Lymphoid Organogenesis

Author : Fritz Melchers
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642572760

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Lymphoid Organogenesis by Fritz Melchers Pdf

It has been clear for a long time that after transplantation of a lymphoid organ, hematopoietic stem cells can regenerate the compartments of the organ, provided that the rest of its architecture - the strome, the epithelia and the vessels - is intact. Ahead lies the even greater challenge to assemble also these other architectural elements of a lymphoid organ by transplanting stem cells. The workshop on lymphoid organogenesis was convened to review current knowledge of and experimental skills involved in this grand project to build a lymphoid organ from its individual cellular components.

Author : Rebekah Tuthill Taylor
Publisher : Unknown
Page : 0 pages
File Size : 55,6 Mb
Release : 2007
Category : Electronic
ISBN : OCLC:1426859324

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Lymphoid Organogenesis in the Small Intestine by Rebekah Tuthill Taylor Pdf

Author : William E. Paul
Publisher : Lippincott Williams & Wilkins
Page : 1658 pages
File Size : 54,7 Mb
Release : 2008
Category : Medical
ISBN : 0781765196

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Fundamental Immunology by William E. Paul Pdf

Now thoroughly revised and updated, this comprehensive, up-to-date text is ideal for graduate students, post-doctoral fellows, microbiologists, infectious disease physicians, and any physician who treats diseases in which immunologic mechanisms play a role.

Author : Changjun Yin,Andreas J.R. Habenicht,Sarajo Mohanta,Pasquale Maffia
Publisher : Frontiers Media SA
Page : 237 pages
File Size : 54,5 Mb
Release : 2017-05-22
Category : Electronic book
ISBN : 9782889451807

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Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity by Changjun Yin,Andreas J.R. Habenicht,Sarajo Mohanta,Pasquale Maffia Pdf

The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.

Author : Anonim
Publisher : Elsevier
Page : 392 pages
File Size : 45,6 Mb
Release : 2006-12-05
Category : Science
ISBN : 0080469086

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The Mouse in Biomedical Research by Anonim Pdf

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

Author : Peter Balogh
Publisher : Springer Science & Business Media
Page : 178 pages
File Size : 42,5 Mb
Release : 2010-11-04
Category : Medical
ISBN : 9783642144295

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Developmental Biology of Peripheral Lymphoid Organs by Peter Balogh Pdf

The human immune system is a complex network of tissues and organs dispersed throughout the body. Immunology, as one of the most rapidly evolving fields in bio¬medical research, has to date covered the essential cellular and molecular events neces¬sary for immune responses to occur. However, it has paid relatively little attention to important developmental processes underlying the formation of the tissues themselves that carry out immune responses in humans and other mammalians. In contrast to the thymus and bone marrow that are the sole tissues for generating mature leukocytes for antigen recognition and han¬dling in humans and most mammalian species, the peripheral lymphoid tissues where adaptive immune responses are focused display broad tissue distribution and possess diverse archi¬tectural characteristics. These organs develop prior to the individual’s exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny. This volume presents a comprehensive overview of the developmental features of the major peripheral lymphoid organs, thus examining the connection between immunological functionality and structural characteristics utilizing a developmental approach, for an audience ranging from undergraduate students to senior researchers in immunology, histology and clinical medicine.

Author : Sankar Ghosh
Publisher : CRC Press
Page : 246 pages
File Size : 54,6 Mb
Release : 2006-10-20
Category : Medical
ISBN : 9781420004274

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Handbook of Transcription Factor NF-kappaB by Sankar Ghosh Pdf

Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is prov

Author : Kenji Kabashima,Gyohei Egawa
Publisher : Springer Nature
Page : 163 pages
File Size : 44,9 Mb
Release : 2020-08-17
Category : Medical
ISBN : 9783030517472

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Inducible Lymphoid Organs by Kenji Kabashima,Gyohei Egawa Pdf

This book sheds new light on “inducible” lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions. The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context. Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.

Author : Jessica Borger,Joanna Kirman,Graham Le Gros
Publisher : Frontiers Media SA
Page : 191 pages
File Size : 45,7 Mb
Release : 2020-08-06
Category : Electronic
ISBN : 9782889639250

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The Role of Innate Lymphoid Cells in Mucosal Immunity by Jessica Borger,Joanna Kirman,Graham Le Gros Pdf

We acknowledge the initiation and support of this Research Topic by the InternationalUnion of Immunological Societies (IUIS). We hereby state publicly that the IUIS hashad no editorial input in articles included in this Research Topic, thus ensuring that allaspects of this Research Topic are evaluated objectively, unbiased by any specific policyor opinion of the IUIS.

Author : Tasuku Honjo,Fritz Melchers
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 40,7 Mb
Release : 2006-10-05
Category : Medical
ISBN : 9783540306573

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Gut-Associated Lymphoid Tissues by Tasuku Honjo,Fritz Melchers Pdf

The intestine is colonized by an impressive community of commensals, that has profound effects on the immune funtions. The relationship between gut microbiota and the immune system is one of reciprocity: commensals have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues plays a key role in shaping the repertoire of gut microbiota.

Author : Shoji Natsugoe
Publisher : Springer
Page : 358 pages
File Size : 42,5 Mb
Release : 2019-01-23
Category : Medical
ISBN : 9789811046995

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Lymph Node Metastasis in Gastrointestinal Cancer by Shoji Natsugoe Pdf

This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists.

Author : Jiri Mestecky,Warren Strober,Michael W. Russell,Hilde Cheroutre,Bart N. Lambrecht,Brian L Kelsall
Publisher : Academic Press
Page : 2540 pages
File Size : 50,5 Mb
Release : 2015-03-06
Category : Medical
ISBN : 9780124159754

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Mucosal Immunology by Jiri Mestecky,Warren Strober,Michael W. Russell,Hilde Cheroutre,Bart N. Lambrecht,Brian L Kelsall Pdf

Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. The most comprehensive text on mucosal immunology from internationally recognized experts in the field Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases Contains nine new chapters and an expanded appendix

Author : Vivek Verma,Catherine Sautes-Fridman,Anna Dimberg
Publisher : Frontiers Media SA
Page : 178 pages
File Size : 47,8 Mb
Release : 2022-04-06
Category : Medical
ISBN : 9782889748624

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Tertiary Lymphoid Structures: from Basic Biology to Translational Impact in Cancer by Vivek Verma,Catherine Sautes-Fridman,Anna Dimberg Pdf

Author : Xian C. Li,Anthony M. Jevnikar
Publisher : John Wiley & Sons
Page : 363 pages
File Size : 51,6 Mb
Release : 2015-11-16
Category : Medical
ISBN : 9780470658215

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Transplant Immunology by Xian C. Li,Anthony M. Jevnikar Pdf

With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: Transplant-related complications Immune responses to transplants Emerging issues in transplantation Biomarkers of Allograft rejection and tolerance T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

Author : Emmanuel Donnadieu
Publisher : Springer
Page : 199 pages
File Size : 49,9 Mb
Release : 2016-08-30
Category : Medical
ISBN : 9783319422237

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Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy by Emmanuel Donnadieu Pdf

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.