Lectures On Statistical Physics And Protein Folding

Author : Kerson Huang
Publisher : World Scientific
Page : 159 pages
File Size : 47,5 Mb
Release : 2005
Category : Science
ISBN : 9789812561435

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Lectures on Statistical Physics and Protein Folding by Kerson Huang Pdf

This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestion on possible research directions, as developed by the author in collaboration with C. C. Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.

Author : Alexei V. Finkelstein,Oleg Ptitsyn
Publisher : Elsevier
Page : 528 pages
File Size : 40,9 Mb
Release : 2016-06-22
Category : Science
ISBN : 9780081012369

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Protein Physics by Alexei V. Finkelstein,Oleg Ptitsyn Pdf

Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

Author : Hamid Arabnia,Quoc-Nam Tran
Publisher : Springer Science & Business Media
Page : 776 pages
File Size : 50,5 Mb
Release : 2011-03-23
Category : Science
ISBN : 9781441970466

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Software Tools and Algorithms for Biological Systems by Hamid Arabnia,Quoc-Nam Tran Pdf

“Software Tools and Algorithms for Biological Systems" is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational biology and software tools. Also, selected authors of accepted papers of BIOCOMP’09 proceedings (International Conference on Bioinformatics and Computational Biology: July 13-16, 2009; Las Vegas, Nevada, USA) were invited to submit the extended versions of their papers for evaluation.

Author : Sauro Succi
Publisher : Oxford University Press
Page : 401 pages
File Size : 54,5 Mb
Release : 2022
Category : Biocomplexity
ISBN : 9780192897893

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Sailing the Ocean of Complexity by Sauro Succi Pdf

"Both superb and essential... Succi, with clarity and wit, takes us from quarks and Boltzmann to soft matter - precisely the frontier of physics and life." Stuart Kauffman, MacArthur Fellow, Fellow of the Royal Society of Canada, Gold Medal Accademia Lincea We live in a world of utmost complexity, outside and within us. There are thousand of billions of billions of stars out there in the Universe, a hundred times more molecules in a glass of water, and another hundred times more in our body, all working in sync to keep us alive and well. At face value, such numbers spell certain doom for our ability to make any sense at all of the world around and within us. And yet, they don't. Why, and how - this book endeavours to provide an answer to these questions with specific reference to a selected window of the physics-biology interface. The story unfolds over four main Parts. Part I provides an introduction to the main organizational principles which govern the functioning of complex systems in general, such as nonlinearity, nonlocality and ultra-dimensions. Part II deals with thermodynamics, the science of change, starting with its historical foundations laid down in the 19th century, and then moving on to its modern and still open developments in connection with biology and cosmology. Part III deals with the main character of this book, free energy, and the wondrous scenarios opened up by its merger with the modern tools of statistical physics. It also describes the basic facts about soft matter, the state of matter most relevant to biological organisms. Finally, Part IV discusses the connection between time and complexity, and its profound implications on the human condition, i.e. the one-sided nature of time and the awareness of human mortality. It concludes with a few personal considerations about the special place of emotions and humility in science.

Author : Giovanni Naldi,Lorenzo Pareschi,Giuseppe Toscani
Publisher : Springer Science & Business Media
Page : 437 pages
File Size : 44,6 Mb
Release : 2010-08-12
Category : Mathematics
ISBN : 9780817649463

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Mathematical Modeling of Collective Behavior in Socio-Economic and Life Sciences by Giovanni Naldi,Lorenzo Pareschi,Giuseppe Toscani Pdf

Using examples from finance and modern warfare to the flocking of birds and the swarming of bacteria, the collected research in this volume demonstrates the common methodological approaches and tools for modeling and simulating collective behavior. The topics presented point toward new and challenging frontiers of applied mathematics, making the volume a useful reference text for applied mathematicians, physicists, biologists, and economists involved in the modeling of socio-economic systems.

Author : Weibo Cai,Hao Hong
Publisher : BoD – Books on Demand
Page : 488 pages
File Size : 52,6 Mb
Release : 2012-03-30
Category : Science
ISBN : 9789535103974

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Protein-Protein Interactions by Weibo Cai,Hao Hong Pdf

Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Author : Giancarlo Franzese,Miguel Rubi
Publisher : Springer
Page : 233 pages
File Size : 48,7 Mb
Release : 2008-12-02
Category : Science
ISBN : 9783540787655

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Aspects of Physical Biology by Giancarlo Franzese,Miguel Rubi Pdf

The application to Biology of the methodologies developed in Physics is attracting an increasing interest from the scientific community. It has led to the emergence of a new interdisciplinary field, called Physical Biology, with the aim of reaching a better understanding of the biological mechanisms at molecular and cellular levels. Statistical Mechanics in particular plays an important role in the development of this new field. For this reason, the XXth session of the famous Sitges Conference on Statistical Physics was dedicated to "Physical Biology: from Molecular Interactions to Cellular Behavior". As is by now tradition, a number of lectures were subsequently selected, expanded and updated for publication as lecture notes, so as to provide both a state-of-the-art introduction and overview to a number of subjects of broader interest and to favor the interchange and cross-fertilization of ideas between biologists and physicists. The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.

Author : Sebastian Doniach
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 49,9 Mb
Release : 2013-11-22
Category : Science
ISBN : 9781489913494

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Statistical Mechanics, Protein Structure, and Protein Substrate Interactions by Sebastian Doniach Pdf

A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 49,7 Mb
Release : 2024-05-12
Category : Electronic
ISBN : 9789814471299

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BIOMAT 2007 by Anonim Pdf

Author : Rubem Mondaini
Publisher : World Scientific
Page : 406 pages
File Size : 44,5 Mb
Release : 2008
Category : Science
ISBN : 9789812812322

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BIOMAT 2007 by Rubem Mondaini Pdf

The present volume contains the contributions of the keynote speakers of the BIOMAT 2007 Symposium as well as selected contributed papers in the areas of mathematical biology, biological physics, biophysics and bioinformatics. It contains new results on some aspects of Lotka?Volterra equations, the proposal of using differential geometry to model neurosurgical tools, recent data on epidemiological modeling, pattern recognition and comprehensive reviews on the structure of proteins, the folding problem and the influence of Allee effects on population dynamics.This book contains some original results on the growth of gliomas: the role played by membrane channels on activity-dependent modulation of spike transmission; a proposal for reconsidering the concept of gene and the understanding of the mechanisms responsible for gene expression; a differential geometric approach to the influence of the drying effect on the dynamics of pods of Leguminosae; the comparison of agent-based models with the approach of differential equations on the study of selection mechanisms in germinal centers; and the synchronization phenomenon for protocell systems driven by linear kinetic equations.

Author : Hwee Boon Low,Kok Khoo Phua,Chi Xiong
Publisher : #N/A
Page : 144 pages
File Size : 40,6 Mb
Release : 2017-07-14
Category : Science
ISBN : 9789813207448

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Memorial Volume For Kerson Huang by Hwee Boon Low,Kok Khoo Phua,Chi Xiong Pdf

Professor Kerson Huang was a well respected theoretical physicist, who was also well versed in English and Chinese literature. He was born in Nanning, China, on 15 March 1928, and he was a fellow at the IAS, Princeton, from 1955-1957 before joining the faculty of MIT. He remained there until he retired from teaching in 1999. His research in theoretical physics included works on Bose-Einstein condensation and quantum field theory. In his long and illustrious career, Prof. Huang has worked with many prominent physicists. In 1957, he published a theory known as the hard-sphere model for Bose gases with Nobel Laureates Chen-Ning Yang and Tsung-Dao Lee. With Noble Laureate Steven Weinberg, he studied the ultimate temperature and the thermodynamics of early universe. While he was at Princeton, he also worked with atomic bomb developer J. Robert Oppenheimer. In recently years, Prof. Huang had been a visiting professor at Nanyang Technological University in Singapore, and worked on both biophysics and quantum cosmology.This memorial volume is dedicated to Prof. Huang who passed away peacefully at home on September 1, 2016 at the age of 88. The volume features the recollections of Prof. Huang by his former colleagues and students, including Profs Chen-Ning Yang and Samuel Ting, as well as their reflections on Prof. Huang's achievements in the various subdivisions of physics.

Author : Jinjiang Li,Mary E. Krause,Raymond Tu
Publisher : Springer Nature
Page : 338 pages
File Size : 54,6 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9783030571771

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Protein Instability at Interfaces During Drug Product Development by Jinjiang Li,Mary E. Krause,Raymond Tu Pdf

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Author : Ali H. Sayed
Publisher : Cambridge University Press
Page : 1105 pages
File Size : 46,7 Mb
Release : 2022-11-30
Category : Computers
ISBN : 9781009218122

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Inference and Learning from Data by Ali H. Sayed Pdf

Discover core topics in inference and learning with the first volume of this extraordinary three-volume set.

Author : Andras Szasz,Nora Szasz,Oliver Szasz
Publisher : Springer Science & Business Media
Page : 575 pages
File Size : 54,8 Mb
Release : 2010-11-23
Category : Medical
ISBN : 9789048194988

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Oncothermia: Principles and Practices by Andras Szasz,Nora Szasz,Oliver Szasz Pdf

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.

Author : Din-Yu Hsieh,Weitao Sun,Meirong Zhang
Publisher : World Scientific
Page : 236 pages
File Size : 52,5 Mb
Release : 2007
Category : Mathematics
ISBN : 9789812770455

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Frontiers of Applied Mathematics by Din-Yu Hsieh,Weitao Sun,Meirong Zhang Pdf

This volume brings together articles on the mathematical aspects of life sciences, astrophysics, and nonlinear wave problems. It covers theoretical problems associated with the nervous system, drosophila embryos, protein folding, biopolymers, protoplanetary disks and extrasolar planets, gaseous disks, spiral galaxies, dark matter dynamics, star formation, solitary waves, photonics, and nonlinear light propagation in periodic media. The contributions are written for a general audience, and the authors have included references for further reading.