Lantibiotics As Alternative Therapeutics

Author : Sanket Joshi,Rajiv K. Kar,Dibyajit Lahiri,Moupriya Nag
Publisher : Elsevier
Page : 524 pages
File Size : 40,8 Mb
Release : 2023-02-17
Category : Medical
ISBN : 9780323991421

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Lantibiotics as Alternative Therapeutics by Sanket Joshi,Rajiv K. Kar,Dibyajit Lahiri,Moupriya Nag Pdf

Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections. Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences. Includes the biology, molecular interaction with target molecule, putative genes and analytical techniques to isolate and identify compounds Incorporates relevant case studies to increase understanding Focuses on recent trends on novel antimicrobial agents and antibiotic resistance research Discusses new arena of diseases, apart from acute and chronic infections

Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
Page : 656 pages
File Size : 42,9 Mb
Release : 2017-11-16
Category : Technology & Engineering
ISBN : 9780081007426

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Peptide Applications in Biomedicine, Biotechnology and Bioengineering by Sotirios Koutsopoulos Pdf

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Author : Tavan Janvilisri,Joseph A. Sorg,Joy Scaria,Michael J. Sadowsky
Publisher : Frontiers Media SA
Page : 131 pages
File Size : 45,5 Mb
Release : 2019-09-20
Category : Electronic
ISBN : 9782889630240

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Alternative Therapeutic Approaches for Multidrug Resistant Clostridium difficile by Tavan Janvilisri,Joseph A. Sorg,Joy Scaria,Michael J. Sadowsky Pdf

Clostridium difficile infection (CDI) is among the leading causes of infectious diarrhea among patients in hospitals. Multidrug resistance in C. difficile continues to plague antimicrobial chemotherapy of CDI, posing a major cause of concerns within healthcare and hospital environments. Hence, there is an urgent need for alternative therapeutic approaches for multidrug resistant C. difficile.

Author : Grewal, Ajmer Singh,Dhingra, Ashwani Kumar,Nepali, Kunal,Deswal, Geeta,Srivastav, Arun Lal
Publisher : IGI Global
Page : 442 pages
File Size : 44,7 Mb
Release : 2024-03-25
Category : Medical
ISBN : 9798369341407

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Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons by Grewal, Ajmer Singh,Dhingra, Ashwani Kumar,Nepali, Kunal,Deswal, Geeta,Srivastav, Arun Lal Pdf

The rise of modern antimicrobial drug resistance has evolved into a pressing global health crisis, challenging the very foundation of our ability to combat infectious diseases. The overuse and accessibility of antibiotics, particularly in emerging nations, have given rise to resilient "superbugs," rendering common medications ineffective. This escalating challenge poses a significant threat to public health and leads to heightened healthcare costs, prolonged patient stays, and increased mortality rates. As communities grapple with the urgent need for a coordinated response, a comprehensive understanding of antimicrobial drug resistance and innovative strategies becomes paramount. Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons is meticulously crafted for academic scholars, researchers, and healthcare professionals. It addresses this critical issue head-on and serves as a beacon of knowledge and a solution-oriented guide. With a focus on elucidating the mechanisms behind antimicrobial drug resistance and exploring emerging therapeutic targets, the book presents an in-depth analysis of the problem. It spans environmental, genetic, and climatic factors influencing resistance, delving into cutting-edge technologies and sustainable strategies for prevention. By offering a holistic view of the issue and proposing evidence-based solutions, the book is an indispensable resource for those seeking to navigate the complex landscape of antimicrobial drug resistance.

Author : Swapan K. Ray
Publisher : Springer Nature
Page : 642 pages
File Size : 43,5 Mb
Release : 2024-06-17
Category : Electronic
ISBN : 9781071636626

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Neuroprotection by Swapan K. Ray Pdf

Author : David Whitehouse,Ralph Rapley
Publisher : John Wiley & Sons
Page : 331 pages
File Size : 45,8 Mb
Release : 2012-02-17
Category : Science
ISBN : 9781119967804

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Molecular and Cellular Therapeutics by David Whitehouse,Ralph Rapley Pdf

Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.

Author : Thomas J. Dougherty,Michael J. Pucci
Publisher : Springer Science & Business Media
Page : 1119 pages
File Size : 47,8 Mb
Release : 2011-12-18
Category : Medical
ISBN : 9781461414001

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Antibiotic Discovery and Development by Thomas J. Dougherty,Michael J. Pucci Pdf

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Author : Guangshun Wang
Publisher : CABI
Page : 286 pages
File Size : 48,5 Mb
Release : 2017-09-01
Category : Medical
ISBN : 9781786390394

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Antimicrobial Peptides by Guangshun Wang Pdf

Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.

Author : Kieran Tuohy,Daniele Del Rio
Publisher : Academic Press
Page : 268 pages
File Size : 55,7 Mb
Release : 2014-08-04
Category : Technology & Engineering
ISBN : 9780124079410

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Diet-Microbe Interactions in the Gut by Kieran Tuohy,Daniele Del Rio Pdf

Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development. One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations

Author : Iqbal Ahmad,Farrukh Aqil
Publisher : John Wiley & Sons
Page : 322 pages
File Size : 55,5 Mb
Release : 2008-11-21
Category : Science
ISBN : 9783527622948

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New Strategies Combating Bacterial Infection by Iqbal Ahmad,Farrukh Aqil Pdf

Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete and comprehensive coverage of topics relevant to new antibacterial drugs. This ready reference and handbook adopts a novel approach, focusing on combating multi-drug resistance in bacteria by developing antibacterials with new target sites, using new advances in drug discovery as well as natural products. Divided into three sections, the first describes the problem of drug resistance and the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non-antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of probiotics in bacterial infections. Invaluable to students of medicine, pharmaceutical sciences, phytomedicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.

Author : Chukwuebuka Egbuna,Abhay Prakash Mishra,Megh R. Goyal
Publisher : Academic Press
Page : 574 pages
File Size : 54,5 Mb
Release : 2020-11-03
Category : Business & Economics
ISBN : 9780128202852

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Preparation of Phytopharmaceuticals for the Management of Disorders by Chukwuebuka Egbuna,Abhay Prakash Mishra,Megh R. Goyal Pdf

Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals, nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals, their history, and current highlights in phytomedicine. Also included are classifications of crude drugs, herbal remedies and toxicity, traditional and alternative systems of medicine, nanotechnology applications, and herbal cosmeticology. Final sections cover applications of microbiology and biotechnology in drug discovery. This book provides key information for everyone interested in drug discovery, including medicinal chemists, nutritionists, biochemists, toxicologists, drug developers and health care professionals. Students, professors and researchers working in the area of pharmaceutical sciences and beyond will also find the book useful. Includes the history and current highlights in phytomedicine, along with classifications of crude drugs, herbal drug technologies and herbal cosmeticology Provides detailed information on herbal remedies and toxicity, traditional and alternative systems of medicine, and applications of microbiology and biotechnology in drug discovery Discusses the nutritional and health benefits of nutraceuticals and how they help in the management and treatment of metabolic diseases

Author : Valerie Edwards-Jones
Publisher : Elsevier Inc. Chapters
Page : 296 pages
File Size : 40,7 Mb
Release : 2013-05-24
Category : Medical
ISBN : 9780128066720

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Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components by Valerie Edwards-Jones Pdf

The global increase in antimicrobial resistance has led to renewed interest in alternative antimicrobial treatment strategies. Research is being done into a wide range of possible treatment regimens, including phage therapy, novel vaccines, and novel peptides, to name a few. Many microbiologists continue to lobby their governments to ensure that the available antibiotics are retained for the treatment of serious infections and their inappropriate use is stopped. In addition, large pharmaceutical companies are being encouraged to develop new treatments for the future. Much research now focuses on medicinal plants and essential oils. These and other alternative approaches are outlined in this chapter.

Author : Djamel Drider,Sylvie Rebuffat
Publisher : Springer Science & Business Media
Page : 451 pages
File Size : 55,6 Mb
Release : 2011-03-08
Category : Science
ISBN : 9781441976925

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Prokaryotic Antimicrobial Peptides by Djamel Drider,Sylvie Rebuffat Pdf

The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.

Author : Ivan Mijakovic,Christophe Grangeasse,Jörg Stülke
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 55,6 Mb
Release : 2015-07-22
Category : Electronic book
ISBN : 9782889196104

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Regulatory potential of post-translational modifications in bacteria by Ivan Mijakovic,Christophe Grangeasse,Jörg Stülke Pdf

Post-translational modifications (PTMs) are widely employed by all living organisms to control the enzymatic activity, localization or stability of proteins on a much shorter time scale than the transcriptional control. In eukarya, global analyses consistently reveal that proteins are very extensively phosphorylated, acetylated and ubiquitylated. Glycosylation and methylation are also very common, and myriad other PTMs, most with a proven regulatory potential, are being discovered continuously. The emergent picture is that PTM sites on a single protein are not independent; modification of one residue often affects (positively or negatively) modification of other sites on the same protein. The best example of this complex behavior is the histone “bar-code” with very extensive cross-talk between phosphorylation, acetylation and methylation sites. Traditionally it was believed that large networks of PTMs exist only in complex eukaryal cells, which exploit them for coordination and fine-tuning of various cellular functions. PTMs have also been detected in bacteria, but the early examples focused on a few important regulatory events, based mainly on protein phosphorylation. The global importance (and abundance) of PTMs in bacterial physiology was systematically underestimated. In recent years, global studies have reported large datasets of phosphorylated, acetylated and glycosylated proteins in bacteria. Other modifications of bacterial proteins have been recently described: pupylation, methylation, sirtuin acetylation, lipidation, carboxylation and bacillithiolation. As the landscape of PTMs in bacterial cells is rapidly expanding, primarily due to advances of detection methods in mass spectrometry, our research field is adapting to comprehend the potential impact of these modifications on the cellular physiology. The field of protein phosphorylation, especially of the Ser/Thr/Tyr type, has been profoundly transformed. We have become aware that bacterial kinases phosphorylate many protein substrates and thus constitute regulatory nodes with potential for signal integration. They also engage in cross-talk and eukaryal-like mutual activation cascades. The regulatory potential of protein acetylation and glycosylation in bacteria is also rapidly emerging, and the cross-talk between acetylation and phosphorylation has been documented. This topic deals with the complexity of the PTM landscape in bacteria, and focus in particular on the physiological roles that PTMs play and methods to study them. The topic is associated to the 1st International Conference on Post-Translational Modifications in Bacteria (September 9-10, 2014, Göttingen, Germany).

Author : Mahendra Rai,Kateryna Kon
Publisher : Academic Press
Page : 291 pages
File Size : 48,5 Mb
Release : 2013-05-24
Category : Science
ISBN : 9780124017085

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Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components by Mahendra Rai,Kateryna Kon Pdf

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more