Zinc Signaling

Author : Toshiyuki Fukada,Taiho Kambe
Publisher : Springer Nature
Page : 412 pages
File Size : 50,8 Mb
Release : 2019-12-13
Category : Medical
ISBN : 9789811505577

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Zinc Signaling by Toshiyuki Fukada,Taiho Kambe Pdf

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Author : Toshiyuki Fukada,Taiho Kambe
Publisher : MDPI
Page : 293 pages
File Size : 53,8 Mb
Release : 2018-05-04
Category : Electronic
ISBN : 9783038428213

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Zinc Signaling in Physiology and Pathogenesis by Toshiyuki Fukada,Taiho Kambe Pdf

This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS

Author : Toshiyuki Fukada,Taiho Kambe
Publisher : Springer
Page : 345 pages
File Size : 50,7 Mb
Release : 2014-09-25
Category : Science
ISBN : 9784431551140

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Zinc Signals in Cellular Functions and Disorders by Toshiyuki Fukada,Taiho Kambe Pdf

This book describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint. Zinc plays an indispensable role in various cellular processes. It regulates a great number of protein functions including transcription factors, enzymes, adapters, and growth factors as a structural or catalytic factor or both. Recently, another function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an intracellular and extracellular signaling factor and thus regulates cellular signaling pathways, which enables communication between cells, conversion of extracellular stimuli to intracellular signals, and control of various intracellular events. These functions of zinc have become recognized as “zinc signals,” which play critical roles in physiology, and therefore their imbalance can cause a variety of problems with regard to human health. Because the notion of zinc signals is quite new and no integrative review books focusing on them have yet been published, we believe this book will provide very timely information on the subject and thus should be of importance and interest to a wide range of readers.

Author : W. Maret
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 52,7 Mb
Release : 2001
Category : Medical
ISBN : 1402002173

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Zinc Biochemistry, Physiology, and Homeostasis by W. Maret Pdf

This text is a collection of fourteen articles previously published in BioMetals, Volume 14, Numbers 3-4, 2001, reviewing advances made in the field of zinc biology during the past decade. Topics include the chemistry of zinc (II) fluorophore sensors; fluorescence- based biosensing of zinc using carbonic anhydrase; cellular zinc sensors; bacterial zinc transporters and regulators; eukaryotic zinc transporters; zinc coordination sphere in biochemical zinc sites; zinc in caspase activation and apoptotic cell death; functions of zinc in signaling, proliferation and differentiation of mammalian cells; zinc homeostasis; synaptically released zinc; extracellular and immunological actions of zinc; and zinc metabolism. For researchers and teachers in bioinorganic chemistry, biological sciences, nutrition, and medicine in relation to mineral metabolism in health and disease. Annotation copyrighted by Book News Inc., Portland, OR.

Author : Patric K. Stanton,Clive Bramham,Helen E. Scharfman
Publisher : Springer Science & Business Media
Page : 554 pages
File Size : 45,6 Mb
Release : 2006-06-14
Category : Medical
ISBN : 9780387254432

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Synaptic Plasticity and Transsynaptic Signaling by Patric K. Stanton,Clive Bramham,Helen E. Scharfman Pdf

Brain functions are realized by the activity of neuronal networks composed of a huge number of neurons. The efficiency of information transfer within the networks is changeable. Even the networks themselves can change through experience. Information transfer between neurons is performed at the synapse (the site of the neurons’ contact) by release of neurotransmitters from the pre-synaptic cell and capture of neurotransmitters by the post-synaptic cell. The amount of released neurotransmitter or the efficacy of capture can change. Moreover, synapses are found to be newly formed upon activity or abandoned upon inactivity. These changes are called "synaptic plasticity". This text focuses on one component of synaptic plasticity called transsynaptic signaling, or communication of synapses during their formation.

Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients
Publisher : National Academies Press
Page : 804 pages
File Size : 48,7 Mb
Release : 2002-07-19
Category : Medical
ISBN : 0309072794

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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients Pdf

This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Author : Riccardo Brambilla,Gilberto Fisone
Publisher : Frontiers E-books
Page : 144 pages
File Size : 52,8 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 9782889190829

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Neuronal cell signaling and behavior by Riccardo Brambilla,Gilberto Fisone Pdf

Learning and memory functions as well as many neurodegenerative and neuropsychiatric disorders, including Parkinson’s disease, drug addiction and schizophrenia are caused by dysregulation of cell signaling mechanisms in the brain. This issue of Frontiers will provide evidence for signal transduction alterations implicated in cognitive and non cognitive behaviors, as investigated by means of pharmacological and genetic approaches. Specialists in the field will be invited to contribute articles covering the impact on behavior of manipulations of neurotransmitter systems, intracellular signaling cascades and gene expression.

Author : Anonim
Publisher : Academic Press
Page : 411 pages
File Size : 41,7 Mb
Release : 2013-12-17
Category : Science
ISBN : 9780123984821

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Endosome Signaling Part A by Anonim Pdf

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes on endosome signaling and includes chapters on such topics as measurement of entry into the endosomal compartment by multi-parametric image analysis, assessment of peptide internalization and endosomal signaling, and VEGF-A in endosomal signaling. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers endosome signaling Contains chapters on such topics as measurement of biological effects of endosomal proteolysis of internalized insulin and multi-vesicular endosome biogenesis.

Author : Pinar Erkekoglu,Belma Kocer-Gumusel
Publisher : BoD – Books on Demand
Page : 208 pages
File Size : 40,8 Mb
Release : 2016-07-20
Category : Science
ISBN : 9789535124375

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Nutritional Deficiency by Pinar Erkekoglu,Belma Kocer-Gumusel Pdf

Intake of a sufficient diet will provide an individual to live a healthy and functional life. However, poor intake of different nutritional components, such as proteins, vitamins, minerals, and trace elements, may lead to health problems that can cause morbidity and finally mortality. Assessment of nutritional status involves physical examination, comprehensive evaluation of biochemical tests, body composition, and organ functions. Both high and low intake of nutritional elements may lead to significant health impairment. The main aim of the book Nutritional Deficiency is to determine the relationships between nutritional status and general health. The authors, who are contributing to the book, particularly focused on iron, vitamin D, and zinc deficiencies, which are global health problems. Besides, some chapters mention the impact of different nutritional deficiencies in susceptible periods of life, such as pregnancy and elderly. Besides, as a result of these deficiencies, different health conditions, such as depression, anemia, loss of neuronal plasticity, and cancer, are widely scrutinized in the book. One chapter mainly focuses on the effects of disasters on nutrition and disaster-caused malnutrition in underdeveloped countries. This book will widen the knowledge store of the readers on the effects of nutrition on general health, how nutritional deficiencies arise when there is a health problem, and how the nutritional status affects susceptible populations.

Author : Anonim
Publisher : ScholarlyEditions
Page : 1180 pages
File Size : 51,6 Mb
Release : 2013-05-01
Category : Science
ISBN : 9781490108650

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Issues in Biochemistry and Biophysics Research: 2013 Edition by Anonim Pdf

Issues in Biochemistry and Biophysics Research: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Amino Acids. The editors have built Issues in Biochemistry and Biophysics Research: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Amino Acids in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biochemistry and Biophysics Research: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Anonim
Publisher : ScholarlyEditions
Page : 459 pages
File Size : 48,5 Mb
Release : 2012-12-26
Category : Science
ISBN : 9781464993404

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Ion Channels—Advances in Research and Application: 2012 Edition by Anonim Pdf

Ion Channels—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Ion Channels. The editors have built Ion Channels—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ion Channels in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ion Channels—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 40,7 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 9789814472371

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Metallothioneins in Biochemistry and Pathology by Anonim Pdf

Author : Masayoshi Yamaguchi
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 46,7 Mb
Release : 2012
Category : Zinc
ISBN : 1619425238

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Zinc by Masayoshi Yamaguchi Pdf

Zinc is one of the most abundant transition metals in the human body, and it has various benefits as an essential trace element in the regulation of the living body. Nutritional deficiency of zinc is known to induce many chronic diseases such as immune system disorders, rheumatoid arthritis, diabetes, obesity, atherosclerosis, cancers, bone growth retardation, osteoporosis and others. This book introduces the recent topics concerning the characteristics, uses and benefits of zinc. This book will be helpful in research development and also in the understanding of the various physiological-pathophysiological roles of zinc.

Author : Jonathan M. Raser
Publisher : Unknown
Page : 358 pages
File Size : 55,5 Mb
Release : 2005
Category : Electronic
ISBN : UCAL:X85752

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Quantitative Analysis of Nutrient-responsive Signal Transduction Pathways in Saccharomyces Cerevisiae by Jonathan M. Raser Pdf

Organisms and their component cells exist in a dynamic and unpredictable environment. Many of these environmental changes are potentially harmful or lethal. It is therefore unsurprising that cells are capable of adaptation to many of these potentially harmful environmental conditions. This adaptation requires both the ability to gather information about the environment, and the ability to convert the information gathered into the appropriate cellular response. Cells have developed specific signal transduction pathways that respond to a specific environmental stimulus and effect a specific, corresponding cellular response. Such signal transduction pathways are quantitative, in that cells do not simply display binary information processing but are capable of more subtle interpretation of different magnitudes of a particular stimulus. In particular, many signaling pathways enable adaptation to changing levels of environmental nutrients by control of cellular gene expression. We employed the single-cell eukaryote Saccharomyces cerevisiae as a model to study several facets of nutrient-responsive signal transduction in a quantitative manner. In the following text, we present our study of the sources of heterogeneity in gene expression in a population of genetically identical cells. In addition, we review recent advances in understanding of heterogeneity or noise in gene expression. Also, we present work characterizing the zinc-responsive signaling pathway in a quantitative manner, and studies uncovering the presence of positive feedback in the phosphate-responsive (PHO) signaling pathway.

Author : J. J. R. Frausto da Silva,Robert Joseph Paton Williams
Publisher : Oxford University Press
Page : 608 pages
File Size : 44,8 Mb
Release : 2001-08-16
Category : Medical
ISBN : 0198508484

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The Biological Chemistry of the Elements by J. J. R. Frausto da Silva,Robert Joseph Paton Williams Pdf

This text describes the functional role of the twenty inorganic elements essential to life in living organisms.