Interaction Of Translational And Transcriptional Controls In The Regulation Of Gene Expression

Author : Marianne Grunberg-Manago
Publisher : Elsevier
Page : 536 pages
File Size : 48,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780444601247

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Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression by Marianne Grunberg-Manago Pdf

Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact. Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.

Author : Anonim
Publisher : Unknown
Page : 524 pages
File Size : 43,9 Mb
Release : 1982
Category : Electronic
ISBN : OCLC:489921410

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Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression by Anonim Pdf

Author : Orna Resnekov,Alexander von Gabain
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 42,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642609299

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Post-transcriptional Control of Gene Expression by Orna Resnekov,Alexander von Gabain Pdf

Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.

Author : Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews
Publisher : CSHL Press
Page : 1034 pages
File Size : 43,5 Mb
Release : 2001
Category : Gene expression
ISBN : 0879696184

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Translational Control of Gene Expression by Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews Pdf

Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Witold Filipowicz,Thomas Hohn
Publisher : Springer Science & Business Media
Page : 419 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400903531

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Post-Transcriptional Control of Gene Expression in Plants by Witold Filipowicz,Thomas Hohn Pdf

A recent volume of this series (Signals and Signal Transduction Pathways in Plants (K. Palme, ed.) Plant Molecular Biology 26, 1237-1679) described the relay races by which signals are transported in plants from the sites of stimuli to the gene expression machinery of the cell. Part of this machinery, the transcription apparatus, has been well studied in the last two decades, and many important mechanisms controlling gene expression at the transcriptional level have been elucidated. However, control of gene expression is by no means complete once the RNA has been produced. Important regulatory devices determine the maturation and usage of mRNA and the fate of its translation product. Post-transcriptional regulation is especially important for generating a fast response to environmental and intracellular signals. This book summarizes recent progress in the area of post-transcriptional regulation of gene expression in plants. 18 chapters of the book address problems of RNA processing and stability, regulation of translation, protein folding and degradation, as well as intracellular and cell-to-cell transport of proteins and nucleic acids. Several chapters are devoted to the processes taking place in plant organelles.

Author : J. Ilan
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461528944

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Translational Regulation of Gene Expression 2 by J. Ilan Pdf

This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.

Author : Anonim
Publisher : Academic Press
Page : 300 pages
File Size : 44,5 Mb
Release : 2009-10-26
Category : Science
ISBN : 008091196X

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Translational Control in Health and Disease by Anonim Pdf

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Author : Michael B. Mathews
Publisher : Unknown
Page : 212 pages
File Size : 43,5 Mb
Release : 1986
Category : Science
ISBN : UOM:39015010141003

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Translational Control by Michael B. Mathews Pdf

Author : Joe B. Harford,David R. Morris
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 45,9 Mb
Release : 1997-03-28
Category : Science
ISBN : 0471142069

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mRNA Metabolism & Post-Transcriptional Gene Regulation by Joe B. Harford,David R. Morris Pdf

mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.

Author : David Latchman
Publisher : Garland Science
Page : 528 pages
File Size : 52,9 Mb
Release : 2015-02-20
Category : Science
ISBN : 9781317407751

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Gene Control, Second Edition by David Latchman Pdf

The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams.The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.

Author : Gary Hime,Helen Abud
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 55,8 Mb
Release : 2013-05-22
Category : Medical
ISBN : 9789400766211

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Transcriptional and Translational Regulation of Stem Cells by Gary Hime,Helen Abud Pdf

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Author : Brian Frederic Carl Clark,Hans Uffe Petersen
Publisher : Unknown
Page : 540 pages
File Size : 44,6 Mb
Release : 1984
Category : Science
ISBN : WISC:89011719531

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Gene Expression by Brian Frederic Carl Clark,Hans Uffe Petersen Pdf

Author : Kathryn Sandberg,Susan E. Mulroney
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 41,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475764468

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RNA Binding Proteins by Kathryn Sandberg,Susan E. Mulroney Pdf

RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins. Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.

Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 350 pages
File Size : 55,6 Mb
Release : 2008-10-29
Category : Science
ISBN : 142004415X

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Biology of the NMDA Receptor by Antonius M. VanDongen Pdf

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.