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Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effecti
Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effectively!
This book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information. Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental processes and multifactorial regulation; etiology and physiopathology of neonatal respiratory distress; and modern methods for functional explorations of the lung in neonates and experimental models in animals. The book also contains a discussion on the management of hyaline membrane disease, from both the experimental and clinical points of view.
Pulmonary Surfactant by Bengt Robertson,Lambert M. G. van Golde,Joseph J. Batenburg Pdf
There has been a spectacular development in both basic research on the pulmonary surfactant system and the clinical use of surfactant for treatment of lung diseases, especially in the neonatal period. In particular, the molecular biology and physiological roles of the surfactant-associated proteins (SP-A) have been clarified during the last few years; the structure and functions of these proteins therefore constitute an important hot topic, and are reviewed in several chapters of this volume. including surface chemistry and ultrastructure of surfactant components, the role of surfactant in lung mechanics and alveolar liquid homeostasis, and surfactant metabolism and its hormonal control. However, as mentioned above, clinical applications of surfactant research have become increasingly important and are therefore dealt with extensively in the remaining chapters. during the last few years to illustrate the fascinating complexity of the surfactant system. Hence, the main mission of this volume is to catalyze the future development in this field with the exchange of ideas between scientific workers from different disciplines.
Lung Surfactant Function and Disorder by Kaushik Nag Pdf
The only source to describe the lung surfactant as a complex membranous system, this guide analyzes lung surfactant function from the aspects of molecular biology, biophysics, membrane science, and surface and interface analysis and reviews the latest basic and clinical issues relating to lung disease and (dys)function.
Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen
Author : Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen Publisher : Elsevier Health Sciences Page : 1163 pages File Size : 45,7 Mb Release : 2012-02-25 Category : Medical ISBN : 9781455740505
Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book by Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen Pdf
Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by Venkataramana K Sidhaye,Michael Koval Pdf
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
Surfactant Replacement Therapy by Burkhard Lachmann Pdf
I am very happy and honoured to have so many famous contrib utors from around the world presenting their knowledge and experience in this book, including Dr. Rufer who, as early as 1967, attempted to improve the pressure-volume curve of a child dying from RDS using dried surfactant from dogs; Drs. Enhorn ing and Robertson who were the first to treat rabbit fetuses with surfactant replacement and impressively demonstrated that sur factant improved lung mechanics; and Dr. Fujiwara who at the end of the 1970's had already successfully treated the first babies with surfactant replacement and published this work al ready in 1980. Thus, the idea of surfactant replacement therapy is now more or less 20 years old and almost 10 years have passed since the first publication by Dr. Fujiwara of his impressive clinical results. Up to now (September, 1988) about 2,200 babies have been treated worldwide with tracheal instillation of surfactant, with most promising results. The type of surfactant used varies from pure natural extracts from bovine or pig lungs, to surfactant extracted from human amniotic fluid, to pure phospholipids. To date, however, there is still no surfactant commercially available (except in Japan), in spite of the fact that it is urgently awaited by neonatologists and intensive care doctors throughout the world. This volume is based on the contributions presented at the international congress on Surfactant Replacement Therapy which was held in Rotterdam, The Netherlands, in November 1987.
James F. Lewis,Richard J. Novick,Rund A. W. Veldhuizen
Author : James F. Lewis,Richard J. Novick,Rund A. W. Veldhuizen Publisher : New York : Springer Page : 181 pages File Size : 44,9 Mb Release : 1997 Category : Lung Transplantation ISBN : 3540625801
Surfactant in Lung Injury and Lung Transplantation by James F. Lewis,Richard J. Novick,Rund A. W. Veldhuizen Pdf
Recent studies have shown significant alterations in pulmonary surfactant in animal models with acute lung injury, and in patients with ARDS and after experimental lung transplantation. Exogenous surfactant therapy has been successful in mitigating lung injury in a wide array of experimental models, including ischemia-reperfusion lung injury. This monograph reviews the alterations in the endogenous surfactant system in lung injury and lung transplantation, and discusses the role of exogenous surfactant therapy in these conditions. Innovative strategies to decrease lung injury are essential in order to improve the outcome of patients with respiratory failure.
Lung Development by Claude Gaultier,Jacques R Bourbon,Martin Post Pdf
Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.
