Kidney Development

Author : Rachel K. Miller
Publisher : Springer
Page : 372 pages
File Size : 46,8 Mb
Release : 2017-04-13
Category : Science
ISBN : 9783319514369

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Kidney Development and Disease by Rachel K. Miller Pdf

Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Author : Melissa Helen Little
Publisher : Academic Press
Page : 614 pages
File Size : 55,6 Mb
Release : 2015-08-06
Category : Medical
ISBN : 9780128004388

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Kidney Development, Disease, Repair and Regeneration by Melissa Helen Little Pdf

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Author : Karen Moritz,E. Marelyn Wintour-Coghlan,M. Jane Black,John F. Bertram,Georgina Caruana
Publisher : Springer Science & Business Media
Page : 88 pages
File Size : 50,9 Mb
Release : 2008-05-11
Category : Medical
ISBN : 9783540777687

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Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life by Karen Moritz,E. Marelyn Wintour-Coghlan,M. Jane Black,John F. Bertram,Georgina Caruana Pdf

In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.

Author : Peter D. Vize,Adrian S. Woolf,Jonathan B.L. Bard
Publisher : Elsevier
Page : 592 pages
File Size : 47,7 Mb
Release : 2003-03-14
Category : Science
ISBN : 0080521541

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The Kidney by Peter D. Vize,Adrian S. Woolf,Jonathan B.L. Bard Pdf

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney. Hundreds of color figures depicting key events in all aspects of kidney development Full coverage of the genetic and cellular basis of kidney development Analysis of the genetic basis of the major congenital kidney diseases

Author : Edith Louise Potter
Publisher : Unknown
Page : 328 pages
File Size : 51,6 Mb
Release : 1972
Category : Medical
ISBN : UOM:39015002421918

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Normal and Abnormal Development of the Kidney by Edith Louise Potter Pdf

Author : Gavino Faa,Vassilios Fanos
Publisher : Springer
Page : 115 pages
File Size : 47,9 Mb
Release : 2014-08-09
Category : Medical
ISBN : 9781493909476

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Kidney Development in Renal Pathology by Gavino Faa,Vassilios Fanos Pdf

This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life and the correlation with renal carcinogenesis. Written by well recognized experts in their fields, Kidney Development in Renal Pathology is a valuable tool for pathologists, neonatologists, nephrologists, gynecologists and researchers with an interest in kidney diseases.

Author : Lauri Saxen
Publisher : Cambridge University Press
Page : 185 pages
File Size : 53,5 Mb
Release : 1987-04-16
Category : Medical
ISBN : 9780521301527

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Organogenesis of the Kidney by Lauri Saxen Pdf

Although this description of a model system for cell differentation and organogenesis emphasizes the mammalian kidney, detailed coverage is also given to the development of the transient excretory organs.

Author : Odyssé Michos
Publisher : Humana Press
Page : 0 pages
File Size : 43,8 Mb
Release : 2012-05-27
Category : Science
ISBN : 1617798509

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Kidney Development by Odyssé Michos Pdf

Over the last decade the development of new molecular biology tools, advanced microscopy, live imaging and systems biology approaches have revolutionized our conception of how embryonic development proceeds. One fundamental aspect of development biology is the concept of morphogenesis: understanding how a group of multipotent cells organize and differentiate into a complex organ. In Kidney Development: Methods and Protocols, expert researchers in the field detail different approaches to tackle kidney development. These approaches include culture and live imaging aspects of kidney development, analyzing the 3-dimensional aspects of branching morphogenesis as well as nephrogenesis, manipulation of the gene/protein expression during kidney development as well as in the adult kidney, and how to assess kidney malformation and disease. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Kidney Development: Methods and Protocols seeks to aid scientists in the further study of the process of morphogenesis which is fundamental important not only for studying developmental biology but also for regenerative medicine.

Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 448 pages
File Size : 47,7 Mb
Release : 1999-09-15
Category : Technology & Engineering
ISBN : 9780309172813

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The Role of Protein and Amino Acids in Sustaining and Enhancing Performance by Institute of Medicine,Committee on Military Nutrition Research Pdf

It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.

Author : Neal Halfon,Christopher B. Forrest,Richard M. Lerner,Elaine M. Faustman
Publisher : Springer
Page : 667 pages
File Size : 49,8 Mb
Release : 2017-11-20
Category : Medical
ISBN : 9783319471433

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Handbook of Life Course Health Development by Neal Halfon,Christopher B. Forrest,Richard M. Lerner,Elaine M. Faustman Pdf

This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Author : Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa
Publisher : Springer Science & Business Media
Page : 2059 pages
File Size : 42,6 Mb
Release : 2009-08-20
Category : Medical
ISBN : 9783540763277

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Pediatric Nephrology by Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa Pdf

Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Author : Linda M. Ernst,Eduardo D. Ruchelli,Chrystalle Katte Carreon,Dale S. Huff
Publisher : Springer Nature
Page : 445 pages
File Size : 42,5 Mb
Release : 2019-08-31
Category : Medical
ISBN : 9783030114251

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Color Atlas of Human Fetal and Neonatal Histology by Linda M. Ernst,Eduardo D. Ruchelli,Chrystalle Katte Carreon,Dale S. Huff Pdf

The first edition of Color Atlas of Fetal and Neonatal Histology was an important step in updating the histology texts available to practicing pathologists and pathology trainees who perform fetal autopsy and/or participate in research involving fetal tissues. It was a well-received volume that filled a major gap in pathology references related to normal histology and provided a comprehensive, state-of-the art review of fetal and neonatal histology. While the basics of fetal histology have changed little in the intervening years since publication of the first edition, this successor edition provides new insights and a fresh perspective. This book contains six new chapters including: blood vessels and lymphatics, external genitalia, eye, ear, skin, and maceration changes. Many existing chapters have also been expanded to address a greater breadth of fetal and neonatal histology such as postnatal testis development and the cardiac conduction system. The “Special Considerations” sections were also expanded in many chapters to address particularly problematic issues within individual organ systems. The book reviews the histology of the major organ systems in the fetus and neonate and provides detailed images, up-to-date references, and practical guidelines for identifying tissues across all gestational ages of development. The second edition of Color Atlas of Fetal and Neonatal Histology serves as the ultimate go-to resource for pathologists and researchers dealing with, and interested in, fetal and neonatal histology. It provides a comprehensive summary of the current status of the field with excellent and extensive illustrative examples that help guide the clinical study of fetal and neonatal histology and stimulate investigative efforts with fetal tissue.

Author : Z.-H. Liui,J.C. He
Publisher : Karger Medical and Scientific Publishers
Page : 274 pages
File Size : 46,7 Mb
Release : 2014-05-16
Category : Science
ISBN : 9783318026511

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Podocytopathy by Z.-H. Liui,J.C. He Pdf

The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Author : K.J. Barteczko,M.I. Jacob
Publisher : Springer Science & Business Media
Page : 116 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642583537

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The Testicular Descent in Human by K.J. Barteczko,M.I. Jacob Pdf

The testicular descent (descensus testis) is described in a complete series of human material from stage 14 CC to the adult state by using own phases. Central points of interest in this work are answers to questions which have been discussed controversially by generations of scientists and which are wrong or inadequately documented in most textbooks of embryology: Does an inner gonadal descent exist? What about origin, role and fate of gubernaculum H., processus vaginalis peritonei and gonadal ligaments? How do the annexes of testis come into their final position? The results are based on serial sections, scanning electron microscopy, three-dimensional reconstructions, microdissection and immunohistochemistry.

Author : Seppo Vainio
Publisher : Humana Press
Page : 248 pages
File Size : 40,7 Mb
Release : 2019-02-13
Category : Science
ISBN : 1493990209

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Kidney Organogenesis by Seppo Vainio Pdf

This book details protocols on classical methods and very modern ex vivo mammalian developmental kidney model systems. Chapters focus on generation of mosaic embryonic kidneys, culture of the kidney tissues ex vivo, embryonic kidney progenitor cell, 3Dkidney model cell line based cultures, programming the kidney cell fates in human pluripotent cells, protocols to target the functional players in kidney ontogenesis, 4D and 3D ex vivo imaging, drosphila, and computational approaches to kidney ontogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Organogenesis: Methods and Protocols aims to ensure successful results in the further study of this vital field.