Laron Syndrome From Man To Mouse

Author : Zvi Laron,J. Kopchick
Publisher : Springer Science & Business Media
Page : 531 pages
File Size : 54,6 Mb
Release : 2010-11-25
Category : Medical
ISBN : 9783642111839

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Laron Syndrome - From Man to Mouse by Zvi Laron,J. Kopchick Pdf

Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

Author : Anonim
Publisher : Unknown
Page : 531 pages
File Size : 51,5 Mb
Release : 2011
Category : HEALTH & FITNESS
ISBN : OCLC:839308998

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Laron Syndrome - from Man to Mouse by Anonim Pdf

Author : Eduardo A. Nillni
Publisher : Springer
Page : 378 pages
File Size : 44,8 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9783319895062

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Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function by Eduardo A. Nillni Pdf

This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.

Author : Nathan A. Berger
Publisher : Springer
Page : 295 pages
File Size : 54,6 Mb
Release : 2015-06-19
Category : Medical
ISBN : 9783319167336

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Murine Models, Energy Balance, and Cancer by Nathan A. Berger Pdf

This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.

Author : Anonim
Publisher : Academic Press
Page : 1656 pages
File Size : 47,6 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9780128160763

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Encyclopedia of Biomedical Gerontology by Anonim Pdf

Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Author : Derek LeRoith
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 41,9 Mb
Release : 2011-09-18
Category : Medical
ISBN : 9781461405986

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Insulin-like Growth Factors and Cancer by Derek LeRoith Pdf

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

Author : Martin O. Savage
Publisher : Unknown
Page : 9 pages
File Size : 43,7 Mb
Release : 1996
Category : Insulin-like growth factor-binding proteins
ISBN : 0702020931

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Growth Hormone Resistance by Martin O. Savage Pdf

Examining growth hormone resistance, this text includes coverage of such topics as: growth hormone receptor signalling; metabolic actions of growth hormone - direct and indirect; and IGF bioactivity and its modification in growth hormone resistance in childhood.

Author : Norman Lavin
Publisher : Lippincott Williams & Wilkins
Page : 986 pages
File Size : 41,5 Mb
Release : 2018-03-13
Category : Medical
ISBN : 9781975107314

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Manual of Endocrinology and Metabolism by Norman Lavin Pdf

Ideal for all health care professionals who evaluate, diagnose, treat, or refer patients with endocrine disease or disorders, Manual of Endocrinology and Metabolism, Fifth Edition, brings together nearly 150 global authorities who share their knowledge and expertise on endocrine disorders in children, adolescents, and adults. Using a concise outline format, this thoroughly updated manual presents clinical information and protocols needed in everyday practice, with an emphasis on diagnosis and treatment. Succinct chapters and an abundance of tables and diagrams make complex information easy to find and understand.

Author : Isabel Varela-Nieto,Julie Ann Chowen
Publisher : Springer Science & Business Media
Page : 420 pages
File Size : 48,7 Mb
Release : 2005-12-17
Category : Medical
ISBN : 9780387262741

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The Growth Hormone/Insulin-Like Growth Factor Axis during Development by Isabel Varela-Nieto,Julie Ann Chowen Pdf

Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.

Author : Zvi Laron,John S. Parks
Publisher : Karger Medical and Scientific Publishers
Page : 384 pages
File Size : 45,5 Mb
Release : 1993-01-01
Category : Medical
ISBN : 3805556713

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Lessons from Laron Syndrome (LS) 1966-1992 by Zvi Laron,John S. Parks Pdf

Laron Syndrome (LS) is a disease characterized by resistance to growth hormone (GH) and caused by molecular defects of the GH receptor, leading to a deficiency of insulin-like growth factor-1 (IGF-1) and a significant impairment of growth. The syndrome is a unique human model of a peptide hormone receptor defect and GH-IGF-1 interaction. It offers the opportunity to study the consequences of long-term IGF-1 deficiency and the role of IGF-1 in growth and metabolism. With the recent biosynthesis of IGF-1 and the initiation of IGF-1 therapy, a whole new world of basic biological interactions is opening up. This volume brings together leading researchers in genetics, endocrinology, pediatrics, biochemistry, physiology and pharmacology to summarize what is now known about LS, and to discuss the lessons learned from studying and treating this disease since its initial description in 1966. Special features include the demography of LS, and the first data on the long-term IGF-1 treatment of a large group of patients.

Author : Mariusz Z. Ratajczak
Publisher : Springer Nature
Page : 410 pages
File Size : 41,5 Mb
Release : 2020-01-02
Category : Science
ISBN : 9783030312060

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Stem Cells by Mariusz Z. Ratajczak Pdf

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 46,5 Mb
Release : 2005-06-10
Category : Medical
ISBN : 9780470869994

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Biology of IGF-1 by Gregory R. Bock,Jamie A. Goode Pdf

An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as: the definition of danger zones the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin possible approaches to preventative intervention the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.

Author : Siegfried Hekimi
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783540480037

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The Molecular Genetics of Aging by Siegfried Hekimi Pdf

The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Author : J. Larry Jameson,Leslie J. De Groot
Publisher : Elsevier Health Sciences
Page : 2700 pages
File Size : 40,6 Mb
Release : 2015-02-25
Category : Medical
ISBN : 9780323321952

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Endocrinology: Adult and Pediatric E-Book by J. Larry Jameson,Leslie J. De Groot Pdf

Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Consult this title on your favorite e-reader.

Author : Anonim
Publisher : Academic Press
Page : 496 pages
File Size : 49,9 Mb
Release : 1995-03-15
Category : Science
ISBN : 0080866476

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Vitamins and Hormones by Anonim Pdf

Under the editorial leadership of Dr Gerald Litwack, Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others interested in the structure and function of biologically active molecules, like hormones and vitamins, will increasingly turn to this successful series for comprehensive reviews by leading contributors to this and related disciplines.