Liquid Biopsy

Author : Seyed Mohammad Kazem Aghamir
Publisher : Academic Press
Page : 210 pages
File Size : 47,7 Mb
Release : 2022-01-30
Category : Science
ISBN : 9780323983976

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Liquid Biopsy in Urogenital Cancers and its Clinical Utility by Seyed Mohammad Kazem Aghamir Pdf

Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers. Presents an overview on liquid biopsy techniques and their applications in cancer diagnosis Explains how to extract circulating tumor DNA, RNA and circulating tumor cells and extracellular vehicles from blood samples to identify the urology cancers, including testis, prostate, bladder and kidney Includes several images and schematic diagrams that illustrate content and facilitate its comprehension

Author : Ilze Strumfa,Janis Gardovskis
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 48,6 Mb
Release : 2019-07-10
Category : Medical
ISBN : 9781838811297

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Liquid Biopsy by Ilze Strumfa,Janis Gardovskis Pdf

Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.

Author : Yujin Hoshida
Publisher : Springer
Page : 366 pages
File Size : 50,7 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9783030215408

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Hepatocellular Carcinoma by Yujin Hoshida Pdf

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Author : Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff
Publisher : Springer
Page : 368 pages
File Size : 43,8 Mb
Release : 2019-10-25
Category : Medical
ISBN : 3030264386

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Tumor Liquid Biopsies by Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff Pdf

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Author : Massimo Cristofanilli
Publisher : Humana
Page : 161 pages
File Size : 49,8 Mb
Release : 2018-05-08
Category : Medical
ISBN : 3319845306

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Liquid Biopsies in Solid Tumors by Massimo Cristofanilli Pdf

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.

Author : Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff
Publisher : Springer Nature
Page : 365 pages
File Size : 48,8 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9783030264390

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Tumor Liquid Biopsies by Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff Pdf

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Author : M.M. Bui,L. Pantanowitz
Publisher : Karger Medical and Scientific Publishers
Page : 120 pages
File Size : 47,5 Mb
Release : 2020-01-13
Category : Medical
ISBN : 9783318065763

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Modern Techniques in Cytopathology by M.M. Bui,L. Pantanowitz Pdf

In the era of precision medicine, physicians are increasingly in need of more definitive diagnostic, prognostic, and predictive information derived from small biopsy specimens such as cytology samples in order to guide effective patient care. Cytopathology is well poised to meet this challenge. Whilst the traditional cytomorphologic component of cytology practice is still valid, enormous advances have been made in the field of cytopathology thanks to transformative technology and innovative individuals that have augmented the cytologists' ability to meet the demands of modern medicine. The purpose of this book is to describe, illustrate, and review many of the most recent developments regarding modern techniques employed in cytopathology. This latest monograph is intended for all cytologists including cytopathologists, cytotechnologists, cytology lab assistants, trainees, research scientists, and anyone who is interested in the field of cytopathology. We have invited pioneering experts in their respective fields to author these chapters. This book is not only the culmination of their groundbreaking work and effort but also presents a critical review of the current literature. We have attempted to provide readers with an informative and comprehensive aid so that they may better appreciate how emerging technology has been applied to cytology. Each chapter in this book presents a stand-alone contemporary review of emerging topics in cytopathology. We hope that you will find this monograph thought-provoking and a valuable reference for your practice.

Author : Ludmilla Thomé Domingos Chinen
Publisher : Springer Nature
Page : 208 pages
File Size : 44,8 Mb
Release : 2021-05-31
Category : Medical
ISBN : 9783030698799

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Atlas of Liquid Biopsy by Ludmilla Thomé Domingos Chinen Pdf

This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting hundreds of cell images from patients with various types of cancer, in many different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at clinical and research laboratories, hospitals and research centers.

Author : Gloria Ravegnini,Ambra A. Grolla,Marzia Del Re,Sabrina Angelini,Ron H. van Schaik
Publisher : Frontiers Media SA
Page : 78 pages
File Size : 45,9 Mb
Release : 2020-12-10
Category : Science
ISBN : 9782889662029

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Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response by Gloria Ravegnini,Ambra A. Grolla,Marzia Del Re,Sabrina Angelini,Ron H. van Schaik Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Massimo Cristofanilli
Publisher : Humana Press
Page : 161 pages
File Size : 46,5 Mb
Release : 2017-03-25
Category : Medical
ISBN : 9783319509563

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Liquid Biopsies in Solid Tumors by Massimo Cristofanilli Pdf

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.

Author : Antonio Russo,Antonio Giordano,Christian Rolfo
Publisher : Humana Press
Page : 214 pages
File Size : 46,9 Mb
Release : 2017-07-26
Category : Medical
ISBN : 9783319556611

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Liquid Biopsy in Cancer Patients by Antonio Russo,Antonio Giordano,Christian Rolfo Pdf

This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.

Author : Janis Gardovskis,Ilze Strumfa
Publisher : Unknown
Page : 158 pages
File Size : 55,6 Mb
Release : 2019
Category : Medicine (General)
ISBN : 1838811311

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Liquid Biopsy by Janis Gardovskis,Ilze Strumfa Pdf

Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.

Author : Catherine Alix-Panabieres,George Calin,Klaus Pantel
Publisher : Frontiers Media SA
Page : 310 pages
File Size : 49,8 Mb
Release : 2022-11-08
Category : Science
ISBN : 9782832504512

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Liquid Biopsy by Catherine Alix-Panabieres,George Calin,Klaus Pantel Pdf

Author : Antonio Russo,Ettore Capoluongo,Antonio Galvano,Antonio Giordano
Publisher : Academic Press
Page : 252 pages
File Size : 41,8 Mb
Release : 2022-11-03
Category : Science
ISBN : 9780128227114

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Liquid Biopsy by Antonio Russo,Ettore Capoluongo,Antonio Galvano,Antonio Giordano Pdf

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research.The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy. Presents a “highlights section in every chapter to help readers summarize the main aspects discussed Encompasses case reports to guide the reader on applying what they read in their clinical practice Includes several tables and figures specially created for the book to illustrate the meaning of what is expressed in the text

Author : Elisabetta Rossi,Matteo Bocci,Francesco Fabbri,Rui P. L. Neves
Publisher : Frontiers Media SA
Page : 199 pages
File Size : 49,9 Mb
Release : 2022-09-21
Category : Medical
ISBN : 9782832500194

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Liquid Biopsy: A Tool for Better Understanding of the Metastatic Process Ecosystem by Elisabetta Rossi,Matteo Bocci,Francesco Fabbri,Rui P. L. Neves Pdf