Machine Learning And Systems Biology In Genomics And Health

Author : Shailza Singh
Publisher : Springer Nature
Page : 239 pages
File Size : 40,6 Mb
Release : 2022-02-04
Category : Science
ISBN : 9789811659935

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Machine Learning and Systems Biology in Genomics and Health by Shailza Singh Pdf

This book discusses the application of machine learning in genomics. Machine Learning offers ample opportunities for Big Data to be assimilated and comprehended effectively using different frameworks. Stratification, diagnosis, classification and survival predictions encompass the different health care regimes representing unique challenges for data pre-processing, model training, refinement of the systems with clinical implications. The book discusses different models for in-depth analysis of different conditions. Machine Learning techniques have revolutionized genomic analysis. Different chapters of the book describe the role of Artificial Intelligence in clinical and genomic diagnostics. It discusses how systems biology is exploited in identifying the genetic markers for drug discovery and disease identification. Myriad number of diseases whether be infectious, metabolic, cancer can be dealt in effectively which combines the different omics data for precision medicine. Major breakthroughs in the field would help reflect more new innovations which are at their pinnacle stage. This book is useful for researchers in the fields of genomics, genetics, computational biology and bioinformatics.

Author : Gianni Russell
Publisher : States Academic Press
Page : 0 pages
File Size : 49,6 Mb
Release : 2023-09-26
Category : Electronic
ISBN : 163989733X

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Bioinformatics: The Machine Learning Approach by Gianni Russell Pdf

Bioinformatics is the application of tools of computation and analysis for capturing and interpreting biological data. Machine learning is a branch of artificial intelligence and computer science that has applications in multiple fields. Machine learning in bioinformatics involves the application of machine learning algorithms to bioinformatics such as proteomics, genomics, microarrays, evolution, text mining and systems biology. Genomics is a prominent area of bioinformatics involved in the study of genome mapping, genomic expression regulation, and genome evolution and editing. In medical diagnostics, some of the major applications of machine learning in genomics are genome sequencing, gene editing, and improving clinical workflow. This book outlines a machine learning approach towards bioinformatics. A number of latest researches have been included to keep the readers updated with the global concepts in this area of study. It aims to serve as a resource guide for students and experts alike and contribute to the growth of the discipline.

Author : Shyamasree Ghosh,Rathi Dasgupta
Publisher : Springer Nature
Page : 337 pages
File Size : 49,9 Mb
Release : 2022-05-04
Category : Medical
ISBN : 9789811688812

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Machine Learning in Biological Sciences by Shyamasree Ghosh,Rathi Dasgupta Pdf

This book gives an overview of applications of Machine Learning (ML) in diverse fields of biological sciences, including healthcare, animal sciences, agriculture, and plant sciences. Machine learning has major applications in process modelling, computer vision, signal processing, speech recognition, and language understanding and processing and life, and health sciences. It is increasingly used in understanding DNA patterns and in precision medicine. This book is divided into eight major sections, each containing chapters that describe the application of ML in a certain field. The book begins by giving an introduction to ML and the various ML methods. It then covers interesting and timely aspects such as applications in genetics, cell biology, the study of plant-pathogen interactions, and animal behavior. The book discusses computational methods for toxicity prediction of environmental chemicals and drugs, which forms a major domain of research in the field of biology. It is of relevance to post-graduate students and researchers interested in exploring the interdisciplinary areas of use of machine learning and deep learning in life sciences.

Author : Abedalrhman Alkhateeb,Luis Rueda
Publisher : Springer Nature
Page : 171 pages
File Size : 45,7 Mb
Release : 2023-12-15
Category : Science
ISBN : 9783031365027

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Machine Learning Methods for Multi-Omics Data Integration by Abedalrhman Alkhateeb,Luis Rueda Pdf

The advancement of biomedical engineering has enabled the generation of multi-omics data by developing high-throughput technologies, such as next-generation sequencing, mass spectrometry, and microarrays. Large-scale data sets for multiple omics platforms, including genomics, transcriptomics, proteomics, and metabolomics, have become more accessible and cost-effective over time. Integrating multi-omics data has become increasingly important in many research fields, such as bioinformatics, genomics, and systems biology. This integration allows researchers to understand complex interactions between biological molecules and pathways. It enables us to comprehensively understand complex biological systems, leading to new insights into disease mechanisms, drug discovery, and personalized medicine. Still, integrating various heterogeneous data types into a single learning model also comes with challenges. In this regard, learning algorithms have been vital in analyzing and integrating these large-scale heterogeneous data sets into one learning model. This book overviews the latest multi-omics technologies, machine learning techniques for data integration, and multi-omics databases for validation. It covers different types of learning for supervised and unsupervised learning techniques, including standard classifiers, deep learning, tensor factorization, ensemble learning, and clustering, among others. The book categorizes different levels of integrations, ranging from early, middle, or late-stage among multi-view models. The underlying models target different objectives, such as knowledge discovery, pattern recognition, disease-related biomarkers, and validation tools for multi-omics data. Finally, the book emphasizes practical applications and case studies, making it an essential resource for researchers and practitioners looking to apply machine learning to their multi-omics data sets. The book covers data preprocessing, feature selection, and model evaluation, providing readers with a practical guide to implementing machine learning techniques on various multi-omics data sets.

Author : Rabinarayan Satpathy,Tanupriya Choudhury,Suneeta Satpathy,Sachi Nandan Mohanty,Xiaobo Zhang
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 44,9 Mb
Release : 2021-01-20
Category : Computers
ISBN : 9781119785613

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Data Analytics in Bioinformatics by Rabinarayan Satpathy,Tanupriya Choudhury,Suneeta Satpathy,Sachi Nandan Mohanty,Xiaobo Zhang Pdf

Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel machine learning computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics approximating classification and prediction of disease, feature selection, dimensionality reduction, gene selection and classification of microarray data and many more.

Author : Altuna Akalin
Publisher : CRC Press
Page : 462 pages
File Size : 46,7 Mb
Release : 2020-12-16
Category : Mathematics
ISBN : 9781498781862

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Computational Genomics with R by Altuna Akalin Pdf

Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Author : W. Dubitzky,Francisco Azuaje
Publisher : Springer Science & Business Media
Page : 231 pages
File Size : 52,7 Mb
Release : 2007-09-29
Category : Science
ISBN : 9781402058110

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Artificial Intelligence Methods and Tools for Systems Biology by W. Dubitzky,Francisco Azuaje Pdf

This book provides simultaneously a design blueprint, user guide, research agenda, and communication platform for current and future developments in artificial intelligence (AI) approaches to systems biology. It places an emphasis on the molecular dimension of life phenomena and in one chapter on anatomical and functional modeling of the brain. As design blueprint, the book is intended for scientists and other professionals tasked with developing and using AI technologies in the context of life sciences research. As a user guide, this volume addresses the requirements of researchers to gain a basic understanding of key AI methodologies for life sciences research. Its emphasis is not on an intricate mathematical treatment of the presented AI methodologies. Instead, it aims at providing the users with a clear understanding and practical know-how of the methods. As a research agenda, the book is intended for computer and life science students, teachers, researchers, and managers who want to understand the state of the art of the presented methodologies and the areas in which gaps in our knowledge demand further research and development. Our aim was to maintain the readability and accessibility of a textbook throughout the chapters, rather than compiling a mere reference manual. The book is also intended as a communication platform seeking to bride the cultural and technological gap among key systems biology disciplines. To support this function, contributors have adopted a terminology and approach that appeal to audiences from different backgrounds.

Author : A. Suresh,S. Vimal,Y. Harold Robinson,Dhinesh Kumar Ramaswami,R. Udendhran
Publisher : John Wiley & Sons
Page : 356 pages
File Size : 41,7 Mb
Release : 2022-04-12
Category : Computers
ISBN : 9781119791836

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Bioinformatics and Medical Applications by A. Suresh,S. Vimal,Y. Harold Robinson,Dhinesh Kumar Ramaswami,R. Udendhran Pdf

BIOINFORMATICS AND MEDICAL APPLICATIONS The main topics addressed in this book are big data analytics problems in bioinformatics research such as microarray data analysis, sequence analysis, genomics-based analytics, disease network analysis, techniques for big data analytics, and health information technology. Bioinformatics and Medical Applications: Big Data Using Deep Learning Algorithms analyses massive biological datasets using computational approaches and the latest cutting-edge technologies to capture and interpret biological data. The book delivers various bioinformatics computational methods used to identify diseases at an early stage by assembling cutting-edge resources into a single collection designed to enlighten the reader on topics focusing on computer science, mathematics, and biology. In modern biology and medicine, bioinformatics is critical for data management. This book explains the bioinformatician’s important tools and examines how they are used to evaluate biological data and advance disease knowledge. The editors have curated a distinguished group of perceptive and concise chapters that presents the current state of medical treatments and systems and offers emerging solutions for a more personalized approach to healthcare. Applying deep learning techniques for data-driven solutions in health information allows automated analysis whose method can be more advantageous in supporting the problems arising from medical and health-related information. Audience The primary audience for the book includes specialists, researchers, postgraduates, designers, experts, and engineers, who are occupied with biometric research and security-related issues.

Author : K. G. Srinivasa,G. M. Siddesh,S. R. Manisekhar
Publisher : Springer Nature
Page : 318 pages
File Size : 47,7 Mb
Release : 2020-01-30
Category : Technology & Engineering
ISBN : 9789811524455

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Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications by K. G. Srinivasa,G. M. Siddesh,S. R. Manisekhar Pdf

This book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics. It also highlights the role of computing and machine learning in knowledge extraction from biological data, and how this knowledge can be applied in fields such as drug design, health supplements, gene therapy, proteomics and agriculture.

Author : Loveleen Gaur,Arun Solanki,Samuel Fosso Wamba,Noor Zaman Jhanjhi
Publisher : CRC Press
Page : 220 pages
File Size : 46,8 Mb
Release : 2021-10-17
Category : Technology & Engineering
ISBN : 9781000463019

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Advanced AI Techniques and Applications in Bioinformatics by Loveleen Gaur,Arun Solanki,Samuel Fosso Wamba,Noor Zaman Jhanjhi Pdf

The advanced AI techniques are essential for resolving various problematic aspects emerging in the field of bioinformatics. This book covers the recent approaches in artificial intelligence and machine learning methods and their applications in Genome and Gene editing, cancer drug discovery classification, and the protein folding algorithms among others. Deep learning, which is widely used in image processing, is also applicable in bioinformatics as one of the most popular artificial intelligence approaches. The wide range of applications discussed in this book are an indispensable resource for computer scientists, engineers, biologists, mathematicians, physicians, and medical informaticists. Features: Focusses on the cross-disciplinary relation between computer science and biology and the role of machine learning methods in resolving complex problems in bioinformatics Provides a comprehensive and balanced blend of topics and applications using various advanced algorithms Presents cutting-edge research methodologies in the area of AI methods when applied to bioinformatics and innovative solutions Discusses the AI/ML techniques, their use, and their potential for use in common and future bioinformatics applications Includes recent achievements in AI and bioinformatics contributed by a global team of researchers

Author : Bharath Ramsundar,Peter Eastman,Patrick Walters,Vijay Pande
Publisher : "O'Reilly Media, Inc."
Page : 244 pages
File Size : 48,8 Mb
Release : 2019-04-10
Category : Science
ISBN : 9781492039785

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Deep Learning for the Life Sciences by Bharath Ramsundar,Peter Eastman,Patrick Walters,Vijay Pande Pdf

Deep learning has already achieved remarkable results in many fields. Now it’s making waves throughout the sciences broadly and the life sciences in particular. This practical book teaches developers and scientists how to use deep learning for genomics, chemistry, biophysics, microscopy, medical analysis, and other fields. Ideal for practicing developers and scientists ready to apply their skills to scientific applications such as biology, genetics, and drug discovery, this book introduces several deep network primitives. You’ll follow a case study on the problem of designing new therapeutics that ties together physics, chemistry, biology, and medicine—an example that represents one of science’s greatest challenges. Learn the basics of performing machine learning on molecular data Understand why deep learning is a powerful tool for genetics and genomics Apply deep learning to understand biophysical systems Get a brief introduction to machine learning with DeepChem Use deep learning to analyze microscopic images Analyze medical scans using deep learning techniques Learn about variational autoencoders and generative adversarial networks Interpret what your model is doing and how it’s working

Author : Angelo Facchiano,Dominik Heider,Davide Chicco
Publisher : Frontiers Media SA
Page : 175 pages
File Size : 51,7 Mb
Release : 2020-06-18
Category : Electronic
ISBN : 9782889637522

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Artificial Intelligence Bioinformatics: Development and Application of Tools for Omics and Inter-Omics Studies by Angelo Facchiano,Dominik Heider,Davide Chicco Pdf

Author : Davide Bacciu,Paulo J G Lisboa,Alfredo Vellido
Publisher : World Scientific
Page : 333 pages
File Size : 50,9 Mb
Release : 2022-01-17
Category : Computers
ISBN : 9781800610958

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Deep Learning In Biology And Medicine by Davide Bacciu,Paulo J G Lisboa,Alfredo Vellido Pdf

Biology, medicine and biochemistry have become data-centric fields for which Deep Learning methods are delivering groundbreaking results. Addressing high impact challenges, Deep Learning in Biology and Medicine provides an accessible and organic collection of Deep Learning essays on bioinformatics and medicine. It caters for a wide readership, ranging from machine learning practitioners and data scientists seeking methodological knowledge to address biomedical applications, to life science specialists in search of a gentle reference for advanced data analytics.With contributions from internationally renowned experts, the book covers foundational methodologies in a wide spectrum of life sciences applications, including electronic health record processing, diagnostic imaging, text processing, as well as omics-data processing. This survey of consolidated problems is complemented by a selection of advanced applications, including cheminformatics and biomedical interaction network analysis. A modern and mindful approach to the use of data-driven methodologies in the life sciences also requires careful consideration of the associated societal, ethical, legal and transparency challenges, which are covered in the concluding chapters of this book.

Author : Kumar Selvarajoo
Publisher : Springer Nature
Page : 457 pages
File Size : 42,5 Mb
Release : 2022-10-13
Category : Science
ISBN : 9781071626177

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Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology by Kumar Selvarajoo Pdf

This volume provides protocols for computational, statistical, and machine learning methods that are mainly applied to the study of metabolic engineering, synthetic biology, and disease applications. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biological complexity. The topics covered in this book are geared toward researchers with a background in engineering, computational analytical, and modeling experience and cover a broad range of topics in computational and machine learning approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology is a valuable resource for any researcher or scientist who wants to learn more about the latest computational methods and how they are applied toward the understanding and prediction of complex biology.

Author : Yanqing Zhang,Jagath C. Rajapakse
Publisher : John Wiley & Sons
Page : 476 pages
File Size : 55,6 Mb
Release : 2009-02-23
Category : Computers
ISBN : 9780470397411

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Machine Learning in Bioinformatics by Yanqing Zhang,Jagath C. Rajapakse Pdf

An introduction to machine learning methods and their applications to problems in bioinformatics Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. From an internationally recognized panel of prominent researchers in the field, Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics. Coverage includes: feature selection for genomic and proteomic data mining; comparing variable selection methods in gene selection and classification of microarray data; fuzzy gene mining; sequence-based prediction of residue-level properties in proteins; probabilistic methods for long-range features in biosequences; and much more. Machine Learning in Bioinformatics is an indispensable resource for computer scientists, engineers, biologists, mathematicians, researchers, clinicians, physicians, and medical informaticists. It is also a valuable reference text for computer science, engineering, and biology courses at the upper undergraduate and graduate levels.