Locoregional Radionuclide Cancer Therapy

Author : Franklin C.L. Wong
Publisher : Springer Nature
Page : 271 pages
File Size : 48,8 Mb
Release : 2020-12-08
Category : Medical
ISBN : 9783030562670

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Locoregional Radionuclide Cancer Therapy by Franklin C.L. Wong Pdf

This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
Page : 564 pages
File Size : 45,7 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451153262

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Targeted Radionuclide Therapy by Tod W. Speer Pdf

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Author : Marco Chinol,Giovanni Paganelli
Publisher : CRC Press
Page : 382 pages
File Size : 53,5 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781000611571

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Radionuclide Peptide Cancer Therapy by Marco Chinol,Giovanni Paganelli Pdf

Offering lower toxicity and higher accuracy than conventional therapies, this source offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers. Accompanied by a CD offering color images, radiolabeling procedures, and tips on radiopharmceutical administration, this source will off

Author : Recep Bekiş,Berna Polack,Murat Fani Bozkurt
Publisher : Unknown
Page : 0 pages
File Size : 41,7 Mb
Release : 2022
Category : Electronic
ISBN : 3030972216

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Radionuclide Therapy by Recep Bekiş,Berna Polack,Murat Fani Bozkurt Pdf

The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.

Author : F. F. (Russ) Knapp,Ashutosh Dash
Publisher : Springer
Page : 347 pages
File Size : 41,8 Mb
Release : 2016-01-20
Category : Medical
ISBN : 9788132226079

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Radiopharmaceuticals for Therapy by F. F. (Russ) Knapp,Ashutosh Dash Pdf

This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.

Author : H. William Strauss,Giuliano Mariani,Duccio Volterrani,Steven M. Larson
Publisher : Springer Science & Business Media
Page : 877 pages
File Size : 40,9 Mb
Release : 2012-11-27
Category : Medical
ISBN : 9780387488943

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Nuclear Oncology by H. William Strauss,Giuliano Mariani,Duccio Volterrani,Steven M. Larson Pdf

This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.

Author : Richard P. Baum
Publisher : Springer
Page : 951 pages
File Size : 51,5 Mb
Release : 2014-08-16
Category : Medical
ISBN : 9783540367192

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Therapeutic Nuclear Medicine by Richard P. Baum Pdf

The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.

Author : Recep Bekiş,Berna Polack,Murat Fani Bozkurt
Publisher : Springer Nature
Page : 387 pages
File Size : 45,5 Mb
Release : 2022-08-01
Category : Medical
ISBN : 9783030972202

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Radionuclide Therapy by Recep Bekiş,Berna Polack,Murat Fani Bozkurt Pdf

The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.

Author : Anonim
Publisher : Unknown
Page : 301 pages
File Size : 45,9 Mb
Release : 2015
Category : Radioisotopes
ISBN : 9201210191

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Yttrium-90 and Rhenium-188 Radiopharmaceuticals for Radionuclide Therapy by Anonim Pdf

"A key requirement for the effective implementation of the therapeutic approach, based on the intravenous administration of radiolabelled compounds (radionuclide therapy), is the sufficient availability of radionuclides with appropriate physical characteristics. Based on their nuclear properties, 188Re and 90Y are considered among the most interesting radionuclides for therapy. Furthermore, they are produced through portable generators, which provide a crucial advantage toward ensuring a worldwide distribution of these radionuclides. This publication illustrates recent studies aimed at investigating efficient quality control methods to ensure both the radionuclidic purity of generator eluates, and the proper preparation of new target specific 188Re and 90Y radiopharmaceuticals for various clinical applications."--Publisher's description.

Author : Wai Lup Wong
Publisher : Springer
Page : 98 pages
File Size : 48,8 Mb
Release : 2018-02-01
Category : Medical
ISBN : 9783319614403

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PET/CT in Head and Neck Cancer by Wai Lup Wong Pdf

This pocket book is an up-to-date guide to the diagnostic imaging of head and neck cancers. The focus is particularly on FDG PET/CT, with coverage of the basic principles, clinical indications, typical and atypical appearances, normal variations and artifacts, advantages, limitations, and pitfalls. Consideration is also given to emerging roles for PET/CT in head and neck cancer, including radiotherapy planning and treatment response monitoring, and to radiotracers beyond FDG. In addition, succinct information is provided on clinical presentation, diagnosis, staging, pathology, management, and other diagnostic imaging techniques. A brief discourse on the practice of guideline adoption is included. The book is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging (compiled under the auspices of the British Nuclear Medicine Society) and will be an excellent asset for clinicians, nuclear medicine physicians, radiologists, radiographers, technologists, and nurses who work in the field of head and neck cancer.

Author : E. Edmund Kim
Publisher : World Scientific
Page : 473 pages
File Size : 42,5 Mb
Release : 2012
Category : Diagnostic imaging
ISBN : 9789814366236

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Handbook of Nuclear Medicine and Molecular Imaging by E. Edmund Kim Pdf

This handbook will provide updated information on nuclear medicine and molecular imaging techniques as well as its clinical applications, including radionuclide therapy, to trainees and practitioners of nuclear medicine, radiology and general medicine. Updated information on nuclear medicine and molecular imaging are vitally important and useful to both trainees and existing practitioners. Imaging techniques and agents are advancing and changing so rapidly that concise and pertinent information are absolutely necessary and helpful. It is hoped that this handbook will help readers be better equipped for the utilization of new imaging methods and treatments using radiopharmaceuticals.

Author : Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 46,6 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642256042

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Stereotactic Body Radiation Therapy by Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter Pdf

Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Author : Keith F. Eckerman,Akira Endo
Publisher : Snmmi
Page : 684 pages
File Size : 48,9 Mb
Release : 2007
Category : Decay schemes (Radioactivity)
ISBN : 0932004806

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MIRD: Radionuclide Data and Decay Schemes by Keith F. Eckerman,Akira Endo Pdf

Author : Sara Harsini,Abass Alavi,Nima Rezaei
Publisher : Springer Nature
Page : 532 pages
File Size : 52,6 Mb
Release : 2021-11-24
Category : Medical
ISBN : 9783030812614

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Nuclear Medicine and Immunology by Sara Harsini,Abass Alavi,Nima Rezaei Pdf

This book explores the close connection between immunology and nuclear medicine, which has led to radioimmunoimaging and radioimmunotherapy (RIT). Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly being used to diagnose, characterize, and monitor disease activity in the context of inflammatory disorders of known and unknown etiology, such as sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease, rheumatoid arthritis, and degenerative joint disease. The first chapters discuss the various radiopharmaceutical agents and radiolabeled preparations that have been employed in inflammation imaging. Of these, FDG-PET imaging has been shown to have the great value in the detection of inflammation and has become the centerpiece of several initiatives over the last several years. This very powerful technique will play an increasingly important role in the management of patients with inflammatory conditions in the future. The book also explores the growing role of nuclear medicine and molecular imaging in the diagnosis and treatment of cancer. The rapid pace of change has been fueled by advances in our understanding of tumor biology, on the one hand, and the development of specifically targeted medical therapies, diagnostic agents, and radiotherapies, on the other. Written by leading international experts in the field, this book is an invaluable tool for nuclear medicine physicians, radiologists, oncologists, and immunologists.

Author : Xiaoyuan Chen,Stephen Wong
Publisher : Academic Press
Page : 544 pages
File Size : 42,9 Mb
Release : 2014-03-20
Category : Medical
ISBN : 9780124078840

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Cancer Theranostics by Xiaoyuan Chen,Stephen Wong Pdf

Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management