Studies Second Edition Book PDF

Author : Walter A. Korfmacher
Publisher : CRC Press
Page : 451 pages
File Size : 44,6 Mb
Release : 2009-11-03
Category : Science
ISBN : 1420092219

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Using Mass Spectrometry for Drug Metabolism Studies, Second Edition by Walter A. Korfmacher Pdf

The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.

Integrated Drug Discovery Technologies

Houng-Yau Mei,Anthony W. Czarnik
Integrated Drug Discovery Technologies Book PDF

Author : Houng-Yau Mei,Anthony W. Czarnik
Publisher : CRC Press
Page : 604 pages
File Size : 53,7 Mb
Release : 2002-03-19
Category : Medical
ISBN : 0203910699

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Integrated Drug Discovery Technologies by Houng-Yau Mei,Anthony W. Czarnik Pdf

Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics,

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Ragu Ramanathan
Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book PDF

Author : Ragu Ramanathan
Publisher : John Wiley & Sons
Page : 326 pages
File Size : 40,6 Mb
Release : 2011-09-20
Category : Science
ISBN : 9781118211571

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Mass Spectrometry in Drug Metabolism and Pharmacokinetics by Ragu Ramanathan Pdf

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.

Mass Spectrometry

Ganesh Shamrao Kamble
Mass Spectrometry Book PDF

Author : Ganesh Shamrao Kamble
Publisher : BoD – Books on Demand
Page : 136 pages
File Size : 54,7 Mb
Release : 2019-11-13
Category : Science
ISBN : 9781839627569

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Mass Spectrometry by Ganesh Shamrao Kamble Pdf

This book provides a comprehensive overview of the emerging techniques and applications of mass spectrophotometry in various fields of sustainable chemistry. At the current level of development, the book provides "real-life" examples of analyses and applications. All the chapters are written by internationally recognized authors, and present qualitative and quantitative applications of mass spectrometry. These multidisciplined chapters cover the fundamentals as well as recent advanced analytical techniques, and offer significant information for various researchers studying biomedical, pharmaceutical, and environmental analysis.

Mass Spectrometry in Medicinal Chemistry

Klaus Wanner,Georg Höfner
Mass Spectrometry in Medicinal Chemistry Book PDF

Author : Klaus Wanner,Georg Höfner
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 43,9 Mb
Release : 2007-06-27
Category : Science
ISBN : 9783527610914

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Mass Spectrometry in Medicinal Chemistry by Klaus Wanner,Georg Höfner Pdf

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Early Drug Development

Mitchell N. Cayen
Early Drug Development Book PDF

Author : Mitchell N. Cayen
Publisher : John Wiley & Sons
Page : 507 pages
File Size : 54,5 Mb
Release : 2011-02-25
Category : Medical
ISBN : 9781118035207

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Early Drug Development by Mitchell N. Cayen Pdf

The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.

Protein Analysis using Mass Spectrometry

Mike S. Lee,Qin C. Ji
Protein Analysis using Mass Spectrometry Book PDF

Author : Mike S. Lee,Qin C. Ji
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 53,6 Mb
Release : 2017-05-30
Category : Science
ISBN : 9781119359357

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Protein Analysis using Mass Spectrometry by Mike S. Lee,Qin C. Ji Pdf

Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

Mass Spectrometry for Drug Discovery and Drug Development

Walter A. Korfmacher
Mass Spectrometry for Drug Discovery and Drug Development Book PDF

Author : Walter A. Korfmacher
Publisher : John Wiley & Sons
Page : 686 pages
File Size : 51,5 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781118516140

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Mass Spectrometry for Drug Discovery and Drug Development by Walter A. Korfmacher Pdf

Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

Characterization of Impurities and Degradants Using Mass Spectrometry

Guodong Chen
Characterization of Impurities and Degradants Using Mass Spectrometry Book PDF

Author : Guodong Chen
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 55,6 Mb
Release : 2011-04-27
Category : Science
ISBN : 9780470922972

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Characterization of Impurities and Degradants Using Mass Spectrometry by Guodong Chen Pdf

The book highlights the current practices and future trends in structural characterization of impurities and degradants. It begins with an overview of mass spectrometry techniques as related to the analysis of impurities and degradants, followed by studies involving characterization of process related impurities (including potential genotoxic impurities), and excipient related impurities in formulated products. Both general practitioners in pharmaceutical research and specialists in analytical chemistry field will benefit from this book that will detail step-by-step approaches and new strategies to solve challenging problems related to pharmaceutical research.

Handbook of LC-MS Bioanalysis

Wenkui Li,Jie Zhang,Francis L. S. Tse
Handbook of LC MS Bioanalysis Book PDF

Author : Wenkui Li,Jie Zhang,Francis L. S. Tse
Publisher : John Wiley & Sons
Page : 709 pages
File Size : 46,6 Mb
Release : 2013-09-03
Category : Science
ISBN : 9781118671351

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Handbook of LC-MS Bioanalysis by Wenkui Li,Jie Zhang,Francis L. S. Tse Pdf

Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.

Frontiers in Drug Design and Discovery

Atta-ur- Rahman,Gary W. Caldwell, M. Iqbal Choudhary,Zhengyin Yan
Frontiers in Drug Design and Discovery Book PDF

Author : Atta-ur- Rahman,Gary W. Caldwell, M. Iqbal Choudhary,Zhengyin Yan
Publisher : Bentham Science Publishers
Page : 467 pages
File Size : 50,6 Mb
Release : 2009
Category : Medical
ISBN : 9781608052028

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Frontiers in Drug Design and Discovery by Atta-ur- Rahman,Gary W. Caldwell, M. Iqbal Choudhary,Zhengyin Yan Pdf

"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

Mass Spectrometry in Drug Metabolism and Disposition

Mike S. Lee,Mingshe Zhu
Mass Spectrometry in Drug Metabolism and Disposition Book PDF

Author : Mike S. Lee,Mingshe Zhu
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 41,6 Mb
Release : 2011-03-16
Category : Science
ISBN : 9780470934692

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Mass Spectrometry in Drug Metabolism and Disposition by Mike S. Lee,Mingshe Zhu Pdf

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.