Key Heterocyclic Cores For Smart Anticancer Drug Design Part Ii

Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
Page : 231 pages
File Size : 41,8 Mb
Release : 2022-09-02
Category : Medical
ISBN : 9789815040050

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Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II by Rajesh Kumar Singh Pdf

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents

Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
Page : 0 pages
File Size : 47,9 Mb
Release : 2022-09-02
Category : Electronic
ISBN : 9815040065

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Key Heterocyclic Cores for Smart Anticancer Drug-Design Part II by Rajesh Kumar Singh Pdf

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents

Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
Page : 285 pages
File Size : 44,9 Mb
Release : 2022-07-05
Category : Medical
ISBN : 9789815040081

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Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I by Rajesh Kumar Singh Pdf

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)

Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
Page : 0 pages
File Size : 46,5 Mb
Release : 2022-07-05
Category : Electronic
ISBN : 981504009X

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Key Heterocyclic Cores for Smart Anticancer Drug-Design Part I by Rajesh Kumar Singh Pdf

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship (sar) studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an updates (2017-2020)

Author : Om Silakari
Publisher : Elsevier
Page : 436 pages
File Size : 41,8 Mb
Release : 2018-06-11
Category : Science
ISBN : 9780081021057

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Key Heterocycle Cores for Designing Multitargeting Molecules by Om Silakari Pdf

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

Author : Shahid Ali Khan,Saad Salman,Youssef O. Al-Ghamdi
Publisher : Unknown
Page : 229 pages
File Size : 41,7 Mb
Release : 2021
Category : Nanomedicine
ISBN : 981503670X

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Nanotherapeutic Strategies and New Pharmaceuticals by Shahid Ali Khan,Saad Salman,Youssef O. Al-Ghamdi Pdf

Author : Betül Gürünlü
Publisher : Bentham Science Publishers
Page : 178 pages
File Size : 54,6 Mb
Release : 2022-01-17
Category : Medical
ISBN : 9789815039245

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Medical Applications of Beta-Glucan by Betül Gürünlü Pdf

Beta-glucan is a polysaccharide and an important food supplement that strengthens the immune system. Beta-glucan can be obtained from many food sources such as mushrooms, yeast, or oats. Beta-glucan has a therapeutic use in the treatment of many diseases, thanks to its immune system strengthening effect. Its use helps curtail the need for administering high levels of antibiotics in case of serious infections. This book presents information about the medical applications of beta-glucan. Starting with an introduction to the basic biochemistry and classification of beta-glucan, the contents explain the readers about its use in treating a variety of medical conditions. These include cancer, allergies, COVID-19, respiratory tract infections, hypercholesterolemia, diabetes and many other other endocrinological, immunological and infectious diseases. This book is a comprehensive resource about the medical use of beta-glucan where any reader can find topical information and learn about recent studies on the therapeutic effects of beta-glucan on the treatment of different diseases.

Author : Angela Casini,Anne Vessières,Samuel M Meier-Menches
Publisher : Royal Society of Chemistry
Page : 370 pages
File Size : 52,8 Mb
Release : 2019-04-05
Category : Science
ISBN : 9781788017671

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Metal-based Anticancer Agents by Angela Casini,Anne Vessières,Samuel M Meier-Menches Pdf

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

Author : Steven Howard,Chris Abell
Publisher : Royal Society of Chemistry
Page : 314 pages
File Size : 48,8 Mb
Release : 2015-07-03
Category : Medical
ISBN : 9781849739085

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Fragment-Based Drug Discovery by Steven Howard,Chris Abell Pdf

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

Author : Aleksey Kuznetsov
Publisher : BoD – Books on Demand
Page : 148 pages
File Size : 49,7 Mb
Release : 2021-06-30
Category : Science
ISBN : 9781839681790

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Azoles by Aleksey Kuznetsov Pdf

Azoles are a broad and promising class of five-membered heterocyclic compounds containing from one up to five nitrogen atom(s) that can also contain sulfur or oxygen atoms. Widely used as potent antifungal agents, various azole derivatives have also demonstrated many other promising biological properties. This book covers studies of several types of thiazole-based heterocyclic scaffolds, the development of 4-thiazolidinone and thiazole derivatives with heterocyclic fragments as potential candidates for new drugs against trypanosomiasis, numerous synthetic approaches for the synthesis of 1,2,3-triazoles, the application of N-azole, N,S-azole, and N,O-azole as well as their derivatives as retarders of metallic corrosion, and the integration of azoles in materials used for renewable energy processing and applications and wood treatment.

Author : Rajesh Kumar Singh
Publisher : Hari Sena Press Pvt. Ltd.
Page : 257 pages
File Size : 53,8 Mb
Release : 2012
Category : Art
ISBN : 9788192510705

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An Introduction to the Ajantā Caves by Rajesh Kumar Singh Pdf

This book presents the latest and updated information about the Ajanta caves, their histories, and painted themes. For the first time, a book accommodates-within the space of a single volume-many dimensions and components of the caves. It includes the latest research by the author on the gradual development of the caves. historical framework formulated by Walter M. Spink. identifications of the narrative paintings by Dieter Schlingloff. identifications of the devotional and ornamental paintings by Monika Zin. summaries of nearly all the narrative paintings (84 stories). corpus of photo documentation on the paintings, sculptures, and architecture. attempt on long exposure photography in poorly lit conditions. The language is so crafted as to help the students, travellers, and general readers grasp the beauty and complexities of Ajanta and the times. At the same time the content is so packed, and the issues discussed in such a manner, as to keep the expert readers engaged.

Author : Gérard Jaouen,Nils Metzler-Nolte
Publisher : Springer Science & Business Media
Page : 305 pages
File Size : 52,5 Mb
Release : 2010-09-14
Category : Science
ISBN : 9783642131844

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Medicinal Organometallic Chemistry by Gérard Jaouen,Nils Metzler-Nolte Pdf

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.

Author : Keith B. Tierney,Anthony P. Farrell,Colin J. Brauner
Publisher : Academic Press
Page : 574 pages
File Size : 44,6 Mb
Release : 2013-12-04
Category : Technology & Engineering
ISBN : 9780123982551

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Fish Physiology: Organic Chemical Toxicology of Fishes by Keith B. Tierney,Anthony P. Farrell,Colin J. Brauner Pdf

Fish Physiology: Organic Chemical Toxicology of Fishes discusses the different types of organic chemical contaminants and their respective toxic effects in fish. The book also covers the detection of dissolved organic compounds and methods to assess organic toxicity. Substances addressed in this book include organometallics, hydrocarbons, endocrine disrupting compounds (EDCs), insecticides, herbicides, and pharmaceuticals. Fish are exposed to an ever-increasing array of organic chemicals that find their way into rivers and oceans. Some of these compounds are no longer being produced but nonetheless persist within the environment (persistent organic pollutants, or POPs). The exposure of fish to toxic organic compounds has potential impact on human, fish, and ecosystem health. Yet the regulations that govern environmental water quality vary worldwide, and compliance is never complete. This book provides a crucial resource on these issues for researchers in zoology, fish physiology, and related fields; applied researchers in environmental monitoring, conservation biology, and toxicology; and university-level students and instructors in these areas. Organized by type of toxic organic chemicals Includes metals, POPs, EDCs, herbicides, insecticides, and pharmaceuticals Measures toxicity in a variety of ways aside from lethality Probes the toxic effects of compound mixtures as well as single pollutants

Author : John Masters,Bernhard Ø Palsson
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 43,9 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306468728

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Cancer Cell Lines Part 1 by John Masters,Bernhard Ø Palsson Pdf

Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Author : Amin Abbasi,Elham Sheykhsaran,Hossein Samadi Kafil
Publisher : Bentham Science Publishers
Page : 135 pages
File Size : 40,6 Mb
Release : 2021-06-04
Category : Medical
ISBN : 9781681088396

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Postbiotics: Science, Technology and Applications by Amin Abbasi,Elham Sheykhsaran,Hossein Samadi Kafil Pdf

Postbiotics: Science, Technology, and Applications explains fundamental and applied knowledge about postbiotics. Chapters cover the definition and classification of postbiotics, principal methods for preparing them, information about the main postbiotic constituents and their biological activities and their clinical health benefits. The authors also familiarize the reader with potential applications of postbiotics in the food industry, pharmaceutical chemistry, medicine, and veterinary practice. The text is supported by informative illustrations, tables, and references for further reading. This comprehensive reference, with its emphasis on both basic and applied knowledge, is useful for researchers, academics, veterinarians, and students in the field of microbiology, immunology, pharmacology, biotechnology, food science, and agriculture.