Protein Physics

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Protein Physics

Author : Alexei V. Finkelstein,Oleg Ptitsyn
Publisher : Elsevier
Page : 528 pages
File Size : 43,9 Mb
Release : 2016-06-22
Category : Science
ISBN : 9780081012369

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Protein Physics by Alexei V. Finkelstein,Oleg Ptitsyn Pdf

Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

Protein Physics

Author : Alexei V. Finkelstein,Oleg Borisovich Ptitsyn
Publisher : Academic Press
Page : 382 pages
File Size : 54,6 Mb
Release : 2002-05-14
Category : Medical
ISBN : 0122567811

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Protein Physics by Alexei V. Finkelstein,Oleg Borisovich Ptitsyn Pdf

"Covers the most general problems of protein structure, folding and function and introduces the concepts and theories. It deals with fibrous, membrane and especially water-soluble globular proteins, in both their native and denatured states. The book summarizes and presents in a systematic way the results of several decades of worldwide fundamental research on protein physics, structure and folding"--Back cover.

The Physics of Proteins

Author : Hans Frauenfelder
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 48,8 Mb
Release : 2010-05-30
Category : Science
ISBN : 9781441910448

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The Physics of Proteins by Hans Frauenfelder Pdf

Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding

Lectures on Statistical Physics and Protein Folding

Author : Kerson Huang
Publisher : World Scientific
Page : 160 pages
File Size : 50,8 Mb
Release : 2005-05-30
Category : Science
ISBN : 9789814481069

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Lectures on Statistical Physics and Protein Folding by Kerson Huang Pdf

' This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix. Contents:EntropyMaxwell–Boltzmann DistributionFree EnergyChemical PotentialPhase TransitionsKinetics of Phase TransitionsThe Order ParameterCorrelation FunctionStochastic ProcessesLangevin EquationThe Life ProcessSelf-AssemblyKinetics of Protein FoldingPower Laws in Protein FoldingSelf-Avoiding Walk and TurbulenceConvergent Evolution in Protein Folding Readership: Graduate students, researchers and academics interested in statistical physics and molecular biology. Keywords:Statistical Physics;Protein Folding;BiophysicsReviews:“My particularly favorite is the chapter on order parameters, explaining with simplicity and clarity this subject so frequently difficult and confusing for the beginning students … the book makes a strong attempt to place the protein folding problem where it really belongs — in the context of fundamental statistical mechanics. Whether the attempt is successful or not is a matter of a reader's opinion, but the very direction is both timely and welcome.”Professor Alexander Grosberg University of Minnesota '

Monte Carlo Methods in Chemical Physics

Author : David M. Ferguson,J. Ilja Siepmann,Donald G. Truhlar
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 46,8 Mb
Release : 2009-09-09
Category : Science
ISBN : 9780470142172

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Monte Carlo Methods in Chemical Physics by David M. Ferguson,J. Ilja Siepmann,Donald G. Truhlar Pdf

In Monte Carlo Methods in Chemical Physics: An Introduction to the Monte Carlo Method for Particle Simulations J. Ilja Siepmann Random Number Generators for Parallel Applications Ashok Srinivasan, David M. Ceperley and Michael Mascagni Between Classical and Quantum Monte Carlo Methods: "Variational" QMC Dario Bressanini and Peter J. Reynolds Monte Carlo Eigenvalue Methods in Quantum Mechanics and Statistical Mechanics M. P. Nightingale and C.J. Umrigar Adaptive Path-Integral Monte Carlo Methods for Accurate Computation of Molecular Thermodynamic Properties Robert Q. Topper Monte Carlo Sampling for Classical Trajectory Simulations Gilles H. Peslherbe Haobin Wang and William L. Hase Monte Carlo Approaches to the Protein Folding Problem Jeffrey Skolnick and Andrzej Kolinski Entropy Sampling Monte Carlo for Polypeptides and Proteins Harold A. Scheraga and Minh-Hong Hao Macrostate Dissection of Thermodynamic Monte Carlo Integrals Bruce W. Church, Alex Ulitsky, and David Shalloway Simulated Annealing-Optimal Histogram Methods David M. Ferguson and David G. Garrett Monte Carlo Methods for Polymeric Systems Juan J. de Pablo and Fernando A. Escobedo Thermodynamic-Scaling Methods in Monte Carlo and Their Application to Phase Equilibria John Valleau Semigrand Canonical Monte Carlo Simulation: Integration Along Coexistence Lines David A. Kofke Monte Carlo Methods for Simulating Phase Equilibria of Complex Fluids J. Ilja Siepmann Reactive Canonical Monte Carlo J. Karl Johnson New Monte Carlo Algorithms for Classical Spin Systems G. T. Barkema and M.E.J. Newman

Physics of Bio-Molecules and Cells

Author : Henrik Flyvbjerg,Frank Jülicher,Pal Ormos,Francois David
Publisher : Springer Science & Business Media
Page : 591 pages
File Size : 42,8 Mb
Release : 2003-07-01
Category : Science
ISBN : 9783540457015

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Physics of Bio-Molecules and Cells by Henrik Flyvbjerg,Frank Jülicher,Pal Ormos,Francois David Pdf

Aimed at those working to enter this rapidly developing field, this volume on biological physics is written in a pedagogical style by leading scientists giving explanations that take their starting point where any physicist can follow and end at the frontier of research in biological physics. These lectures describe the state-of-the-art physics of biomolecules and cells. In biological systems ranging from single biomolecules to entire cells and larger biological systems, it focuses on aspects that require concepts and methods from physics for their analysis and understanding, such as the mechanics of motor proteins; how the genetic code is physically read and managed; the machinery of protein--DNA interactions; force spectroscopy of biomolecules' velopes, cytoskeletons, and cytoplasms; polymerization forces; listeria propulsion; cell motility; lab-on-a-chip nanotechnology for single-molecule analysis of biomolecules; bioinformatics; and coding and computational strategies of the brain.

Soft Condensed Matter Physics in Molecular and Cell Biology

Author : W.C.K. Poon,David Andelman
Publisher : CRC Press
Page : 340 pages
File Size : 55,5 Mb
Release : 2006-01-13
Category : Science
ISBN : 9781420003338

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Soft Condensed Matter Physics in Molecular and Cell Biology by W.C.K. Poon,David Andelman Pdf

Soft condensed matter physics, which emerged as a distinct branch of physics in the 1990s, studies complex fluids: liquids in which structures with length scale between the molecular and the macroscopic exist. Polymers, liquid crystals, surfactant solutions, and colloids fall into this category. Physicists deal with properties of soft matter system

Proteins

Author : Charles L. Brooks,Martin Karplus,B. Montgomery Pettitt
Publisher : John Wiley & Sons
Page : 278 pages
File Size : 43,5 Mb
Release : 2009-09-08
Category : Science
ISBN : 9780470141816

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Proteins by Charles L. Brooks,Martin Karplus,B. Montgomery Pettitt Pdf

Presenting a wide-ranging view of current developments in protein research, the papers in this collection, each written by highly regarded experts in the field, examine various aspects of protein structure, functions, dynamics, and experimentation. Topics include dynamical simulation methods, the biological role of atom fluctuations, protein folding, influences on protein dynamics, and a variety of analytical techniques, such as X-ray diffraction, vibrational spectroscopy, photodissociation and rebinding kinetics. This is part of a series devoted to providing general information on a wide variety of topics in chemical physics in order to stimulate new research and to serve as a text for beginners in a particular area of chemical physics.

Physics of Charged Macromolecules

Author : Murugappan Muthukumar
Publisher : Cambridge University Press
Page : 523 pages
File Size : 44,6 Mb
Release : 2023-02-28
Category : Science
ISBN : 9780521864879

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Physics of Charged Macromolecules by Murugappan Muthukumar Pdf

A clear and intuitive introduction to the physics of charged macromolecules, from fundamentals to the latest research developments.

Protein Actions: Principles and Modeling

Author : Ivet Bahar,Robert L. Jernigan,Ken A. Dill
Publisher : Garland Science
Page : 336 pages
File Size : 40,8 Mb
Release : 2017-02-14
Category : Science
ISBN : 9781351815017

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Protein Actions: Principles and Modeling by Ivet Bahar,Robert L. Jernigan,Ken A. Dill Pdf

Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.

Physics in Molecular Biology

Author : Kim Sneppen,Giovanni Zocchi
Publisher : Cambridge University Press
Page : 328 pages
File Size : 50,6 Mb
Release : 2005-08-25
Category : Science
ISBN : 0521844193

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Physics in Molecular Biology by Kim Sneppen,Giovanni Zocchi Pdf

This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems.

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology

Author : Vladimir Uversky
Publisher : Academic Press
Page : 426 pages
File Size : 40,6 Mb
Release : 2019-09-15
Category : Electronic
ISBN : 9780128168516

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Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology by Vladimir Uversky Pdf

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Protein Structure

Author : Robert Austin,Ephraim Buhks,Britton Chance,Don De Vault,Paul L. Dutton,Hans Frauenfelder,Vitalli I. Gol'danskii
Publisher : Springer
Page : 515 pages
File Size : 55,9 Mb
Release : 2014-11-14
Category : Science
ISBN : 9781461247968

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Protein Structure by Robert Austin,Ephraim Buhks,Britton Chance,Don De Vault,Paul L. Dutton,Hans Frauenfelder,Vitalli I. Gol'danskii Pdf

This book is concerned with the physical aspects of molecular and electronic tunneling in biological systems, and the extent to which protein structure controls these events. The scope is very broad and this volume could almost be a textbook in biophysics. Both fundamental processes and the extrapolation to physiological events are stressed. The discussion sections are remarkably frank and offer insight into the basic problems confronting physists and chemists as they seek to apply their techniques to biological systems. This book on the physics of biomolecules reflects recent progress in understanding the biological function of the key protein molecules from detailed knowledge of their physics. New and exciting are the glasslike aspects of protein structures and the discussion of proteins as fractals. Other topics dealt with are low-temperature kinetics and reactivity, structure and charge exchange, and charge separation in photosynthetic reaction centers.

Biophysics of DNA-Protein Interactions

Author : Mark C. Williams,L. James Maher, III
Publisher : Springer Science & Business Media
Page : 354 pages
File Size : 47,9 Mb
Release : 2010-10-05
Category : Science
ISBN : 9780387928081

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Biophysics of DNA-Protein Interactions by Mark C. Williams,L. James Maher, III Pdf

Depite the rapid expansion of the field of biophysics, there are very few books that comprehensively treat specific topics in this area. Recently, the field of single molecule biophysics has developed very quickly, and a few books specifically treating single molecule methods are beginning to appear. However, the promise of single molecule biophysics is to contribute to the understanding of specific fields of biology using new methods. This book would focus on the specific topic of the biophysics of DNA-protein interactions, and would include the use of new approaches, including both bulk methods as well as single molecule methods. This would make the book attractive to anyone working in the general area of DNA-protein interactions, which is of course a much wider market than just single molecule biophysicists or even biophysicists. The subject of the book will be the biophysics of DNA-protein interactions, and will include new methods and results that describe the physical mechanism by which proteins interact with DNA. For example, there has been much recent work on the mechanism by which proteins search for specific binding sites on DNA. A few chapters will be devoted to experiments and theory that shed light on this important problem. We will also cover proteins that alter DNA properties to facilitate interactions important for transcription or replication. Another section of the book will cover the biophysical mechanism by which motor proteins interact with DNA. Finally, we will cover larger protein-DNA complexes, such as replication forks, recombination complexes, DNA repair interactions, and their chromatin context.

The Physics of Proteins

Author : Hans Frauenfelder
Publisher : Springer
Page : 448 pages
File Size : 50,6 Mb
Release : 2010-06-10
Category : Science
ISBN : 1441910433

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The Physics of Proteins by Hans Frauenfelder Pdf

Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding