Interleukin 10

Author : Simon Fillatreau,Anne O'Garra
Publisher : Springer
Page : 238 pages
File Size : 45,9 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783662434925

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Interleukin-10 in Health and Disease by Simon Fillatreau,Anne O'Garra Pdf

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Author : Francesco M. Marincola
Publisher : CRC Press
Page : 206 pages
File Size : 49,5 Mb
Release : 2006-01-26
Category : Science
ISBN : 9781498713405

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Interleukin-10 by Francesco M. Marincola Pdf

Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-t

Author : Jan E.de Vries,Rene de Waal Malefyt
Publisher : Springer Science & Business Media
Page : 176 pages
File Size : 43,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662220382

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Interleukin-10 by Jan E.de Vries,Rene de Waal Malefyt Pdf

The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.

Author : Jan Egbert De Vries,René De Waal Malefyt
Publisher : R G Landes Company
Page : 162 pages
File Size : 46,7 Mb
Release : 1995
Category : Science
ISBN : 1570590923

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Interleukin-10 by Jan Egbert De Vries,René De Waal Malefyt Pdf

This book examines the structure and the in vitro and in vivo biological characterization of a recently discovered cytokine: interleukin - 10 (IL-10). The information collected in this volume is a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and significantly contributes to our understanding of the role of IL-10 in the immune system and its potential clinical utility in the near future.

Author : Gerard Socie,Robert Zeiser,Bruce R. Blazar
Publisher : Academic Press
Page : 430 pages
File Size : 43,9 Mb
Release : 2018-11-22
Category : Science
ISBN : 9780128134399

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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation by Gerard Socie,Robert Zeiser,Bruce R. Blazar Pdf

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Author : Mathias Freund,Hartmut Link,Reinhold E. Schmidt,Karl Welte
Publisher : Springer
Page : 0 pages
File Size : 46,7 Mb
Release : 1992-11-18
Category : Medical
ISBN : 3540552421

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Cytokines in Hemopoiesis, Oncology, and AIDS II by Mathias Freund,Hartmut Link,Reinhold E. Schmidt,Karl Welte Pdf

This book is dealing with most recent advances in the field of cytokines in hemopoiesis, oncology and AIDS. It covers a wide range from basic research to clinical applications. Overviews on the biological role of cytokines are represented within the book as well as experiments with research on new cytokines and special effects of cytokines. The book will be of interestto hematologists and oncologists as well as imunologists who are engaged in the development of innovative therapy. It gives an overview on the most recent status of the discussion in this field.

Author : Anthony R. Mire-Sluis,Robin Thorpe
Publisher : Academic Press
Page : 584 pages
File Size : 43,9 Mb
Release : 1998-04-15
Category : Medical
ISBN : 0080530214

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Cytokines by Anthony R. Mire-Sluis,Robin Thorpe Pdf

This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book. Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information. Genetic information and sequences Protein structure Cell sources and production Biological activity Cytokine receptor structure and signal transduction Discussion of the role of cytokines in disease and the potential for therapy Summary table of essential facts Comprehensive bibliography

Author : Kathleen E. Sullivan,E. Richard Stiehm
Publisher : Academic Press
Page : 1334 pages
File Size : 52,9 Mb
Release : 2020-05-23
Category : Medical
ISBN : 9780128172957

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Stiehm's Immune Deficiencies by Kathleen E. Sullivan,E. Richard Stiehm Pdf

Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians Fills an increasingly deep gap in the information available to clinicians Presents both clinical management and scientific advances for immune deficiencies Provides a primary resource for physicians in the field of immunodeficiencies Includes website access to a range of videos relevant to the topics discussed

Author : Xiaojing Ma
Publisher : Springer
Page : 225 pages
File Size : 52,5 Mb
Release : 2016-10-12
Category : Medical
ISBN : 9789402409215

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Regulation of Cytokine Gene Expression in Immunity and Diseases by Xiaojing Ma Pdf

This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.

Author : Gerrit Jan Hendrik Lubberts
Publisher : Unknown
Page : 167 pages
File Size : 53,9 Mb
Release : 1999
Category : Electronic
ISBN : 9090130802

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The role of Interleukin-4 and Interleukin-10 in the regulation of experimental arthritis by Gerrit Jan Hendrik Lubberts Pdf

Author : E. Carstens,Tasuku Akiyama
Publisher : CRC Press
Page : 482 pages
File Size : 45,5 Mb
Release : 2014-02-25
Category : Science
ISBN : 9781466505438

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Itch by E. Carstens,Tasuku Akiyama Pdf

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Author : Koen Vandenbroeck
Publisher : CRC Press
Page : 488 pages
File Size : 41,6 Mb
Release : 2006-06-21
Category : Medical
ISBN : 9781420005325

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Cytokine Gene Polymorphisms in Multifactorial Conditions by Koen Vandenbroeck Pdf

The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions. Unique to this book are the "disease-centered" chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diseases, and longevity. "This section is a real tour de force" (Grant Gallagher and Michael F. Seldin, March 2006). Broadening the understanding of the effect of genetic variations on human immune responses, the organization, scope, and content of this book make it a valuable and easily accessible resource. The book integrates genetic, immunological, and clinical information and will serve as a reference for novice and expert geneticists, immunologists, cell biologists and clinicians. It is a must for everyone involved in, or planning, cytokine genetics or immunogenetics studies.

Author : Peter Riederer,Heinz Reichmann,Moussa B. H. Youdim,Manfred Gerlach
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 54,8 Mb
Release : 2006-11-23
Category : Medical
ISBN : 9783211452950

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Parkinson's Disease and Related Disorders by Peter Riederer,Heinz Reichmann,Moussa B. H. Youdim,Manfred Gerlach Pdf

This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.

Author : Michael T. Lotze
Publisher : Unknown
Page : 488 pages
File Size : 43,9 Mb
Release : 1996
Category : Immunity, Cellular
ISBN : UVA:X004125830

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Interleukin 12 by Michael T. Lotze Pdf

This work focuses on the understanding of IL-12, including its production, receptor interactions, signal transduction, interactions with other cytokines, its use as a therapy for AIDS and cancer, and its role in promoting an effective cellular response to microbial pathogens.

Author : Tengchuan Jin,Qian Yin
Publisher : Springer Nature
Page : 226 pages
File Size : 50,7 Mb
Release : 2019-10-18
Category : Medical
ISBN : 9789811393679

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Structural Immunology by Tengchuan Jin,Qian Yin Pdf

This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.