Neuroprotection

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The Handbook of Neuroprotection

Kewal K. Jain
The Handbook of Neuroprotection Book PDF

Author : Kewal K. Jain
Publisher : Humana
Page : 0 pages
File Size : 54,7 Mb
Release : 2020-08-14
Category : Medical
ISBN : 1493994670

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The Handbook of Neuroprotection by Kewal K. Jain Pdf

This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

The Handbook of Neuroprotection

Kewal K. Jain
The Handbook of Neuroprotection Book PDF

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 46,8 Mb
Release : 2011-02-14
Category : Medical
ISBN : 9781617790492

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The Handbook of Neuroprotection by Kewal K. Jain Pdf

Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Neuroprotection in Alzheimer's Disease

Illana Gozes
Neuroprotection in Alzheimer s Disease Book PDF

Author : Illana Gozes
Publisher : Academic Press
Page : 342 pages
File Size : 40,6 Mb
Release : 2016-12-30
Category : Medical
ISBN : 9780128037126

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Neuroprotection in Alzheimer's Disease by Illana Gozes Pdf

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Oxidative Stress and Neuroprotection

S.H. Parvez,Peter Riederer
Oxidative Stress and Neuroprotection Book PDF

Author : S.H. Parvez,Peter Riederer
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 49,7 Mb
Release : 2006-12-26
Category : Medical
ISBN : 9783211333280

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Oxidative Stress and Neuroprotection by S.H. Parvez,Peter Riederer Pdf

This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson’s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson’s therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.

Neuroprotection

Raymond Chuen-Chung Chang,Yuen-Shan Ho
Neuroprotection Book PDF

Author : Raymond Chuen-Chung Chang,Yuen-Shan Ho
Publisher : BoD – Books on Demand
Page : 104 pages
File Size : 45,6 Mb
Release : 2019-08-28
Category : Medical
ISBN : 9781789847369

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Neuroprotection by Raymond Chuen-Chung Chang,Yuen-Shan Ho Pdf

Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.

Molecular Aspects of Neurodegeneration and Neuroprotection

Akhlaq A. Farooqui,Tahira Farooqui
Molecular Aspects of Neurodegeneration and Neuroprotection Book PDF

Author : Akhlaq A. Farooqui,Tahira Farooqui
Publisher : Bentham Science Publishers
Page : 156 pages
File Size : 44,8 Mb
Release : 2011-01-26
Category : Science
ISBN : 9781608050925

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Molecular Aspects of Neurodegeneration and Neuroprotection by Akhlaq A. Farooqui,Tahira Farooqui Pdf

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Discovery and Development of Neuroprotective Agents from Natural Products

Goutam Brahmachari
Discovery and Development of Neuroprotective Agents from Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 490 pages
File Size : 52,7 Mb
Release : 2017-05-18
Category : Science
ISBN : 9780128097694

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Discovery and Development of Neuroprotective Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

CNS Neuroprotection

Frank W. Marcoux,Dennis W. Choi
CNS Neuroprotection Book PDF

Author : Frank W. Marcoux,Dennis W. Choi
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 40,5 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783662062746

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CNS Neuroprotection by Frank W. Marcoux,Dennis W. Choi Pdf

"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr.

Neuroprotection Methods and Protocols

Tiziana Borsello
Neuroprotection Methods and Protocols Book PDF

Author : Tiziana Borsello
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 53,6 Mb
Release : 2007-08-08
Category : Medical
ISBN : 9781588296665

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Neuroprotection Methods and Protocols by Tiziana Borsello Pdf

This book examines current research into the role of neuronal death in cell signaling pathways, and its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. After introducing neurodegenerative, traumatic, and ishemic disorders, the authors cover in vitro and animal systems, and cellular and molecular mechanisms.

Natural Molecules in Neuroprotection and Neurotoxicity

Marcos Roberto de Oliveira
Natural Molecules in Neuroprotection and Neurotoxicity Book PDF

Author : Marcos Roberto de Oliveira
Publisher : Elsevier
Page : 2202 pages
File Size : 44,8 Mb
Release : 2023-11-24
Category : Science
ISBN : 9780443237645

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Natural Molecules in Neuroprotection and Neurotoxicity by Marcos Roberto de Oliveira Pdf

Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This book is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection. Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This book provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease. Covers both neuroprotective and neurotoxic outcomes resulted from the exposure of brain cells to natural molecules Analyzes numerous natural compounds, including animal, vegetal, fungal, bacterial, and marine-derived molecules Discusses the effects of the metabolism of microbiota on the biotransformation of natural molecules and the consequences of these processes on brain cells Contains a section focused on the nanotechnology-related strategies utilized to enhance the bioavailability of natural molecules to brain cells

Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection

Carlo Nucci,Luciano Cerulli,Neville N. Osborne,Giacinto Bagetta
Glaucoma An Open Window to Neurodegeneration and Neuroprotection Book PDF

Author : Carlo Nucci,Luciano Cerulli,Neville N. Osborne,Giacinto Bagetta
Publisher : Newnes
Page : 639 pages
File Size : 42,5 Mb
Release : 2008-11-05
Category : Medical
ISBN : 9780080932804

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Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection by Carlo Nucci,Luciano Cerulli,Neville N. Osborne,Giacinto Bagetta Pdf

Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS), leading researchers to look at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS. This book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma. Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols Discusses new strategies for the prevention of neuronal injury in glaucoma patients Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma

New Perspectives of Central Nervous System Injury and Neuroprotection

Hari Shanker Sharma
New Perspectives of Central Nervous System Injury and Neuroprotection Book PDF

Author : Hari Shanker Sharma
Publisher : Academic Press
Page : 420 pages
File Size : 45,9 Mb
Release : 2012-07-10
Category : Medical
ISBN : 9780123869869

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New Perspectives of Central Nervous System Injury and Neuroprotection by Hari Shanker Sharma Pdf

Annotation Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Reviews written by experts in such a way thatprovides basic knowledge for beginners and advanced information for researchers and experts. New aspects of Neurodegenerative diseasessuch as;Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis are presented with thelatest therapeutic measures. Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time.

Molecular and Cellular Biology of Neuroprotection in the CNS

Christian Alzheimer
Molecular and Cellular Biology of Neuroprotection in the CNS Book PDF

Author : Christian Alzheimer
Publisher : Springer Science & Business Media
Page : 507 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461501237

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Molecular and Cellular Biology of Neuroprotection in the CNS by Christian Alzheimer Pdf

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

Neuropeptides in Neuroprotection and Neuroregeneration

Fred Nyberg
Neuropeptides in Neuroprotection and Neuroregeneration Book PDF

Author : Fred Nyberg
Publisher : CRC Press
Page : 319 pages
File Size : 48,6 Mb
Release : 2012-06-19
Category : Medical
ISBN : 9781439830635

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Neuropeptides in Neuroprotection and Neuroregeneration by Fred Nyberg Pdf

Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

Neuroprotection in Autism, Schizophrenia and Alzheimer's disease

Illana Gozes,Joseph Levine
Neuroprotection in Autism Schizophrenia and Alzheimer s disease Book PDF

Author : Illana Gozes,Joseph Levine
Publisher : Academic Press
Page : 322 pages
File Size : 49,5 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128140383

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Neuroprotection in Autism, Schizophrenia and Alzheimer's disease by Illana Gozes,Joseph Levine Pdf

Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer’s disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry