Iron Deficiency And Overload

Author : Shlomo Yehuda,David I. Mostofsky
Publisher : Springer Science & Business Media
Page : 377 pages
File Size : 43,8 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781597454629

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Iron Deficiency and Overload by Shlomo Yehuda,David I. Mostofsky Pdf

Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.

Author : Kenneth Kaushansky,Marshall A. Lichtman,Josef Prchal,Marcel M. Levi,Oliver W Press,Linda J Burns,Michael Caligiuri
Publisher : McGraw Hill Professional
Page : 2528 pages
File Size : 51,8 Mb
Release : 2015-12-23
Category : Medical
ISBN : 9780071833011

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Williams Hematology, 9E by Kenneth Kaushansky,Marshall A. Lichtman,Josef Prchal,Marcel M. Levi,Oliver W Press,Linda J Burns,Michael Caligiuri Pdf

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2019! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 54,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938

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Iron Chelation Therapy by Chaim Hershko Pdf

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Author : Cheryl Garrison
Publisher : Sourcebooks, Inc.
Page : 498 pages
File Size : 52,8 Mb
Release : 2009-06-01
Category : Health & Fitness
ISBN : 9781402247521

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The Iron Disorders Institute Guide to Anemia by Cheryl Garrison Pdf

Unravel the mysteries behind anemia's diverse forms, from iron deficiency anemia to hemolytic and aplastic anemia, and gain a deep understanding of their underlying mechanisms. Empower yourself with the treatments and prevention strategies, carefully curated by the Iron Disorders Institute. Inside these pages, you'll find: Comprehensive explanations of different types of anemia, their prevalence, and risk factors. An in-depth exploration of iron metabolism, absorption, and utilization in the body. Expert advice on diagnosing anemia accurately, distinguishing its various forms, and addressing related health concerns. Essential dietary guidelines and supplementation recommendations to combat iron deficiency and optimize iron levels. Practical tips on managing anemia-related symptoms, such as fatigue, weakness, and shortness of breath, to enhance your overall well-being. Empower yourself with the knowledge to promote healing, vitality, and a healthier life.

Author : Sheila T. Callender
Publisher : Unknown
Page : 189 pages
File Size : 40,5 Mb
Release : 1973
Category : Iron
ISBN : OCLC:7303344

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Iron Deficiency and Iron Overload by Sheila T. Callender Pdf

Author : Cheryl Garrison
Publisher : Sourcebooks, Inc.
Page : 370 pages
File Size : 54,8 Mb
Release : 2009-11-01
Category : Health & Fitness
ISBN : 9781402247545

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The Iron Disorders Institute Guide to Hemochromatosis by Cheryl Garrison Pdf

The number-one bestselling and most comprehensive guide to hemochromatosis Endorsed by the Iron Disorders Institute, this guide provides reliable, evidence-based information about the disease. It explains the underlying genetic causes, common symptoms, and potential health impacts of hemochromatosis. Detailed yet easy-to-understand, this book offers valuable knowledge to those diagnosed with the condition, family members, caregivers, and medical professionals alike. The guide also focuses on effective strategies for managing hemochromatosis. It covers the role of diet, the importance of regular medical check-ups, and the benefits of therapeutic phlebotomy. By outlining the right preventative measures and treatment options, it empowers readers to take control of their health. Step into an empowered life with The Iron Disorders Institute Guide to Hemochromatosis, your comprehensive companion for understanding, managing, and living well with this iron disorder. Key Features: In-depth Understanding: Provides a comprehensive overview of hemochromatosis, including causes, symptoms, and health impacts. Management Strategies: Covers effective strategies for managing hemochromatosis, from dietary considerations to therapeutic phlebotomy. Evidence-Based Information: Presents reliable, evidence-based information endorsed by the Iron Disorders Institute. Accessible Language: Written in easy-to-understand language, making complex medical concepts accessible to all readers.

Author : Gregory J. Anderson,Gordon D. McLaren
Publisher : Springer Science & Business Media
Page : 705 pages
File Size : 55,6 Mb
Release : 2012-01-14
Category : Medical
ISBN : 9781603274852

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Iron Physiology and Pathophysiology in Humans by Gregory J. Anderson,Gordon D. McLaren Pdf

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients
Publisher : National Academies Press
Page : 804 pages
File Size : 49,9 Mb
Release : 2002-07-19
Category : Medical
ISBN : 0309072794

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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients Pdf

This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Author : Virgil F. Fairbanks,John L. Fahey,Ernest Beutler
Publisher : Saunders
Page : 504 pages
File Size : 47,7 Mb
Release : 1971
Category : Anemia
ISBN : UOM:39015026977598

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Clinical Disorders of Iron Metabolism by Virgil F. Fairbanks,John L. Fahey,Ernest Beutler Pdf

Author : Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams
Publisher : Newnes
Page : 1014 pages
File Size : 43,6 Mb
Release : 2013-05-13
Category : Science
ISBN : 9780123977885

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Transfusion Medicine and Hemostasis by Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams Pdf

The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

Author : Manfred Wick
Publisher : Unknown
Page : 132 pages
File Size : 54,9 Mb
Release : 1995
Category : Anemia
ISBN : UOM:39015037491183

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Ferritin in Iron Metabolism by Manfred Wick Pdf

Author : Robert Crichton
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 49,9 Mb
Release : 2009-02-25
Category : Medical
ISBN : 0470010290

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Iron Metabolism by Robert Crichton Pdf

Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include: Solution chemistry of iron in biological media The importance of iron for biological systems Microbial iron transport and metabolism Iron uptake by plants and fungi Cellular iron uptake and export in mammals Intracellular iron storage and biomineralization Intracellular iron metabolism and cellular iron homeostasis Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance Pathophysiology of iron deficiency and iron overload in man Iron and oxidative stress Brain iron homeostasis and its perturbation in various neurodegenerative diseases Interactions between iron and other metals Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer’s disease. Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.

Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 42,5 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186

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Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Author : Franz Gross,S.R. Naegeli,H.D. Philips
Publisher : Springer Science & Business Media
Page : 645 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642871528

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Iron Metabolism by Franz Gross,S.R. Naegeli,H.D. Philips Pdf

International Symposia sponsored by ClBA Basle have been held once a year since 1959 in various European countries. In con trast to the many scientific meetings organised by the ClBA FOUN DATION either at its headquarters in London or occasionally abroad, the subjects dealt with at these International Symposia have con cerned problems more directly related to ClBA'S own research work in the pharmaceutical field. The various topics covered up to the present reflect the far-reaching interests and the wide spread activities that a pharmaceutical enterprise develops in quite diverse fields of chemical, biological, and medical research, and to which the ba.sic approach is an increasingly important prerequisite for the development of a new and useful therapeutic agent. Iron metabolism came into the sphere of interest in connection with CIBA'S research on antibiotics and related natural products containing iron, substances which act in their metal-free form as strong and specific chelating agents. Of course, these observations, interesting though they are, would not in themselves have justi fied a symposium. It seemed, however, useful to examine the new results from a wider perspective and to attempt to relate them to present-day knowledge of iron metabolism in general its physiology, its pathology, and therapeutic aspects. The success of a scientific symposium depends on the concep tion of the programme and the selection of the participants.

Author : Christoph Gasche
Publisher : Uni-Med
Page : 95 pages
File Size : 41,7 Mb
Release : 2008
Category : Anemia
ISBN : 1848151241

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Anemia in Inflammatory Bowel Diseases by Christoph Gasche Pdf

Inflammatory bowel diseases are increasingly common and complex. Modern therapeutic strategies involve infusion therapy and the use anti-TNF or other biologicals as well as intravenous iron preparations. This book covers the pathophysiology and treatment of anemia in inflammatory bowel diseases and discusses controversial aspects specifically when it comes to iron therapy.