Intercellular Signaling In Development And Disease

Author : Edward A. Dennis,Ralph A. Bradshaw
Publisher : Academic Press
Page : 540 pages
File Size : 44,5 Mb
Release : 2011-04-05
Category : Science
ISBN : 9780123822161

Get Book

Intercellular Signaling in Development and Disease by Edward A. Dennis,Ralph A. Bradshaw Pdf

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease. Articles written and edited by experts in the field Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publisher : Springer
Page : 0 pages
File Size : 44,6 Mb
Release : 2018-06-07
Category : Medical
ISBN : 4431566333

Get Book

Etiology and Morphogenesis of Congenital Heart Disease by Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi Pdf

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Author : Edward A. Dennis,Ralph A. Bradshaw
Publisher : Academic Press
Page : 550 pages
File Size : 43,9 Mb
Release : 2011-04-08
Category : Science
ISBN : 9780123822154

Get Book

Intercellular Signaling in Development and Disease by Edward A. Dennis,Ralph A. Bradshaw Pdf

"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Gail Cardew,Novartis Foundation
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 43,5 Mb
Release : 1999-04-06
Category : Medical
ISBN : UOM:39015042001936

Get Book

Gap Junction-Mediated Intercellular Signalling in Health and Disease by Gail Cardew,Novartis Foundation Pdf

Gap Junction-Mediated Intercellular Signalling in Health and Disease Chairman: Norton B. Gilula 1999 The last few years have seen considerable progress in this field, and exciting new implications concerning the roles of gap junctional intercellular communication are being raised. It is clear that good communication is essential for normal embryonic development and function in adult organs, although the individual functions of the proteins that form channels (connexins) are not yet fully understood. It is an exciting time in the gap junction field because the associations between failures in gap junction communication and resultant diseases are beginning to emerge. For example, mutations in the major connexin of the heart (C×43) have been found in human patients suffering from visceroatrial heterotaxia syndrome, and mutations in the gene encoding C×32 have been found in patients suffering from Charcot-Marie-Tooth disease. This book is the first of its kind to highlight the recent progress in understanding gap junction structure, and discuss the specific roles of individual connexins. It brings together an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and cell proliferation and cancer. It will appeal to all those interested in cell biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.

Author : Nikolai V. Gorbunov
Publisher : Elsevier
Page : 208 pages
File Size : 49,7 Mb
Release : 2021-06-19
Category : Science
ISBN : 9780128227565

Get Book

Tissue Barriers in Disease, Injury and Regeneration by Nikolai V. Gorbunov Pdf

Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium

Author : Maria Pia Felli,Lisa M. Minter,Eleni Anastasiadou
Publisher : Frontiers Media SA
Page : 291 pages
File Size : 48,9 Mb
Release : 2022-01-05
Category : Science
ISBN : 9782889719464

Get Book

Targeting Developmental Pathways in Inflammation and Disease by Maria Pia Felli,Lisa M. Minter,Eleni Anastasiadou Pdf

Author : Robert Malenka
Publisher : Academic Press
Page : 776 pages
File Size : 54,8 Mb
Release : 2010-05-22
Category : Science
ISBN : 9780123785725

Get Book

Intercellular Communication in the Nervous System by Robert Malenka Pdf

Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signaling. * Chapters offer impressive scope with topics addressing neurotransmitters/receptors, synaptic structure and organization, neuropeptides, gap junctions, neuropharmacology and more * Richly illustrated in full color with over 200 figures * Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge

Author : Z. Kmiec
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 52,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642565533

Get Book

Cooperation of Liver Cells in Health and Disease by Z. Kmiec Pdf

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Author : Toshiyuki Fukada,Taiho Kambe
Publisher : Springer Nature
Page : 412 pages
File Size : 52,9 Mb
Release : 2019-12-13
Category : Medical
ISBN : 9789811505577

Get Book

Zinc Signaling by Toshiyuki Fukada,Taiho Kambe Pdf

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Author : Jonathan W. Boyd,Richard R. Neubig
Publisher : John Wiley & Sons
Page : 336 pages
File Size : 51,6 Mb
Release : 2019-04-16
Category : Science
ISBN : 9781119060260

Get Book

Cellular Signal Transduction in Toxicology and Pharmacology by Jonathan W. Boyd,Richard R. Neubig Pdf

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques

Author : Anonim
Publisher : Elsevier
Page : 436 pages
File Size : 55,9 Mb
Release : 2023-03-24
Category : Science
ISBN : 9780128201640

Get Book

Wnt Signaling in Development and Disease by Anonim Pdf

Wnt Signaling in Stem Cells, Development and Regeneration, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer. Presents newest findings on the role of Wnt signaling in a variety of tissues and organisms Illustrates the diverse actions of Wnt signaling in development and disease Highlight tools and technologies to interrogate Wnt signaling in any biological system

Author : Otto Mayr
Publisher : Unknown
Page : 151 pages
File Size : 41,8 Mb
Release : 1970
Category : Automatic control
ISBN : 0262630354

Get Book

The Origins of Feedback Control by Otto Mayr Pdf

Author : Frederick R. Maxfield,James M. Willard,Shuyan Lu
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 46,5 Mb
Release : 2016-06-22
Category : Medical
ISBN : 9781118978313

Get Book

Lysosomes by Frederick R. Maxfield,James M. Willard,Shuyan Lu Pdf

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Author : A. Goldbeter
Publisher : Academic Press
Page : 672 pages
File Size : 46,8 Mb
Release : 2014-06-28
Category : Science
ISBN : 9781483276793

Get Book

Cell to Cell Signalling by A. Goldbeter Pdf

Cell to Cell Signalling: From Experiments to Theoretical Models is a collection of papers from a NATO Workshop conducted in Belgium in September 1988. The book discusses nerve cells and neural networks involved in signal transfers. The works of Hodgkin and Huxley presents a prototypic combination between experimental and theoretical approaches. The book discusses the coupling process found between secretory cells that modify their behavior. The text also analyzes morphogenesis and development, and then emphasizes the pattern formation found in Drosophila and in the amphibian embryo. The text also cite examples of immunological modeling that is related to the dynamics of immune networks based on idiotypic regulation. One paper analyzes the immune dynamism of HIV infection. The text notes that hormone signaling can be attributed as responsible for intercellular communication. Another paper examines how the dominant follicle in the ovarian cycle is selected, as well as the effectiveness of hormone secretion responsible for encoding the frequency of occurrence of periodic signals. The book also discusses heart signal sources such as cardiac dynamics and the response of periodically excited cardiac cells. The text can prove valuable for practioners in the field of neurology and cardiovascular medicine, and for researchers in molecular biology and molecular chemistry.