Iron Chelation Therapy

Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938

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Iron Chelation Therapy by Chaim Hershko Pdf

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 51,7 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Author : Jan Aaseth,Guido Crisponi,Ole Anderson
Publisher : Academic Press
Page : 388 pages
File Size : 54,9 Mb
Release : 2016-04-18
Category : Medical
ISBN : 9780128030738

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Chelation Therapy in the Treatment of Metal Intoxication by Jan Aaseth,Guido Crisponi,Ole Anderson Pdf

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 49,9 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Author : Robert R Crichton,Roberta J Ward,Robert C Hider
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 44,7 Mb
Release : 2016-10-18
Category : Science
ISBN : 9781782623892

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Metal Chelation in Medicine by Robert R Crichton,Roberta J Ward,Robert C Hider Pdf

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Author : Maria-Domenica Cappellini
Publisher : Unknown
Page : 128 pages
File Size : 53,9 Mb
Release : 2008
Category : Electronic
ISBN : 9963623700

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Guidelines for the Clinical Management of Thalassaemia by Maria-Domenica Cappellini Pdf

Author : Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams
Publisher : Newnes
Page : 1014 pages
File Size : 51,6 Mb
Release : 2013-05-13
Category : Science
ISBN : 9780123977885

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Transfusion Medicine and Hemostasis by Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams Pdf

The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

Author : Raymond J. Bergeron,Gary M. Brittenham
Publisher : CRC Press
Page : 438 pages
File Size : 54,5 Mb
Release : 1993-12-06
Category : Medical
ISBN : 0849386799

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The Development of Iron Chelators for Clinical Use by Raymond J. Bergeron,Gary M. Brittenham Pdf

Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators.

Author : Shlomo Yehuda,David I. Mostofsky
Publisher : Springer Science & Business Media
Page : 377 pages
File Size : 46,9 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781597454629

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Iron Deficiency and Overload by Shlomo Yehuda,David I. Mostofsky Pdf

Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.

Author : Ali Taher,Khaled Musallam,Maria-Domenica Cappellini
Publisher : Unknown
Page : 114 pages
File Size : 51,9 Mb
Release : 2017
Category : Iron deficiency anemia
ISBN : 996371711X

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Guidelines for the Management of Non Transfusion Dependent Thalassaemia (NTDT) by Ali Taher,Khaled Musallam,Maria-Domenica Cappellini Pdf

Author : Warren J. Manning,Dudley J. Pennell
Publisher : Elsevier Health Sciences
Page : 672 pages
File Size : 44,9 Mb
Release : 2018-04-26
Category : Medical
ISBN : 9780323497374

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Cardiovascular Magnetic Resonance by Warren J. Manning,Dudley J. Pennell Pdf

Provides state-of-the-art coverage of CMR technologies and guidelines, including basic principles, imaging techniques, ischemic heart disease, right ventricular and congenital heart disease, vascular and pericardium conditions, and functional cardiovascular disease. Includes new chapters on non-cardiac pathology, pacemaker safety, economics of CMR, and guidelines as well as new coverage of myocarditis and its diagnosis and assessment of prognosis by cardiovascular magnetic resonance, and the use of PET/CMR imaging of the heart, especially in sarcoidosis. Features more than 1,100 high-quality images representing today’s CMR imaging. Covers T1, T2 and ECV mapping, as well as T2* imaging in iron overload, which has been shown to save lives in patients with thalassaemia major Discusses the cost-effectiveness of CMR.

Author : Gary Greenberg
Publisher : Humanix Books
Page : 175 pages
File Size : 40,7 Mb
Release : 2020-08-04
Category : Health & Fitness
ISBN : 9781630061203

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The Chelation Revolution by Gary Greenberg Pdf

The Medical Breakthrough of Chelation Therapy: A treatment that uses medicine to remove toxic metals from the body so they don't make you sick. Chelation has long been approved by the FDA to rid the body of lead by using a synthetic amino acid (ethylene diamine tetraacetic acid), which binds to toxic metals and minerals in the bloodstream, allowing a patient to excrete them. When metals like lead, mercury, iron, and arsenic build up in your body, they can be toxic. Alternative medical practitioners have used chelation for nearly 60 years, especially to treat heavy metal contamination that causes or contributes to heart disease. Chelation rids the body of deposits that can lead to atherosclerosis, which causes coronary arteries to narrow, leading to heart attacks. Patients have also found relief through chelation for improving the symptoms of autism. One of the most promising areas of research is in the treatment of Alzheimer’s disease. Because the buildup of metals like copper, iron, and zinc are thought to play a role in Alzheimer's disease, Chelation Therapy might have a place in treating it. Full of hope-inspiring case histories, expert findings and where to find treatment, The Chelation Revolution: Breakthrough Detox Therapy shows how Chelation Therapy can alleviate suffering in numerous medical conditions and lead to a healthier, happier, and longer life. Includes a Foreword by Tammy Born Huizenga, D.O., owner of the internationally recognized Born Clinic in Grand Rapids, MI, an internationally respected organization in preventive medicine with a speciality in Chelation Therapy.

Author : S.H. Parvez,Peter Riederer
Publisher : Springer
Page : 0 pages
File Size : 48,6 Mb
Release : 2014-11-28
Category : Medical
ISBN : 3709117364

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Oxidative Stress and Neuroprotection by S.H. Parvez,Peter Riederer Pdf

This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson’s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson’s therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.

Author : Edward C. Zaino,Richard H. Roberts
Publisher : Unknown
Page : 145 pages
File Size : 53,6 Mb
Release : 1977
Category : Electronic
ISBN : OCLC:37953920

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Chelation Therapy in Chronic Iron Overload by Edward C. Zaino,Richard H. Roberts Pdf

Author : Juan M. Pascual
Publisher : Cambridge University Press
Page : 507 pages
File Size : 53,7 Mb
Release : 2017-04-20
Category : Medical
ISBN : 9781107042056

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Progressive Brain Disorders in Childhood by Juan M. Pascual Pdf

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.