Interferon

Author : Paula M. Pitha
Publisher : Springer Science & Business Media
Page : 385 pages
File Size : 40,6 Mb
Release : 2007-08-29
Category : Medical
ISBN : 9783540713296

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Interferon: The 50th Anniversary by Paula M. Pitha Pdf

A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine’s most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction. Recent work with genetically modified mice seems to confirm the original idea that interferon is the first cellular defense against viral infection.

Author : G. I. Bryne
Publisher : CRC Press
Page : 340 pages
File Size : 51,9 Mb
Release : 1988-07-29
Category : Science
ISBN : 0824779738

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Interferon and Nonviral Pathogens by G. I. Bryne Pdf

This book explores the important role of the interferons in infections due to nonviral intracellular pathogens. It deals with the induction of interferons by a variety of intracellular microorganisms and the effects of interferons on the host cells and the microorganisms.

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 53,6 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Author : Thomas C. Merigan,Robert Morris Friedman
Publisher : Unknown
Page : 520 pages
File Size : 43,6 Mb
Release : 1982
Category : Medical
ISBN : UCAL:B4492602

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Interferons by Thomas C. Merigan,Robert Morris Friedman Pdf

Author : Anonim
Publisher : Unknown
Page : 148 pages
File Size : 44,9 Mb
Release : 2024-06-02
Category : Interferon
ISBN : MINN:30000009112495

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Interferon Bibliography from MEDLARS. by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 226 pages
File Size : 50,5 Mb
Release : 1979
Category : Antiviral agents
ISBN : MINN:30000010714685

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Interferon and Antiviral Substances Bibliography from MEDLARS. by Anonim Pdf

Author : Toine Pieters
Publisher : Routledge
Page : 285 pages
File Size : 54,9 Mb
Release : 2005-03-15
Category : Business & Economics
ISBN : 9781134293063

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Interferon by Toine Pieters Pdf

This book charts the history and development of one of the most important medical substances of the twentieth century, Interferon, as a drug.

Author : W.E. Stewart II
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 46,9 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783709134320

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The Interferon System by W.E. Stewart II Pdf

This book is an update of Interferon, published in 1969 by Dr. Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor activities. The steadily increasing number of these non-antiviral functions of interferons emphasizes the need for a comprehensive - and critical - review of the entire literature of interferon studies. The text, with its supporting bibliography, provides complete coverage of interferon research. A newcomer to the area should find here all the informa tion necessary to understand why interferon, which has been studied for more than twenty years and which originally stirred excitement over its clinical pros pects, is still inspiring speculation about this potential. For those already fa miliar with the seemingly perpetual clinical promise of interferon, this volume should serve as a valuable reference source, the largest bibliography on the subject ever to appear under one cover. Clearly, this book should be considered only as an introduction to the topic and as a reference source; most questions about the interferon system are still unanswered - even unasked. Hopefully this summation and critical evalua tion of work done to date will stimulate and facilitate further progress. William E. Stewart II New York, N. Y., February 1979 Contents I. Introduction ............................................................. .

Author : Thomas Merigan
Publisher : Elsevier
Page : 504 pages
File Size : 43,8 Mb
Release : 2012-12-02
Category : Health & Fitness
ISBN : 9780323147903

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Interferons by Thomas Merigan Pdf

Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Squaw Valley, California, in March 1982. The meeting was one of the 1982 UCLA Symposia on Molecular and Cellular Biology organized through the Molecular Biology Institute of the University of California at Los Angeles. The book is organized into four parts. Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons. Part II deals with the biology of interferons, covering topics such as interferon production control process; the effect of interferon on cellular enzymes; and human amniotic interferon. Part III examines the factors relevant to clinical application of interferons, including structure-function studies with human interferon-gamma and on human alpha interferon. Part IV presents clinical studies of interferon, such as interferon α trials in human tumor diseases and interferon in renal transplant recipients.

Author : Carlo Aul,Wolfgang Schneider
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642604119

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Interferons by Carlo Aul,Wolfgang Schneider Pdf

Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Interferons were soon employed in the treatment of tumors and it was shown that those hematopoietic neoplasias which had been difficult to treat with chemotherapy responded well to interferon treatment. In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains a general introduction into the classification, structure, and mode of action of interferons. Further chapters discuss the range of side effects of these substances and point out possible focuses of further clinical interferon research.

Author : Robert Friedman
Publisher : Elsevier
Page : 164 pages
File Size : 44,7 Mb
Release : 2012-12-02
Category : Health & Fitness
ISBN : 9780323160858

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Interferons A Primer by Robert Friedman Pdf

Interferons: A Primer covers general information on interferon, including analysis, purification, production, properties, mechanism of action, and clinical uses. Organized into 10 chapters, the book starts with a short history of interferon’s discovery by Isaacs and Lindenmann, followed by topics on assays for interferon, such as factors affecting interferon assays and rapid biological assay. Chapters 3 to 6 discuss the purification, properties, production, antiviral action, and other functions of interferon. Chapters 7 and 8 examine the recovery from viral infection and clinical uses of interferon, with emphasis on treatment of human cancer. The concluding chapters focus on the application of interferon studies on two revolutionizing fields of biology, namely, the cloning of animal genes in microorganisms and the production of monoclonal antibodies. This book is intended for students, scientists, physicians, or educated laypersons who wish to know something about interferons, but do not plan carrying out research in this area.

Author : P.E. Came,W.A. Carter
Publisher : Springer Science & Business Media
Page : 585 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642691782

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Interferons and Their Applications by P.E. Came,W.A. Carter Pdf

Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optimism had given way to an attitude almost of disenchantment as public and scientific expectations were raised steeply, then rapidly waned, as it turns out, prematurely. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably unprecedented in this century. Virtually every oncologist, it would seem, was plagued by requests for the experimental agent, although they already had therapies of more proven value. As recently as 1980, even though interferon had achieved success against certain cancers and certain viral diseases, the variability in clinical results was seemingly ever present and little evidence emerged to suggest interferons could cure advanced diseases. Why then the resurgence of an optimistic mood? There are almost always many elements which contribute to happiness, and this is certainly true of the broad frontier of interferon and its place in biochemical research and treatment.

Author : Anthony Meager
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 43,5 Mb
Release : 2006-08-21
Category : Science
ISBN : 9783527607921

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The Interferons by Anthony Meager Pdf

At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. For immunologists, cancer researchers, medicinal chemists, cell biologists, developmental biologists and the pharmaceutical industry.

Author : W.E.G. Müller,H.C. Schröder
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642785498

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Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates by W.E.G. Müller,H.C. Schröder Pdf

Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

Author : Michel Revel
Publisher : Springer Science & Business Media
Page : 377 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317371

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Clinical Aspects of Interferons by Michel Revel Pdf