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Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effectively!
Author : Donald L. Shapiro,Robert H. Notter Publisher : Alan R. Liss Page : 344 pages File Size : 54,7 Mb Release : 1989 Category : Medical ISBN : UOM:39015014473956
Lung Development by Claude Gaultier,Jacques R Bourbon,Martin Post Pdf
Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.
This book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information. Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental processes and multifactorial regulation; etiology and physiopathology of neonatal respiratory distress; and modern methods for functional explorations of the lung in neonates and experimental models in animals. The book also contains a discussion on the management of hyaline membrane disease, from both the experimental and clinical points of view.
Lung Surfactant Function and Disorder by Kaushik Nag Pdf
The only source to describe the lung surfactant as a complex membranous system, this guide analyzes lung surfactant function from the aspects of molecular biology, biophysics, membrane science, and surface and interface analysis and reviews the latest basic and clinical issues relating to lung disease and (dys)function.
Bengt Robertson,Lambert M. G. van Golde,Joseph J. Batenburg
Author : Bengt Robertson,Lambert M. G. van Golde,Joseph J. Batenburg Publisher : Elsevier Publishing Company Page : 800 pages File Size : 51,7 Mb Release : 1992 Category : Medical ISBN : UOM:39015029244137
Pulmonary Surfactant by Bengt Robertson,Lambert M. G. van Golde,Joseph J. Batenburg Pdf
There has been a spectacular development in both basic research on the pulmonary surfactant system and the clinical use of surfactant for treatment of lung diseases, especially in the neonatal period. In particular, the molecular biology and physiological roles of the surfactant-associated proteins (SP-A) have been clarified during the last few years; the structure and functions of these proteins therefore constitute an important hot topic, and are reviewed in several chapters of this volume. including surface chemistry and ultrastructure of surfactant components, the role of surfactant in lung mechanics and alveolar liquid homeostasis, and surfactant metabolism and its hormonal control. However, as mentioned above, clinical applications of surfactant research have become increasingly important and are therefore dealt with extensively in the remaining chapters. during the last few years to illustrate the fascinating complexity of the surfactant system. Hence, the main mission of this volume is to catalyze the future development in this field with the exchange of ideas between scientific workers from different disciplines.
Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen
Author : Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen Publisher : Elsevier Health Sciences Page : 1163 pages File Size : 55,8 Mb Release : 2012-02-25 Category : Medical ISBN : 9781455740505
Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book by Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen Pdf
Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.
Author : Alan H. Jobe,Jeffrey A. Whitsett,Steven H. Abman Publisher : Cambridge University Press Page : 128 pages File Size : 51,7 Mb Release : 2016-04-18 Category : Medical ISBN : 9781316665176
Fetal and Neonatal Lung Development by Alan H. Jobe,Jeffrey A. Whitsett,Steven H. Abman Pdf
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
Disorders of Lipid Metabolism by G.V. Marinetti Pdf
For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students. The major topics covered in my courses were fatty acids, prostaglandins, leukotrienes, phospholipids, glyco lipids, triacylglycerols, cholesterol, bile acids, and plasma lipoproteins. Empha sis was placed on the regulation and disorders of lipid metabolism. The latter included hyperlipidemias, atherosclerosis, and alcohol-induced liver damage. In this volume, I have chosen to focus on the disorders of lipid metabolism at a level appropriate both for medical students and for graduate and undergradu ate students majoring in the biological sciences. The biochemistry, nutrition, genetics, and cell biology aspects of lipids and lipid metabolism will be covered as they relate to lipid disorders. I am not aware of any textbook that integrates the disorders of lipid metabolism in this manner. Chapter 1 includes a brief discussion of the basic structures, properties, and metabolism of lipids. This chapter is not very detailed, since the material covered is available in basic textbooks on biochemistry. The major fpcus of this volume is the various lipid disorders, with emphasis on polyunsaturated fatty acids, the molecular biology and pathogenesis of the hyperlipidemias, dietary and drug therapy for the hyperlipidemias, and alcohol-induced liver damage. The material presented has been obtained from several textbooks on biochemistry and from a variety of recent articles in the scientific literature.
Effective Care of the Newborn Infant by John C. Sinclair,Michael B. Bracken Pdf
This companion volume to the highly acclaimed Effective Care in Pregnancy and Childbirth (OUP 1989, edited by Iain Chalmers et al.) evaluates the care of newborn infants. Medical research has produced an explosion of new knowledge concerning the causes, diagnosis, prognosis, treatment and prevention of diseases of the newborn infant. As the pace of therapeutic innovation quickens, there is an increasing need for efficient access to information concerning the probable effects of therapy. This book meets the urgent demand for a systematic summary of the best available evidence concerning the expected outcomes of therapeutic decisions in neonatology. This revolutionary work consists fundamentally of quantitative reviews of randomized trials of alternative courses of action. It contains some 2000 new analyses of data from the clinical trials literature, representing the vast majority of randomized trials in neonatology. The result is the first systematic review of evidence from randomized clinical trials in this field and an explicit dissection of the research data supporting, or in some cases not supporting, clinical management of the newborn. This book will interest pediatricians, especially neonatologists; obstetricians, especially maternal-fetal medicine specialists; family practitioners; and epidemiologists.
Surfactant Replacement Therapy by Burkhard Lachmann Pdf
I am very happy and honoured to have so many famous contrib utors from around the world presenting their knowledge and experience in this book, including Dr. Rufer who, as early as 1967, attempted to improve the pressure-volume curve of a child dying from RDS using dried surfactant from dogs; Drs. Enhorn ing and Robertson who were the first to treat rabbit fetuses with surfactant replacement and impressively demonstrated that sur factant improved lung mechanics; and Dr. Fujiwara who at the end of the 1970's had already successfully treated the first babies with surfactant replacement and published this work al ready in 1980. Thus, the idea of surfactant replacement therapy is now more or less 20 years old and almost 10 years have passed since the first publication by Dr. Fujiwara of his impressive clinical results. Up to now (September, 1988) about 2,200 babies have been treated worldwide with tracheal instillation of surfactant, with most promising results. The type of surfactant used varies from pure natural extracts from bovine or pig lungs, to surfactant extracted from human amniotic fluid, to pure phospholipids. To date, however, there is still no surfactant commercially available (except in Japan), in spite of the fact that it is urgently awaited by neonatologists and intensive care doctors throughout the world. This volume is based on the contributions presented at the international congress on Surfactant Replacement Therapy which was held in Rotterdam, The Netherlands, in November 1987.
James F. Lewis,Richard J. Novick,Rund A. W. Veldhuizen
Author : James F. Lewis,Richard J. Novick,Rund A. W. Veldhuizen Publisher : New York : Springer Page : 181 pages File Size : 54,6 Mb Release : 1997 Category : Lung Transplantation ISBN : 3540625801
Surfactant in Lung Injury and Lung Transplantation by James F. Lewis,Richard J. Novick,Rund A. W. Veldhuizen Pdf
Recent studies have shown significant alterations in pulmonary surfactant in animal models with acute lung injury, and in patients with ARDS and after experimental lung transplantation. Exogenous surfactant therapy has been successful in mitigating lung injury in a wide array of experimental models, including ischemia-reperfusion lung injury. This monograph reviews the alterations in the endogenous surfactant system in lung injury and lung transplantation, and discusses the role of exogenous surfactant therapy in these conditions. Innovative strategies to decrease lung injury are essential in order to improve the outcome of patients with respiratory failure.
