Into The Heart Of Systemic Autoimmune Diseases

Author : Franco Franceschini,Antonio Brucato,Micaela Fredi,Silvia Piantoni
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 43,6 Mb
Release : 2024-03-27
Category : Medical
ISBN : 9782832546826

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Into the Heart of Systemic Autoimmune Diseases by Franco Franceschini,Antonio Brucato,Micaela Fredi,Silvia Piantoni Pdf

Systemic autoimmune diseases are a heterogeneous group of disorders characterized by humoral and cell-mediated immune responses against various self-constituents. In specific cases, the heart and cardiovascular (CV) system are the primary organs targeted by the disease. On the other hand, several systemic autoimmune conditions are linked to enhanced atherosclerosis, with a consequently high CV morbidity and mortality rates. Persistent low-grade inflammation in the vascular wall is described to be important in the physiopathology of CV events. At first, inflammation is linked to endothelial dysfunction supporting the proliferation of vascular smooth muscle cells with subsequent vascular remodeling. Furthermore, the infiltration of innate and adaptive immune cells promotes a milieu of molecules that contributes to the perpetuation of inflammation itself. Although CV risk assessment should be part of routine care in patients with autoimmune diseases, no disease-specific models are currently available for this purpose. The main pillars of CV risk reduction are pharmacological and nonpharmacological management of cardiovascular CV risk factors, as well as tight control of disease activity.

Author : Andrea Dorea
Publisher : Elsevier
Page : 276 pages
File Size : 45,8 Mb
Release : 2004-01-20
Category : Medical
ISBN : 9780080507965

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The Heart in Systemic Autoimmune Diseases by Andrea Dorea Pdf

This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined. This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.

Author : Udi Nussinovitch
Publisher : Academic Press
Page : 766 pages
File Size : 41,8 Mb
Release : 2017-02-10
Category : Medical
ISBN : 9780128032688

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The Heart in Rheumatic, Autoimmune and Inflammatory Diseases by Udi Nussinovitch Pdf

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. Presents an up-to-date “level of evidence and “strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

Author : Michael Lockshin,Ware Branch
Publisher : Gulf Professional Publishing
Page : 197 pages
File Size : 53,8 Mb
Release : 2006-01-04
Category : Medical
ISBN : 9780444518019

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Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases by Michael Lockshin,Ware Branch Pdf

This volume of the Handbook of Systemic Autoimmune Diseases series represents a medical collaboration focusing primarily on female aspects of rheumatic diseases. This collaboration recognizes the need to understand and optimally manage the care of women with autoimmune conditions that may affect their reproduction and hormonal status. This handbook will prove useful to clinicians and researchers alike. It covers practical points, ranging from which anti-rheumatic medications are safe in pregnancy to how to counsel women with scleroderma contemplating pregnancy. * Authors share an academic interest in the unique relationship between being a woman and having an autoimmune disease * Touches on controversial topics, such as the mechanism of antiphospholipid-related fetal loss and whether or not non-steroidal anti-inflammatory agents should be used in pregnancy * Includes critical and balanced reviews of the controversial association between autoimmune disease and female infertility

Author : Ricard Cervera,Gerard Espinosa,Munther Khamashta
Publisher : Elsevier
Page : 326 pages
File Size : 55,7 Mb
Release : 2016-06-18
Category : Medical
ISBN : 9780444636560

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Antiphospholipid Syndrome in Systemic Autoimmune Diseases by Ricard Cervera,Gerard Espinosa,Munther Khamashta Pdf

Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics. Brings the reader up-to-date and allows easy access to individual topics in one place Written by a respected panel of distinguished physicians/scientists actively involved in the field of Antiphospholipid Syndrome Includes box summaries at the end of each chapter that highlight important topics Gives up-to-date, basic knowledge and a modern approach to diagnosis and therapy Provides a comprehensive review of this major disease Includes information on treatment options available

Author : Rolando Cimaz,Thomas J.A. Lehman
Publisher : Elsevier
Page : 300 pages
File Size : 50,7 Mb
Release : 2007-11-13
Category : Medical
ISBN : 0080553443

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Pediatrics in Systemic Autoimmune Diseases by Rolando Cimaz,Thomas J.A. Lehman Pdf

Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.

Author : Munther A Khamashta,Manuel Ramos-Casals
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 45,7 Mb
Release : 2011-05-26
Category : Medical
ISBN : 9780857293589

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Autoimmune Diseases by Munther A Khamashta,Manuel Ramos-Casals Pdf

Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

Author : Piercarlo Sarzi-Puttini
Publisher : Elsevier
Page : 358 pages
File Size : 48,7 Mb
Release : 2006-01-26
Category : Medical
ISBN : 0080461921

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The Skin in Systemic Autoimmune Diseases by Piercarlo Sarzi-Puttini Pdf

This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity. * Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity * Box summaries at the end of each chapter highlight important topics * Up-to-date basic knowledge as well as modern approach to diagnosis and therapy

Author : Justin C Mason,Charles Pusey
Publisher : Elsevier
Page : 432 pages
File Size : 55,7 Mb
Release : 2007-12-14
Category : Medical
ISBN : 008055704X

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The Kidney in Systemic Autoimmune Diseases by Justin C Mason,Charles Pusey Pdf

This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease, combined with a detailed overview of treatment strategies. An essential reference source for all those involved with the care of patients with renal involvement in systemic autoimmune disease, and for those contributing to research into the underlying pathogenic mechanisms in these disorders.

Author : Anonim
Publisher : Elsevier
Page : 296 pages
File Size : 48,6 Mb
Release : 2004-11-05
Category : Medical
ISBN : 0080479685

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The Neurologic Involvement in Systemic Autoimmune Diseases by Anonim Pdf

Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients. This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases. Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

Author : Rolando Cimaz,Thomas J.A. Lehman
Publisher : Elsevier
Page : 606 pages
File Size : 46,8 Mb
Release : 2016-06-08
Category : Medical
ISBN : 9780444635976

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Pediatrics in Systemic Autoimmune Diseases by Rolando Cimaz,Thomas J.A. Lehman Pdf

Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. Includes completely updated chapters and five new chapters Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties Brings the reader up-to-date and allows easy access to individual topics in one place Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care

Author : Fabiola Atzeni,Andrea Dorea,Mike Nurmohamed,Paolo Pauletto
Publisher : Elsevier
Page : 566 pages
File Size : 50,7 Mb
Release : 2017-02-11
Category : Medical
ISBN : 9780444636690

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The Heart in Systemic Autoimmune Diseases by Fabiola Atzeni,Andrea Dorea,Mike Nurmohamed,Paolo Pauletto Pdf

The Heart in Systemic Autoimmune Diseases, Second Edition, provides an overview on our current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population. This excess mortality is largely due to cardiovascular diseases (CVDs)-particularly those of atherosclerotic origin, such as ischemic heart disease-and is gaining recognition in all branches of medicine, from cardiology, to internal medicine, and from rheumatologists to orthopedics. Presents an impressive body of well ordered information on the topic of cardiovascular diseases and their relationship to autoimmune illness Highlights key references Summarizes the experience of a selected panel of distinguished physician-scientists who are actively involved in the field of cardiovascular disease and systemic autoimmunity

Author : Conrad
Publisher : Pabst Science Publishers
Page : 268 pages
File Size : 42,5 Mb
Release : 2002-01-01
Category : Electronic
ISBN : 1593260075

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Autoantibodies in Systemic Autoimmune Diseases by Conrad Pdf

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 46,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Sanjay Saint,Vineet Chopra
Publisher : Oxford University Press, USA
Page : 609 pages
File Size : 51,8 Mb
Release : 2018
Category : Medical
ISBN : 9780190862800

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The Saint-Chopra Guide to Inpatient Medicine by Sanjay Saint,Vineet Chopra Pdf

Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.