Intrinsically Disordered Proteins

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Intrinsically Disordered Proteins

Vladimir N. Uversky
Intrinsically Disordered Proteins Book PDF

Author : Vladimir N. Uversky
Publisher : Springer
Page : 61 pages
File Size : 49,7 Mb
Release : 2014-08-05
Category : Science
ISBN : 9783319089218

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Intrinsically Disordered Proteins by Vladimir N. Uversky Pdf

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Intrinsically Disordered Proteins

Nicola Salvi
Intrinsically Disordered Proteins Book PDF

Author : Nicola Salvi
Publisher : Academic Press
Page : 355 pages
File Size : 40,8 Mb
Release : 2019-06-14
Category : Science
ISBN : 9780128167328

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Intrinsically Disordered Proteins by Nicola Salvi Pdf

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs. Provides in-depth discussion of fundamental IDP and IDR dynamics, function, and binding, with mechanistic insight to support new drug development Describes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targets Features chapter contributions from international experts in IDP and IDR biochemical function and methods of study

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Isabella C. Felli,Roberta Pierattelli
Intrinsically Disordered Proteins Studied by NMR Spectroscopy Book PDF

Author : Isabella C. Felli,Roberta Pierattelli
Publisher : Springer
Page : 421 pages
File Size : 50,8 Mb
Release : 2015-09-19
Category : Science
ISBN : 9783319201641

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Intrinsically Disordered Proteins Studied by NMR Spectroscopy by Isabella C. Felli,Roberta Pierattelli Pdf

This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research. Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments. Intrinsically Disordered Proteins Studied by NMR Spectroscopy provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Intrinsically Disordered Proteins

Birthe B. Kragelund,Karen Skriver
Intrinsically Disordered Proteins Book PDF

Author : Birthe B. Kragelund,Karen Skriver
Publisher : Humana
Page : 951 pages
File Size : 49,6 Mb
Release : 2021-07-23
Category : Science
ISBN : 1071605267

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Intrinsically Disordered Proteins by Birthe B. Kragelund,Karen Skriver Pdf

The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims to help scientists with different backgrounds to further their investigations into these fascinating and dynamic molecules. Chapter 24 is available open access under a CC BY 4.0 license via link.springer.com. Chapters “40 and 42 ” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Structure and Function of Intrinsically Disordered Proteins

Peter Tompa,Alan Fersht
Structure and Function of Intrinsically Disordered Proteins Book PDF

Author : Peter Tompa,Alan Fersht
Publisher : CRC Press
Page : 359 pages
File Size : 44,8 Mb
Release : 2009-11-18
Category : Science
ISBN : 1420078933

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Structure and Function of Intrinsically Disordered Proteins by Peter Tompa,Alan Fersht Pdf

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs. Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.

Instrumental Analysis of Intrinsically Disordered Proteins

Vladimir Uversky,Sonia Longhi
Instrumental Analysis of Intrinsically Disordered Proteins Book PDF

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 792 pages
File Size : 50,5 Mb
Release : 2011-01-31
Category : Science
ISBN : 9780470602607

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Instrumental Analysis of Intrinsically Disordered Proteins by Vladimir Uversky,Sonia Longhi Pdf

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology

Vladimir Uversky
Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Book PDF

Author : Vladimir Uversky
Publisher : Academic Press
Page : 426 pages
File Size : 55,7 Mb
Release : 2019-09-15
Category : Electronic
ISBN : 9780128168516

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Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology by Vladimir Uversky Pdf

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Intrinsically Disordered Protein Analysis

Vladimir N. Uversky,A. Keith Dunker
Intrinsically Disordered Protein Analysis Book PDF

Author : Vladimir N. Uversky,A. Keith Dunker
Publisher : Humana Press
Page : 0 pages
File Size : 42,8 Mb
Release : 2012-07-05
Category : Science
ISBN : 1617799262

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Intrinsically Disordered Protein Analysis by Vladimir N. Uversky,A. Keith Dunker Pdf

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis :Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 1 includes sections on assessing IDPs in the living cell,NMR based techniques, vibrational spectroscopy, and other spectroscopic techniques. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Intrinsically Disordered Protein Analysis: Methods and Experimental Tools helps scientists further their investigations of these fascinating and dynamic molecules.

Fuzziness

Monika Fuxreiter,Peter Tompa
Fuzziness Book PDF

Author : Monika Fuxreiter,Peter Tompa
Publisher : Springer Science & Business Media
Page : 190 pages
File Size : 52,7 Mb
Release : 2012-03-07
Category : Medical
ISBN : 9781461406594

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Fuzziness by Monika Fuxreiter,Peter Tompa Pdf

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Structural Biology in Drug Discovery

Jean-Paul Renaud
Structural Biology in Drug Discovery Book PDF

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Page : 1367 pages
File Size : 54,9 Mb
Release : 2020-01-09
Category : Medical
ISBN : 9781118900505

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Structural Biology in Drug Discovery by Jean-Paul Renaud Pdf

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Anonim
Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C Book PDF

Author : Anonim
Publisher : Academic Press
Page : 438 pages
File Size : 52,9 Mb
Release : 2021-10-14
Category : Science
ISBN : 9780323853002

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Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C by Anonim Pdf

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field

Advances in Protein Molecular and Structural Biology Methods

Timir Tripathi,Vikash Kumar Dubey
Advances in Protein Molecular and Structural Biology Methods Book PDF

Author : Timir Tripathi,Vikash Kumar Dubey
Publisher : Academic Press
Page : 716 pages
File Size : 50,9 Mb
Release : 2022-01-14
Category : Science
ISBN : 9780323902656

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Advances in Protein Molecular and Structural Biology Methods by Timir Tripathi,Vikash Kumar Dubey Pdf

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. Presents a thorough overview of the latest and emerging methods and technologies for protein study Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy Includes computational and machine learning methods Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins

Biomolecular Forms and Functions

Manju Bansal,N. Srinivasan
Biomolecular Forms and Functions Book PDF

Author : Manju Bansal,N. Srinivasan
Publisher : World Scientific
Page : 515 pages
File Size : 54,5 Mb
Release : 2013
Category : Computers
ISBN : 9789814449144

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Biomolecular Forms and Functions by Manju Bansal,N. Srinivasan Pdf

This volume is primarily a compilation of contributed articles representing the impact and application of Ramachandran's work on conformation analysis of biopolymers, as well as recent advances in macromolecular structural biology, involving diverse experimental and computational approaches. This volume is being published to coincide with a conference on "Biomolecular Forms and Functions: A celebration of 50 years of the Ramachandran Map" being held at the Indian Institute of Science, Bangalore, in January 2013.

Non-covalent Interactions In Proteins

Karshikoff Andrey
Non covalent Interactions In Proteins Book PDF

Author : Karshikoff Andrey
Publisher : World Scientific
Page : 348 pages
File Size : 49,7 Mb
Release : 2006-11-23
Category : Proteins
ISBN : 9781911299288

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Non-covalent Interactions In Proteins by Karshikoff Andrey Pdf

Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the other hand, books on biochemistry, molecular modeling or molecular simulation introduce these interactions in the context of the corresponding topic, which sometimes results in superficial explanations of their nature. This book succeeds in uniting comprehensive considerations of non-covalent interactions with the specificity of their application in protein sciences.The ideal aid for students of physics or chemistry, with interests in biology and biophysics, the book can also be useful for students of biology, biochemistry, or biomedicine who want to extend their knowledge of how protein properties are described at the molecular level./a

Flexible Viruses

Vladimir Uversky,Sonia Longhi
Flexible Viruses Book PDF

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 43,6 Mb
Release : 2012-02-07
Category : Science
ISBN : 9780470618318

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Flexible Viruses by Vladimir Uversky,Sonia Longhi Pdf

This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.